Search

The article explores the impact of thyroid dysfunction on heart health and highlights the role of micronutrients in managing related cardiac symptoms. It discusses how both hypo- and hyperthyroidism affect heart function and suggests that essential nutrients like iodine, selenium, magnesium, and others can help improve cardiac conditions associated with thyroid disorders. It also notes that while thyroid medications are crucial, adding vital nutrients can enhance cardiac outcomes.

This article will highlight the oral disease risk factors present in patients with Graves' disease and help restructure the dental management for these patients. Graves' disease is an autoimmune disorder affecting thyroid function and is the most common cause of hyperthyroidism, which is the overproduction of thyroid hormone. Graves' disease positively correlates with periodontitis and can also cause a greater susceptibility to dental caries, osteoporosis of the maxilla and mandible, burning mouth syndrome, and Sjögren's syndrome. Collaboration between dental professionals and endocrinologists is needed to ensure optimal oral and systemic health for patients with Graves' disease and to accelerate the prevention and detection of the associated oral diseases. Dental professionals should be aware of the symptoms of Graves' disease and adverse reactions to treatment options. A shorter dental recall interval for patients with Graves' disease is beneficial for preventing and arresting multiple dental diseases. [ABSTRACT FROM AUTHOR]

Researchers at Sun Yat-sen University First Affiliated Hospital in China conducted a study on patients with Graves' ophthalmopathy (GO) using optical coherence tomography (OCT) to analyze choroidal components. The study found that patients with active GO had thicker choroids and larger stromal areas compared to those with inactive GO. Factors such as age, diopter, and intraocular pressure were identified as independent factors affecting choroidal area and components in patients with GO. Further research with larger sample sizes is recommended for a better understanding of these findings. [Extracted from the article]

A recent study conducted at Bournemouth University focused on improving carbimazole dosing for patients with autoimmune hyperthyroidism using machine learning models. The research aimed to streamline the dose adjustment process, reduce treatment delays, and alleviate pressure on healthcare professionals. By analyzing data from 421 hyperthyroidism patients, the study found that a random forest approach yielded the best results with an average F1 score of 0.731. The research suggests that implementing this model in practice could lead to improved accuracy over time. [Extracted from the article]

A study conducted at Christian Medical College and Hospital Vellore in southern India focused on thyrotoxic periodic paralysis, a rare manifestation of thyrotoxicosis. The research compared clinical and biochemical features, treatment outcomes, and prevalence of different conditions among patients with and without paralysis. The study found that serum potassium, free T4, and Total T3 levels were significantly lower in patients with periodic paralysis compared to those without. This study provides valuable insights into this condition and its management, contributing to the existing research on thyrotoxicosis. [Extracted from the article]

Researchers at Seoul National University Bundang Hospital in South Korea are conducting a study on artificial intelligence-based CT-free quantitative thyroid SPECT for thyrotoxicosis. The study aims to compare the diagnostic accuracy of CT-free SPECT and SPECT/CT for the differential diagnosis of thyrotoxicosis. Funders for this research include the Korean Society of Nuclear Medicine and the National Research Foundation of Korea. The study protocol has been approved by the institutional review boards of several hospitals in South Korea. Findings from this research will be disseminated through reports, presentations, and peer-reviewed journal articles. [Extracted from the article]

A recent study conducted at I.M. Sechenov First Moscow State Medical University focused on the efficacy of tablet glucocorticoids in patients with type 2 amiodarone-induced thyrotoxicosis. The study compared two starting doses of prednisolone and found no significant differences in the time to euthyroidism, duration of thyrotoxicosis, or rate of relapses between the two groups. High doses of glucocorticoids were associated with more severe side effects, and potential factors influencing the clinical course of thyrotoxicosis included age, body mass index, and cumulative amiodarone dose. [Extracted from the article]

