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A reconfigurable transducer interface circuit that combines the communication and signal conditioning necessary to link a variety of sensors and actuators to a microsystem controller is reported. The adaptive readout circuitry supports high-resolution signal acquisition from capacitive, resistive, voltage and current mode sensors with programmable control of gain and offset to match sensor range and sensitivity. The chip accommodates sensor self test and self calibration and supports several power management schemes. It provides digital and analog outputs to control actuators and a standard interface to peripheral components. The 2.2 × 2.2 mm CMOS chip was fabricated in 0.5-μm, 3-metal, 2-poly process, dissipates ∼ 50 μW at 3.3 V in a typical multisensor application utilizing periodic sleep mode, and can read out a wide range of sensors with high sensitivity. A prototype microsystem with a microcontroller and MEMS pressure, humidity, and temperature sensors has been implemented to characterize interface chip performance. [ABSTRACT FROM AUTHOR]