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Ion-conducting polymer membranes are essential in many separation processes and electrochemical devices, including electrodialysis1, redox flow batteries2, fuel cells3and electrolysers4,5. Controlling ion transport and selectivity in these membranes largely hinges on the manipulation of pore size. Although membrane pore structures can be designed in the dry state6, they are redefined upon hydration owing to swelling in electrolyte solutions. Strategies to control pore hydration and a deeper understanding of pore structure evolution are vital for accurate pore size tuning. Here we report polymer membranes containing pendant groups of varying hydrophobicity, strategically positioned near charged groups to regulate their hydration capacity and pore swelling. Modulation of the hydrated micropore size (less than two nanometres) enables direct control over water and ion transport across broad length scales, as quantified by spectroscopic and computational methods. Ion selectivity improves in hydration-restrained pores created by more hydrophobic pendant groups. These highly interconnected ion transport channels, with tuned pore gate sizes, show higher ionic conductivity and orders-of-magnitude lower permeation rates of redox-active species compared with conventional membranes, enabling stable cycling of energy-dense aqueous organic redox flow batteries. This pore size tailoring approach provides a promising avenue to membranes with precisely controlled ionic and molecular transport functions.

The incorporation of photoresponsive groups into porous materials is attractive as it offers potential advantages in controlling the pore size and selectivity to guest molecules. A combination of computational modeling and experiment resulted in the synthesis of two azobenzene-derived organic cages based on building blocks identified in a computational screen. Both cages incorporate three azobenzene moieties, and are therefore capable of 3-fold isomerization, using either ditopic or tetratopic aldehydes containing diazene functionality. The ditopic aldehyde forms a Tri2Di3cage via a 6-fold imine condensation and the tritopic aldehyde forms a Tet3Di6cage via a 12-fold imine condensation. The relative energies and corresponding intrinsic cavities of each isomeric state were computed, and the photoswitching behavior of both cages was studied by UV–Vis and 1H NMR spectroscopy, including a detailed kinetic analysis of the thermal isomerization for each of the EEZ, EZZand ZZZmetastable isomers of the Tet3Di6cage. Both cages underwent photoisomerization, where a photostationary state of up to 77% of the cis-isomer and overall thermal half-life of 110 h was identified for the Tet3Di6species. Overall, this work demonstrates the potential of computational modeling to inform the design of photoresponsive materials and highlights the contrasting effects on the photoswitching properties of the azobenzene moieties on incorporation into the different cage species.

•Germ line ERG LOF variants predispose to cytopenias and HMs.•Somatic genetic rescue of ERG pathogenic variants in hematopoietic tissues impacts diagnosis, disease severity, and potential for correction.

IMPORTANCE: Pediatric oncology patients are increasingly recognized as having an underlying cancer predisposition syndrome (CPS). Surveillance is often recommended to detect new tumors at their earliest and most curable stages. Data on the effectiveness and outcomes of surveillance for children with CPS are limited. OBJECTIVE: To evaluate the performance of surveillance across a wide spectrum of CPSs. DESIGN, SETTING, AND PARTICIPANTS: This cohort study reviewed surveillance outcomes for children and young adults from birth to age 23 years with a clinical and/or molecular CPS diagnosis from January 1, 2009, through September 31, 2021. Patients were monitored using standard surveillance regimens for their corresponding CPS at a specialty pediatric oncology center. Patients with hereditary retinoblastoma and bone marrow failure syndromes were excluded. Data were analyzed between August 1, 2021, and December 6, 2023. EXPOSURE: Cancer predisposition syndrome. MAIN OUTCOMES AND MEASURES: Outcomes of surveillance were reviewed to evaluate the incidence, spectrum, and clinical course of newly detected tumors. Surveillance modalities were classified for accuracy and assessed for common strengths and weaknesses. RESULTS: A total of 274 children and young adults (mean age, 8 years [range, birth to 23 years]; 144 female [52.6%]) with 35 different CPSs were included, with a median follow-up of 3 years (range, 1 month to 12 years). During the study period, 35 asymptomatic tumors were detected in 27 patients through surveillance (9.9% of the cohort), while 5 symptomatic tumors were detected in 5 patients (1.8% of the cohort) outside of surveillance, 2 of whom also had tumors detected through surveillance. Ten of the 35 tumors (28.6%) were identified on first surveillance imaging. Malignant solid and brain tumors identified through surveillance were more often localized (20 of 24 [83.3%]) than similar tumors detected before CPS diagnosis (71 of 125 [56.8%]; P < .001). Of the 24 tumors identified through surveillance and surgically resected, 17 (70.8%) had completely negative margins. When analyzed across all imaging modalities, the sensitivity (96.4%), specificity (99.6%), positive predictive value (94.3%), and negative predictive value (99.6%) of surveillance were high, with few false-positive (6 [0.4%]) or false-negative (5 [0.3%]) findings. CONCLUSIONS AND RELEVANCE: These findings suggest that standardized surveillance enables early detection of new tumors across a wide spectrum of CPSs, allowing for complete surgical resection and successful treatment in the majority of patients.