A case report from Bangalore Medical College and Research Institute discusses a middle-aged male patient who presented with manic symptoms due to thyrotoxicosis, a condition characterized by excessive thyroid hormone levels. The patient was diagnosed with a thyroid storm secondary to Graves' disease and was treated with lithium and antipsychotics to address the manic symptoms. The research emphasizes the importance of considering medical causes in psychiatric presentations and highlights the need for early diagnosis and multidisciplinary management to reduce morbidity. [Extracted from the article]

A study conducted by the Catholic University of Korea focused on the association between methimazole tapering and intractable Graves' disease in children. The research involved 93 patients with Graves' disease, with 28% classified as the 'remission group' and 72% as the 'intractable group.' The study found that difficulty in tapering the methimazole dosage in the first 4 months of treatment was an independent predicting factor for intractable Graves' disease. The research was published in Pediatrics International and can be accessed online for further information. [Extracted from the article]

A recent study conducted by the Faculty of Medicine University of Indonesia focused on pediatric Graves' disease, the most common cause of hyperthyroidism in children and adolescents. The study highlighted the challenges in diagnosing and treating pediatric GD in Indonesia, emphasizing the importance of total thyroidectomy as a definitive therapy. The research analyzed cases of pediatric GD over an eight-year period, noting that all patients presented with neck lumps and experienced postoperative complications such as hoarseness and hypocalcemia. The study concluded that close postoperative surveillance is necessary for pediatric GD patients undergoing total thyroidectomy. [Extracted from the article]

A study conducted at the Second Affiliated Hospital of Chongqing Medical University in China explored the use of 131I and/or artificial liver support system (ALSS) in managing hyperthyroidism and liver failure. The research involved 74 patients with severe liver failure due to Graves' disease, divided into three groups receiving different treatments. Results showed that combining 131I and ALSS led to better outcomes in terms of thyroid and liver function compared to using ALSS alone. The study recommended prompt administration of 131I in cases of severe liver failure with hyperthyroidism to improve liver function and reduce mortality rates. [Extracted from the article]

A study conducted at Sichuan University in Chengdu, People's Republic of China, explored the relationship between gut microbiota and autoimmune thyroid diseases, specifically Graves' disease and Hashimoto's thyroiditis. The research utilized genome-wide association study data to analyze the causal impacts of specific gut microbiota on these diseases and identified immune cell traits that mediate these effects. The study found that certain gut microbiota taxa were associated with autoimmune thyroid diseases and highlighted potential mediating immunophenotypes. This research provides evidence supporting causal relationships between specific gut microbiota and autoimmune thyroid diseases. [Extracted from the article]

Researchers at the University of Mosul conducted a study on the interplay between growth hormone and thyroid hormones in hypo- and hyperthyroid conditions in male rats. The study involved different groups of rats receiving various hormone treatments to observe physiological impacts and genetic effects. Results showed significant differences in thyroid stimulating hormone, Triiodothyronine, Thyroxin, Reverse Triiodothyronine, and other hormone levels across the groups. The research emphasized the interconnectedness of hormonal systems and the importance of a comprehensive endocrine approach. For more information, the full study can be accessed in the Mesopotamia Journal of Agriculture. [Extracted from the article]

A study conducted by Guilan University of Medical Sciences in Iran investigated the frequency of hypocalcemia (low calcium levels) following total thyroidectomy in patients with hyperthyroidism. The study found that out of 49 patients, 20 experienced hypocalcemia after surgery, with most of them being women. The results showed that vitamin D deficiency was significantly associated with hypocalcemia. The researchers concluded that hypocalcemia can occur in patients with hyperthyroidism unrelated to parathyroid damage, and clinicians should consider prophylaxis supplements to reduce its incidence, especially in women. [Extracted from the article]

Researchers from the University of Isfahan in Iran have published a comprehensive review on the relationship between immune checkpoints and Graves' disease, thyroid eye disease, and orbital myopathy. Immune checkpoints are important regulators of the immune system, but their inhibition as a cancer treatment strategy can sometimes lead to autoimmune diseases. The study focuses on the biological mechanisms of immune checkpoints targeted in cancer therapy, such as CTLA-4, PD-1, PDL-1, and LAG3, and explores the potential risks and adverse events associated with their inhibition, particularly in ocular and orbital tissues. This research provides valuable insights into the immune-checkpoint axis in autoimmune diseases and its implications for cancer treatment. [Extracted from the article]

