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After pylorus-resecting pancreatoduodenectomy (PrPD), delayed gastric emptying (DGE) might partially be attributed to biliary reflux. We investigated whether the incidence of primary DGE is reduced after Roux-en-Y instead of Billroth-II reconstruction.

Colorectal surgery still experiences high rates of infectious complications, such as anastomotic leakage (AL) and surgical site infections (SSIs). Therefore, oral antibiotic bowel decontamination (OABD) has experienced a renaissance. However, data on perioperative selective digestive tract decontamination (SDD)–based regimens or combined bowel preparation are inconsistent. Nonetheless, with widespread use of Enhanced Recovery After Surgery concepts, the ideal length for perioperative SDD treatment has to be reconsidered.

Surveillance fishing surveys can be performed to estimate the proportion of farmed salmon represented in the spawning stock of native Atlantic Salmon Salmo salarpopulations. These surveys take place after the recreational fishing period and therefore closer to the spawning period than the open recreational fishing season. Although catch‐and‐release angling has been demonstrated to affect salmon migration during the summer months, surveillance fishing that is conducted close to the spawning time could have more severe effects. To test this, the migration distance of Atlantic Salmon (n= 74) caught in the Orkla River, Norway, was tracked by use of radiotelemetry. One group was tagged during the regular fishing season in the summer (control group), whereas another group was tagged in autumn during surveillance fishing (surveillance group). Sixty‐one salmon remained for analysis after we excluded fish that were recaptured, died, or migrated to other rivers. Relocation of the salmon during autumn (October 11–31) was used to compare movements and test for differences in migration using negative binomial regression because distances were nonnegative integers. During the tracking period, the surveillance group moved 12 ± 14 km (mean ± standard deviation) and the control group moved 13 ± 15 km; both groups moved 1 ± 2 km/day on average. There was no evidence that surveillance fishing impacted movement of the salmon compared to controls. However, one salmon died after tagging and three were not released due to injuries; total mortality of 9% during surveillance fishing could be unsustainable for smaller populations. Consequently, factors such as surveillance sample size, the status of the salmon population, and the population size should be assessed for each river individually when deciding the necessity of and approach to surveillance fishing. The results support existing recommendations to use careful handling and to end surveillance at least 2 weeks prior to the expected onset of spawning, thus providing a sufficiently long period for recovery after surveillance fishing. Impact statementSurveillance fishing is a method to determine the number of farmed salmon in a river. Capture and release of wild salmon during an autumn surveillance period may negatively impact these important spawners, but we found that movement of surveillance‐captured fish was not different from a control group. Surveillance fishing is a method to determine the number of farmed salmon in a river. Capture and release of wild salmon during an autumn surveillance period may negatively impact these important spawners, but we found that movement of surveillance‐captured fish was not different from a control group.

The critical micelle concentration (CMC) of surfactant molecules is an essential property for surfactant applications in the industry. Recently, classical quantitative structure–property relationship (QSPR) and graph neural networks (GNNs), a deep learning technique, have been successfully applied to predict the CMC of surfactants at room temperature. However, these models have not yet considered the temperature dependence of the CMC, which is highly relevant to practical applications. We herein develop a GNN model for the temperature-dependent CMC prediction of surfactants. We collected about 1400 data points from public sources for all surfactant classes, i.e., ionic, nonionic, and zwitterionic, at multiple temperatures. We test the predictive quality of the model for the following scenarios: (i) when CMC data for surfactants are present in the training of the model in at least one different temperature and (ii) CMC data for surfactants are not present in the training, i.e., generalizing to unseen surfactants. In both test scenarios, our model exhibits a high predictive performance of R2≥ 0.95 on test data. We also find that the model performance varies with the surfactant class. Finally, we evaluate the model for sugar-based surfactants with complex molecular structures, as these represent a more sustainable alternative to synthetic surfactants and are therefore of great interest for future applications in the personal and home care industries.