What is certain, based on Djuna's film criticism, is that Djuna loves Anna Paquin, Cate Blanchett, and movies with strong female leads - and likes to poke fun at the autoerotic repetitions in the movies of Hong Sang-soo. BOOKS & the ARTS IT WOULD BE EASY TO LIST THE CONDItions that make South Korea ideal for science fiction. One of the most popular science fiction writers in South Korea is Djuna, a mononymous, pseudonymous, and officially anonymous novelist and film critic who emerged in the mid-1990s as an active poster on the chat server Hi-Tel. [Extracted from the article]

The sulfur recovery unit (SRU) separates sulfur from sulfur compounds. Within the SRU, a waste heat boiler (WHB) produces high-pressure steam, using the heat generated in this process. Since it [...]

•Heterozygous carriers of deleterious germ line NBNvariants are at risk of B-ALL development.•Protein instability is the main mechanism for loss-of-function variants in the NBNgene.

•Compared with historical studies, 3-year survival for patients with pHLH improved to 77% for patients receiving first-line etoposide.•Contemporary outcome of patients with pHLH is better than anticipated, providing a benchmark for evaluation of novel treatment regimens.

In 1996, Manuel Miranda, a second-generation Filipino American from Kent, Wash., graduated from Evergreen State College. He had majored in literature and got a job in Seattle, taking care of [...]

Background and introductionThe ED is often perceived as noisy. Excessive noise has deleterious effects on health and productivity. This study evaluated if a package of noise-reducing interventions altered workload, physical complaints, productivity and room acoustics.MethodsThis was an observational pre-post implementation study. It was performed in our non-academic ED in the Netherlands from July 2021 to April 2022. Our primary objective was to determine if a combination of technical, acoustical and behavioural interventions was associated with improved staff well-being, and the secondary objective was to evaluate if these interventions resulted in better room acoustics. Moreover, the correlation of noise sensitivity with staff well-being and its effect on interventions were evaluated. All ED staff that were sufficiently exposed to the interventions received questionnaires to assess their well-being before and after the interventions. Room acoustics before and after interventions were expressed in reverberation time (seconds) and participant ratings are reflected as the mean of the sum of their Likert scale ratings.Results43 participants were included. At baseline, individual noise sensitivity was significantly correlated with physical complaints (r=0.409, p=0.006) and productivity (r=0.399, p=0.008). After the interventions, a reduction in reverberation time was reached in the central ED area (0.49 s, SD 0.06 s vs 0.39 s, SD 0.05; p<0.001). Participants experienced significantly less noise disturbance during work (sum score 7.28 vs 3.19; p<0.001). Productivity and physical complaints improved significantly (sum score 4.81 vs 2.70; p<0.001 and sum score −3.74 vs −8.14; p<0.001, respectively). Participants also showed a perceived change in behaviour (sum score −2.00 vs −4.70; p<0.001). There was no confounding by noise sensitivity nor age.ConclusionThe package of behavioural, acoustical and technical interventions was associated with increased staff well-being, reflected by decreased perception of noise, increased productivity, decreased physical complaints and observable changes in behaviour. Furthermore, the interventions positively influenced the room acoustics.