A recent study conducted by researchers at the Department of Endocrinology and Metabolism investigated the association between drugs used in the treatment of hyperthyroidism and the risk of acute pancreatitis (AP). The study analyzed data from over 85 million patient records and found that the use of propylthiouracil (PTU) increased the probability of AP diagnosis, while the use of propranolol decreased the risk. However, there was no statistically significant association between the use of methimazole (MMI) and the risk of AP. The researchers concluded that understanding the drugs associated with drug-induced acute pancreatitis is important for appropriate diagnosis and treatment. [Extracted from the article]

Researchers from Zhejiang Chinese Medical University in Hangzhou, China have conducted a study to investigate the causal relationship between gut microbiota (GM) and six thyroid diseases (TDs). Using genome-wide association study (GWAS) data, they identified specific microbial taxa that were linked to the risk of each TD. The study found that certain microbial taxa exhibited protective effects against some TDs, while others increased the risk. These findings provide evidence for a genetic-level causal connection between GM and TDs, which could lead to further research on potential mechanisms and therapeutic targets. [Extracted from the article]

A recent study conducted by researchers at Al Andalus University for Medical Sciences has provided new insights into hypokalemic periodic paralysis (HypoPP). HypoPP is a rare genetic disorder characterized by recurrent episodes of muscle weakness and low levels of potassium in the blood. The study focused on a case of a 40-year-old African American man who presented with muscle weakness and was diagnosed with familial HypoPP and hyperthyroidism induced by Graves' disease. The researchers emphasized the importance of considering a genetic basis for HypoPP in patients with a family history of the condition, even when hyperthyroidism is present. Treatment should focus on correcting low potassium levels, managing hyperthyroidism, and making lifestyle modifications to prevent recurrence. [Extracted from the article]

Two patients with hyperthyroidism developed adverse drug reactions (ADRs) while being treated with propylthiouracil or thiamazole, as reported in a retrospective study. One patient experienced neutropenia and did not respond to propylthiouracil treatment, while the other developed a rash and switched from thiamazole to propylthiouracil. The outcomes of these ADRs were not specified in the study. [Extracted from the article]

A retrospective study in the journal "Reactions Weekly" reported on six cases of drug-induced thyrotoxicosis in patients treated with amiodarone. The study, conducted from January 2006 to December 2008, found that the patients developed this condition, with thyroid gland volumes ranging from 25.3-84mL, suggesting thyroid volume overload. The article did not provide specific details on the patients' ages, sexes, indications for treatment, routes, dosages, durations of treatments, or outcomes. [Extracted from the article]

A new study conducted at Wollo University in Ethiopia has found that atrial fibrillation (AF) is the most prevalent heart symptom of hyperthyroidism. The study aimed to determine the prevalence and associated factors of AF among adult hyperthyroid patients attending the University of Gondar Referral Hospital. The researchers found that AF was present in 14% of the patients, and identified age over 61 years, female sex, and high serum FT4 levels as significant predictors of AF in hyperthyroid patients. This study provides valuable insights into the relationship between hyperthyroidism and AF. [Extracted from the article]

A recent study conducted by researchers at Link Campus University in Rome, Italy, has shed light on myxedema, a potentially life-threatening condition associated with severe hypothyroidism. The researchers found that myxedema can also occur in hyperthyroidism, although the exact cause and mechanism of this paradoxical situation are not yet clear. The study analyzed body fluid distribution in 103 thyroid patients and found that differences in fluid body composition were more evident in hyperthyroidism than in hypothyroidism. The researchers concluded that myxedema represents a hormetic response to thyroid hormones and that bioelectrical impedance analysis (BIA) can be a valuable method for evaluating and monitoring body fluid composition in severe thyroid dysfunctions. [Extracted from the article]