Laser-induced crystallization is a novel alternative to classical methods for crystallizing organic molecules but requires a judicious choice of experimental parameters for the onset of crystallization to be predictable. This study investigated the impact of the laser repetition rate on the time delay from the start of the pulsed laser illumination to the initiation of crystallization, the so-called induction time. A supersaturated urea solution was irradiated with near-infrared (? = 1030 nm) laser pulses of pulse duration t = 5 ps at a pulse energy of approximately E= 340 µJ while varying the repetition rate from 10 to 20,000 Hz. The optimal rate discovered ranged from 500 Hz to 1 kHz, quantified by the measured induction time (median 2–5 s) and the mean probability of inducing a successful crystallization event (5 × 10–2%). For higher repetition rates (5–20 kHz), the mean probability dropped to 3 × 10–3%. The reduced efficiency at high repetition rates is likely due to an interaction between an existing thermocavitation bubble and subsequent pulses. These results suggest that an optimized pulse repetition rate can be a means to gain further control over the laser-induced crystallization process.

We report piperazine-fused six-membered-cyclic disulfides as redox substrates that unlock best-in-class bioreduction probes for live cell biology, since their self-immolation after reduction is unprecedentedly rapid. We develop scalable, diastereomerically pure, six-step syntheses that access four key cis- and trans-piperazine-fused cyclic dichalcogenides without chromatography. Fluorogenic redox probes using the disulfide piperazines are activated >100-fold faster than the prior art monoamines, allowing us to deconvolute reduction and cyclization rates during activation. The cis-and trans-fused diastereomers have remarkably different reductant specificities, which we trace back to piperazine boat/chair conformation effects: the cis-fused disulfide C-DiThiais activated only by strong vicinal dithiol reductants, but the trans-disulfide T-DiThiais activated even by moderate concentrations of monothiols such as GSH. Thus, in cellular applications, cis-disulfide probes selectively report on the reductive activity of the powerful thioredoxin proteins, while trans-disulfides are rapidly but promiscuously reactive. Finally, we showcase late-stage diversifications of the piperazine-disulfides, promising their broad applicability as redox-cleavable cores for probes and prodrugs that interface powerfully with cellular thiol/disulfide redox biology, for solid phase synthesis and purification, and for stimulus-responsive linkers in bifunctional reagents and antibody-drug conjugates - in addition to their dithiols’ potential as high-performance reducing agents.

Even though the number of studies aiming to improve comprehension of ADHD pathology has increased in recent years, there still is an urgent need for more effective studies, particularly in understanding adult ADHD, both at preclinical and clinical levels, due to the increasing evidence that adult ADHD is highly distinct and a different entity from childhood ADHD. This review paper outlines the symptoms, diagnostics, and neurobiological mechanisms of ADHD, with emphasis on how adult ADHD could be different from childhood-onset. Data show a difference in the environmental, genetic, epigenetic, and brain structural changes, when combined, could greatly impact the behavioral presentations and the severity of ADHD in adults. Furthermore, a crucial aspect in the quest to fully understand this disorder could be through longitudinal analysis. In this way, we will determine if and how the pathology and pharmacology of ADHD change with age. This goal could revolutionize our understanding of the disorder and address the weaknesses in the current clinical classification systems, improving the characterization and validity of ADHD diagnosis, specifically those in adults.

In two phase 3 trials for first-line therapy in adults with HIV-1, doravirine showed non-inferior efficacy, a favourable safety profile, and a superior lipid profile to darunavir and efavirenz through to 48 and 96 weeks. Here we report 192-week results from both studies.

TABLE OF CONTENTS Introduction 410 I. The Scope of the Problem 414 A. The Number of Abandoned Mine Lands 415 B. The Number of Affected Watersheds 417 C. Probability Theory [...]

