1. 2-Undecanone derived from Pseudomonas aeruginosa modulates the neutrophil activity.
- Author
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Jeong YS, Huh S, Kim JC, Park JY, Lee C, Kim MS, Koo J, and Bae YS
- Subjects
- Animals, Ketones, Mice, Neutrophils metabolism, Pseudomonas Infections metabolism, Pseudomonas aeruginosa
- Abstract
Pseudomonas aeruginosa (P. aeruginosa) is a well-known Gramnegative opportunistic pathogen. Neutrophils play key roles in mediating host defense against P. aeruginosa infection. In this study, we identified a metabolite derived from P. aeruginosa that regulates neutrophil activities. Using gas chromatography-mass spectrometry, a markedly increased level of 2-undecanone was identified in the peritoneal fluid of P. aeruginosa-infected mice. 2-Undecanone elicited the activation of neutrophils in a G
αi -phospholipase C pathway. However, 2-undecanone strongly inhibited responses to lipopolysaccharide and bactericidal activity of neutrophils against P. aeruginosa by inducing apoptosis. Our results demonstrate that 2-undecanone from P. aeruginosa limits the innate defense activity of neutrophils, suggesting that the production of inhibitory metabolites is a strategy of P. aeruginosa for escaping the host immune system. [BMB Reports 2022; 55(8): 395-400].- Published
- 2022