1. Bioactive Benzofuran Neolignans from Aristolochia fordiana.
- Author
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Zhong-bo Zhou, Jian-guang Luo, Ke Pan, Si-ming Shan, Wei Zhang, and Ling-yi Kong
- Subjects
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CHROMATOGRAPHIC analysis , *ANIMAL experimentation , *BIOLOGICAL assay , *CELL culture , *HETEROCYCLIC compounds , *LIGNANS , *MASS spectrometry , *MICE , *MOLECULAR structure , *NITRIC oxide , *NUCLEAR magnetic resonance spectroscopy , *PHARMACEUTICAL chemistry , *RESEARCH funding , *TOXICITY testing , *PLANT anatomy , *LIPOPOLYSACCHARIDES , *DESCRIPTIVE statistics - Abstract
Six new benzofuran neolignans (1-6) were isolated from the EtOAc-soluble fraction of the aerial part of Aristolochia fordiana, together with twelve known analogues (7-18). The structures of the isolated compounds were elucidated by spectroscopic methods. All isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccaride-activated RAW264.7 macrophages and for their cytotoxic activities on three human cancer cell lines. Compound 2 showed significant nitric oxide production inhibitory activity with an IC50 value of 10.00 μM, while compound 16 exhibited cytotoxic activity with an IC50 value of 11.9 μM against MG-63 and compound 18 of 9.15 μM against HepG2 cell lines, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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