BackgroundYoung patients suffering from cryptogenic stroke alongside a patent foramen ovale (PFO) are often considered for percutaneous device closure to reduce the risk of stroke recurrence. Residual right-to-left shunt after device closure may persist in approximately a quarter of the patients at 6 months, and some may close at a later time point. This study aimed to assess the prevalence and persistence of residual right-to-left shunt after percutaneous PFO closure.MethodsConsecutive patients undergoing transoesophageal echocardiography-guided PFO closure for cryptogenic stroke between 2006 and 2021, with echocardiographic follow-up including contrast bubble study and Valsalva manoeuvre, were enrolled. Follow-up transthoracic echocardiography was performed at 6 months and repeated at 12 months in case of residual right-to-left shunt. Primary outcomes included the prevalence and grade of residual right-to-left shunt at 6 and 12 months after percutaneous PFO closure.Results227 patients were included with a mean age of 43±11 years and 50.2% were women. At 6-month follow-up, 72.7% had no residual right-to-left shunt, 12.3% small residual right-to-left shunt, 6.6% moderate residual right-to-left shunt and 8.4% large residual right-to-left shunt. At 12-month follow-up, the presence of residual right-to-left shunt in all patients was 12.3%, of whom 6.6% had small residual right-to-left shunt, 2.6% had moderate residual right-to-left shunt and 3.1% had large residual right-to-left shunt.ConclusionsResidual right-to-left shunts are common at 6 months after percutaneous closure of PFO. However, the majority are small and two-thirds of residual right-to-left shunts achieve complete closure between 6 and 12 months.

Volumetric brain atlases are increasingly used to integrate and analyze diverse experimental neuroscience data acquired from animal models, but until recently a publicly available digital atlas with complete coverage of the rat brain has been missing. Here we present an update of the Waxholm Space rat brain atlas, a comprehensive open-access volumetric atlas resource. This brain atlas features annotations of 222 structures, of which 112 are new and 57 revised compared to previous versions. It provides a detailed map of the cerebral cortex, hippocampal region, striatopallidal areas, midbrain dopaminergic system, thalamic cell groups, the auditory system and main fiber tracts. We document the criteria underlying the annotations and demonstrate how the atlas with related tools and workflows can be used to support interpretation, integration, analysis and dissemination of experimental rat brain data.

The aim of this study is to apply and evaluate the usefulness of the hybrid classifier to predict the presence of serious coronary artery disease based on clinical data and 24-hour Holter ECG monitoring. Our approach relies on an ensemble classifier applying the distributivity equation aggregating base classifiers accordingly. Such a method may be helpful for physicians in the management of patients with coronary artery disease, in particular in the face of limited access to invasive diagnostic tests, i.e., coronary angiography, or in the case of contraindications to its performance. The paper includes results of experiments performed on medical data obtained from the Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland. The data set contains clinical data, data from Holter ECG (24-hour ECG monitoring), and coronary angiography. A leave-one-out cross-validation technique is used for the performance evaluation of the classifiers on a data set using the WEKA (Waikato Environment for Knowledge Analysis) tool. We present the results of comparing our hybrid algorithm created from aggregation with the distributive equation of selected classification algorithms (multilayer perceptron network, support vector machine, k-nearest neighbors, naïve Bayes, and random forests) with themselves on raw data.

Engineered living materials (ELMs) are the most relevant contemporary revolution in the field of materials science. ELMs aim to generate next-generation advanced materials, outperforming current examples of smart, active, or multifunctional materials. Current examples of ELMs have mostly focused on either cell-derived biofilms or polymer-based hybrid living materials. This article aims to establish carbon materials as ideal candidates for the non-living counterpart in a hybrid living material system because of their excellent biocompatibility and unique functional properties. Hybrid living carbon materials (HLCMs), arising from the cooperation of living cells and functional carbon scaffold, can potentially offer a variety of exciting properties, significantly superior to other examples of ELMs. Furthermore, the existence of several carbon allotropes can lead to the development of different families of HLCMs, expanding the opportunities for ELMs. This article emphasizes the potential of HLCMs by reviewing currently available examples of HLCMs, identifying current challenges, and proposing a methodology for HLCMs. These HLCMs can exhibit revolutionary potential in a plethora of applications, ranging from biomedical and biotechnological applications to space exploration.