A new report from Changi General Hospital discusses research findings on Graves' disease. The report focuses on a case study of a Singaporean Chinese female with Graves' disease who experienced persistent bilateral atypical femoral fractures (AFFs). The patient had a complete right AFF that required surgical fixation and a persistent left incomplete AFF for over four years. The research suggests that factors such as femoral bowing, varus femoral geometry, and ethnic influence may have contributed to the formation of the AFFs. This case study provides insights into the pathogenesis of AFFs in high-risk Asian populations. [Extracted from the article]

A study conducted at Ito Hospital in Tokyo, Japan, evaluated the effectiveness of machine learning in predicting thyrotoxicosis and hypothyroidism. The study analyzed data from untreated patients with Graves' disease, painless thyroiditis, Hashimoto's thyroiditis, and healthy individuals. The results showed that machine learning had a high discriminative capacity for distinguishing thyrotoxicosis and hypothyroidism patients from the healthy control group. The researchers concluded that machine learning is a powerful screening tool for these thyroid conditions. This research has been peer-reviewed and published in Internal Medicine. [Extracted from the article]

Researchers from Nanjing University of Chinese Medicine have conducted a study on hyperthyroidism, specifically focusing on the pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction (HYD) in treating the condition. The study utilized network pharmacology, molecular docking, and non-targeted serum metabolomics to identify therapeutic targets and hub genes associated with hyperthyroidism. Through their analysis, the researchers identified 214 common targets between HYD compounds and therapeutic targets of hyperthyroidism, which were mainly enriched in biological processes related to gene expression, MAPK cascade, and protein phosphorylation. The study concluded that HYD exerts its pharmacological effect on hyperthyroidism by inhibiting pathological angiogenesis in the thyroid and rebalancing immunity. [Extracted from the article]

Researchers from the Universidad Nacional de Cordoba in Argentina have published a case report on a 28-year-old Latin American woman with Graves' disease who developed insulin autoimmune syndrome (IAS) and subsequently became pregnant. The woman experienced severe hypoglycemia due to hyperinsulinemia, elevated C-peptide, and anti-insulin antibodies. She was treated with corticosteroids and underwent ablative treatment with iodine-131 before becoming pregnant. During pregnancy, her thyroid function remained normal, and she gave birth to a healthy baby girl. Genetic analysis revealed specific genotypes associated with susceptibility to IAS. The researchers advised the patient to avoid certain drugs and triggering factors for IAS in the future. The daughter remained healthy and had normal growth and development at the 6-month and 5-year follow-ups. [Extracted from the article]

A research study conducted by Shandong University of Traditional Chinese Medicine aimed to explore the correlation between dilated cardiomyopathy (DCM) and various factors using the Mendelian randomization (MR) approach. The study analyzed data from genome-wide association study databases and found that titin, CTnI, and desmocollin-2 proteins were identified as independent risk factors for DCM. However, no causal relationship was found between DCM and the perinatal period, alcoholism, Behcet's disease, systemic lupus erythematosus, hyperthyroidism and thyrotoxicosis, hypothyroidism, carnitine metabolic disorder, or renal insufficiency. The study concluded that previous observational studies may have overestimated the associations between DCM and these factors. [Extracted from the article]

A recent study conducted at Aarhus University Hospital in Denmark examined the effects of vitamin D supplementation on bone health in patients with Graves' disease, a condition that can lead to bone loss. The study found that adding vitamin D supplementation to standard care did not improve bone density or microarchitecture in these patients. However, treatment for thyrotoxicosis, a symptom of Graves' disease, was associated with improvements in bone density and microarchitecture. The study suggests that vitamin D supplementation may not offer benefits for skeletal health in newly diagnosed Graves' disease patients. [Extracted from the article]

A study conducted at the University of Campinas in Brazil has found that smoking and age are predictive factors for cardiac autonomic neuropathy (CAN) in patients with Graves' disease (GD). The researchers evaluated euthyroid GD patients and a control group of healthy euthyroid individuals. They diagnosed CAN in 20% of GD patients and 14% in the control group. The study highlights the importance of evaluating CAN as a possible complication in GD patients and suggests that smoking increases the risk of CAN in these individuals. [Extracted from the article]