Chiral π-conjugated organic molecules hold potential for emerging technologies as they are capable of introducing novel functionalities into electronic devices owing to their strong chiroptical properties. However, capitalizing on chiral molecules for electronic devices is reliant on their molecular packing─a factor that impacts their charge-transport properties. The solid-state behavior of molecules is sensitive to subtle differences in molecular interactions, chirality, and shape, but these relationships are not fully understood. Here, we employ crystal structure prediction (CSP) as a tool to probe the lattice-energy landscape for a family of chiral organic molecules: [n]helicenes, where nranges from 3 to 12. Our results show excellent agreement between the CSP landscapes and experimentally reported structures. By analyzing the packing motifs within the polymorph landscapes, we begin to develop an understanding of how helicene length affects the shape and π–π stacking interactions seen in the polymorphs. Furthermore, we propose how helicene length can be used as a tool to design new functional organic electronics.

•Germline heterozygosity for a thrombocytopenia 5–associated ETV6variant impairs the repopulating capacity of mouse HSPCs.•In HSPCs, ETV6 binds to Tnfand other inflammatory gene loci and represses their expression during stress hematopoiesis.

Yi combined words with modified numbers and ornaments, proving poet Elisa Gab-bert's argument that punctuation (think: Emily Dickinson's feral dashes) may be the "bare-minimum" criterion for what makes a piece of writing poetry. The BOOKS & ARTS NOT LONG AFTER THE PUBLICATION AND SURPRISE SUCCESS of her first novel, The God of Small Things, in 1997, Arundhati Roy was invited onto a live radio show in London. Yi Sang: Selected Works By Yi Sang Edited by Don Mee Choi Translated by Jack Jung, Don Mee Choi, Sawako Nakayasu, Joyelle McSweeney Wave Books. The question of speech and empire, and what language a colonial subject should use, is a constant subtext in the poems, essays, and fiction of the avant-garde modernist Yi Sang. [Extracted from the article]

It may be surprising, though it shouldn't be, to learn that North Korea has novelists and literary critics, fiction prizes and best sellers. Some books have been republished in South [...]

In Connecticut she led the AFL-CIO's Stamford Organizing Project, a citywide multiunion campaign that aimed not only to unionize nursing-home workers and janitors but also to protect affordable housing. McAlevey is right that a whole worker approach is needed to create lasting strength, but in a given campaign, for a given set of workers, the precise alchemy and sequence of organizing, mobilization, and advocacy may vary. McAlevey does not identify restaurants, nail salons, day labor corners, or private homes as strategic sites for organizing, but the workers in these spaces and the immigrant worker centers supporting them have developed their own ways to win self-determination and power. Because the workers in some Asian countries are so explicitly repressed: they aren't allowed to use an independent Internet search engine to read stories of workers forming unions in places where the government doesn't attack them", she writes. [Extracted from the article]

This article applies a mixed‐method approach to explore the complexities of post‐mergers and acquisitions (M&A) integration processes. Extant literature provides significant insights regarding the impact of task and human integration and their influence on post‐integration processes. However, the literature often fails to differentiate between subelements of these two dimensions. This article investigates task and human integration in a cross‐border M&A aimed at efficiency and innovativeness. We highlight the importance of a clear distinction between two subelements of task integration (product harmonization and structural integration) and show that different interorganizational contexts matter. Consequently, we propose a conceptual framework based on two contextual characteristics—source of synergy and choice of location—suggesting that different integration approaches should be applied simultaneously in different contexts of the same post‐M&A organization. Due to the complexity of the post‐M&A integration process, organizing and managing such a process is a challenge to most practitioners. Understanding how to manage different integration dimensions increases the need for prioritization in order to bypass a one‐size‐fits‐all initiative. We suggest that managers should apply a differentiated postintegration approach, depending on specific organizational contexts. A product‐focused approach seems to fit best in a context where target and acquirer remain working in separate locations, but on similar products. A structure‐focused approach is recommended when target and acquirer remain separated, but work on complementary products. Finally, a people‐focused approach is proposed when target and acquirer are colocated.

There are many different approaches for assessing process parameter criticality, and assessing which process parameters have a significant impact on critical quality attributes (CQAs) is a particular challenge. Including an [...]