Background: Phenprocoumon is a vitamin K antagonist that is widely prescribed in Europe and Latin America for the prophylaxis and treatment of thromboembolic events.Case Presentation: A 90-year-old female was admitted to our hospital with tonic-clonic seizures, possibly due to dementia syndrome.Valproic acid (VPA) was prescribed for the treatment of seizures. VPA is an inhibitor of cytochrome P450 (CYP) 2C9 enzymes. A pharmacokinetic interaction with phenprocoumon occurred, which is a substrate for CYP2C9 enzymes. The interaction resulted in a strong INR increase and subsequent clinically relevant bleeding in our patient.Valproic acid is not specifically mentioned in the phenprocoumon drug label as a CYP2C9 inhibitor, and in the Dutch medication surveillance database, no medication alert is shown when prescribing this combination, and no interaction with phenprocoumon has been reported so far.Conclusion: When prescribing this combination, the prescriber should be warned and advised to intensify INR monitoring if the combination is to be continued.

The appropriate duration of postoperative antibiotics for complex appendicitis is unclear. The increasing global threat of antimicrobial resistance warrants restrictive antibiotic use, which could also reduce side-effects, length of hospital stay, and costs.

The design methods for gradient coils are mostly based on discrete extrinsic methods (e.g., the Biot–Savartintegration calculation), for which the surface normal vector strongly influences any numerical calculation of the discretized surface. Previous studies are mostly based on regular or analytical surfaces, which allow normal vectors to be expressed analytically. For certain applications, design methods for extending current-carrying surfaces from developable or analytic geometries to arbitrary surfaces generated from a scanned point cloud are required. The key task is to correctly express the discretized normal vectors to ensure geometrical accuracy of the designed coils. Mathematically, it has been proven that applying a Delaunay triangulation to approximate a smooth surface can result in the discrete elemental normal vectors converging to those of the original surface. Accordingly, this article uses Delaunay triangulation to expand upon previous design methods so that they encompass arbitrary piecewise continuous surfaces. Two design methods, the stream function and the so-called solid isotropic material with penalization (SIMP) method, are used to design circumvolute and noncircumvolute gradient coils on general surfaces.

Co-design of alternative fuels and future spark-ignition (SI) engines allows very high engine efficiencies to be achieved. To tailor the fuel’s molecular structure to the needs of SI engines with very high compression ratios, computer-aided molecular design (CAMD) of renewable fuels has received considerable attention over the past decade. To date, CAMD for fuels is typically performed by computationally screening the physicochemical properties of single molecules against property targets. However, achievable SI engine efficiency is the result of the combined effect of various fuel properties, and molecules should not be discarded because of individual unfavorable properties that can be compensated for. Therefore, we present an optimization-based fuel design method directly targeting SI engine efficiency as the objective function. Specifically, we employ an empirical model to assess the achievable relative engine efficiency increase compared to conventional RON95 gasoline for each candidate fuel as a function of fuel properties. For this purpose, we integrate the automated prediction of various fuel properties into the fuel design method: Thermodynamic properties are calculated by COSMO-RS; combustion properties, indicators for environment, health and safety, and synthesizability are predicted using machine learning models. The method is applied to design pure-component fuels and binary ethanol-containing fuel blends. The optimal pure-component fuel tert-butyl formate is predicted to yield a relative efficiency increase of approximately 8% and the optimal fuel blend with ethanol and 3,4-dimethyl-3-propan-2-yl-1-pentene of 19%.

In this paper, we present the design and experimental validation of a miniaturized Overhauser dynamic nuclear polarization (ODNP) platform for both continuous-wave (CW) and pulsed DNP enhancement experiments at a B0field strength of 0.25T. The platform is centered around chip-integrated nuclear magnetic resonance (NMR) and microwave (MW) electronics and further incorporates a custom-designed laser-engraved ODNP probe, providing phase-coherent radio frequency (RF) excitation, low-noise amplification and acquisition of NMR signals, MW frequency synthesis, MW signal modulation, and MW power amplification. An experimental validation using TEMPOL solutions with different concentrations demonstrates the functionality and good performance of the presented ODNP platform. A maximum enhancement of −92with CW pumping was achieved using a 500nL 10mM non-degassed TEMPOL solution in water, representing the largest enhancement achieved to date in a chip-based ODNP platform. We also include a preliminary comparison between CW pumping and pulsed pumping using TEMPOL solutions with different electron relaxation times (apparent T1e∗and T2e). Our study indicates that, for a power-limited miniaturized ODNP platform, pulsed pumping can surpass CW pumping in power efficiency for a given average power when the solution possesses a sufficiently long electron spin-lattice relaxation time.

