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A simple, practical and scalable approach for the synthesis of 2-aminobenzothiazolomethyl naphthols using one-flask three-component reaction of 2-aminobenzothiazole, substituted aromatic aldehydes and β-naphthol in water is reported. The reaction is catalyzed by l-valine as non-toxic, green, easily available, cheap, sustainable and biodegradable catalyst. The product formation takes shorter reaction time with good to excellent yield. The method is demonstrated on multi gram level. Easy workup procedure, short reaction time and most importantly environmentally benign are the most outstanding advantages of this procedure.

New and facile eco-friendly approach for the synthesis of novel substituted 3H-benzo[b][1,4]diazepine derivatives using non-toxic basic alumina as a reusable catalyst under microwave irradiations is presented for the first time. The influence of different types of alumina as catalyst was studied. It was found that the best yield of the product was obtained with basic alumina catalyst. The best yield of the desired product was achieved using 1 mol% of the catalyst. The procedure resulted in high yields of the product, short reaction duration; operational simplicity, solvent free condition, high atom-economy and low E-factor are the salient features of the present method.

A series of curcumin dihydropyrimidinone derivatives have been synthesized using modified procedure and evaluated for antioxidant and anti-inflammatory activities.

Synthesis of 3,4-dihydropyrimidin-2(1H)-one using nickel (II) oxide under solvent free conditions and microwave irradiations leads to excellent yield. The product formation takes shorter time under microwave irradiations. Acetonitrile was the best solvent at 75 °C. In the present methodology, the catalyst nickel oxide is inexpensive, readily available, efficient, recyclable and green.