In Tastes Like War, Cho uses food to pry open her mother's history. BOOKS & the ARTS SOME 20 YEARS AGO, IN BEYOND THE SHADOW OF CAMPTOWN, a book about Korean military brides in the United States, the historian Ji-Yeon Yuh devoted considerable attention to food. There was little change in her condition as Cho went off to college at Brown and graduate school at the City University of New York, or when Cho's father died in 1998. "The mother of my thirties", Cho writes, was deeply unwell and lived with Cho's brother in Manhattan, then with Cho and her boyfriend in Queens, then in a Princeton apartment adjoining Cho's brother's home. [Extracted from the article]

Episode 376 of ''Now on My Way to Meet You'' aired in late February, three days after the second summit meeting between Donald Trump and Kim Jong-un. Labeled a ''special [...]

AbstractBrands and digital marketing rely on influencers more than ever. As the marketing landscape for social media influencers quickly changes, policies and regulations require standardized sponsorship disclosures. This study examined the effectiveness of three different types of sponsorship disclosure—no disclosure, implicit disclosure, and explicit (standardized) disclosure. This study also compared three different types of influencers and their effectiveness as endorsers: a celebrity, a micro-influencer, and a layperson. The results of an online experiment showed that the presence of sponsorship disclosure and explicit disclosure successfully activated consumers’ conceptual persuasion knowledge, which leads to diminished message credibility, engagement, product attitude, and purchase intention. Furthermore, the results show that a layperson is the most influential endorser; celebrities and micro-celebrities were indifferent as influencers.

Rubus(Rosaceae), one of the most complicated angiosperm genera, contains about 863 species, and is notorious for its taxonomic difficulty. The most recent (1910–1914) global taxonomic treatment of the genus was conducted by Focke, who defined 12 subgenera. Phylogenetic results over the past 25 years suggest that Focke's subdivisions of Rubusare not monophyletic, and large‐scale taxonomic revisions are necessary. Our objective was to provide a comprehensive phylogenetic analysis of the genus based on an integrative evidence approach. Morphological characters, obtained from our own investigation of living plants and examination of herbarium specimens are combined with chloroplast genomic data. Our dataset comprised 196 accessions representing 145 Rubusspecies (including cultivars and hybrids) and all of Focke's subgenera, including 60 endemic Chinese species. Maximum likelihood analyses inferred phylogenetic relationships. Our analyses concur with previous molecular studies, but with modifications. Our data strongly support the reclassification of several subgenera within Rubus. Our molecular analyses agree with others that only R. subg. Anoplobatusforms a monophyletic group. Other subgenera are para‐ or polyphyletic. We suggest a revised subgeneric framework to accommodate monophyletic groups. Character evolution is reconstructed, and diagnostic morphological characters for different clades are identified and discussed. Based on morphological and molecular evidence, we propose a new classification system with 10 subgenera: R. subg. Anoplobatus, R. subg. Batothamnus, R. subg. Chamaerubus, R. subg. Cylactis, R. subg. Dalibarda, R. subg. Idaeobatus, R. subg. Lineati, R. subg. Malachobatus, R. subg. Melanobatus, and R. subg. Rubus. The revised infrageneric nomenclature inferred from our analyses is provided along with synonymy and type citations. Our new taxonomic backbone is the first systematic and complete global revision of Rubussince Focke's treatment. It offers new insights into deep phylogenetic relationships of Rubusand has important theoretical and practical significance for the development and utilization of these important agronomic crops.

•Whole genome sequencing of 36 Hodgkin lymphoma (HL) families identifies 33 coding and 11 noncoding HL-risk variants.•Recurrent damaging variants are observed in known (KDR and KLHDC8B) and novel (PAX5, GATA3, and POLR1E) predisposing loci.