•Spinal MR-imaging in MOGAD, MS, anti-AQP4-IgG positive NMOSD and double seronegative children with clinical signs of TM does show important differences at disease onset.•Children with TM and antibodies to MOG show a faster resolution of radiological lesions compared to children with MS and NMOSD.•Interestingly, children with anti-MOG-IgG and double seronegative children initially show a similar radiological disease course.

This paper presents a topology optimization approach for the surface flows on variable design domains. Via this approach, the matching between the pattern of a surface flow and the 2-manifold used to define the pattern can be optimized, where the 2-manifold is implicitly defined on another fixed 2-manifold named as the base manifold. The fiber bundle topology optimization approach is developed based on the description of the topological structure of the surface flow by using the differential geometry concept of the fiber bundle. The material distribution method is used to achieve the evolution of the pattern of the surface flow. The evolution of the implicit 2-manifold is realized via a homeomorphous map. The design variable of the pattern of the surface flow and that of the implicit 2-manifold are regularized by two sequentially implemented surface-PDE filters. The two surface-PDE filters are coupled, because they are defined on the implicit 2-manifold and base manifold, respectively. The surface Navier-Stokes equations, defined on the implicit 2-manifold, are used to describe the surface flow. The fiber bundle topology optimization problem is analyzed using the continuous adjoint method implemented on the first-order Sobolev space. Several numerical examples have been provided to demonstrate this approach, where the combination of the viscous dissipation and pressure drop is used as the design objective.

Nuclear magnetic resonance (NMR) spectroscopy is commonly employed in a wide range of metabolomic research. Unfortunately, due to its relatively low sensitivity, smaller samples become challenging to study by NMR. Cryoprobes can be used to increase sensitivity by cooling the coil and preamplifier, offering sensitivity improvements of ∼3 to 4x. Alternatively, microcoils can be used to increase mass sensitivity by improving sample filling and proximity, along with decreased electrical resistance. Unfortunately, combining the two approaches is not just technically challenging, but as the coil decreases, so does its thermal fingerprint, reducing the advantage of cryogenic cooling. Here, an alternative solution is proposed in the form of a Lenz lens inside a cryoprobe. Rather than replacing the detection coil, Lenz lenses allow the B1field from a larger coil to be refocused onto a much smaller sample area. In turn, the stronger B1field at the sample provides strong coupling to the cryocoil, improving the signal. By combining a 530 I.D. Lenz lens with a cryoprobe, sensitivity was further improved by 2.8xand 3.5xfor 1H and 13C, respectively, over the cryoprobe alone for small samples. Additionally, the broadband nature of the Lenz lenses allowed multiple nuclei to be studied and heteronuclear two-dimensional (2D) NMR approaches to be employed. The sensitivity improvements and 2D capabilities are demonstrated on 430 nL of hemolymph and eight eggs (∼350 μm O.D.) from the model organismDaphnia magna. In summary, combining Lenz lenses with cryoprobes offers a relatively simple approach to boost sensitivity for tiny samples while retaining cryoprobe advantages.