A study conducted at Wannan Medical College in Anhui, China aimed to develop a prediction model for pulmonary artery hypertension (PAH) in patients with hyperthyroidism. The study involved 166 hyperthyroid patients and found that a nomogram model combining the tricuspid annular plane systolic excursion (TAPSE)/PASP ratio with serological markers and conventional ultrasound parameters demonstrated strong predictive performance for PAH. The researchers concluded that this model could be a valuable tool for assessing the risk of developing PAH in hyperthyroidism patients. The study was supported by the Anhui Province Public Welfare Technology Application Research Linkage Program. [Extracted from the article]

A report from Sestre Milosrdnice University Hospital in Zagreb, Croatia discusses the rare occurrence of alternating hypothyroidism and hyperthyroidism in a pediatric patient. The case study focuses on a 12-year-old boy who experienced fluctuations in thyroid function over a period of six years. Despite persistently elevated thyroid peroxidase antibodies, thyroid stimulating hormone receptor antibodies were repeatedly negative. The research emphasizes the need for individualized therapeutic decisions based on clinical manifestations and thyroid function tests, regardless of the underlying cause. [Extracted from the article]

A recent study conducted at State University Campinas in Brazil explored the role of MMP-9, a protein involved in inflammation, in Graves' disease and thyroid eye disease (TED). The researchers found that levels of MMP-9 were higher in patients with active TED compared to healthy controls. They also observed that MMP-9 levels were lower in patients with inactive TED who underwent certain treatments, and that MMP-9 was associated with thyroid function in patients with Graves' disease without TED. These findings suggest that MMP-9 may play a role in both the active phase of TED and the inflammation associated with Graves' disease. [Extracted from the article]

A recent study conducted at St. Luke's Medical Center in Quezon City, Philippines focused on Graves disease, an autoimmune condition that affects the thyroid gland. The study examined a 56-year-old Filipino male who presented with bilateral lower limb swelling. The patient had a history of Graves' disease and was initially treated with methimazole for thyrotoxicosis. Five months prior to consultation, he received oral radioactive iodine for definitive treatment. The study provides further information on the dermatopathy, acropachy, and orbitopathy associated with Graves' disease. For more details, the full article can be accessed through the Journal of the ASEAN Federation of Endocrine Societies. [Extracted from the article]

A study conducted by the National and Kapodistrian University of Athens in Greece explores the concomitant presentation of thyroid-associated ophthalmopathy (TAO) and ocular myasthenia gravis in patients with Graves Disease (GD). The research highlights the occurrence of symptomatic transient neuromuscular junction disorder due to the effect of thyroid hormones at the neuromuscular synapse. Diagnostic clues for this disorder include clinical and electrophysiologic remission synchronous with restoration of euthyroidism, as well as the occurrence of thymic hyperplasia in GD. The study provides a case report of a 43-year-old male patient with TAO and transient neuromuscular junction disorder due to GD. [Extracted from the article]

A researcher from Lanzhou University in China has conducted a study on hyperthyroidism, specifically focusing on the clinical application of thyrotropin receptor antibodies (TRAb). TRAb is important in the diagnosis, prognosis, and treatment of Graves' disease (GD), a common cause of hyperthyroidism. The study discusses the use of TRAb in the differential diagnosis of hyperthyroidism, the prognosis of GD, GD in gestation and pediatrics, and GD-related ophthalmopathy. The research concludes that regular measurement of TRAb is crucial in guiding treatment decisions for GD in pregnancy and pediatric patients, as well as in monitoring the progression of GD-related ophthalmopathy. [Extracted from the article]

A case report published in Reactions Weekly describes a 31-year-old man who did not respond to treatment with thiamazole and lithium for thyrotoxicosis. The man, who was at risk of thyroid storm, received thiamazole initially and later started receiving lithium. However, despite these treatments, he did not show any therapeutic response. As a result, the man underwent plasmapheresis. The report does not provide information on the outcome or duration of the treatment. [Extracted from the article]