The thermal distillation of crude oil mixtures is an energy-intensive process, accounting for nearly 1% of global energy consumption. Membrane-based separations are an appealing alternative or tandem process to distillation due to intrinsic energy efficiency advantages. We developed a family of spirocyclic polytriazoles from structurally diverse monomers for membrane applications. The resulting polymers were prepared by a convenient step-growth method using copper-catalysed azide–alkyne cycloaddition, providing very fast reaction rates, high molecular weights and solubilities in common organic solvents and non-interconnected microporosity. Fractionation of whole Arabian light crude oil and atmospheric tower bottom feeds using these materials enriched the low-boiling-point components and removed trace heteroatom and metal impurities (comparable performance with the lighter feed as the commercial polyimide, Matrimid), demonstrating opportunities to reduce the energy cost of crude oil distillation with tandem membrane processes. Membrane-based molecular separation under these demanding conditions is made possible by high thermal stability and a moderate level of dynamic chain mobility, leading to transient interconnections between micropores, as revealed by the calculations of static and swollen pore structures.

Heterozygous germline pathogenic variants (GPVs) in SMARCA4, the gene encoding the ATP-dependent chromatin remodelling protein SMARCA4 (previously known as BRG1), predispose to several rare tumour types, including small cell carcinoma of the ovary, hypercalcaemic type, atypical teratoid and malignant rhabdoid tumour, and uterine sarcoma. The increase in germline testing of SMARCA4in recent years has revealed putative GPVs affecting SMARCA4in patients with other cancer types. Here we describe 11 patients with neuroblastoma (NBL), including 4 previously unreported cases, all of whom were found to harbour heterozygous germline variants in SMARCA4. Median age at diagnosis was 5 years (range 2 months–26 years); nine were male; and eight of nine cases had tumour location information in the adrenal gland. Eight of the germline variants were expected to result in loss of function of SMARCA4(large deletion, truncating and canonical splice variants), while the remaining four were missense variants. Loss of heterozygosity of the wild-type SMARCA4allele was found in all eight cases where somatic testing was performed, supporting the notion that SMARCA4 functions as a classic tumour suppressor. Altogether, these findings strongly suggest that NBL should be included in the spectrum of SMARCA4-associated tumours.

Chiral π-conjugated molecules bring new functionality to technological applications and represent an exciting, rapidly expanding area of research. Their functional properties, such as the absorption and emission of circularly polarized light or the transport of spin-polarized electrons, are highly anisotropic. As a result, the orientation of chiral molecules critically determines the functionality and efficiency of chiral devices. Here we present a strategy to control the orientation of a small chiral molecule (2,2′-dicyano[6]helicene) by the use of organic and inorganic templating layers. Such templating layers can either force 2,2′-dicyano[6]helicene to adopt a face-on orientation and self-assemble into upright supramolecular columns oriented with their helical axis perpendicular to the substrate, or an edge-on orientation with parallel-lying supramolecular columns. Through such control, we show that low- and high-energy chiroptical responses can be independently ‘turned on’ or ‘turned off’. The templating methodologies described here provide a simple way to engineer orientational control and, by association, anisotropic functional properties of chiral molecular systems for a range of emerging technologies.

In October 1881, the Dane County Court dissolved the marriage of Anna and George Ott based on the diagnosis of Anna's insanity, determining that George had neither caused nor contributed to her insanity. Late one cold and windy December night in 1858, Madison physician Dr. Anna B. Ott sought refuge at the home of a neighbor. Once again, Anna alleged that George beat her and George alleged that it was all in self-defense against Anna's "unreasonable" behaviors. Circuit court officials likely gave some credence to Anna's claims, for the judge ordered George to pay Anna's legal costs so that she could "carry on this action."10 For reasons unstated, in February Anna dropped the divorce case and moved back into the home on East Wilson Street with George. [Extracted from the article]

Kawasaki disease (KD) is a systemic vasculitis potentially mediated by elevated tumor necrosis factor (TNF)-alpha levels, associated with complications including coronary artery aneurysms. TNF-alpha inhibitors are adjunctive KD treatment. We present a case of breakthrough KD despite long-term adalimumab, a TNF-alpha inhibitor, masquerading as potential Drug Rash with Eosinophilia Syndrome (DRESS).

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease involving esophageal dysfunction and eosinophilic infiltration. EoE management utilizes esophagogastroduodenoscopy (EGD), which requires anesthesia/sedation, and can be time consuming, costly and has risks. The Esophageal String Test (EST) is a novel method for sampling the esophagus where a string attached to a capsule is swallowed and analyzed to distinguish between active and inactive EoE. This case presents successful food re-introduction in a patient with EoE using EST.