Whereas truncating variants of the giant protein Titin (TTNtv) are the main cause of familial dilated cardiomyopathy (DCM), recently Filamin C truncating variants (FLNCtv) were identified as a cause of arrhythmogenic cardiomyopathy (ACM). Our aim was to characterize and compare clinical and MRI features of TTNtvand FLNCtvin the Belgian population. In index patients referred for genetic testing of ACM/DCM, FLNCtvand TTNtvwere found in 17 (3.6%) and 33 (12.3%) subjects, respectively. Further family cascade screening yielded 24 and 19 additional truncating variant carriers in FLNCand TTN, respectively. The main phenotype was ACM in FLNCtvcarriers whereas TTNtvcarriers showed either an ACM or DCM phenotype. Non-sustained Ventricular Tachycardia was frequent in both populations. MRI data, available in 28/40 FLNCtvand 32/52 TTNtvpatients, showed lower Left Ventricular (LV) ejection fraction and lower LV strain in TTNtvpatients (p< 0.01). Conversely, both the frequency (68% vs 22%) and extent of non-ischemic myocardial late gadolinium enhancement (LGE) was significantly higher in FLNCtvpatients (p< 0.01). Hereby, ring-like LGE was found in 16/19 (84%) FLNCtvversus 1/7 (14%) of TTNtvpatients (p< 0.01). In conclusion, a large number of FLNCtvand TTNtvpatients present with an ACM phenotype but can be separated by cardiac MRI. Whereas FLNCtvpatients often have extensive myocardial fibrosis, typically following a ring-like pattern, LV dysfunction without or limited replacement fibrosis is the common TTNtvphenotype.

The use of low-cost cyanide heap leaching techniques to recover metal from ores has allowed miners to profitably extract gold deposits. The chemical compound has on occasion been mishandled, and [...]

INTRODUCTION I. BARRIERS TO AND BENEFITS OF BROWNFIELD DEVELOPMENT A. Regulatory, Financial, and Physical Barriers to Brownfield Development B. Challenges to Communities Where Brownfields are Left Undeveloped C. Benefits of [...]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.im.2008.09.004 Byline: Yoris A. Au, Darrell Carpenter, Xiaogang Chen, Jan G. Clark Keywords: Virtual organizational learning; Organizational learning curve; Virtual organization; Open source software; Software development; Project performance Abstract: We studied virtual organizational learning in open source software (OSS) development projects. Specifically, our research focused on learning effects of OSS projects and the factors that affect the learning process. The number and percentage of resolved bugs and bug resolution time of 118 SourceForge.net OSS projects were used to measure the learning effects. Projects were characterized by project type, number and experience of developers, number of bugs, and bug resolution time. Our results provided evidence of virtual organizational learning in OSS development projects and support for several factors as determinants of performance. Team size was a significant predictor, with mid-sized project teams functioning best. Teams of three to seven developers exhibited the highest efficiency over time and teams of eight to 15 produced the lowest mean time for bug resolution. Increasing the percentage of bugs assigned to specific developers or boosting developer participation in other OSS projects also improved performance. Furthermore, project type introduced variability in project team performance. Author Affiliation: Department of Information Systems and Technology Management, College of Business, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA Article History: Received 3 May 2007; Revised 23 May 2008; Accepted 26 September 2008

Although they are not as favorable as other influential gas sensors, metal-oxide semiconductor-based chemiresistors ensure minimal surface reactivity, restricting their gas selectivity, gas response, and reaction kinetics, particularly when functioning at room temperature (RT). A hybrid design, which includes metal-oxide/carbon nanostructures and passivation with specific gas filtration layers, can address the concerns of surface reactivity. We present a novel hierarchical nanostructured zinc oxide (ZnO), decorated with graphitic carbon (GC) and synthesized via a wet-chemical strategy, which is then followed by the self-assembly of a zeolitic imidazolate framework (ZIF-8). Because of its large surface area, high porosity, and efficient inspection of other analyte (interfering) gases, the ZnO@GC can provide intensified surface reactivity at RT. In the present study, such a hybrid sensor confirmed extraordinary gas sensing properties, which was characterized by excellent H2selectivity, fast response, rapid recovery kinetics, and high gas response (ΔR/R0∼ 124.6%@10 ppm), particularly in extremely humid environments. The results reveal that adsorption sites provided by the ZIF-8 template-based ZnO@GC frameworks facilitate the adsorption and desorption of H2.

ABSTRACTPrenatal exposure to endocrine disrupting chemicals can interfere with development, and has been associated with social-cognitive functioning and adverse health outcomes later in life. Exposure-associated changes of DNA methylation (DNAm) patterns have been suggested as a possible mediator of this relationship. This study investigated whether prenatal low-dose exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) is associated with altered DNAm patterns across the genome in a Western urban-industrial population. In 142 mother-infant pairs from the Duisburg Birth Cohort Study, PCBs and PCDD/Fs levels were quantified from maternal blood during late pregnancy and associated with DNAm levels in cord blood using the Illumina EPIC beadchip. The epigenome-wide association studies (EWAS) identified 32 significantly differentially methylated positions (DMPs) and eight differentially methylated regions (DMRs) associated with six congeners of PCB and PCDD in females or males (FDRs < 0.05). DMPs and DMRs mapped to genes involved in neurodevelopment, gene regulation, and immune functioning. Weighted gene correlation network analysis (WGCNA) showed 31 co-methylated modules (FDRs < 0.05) associated with one congener of PCDF levels in females. Results of both analytical strategies indicate that prenatal exposure to PCBs and PCDD/Fs is associated with altered DNAm of genes involved in neurodevelopment, gene expression and immune functioning. DNAm and gene expression levels of several of these genes were previously associated with EDC exposure in rodent models. Follow-up studies will clarify whether these epigenetic changes might contribute to the origin for adverse mental and health outcomes.

Acetaldehyd kommt natürlicherweise in zahlreichen Lebensmitteln vor und wird aufgrund seines fruchtigen Aromas auch als Aromastoff eingesetzt. Die Internationale Agentur für Krebsforschung (IARC) stufte Acetaldehyd als möglicherweise krebserregend sowie in Verbindung mit der oralen Aufnahme über alkoholhaltige Getränke als humanes Kanzerogen ein. Vor diesem Hintergrund stellt sich die Frage, ob die Verwendung von Acetaldehyd als Aromastoff weiterhin vertretbar ist. Die Senatskommission zur gesundheitlichen Bewertung von Lebensmitteln (SKLM) der Deutschen Forschungsgemeinschaft (DFG) hat die aktuelle Datenlage zur Bewertung des gesundheitlichen Risikos der Verwendung von Acetaldehyd als Aromastoff geprüft und hierzu eine Stellungnahme verabschiedet. Demnach kann die Frage, ob Acetaldehyd nach oraler Exposition in vivo gentoxisch und mutagen wirkt, derzeit nicht abschließend beantwortet werden. Weiterhin ist auch unklar, welchen Beitrag die Verwendung von Acetaldehyd als Aromastoff zur Gesamtexposition des Verbrauchers gegenüber Acetaldehyd leistet. Eine wissenschaftliche Bewertung des gesundheitlichen Risikos der Verwendung von Acetaldehyd als Aromastoff ist daher weiterhin nicht möglich. Die SKLM weist darauf hin, dass aufgrund des gentoxischen Gefährdungspotenzials sowie zahlreicher Datenlücken, die für eine vollständige Risikobewertung geschlossen werden müssen, Zweifel an der Sicherheit von Acetaldehyd als Aromastoff bestehen. Nach Ansicht der SKLM sollte der gezielte Zusatz von Acetaldehyd als Aromastoff aus Gründen des vorsorgenden Verbraucherschutzes neu beurteilt werden.

The autofluorescence reader (AFR) is used to assess skin autofluorescence of arm and leg in women with an early-onset preeclampsia and also investigate its relationship with intima-media thickness (IMT) of carotid and femoral arteries, which are markers of early atherosclerosis. The results have indicated an accelerated atherosclerosis in recently preeclamptic women and also the possible involvement of advanced glycation end-product accumulation.

An 18-year-old man was transferred to our ICU because of progressive renal and hepatic failure. Three weeks earlier, he had been admitted to another hospital because of a 1-week history [...]

Abstract The use of amphetamine and 'ecstasy' (MDMA) has increased exponentially in many European countries since the late nineties, leading to a rapid growth in the number of clinical and [...]

Abstract We present a validated method for the simultaneous analysis of basic drugs which comprises a sample clean-up step, using mixed-mode solid-phase extraction (SPE), followed by LC-MS/MS analysis. Deuterated analogues [...]

Study objective: Part 1: To describe eases of emphysema (subcutaneous and/or mediastinal) and pneumothorax after percutaneous dilational tracheostomy (PDT) in a series of 326 patients, and to review the existing [...]