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ObjectiveTo determine the efficacy and toxicity of chemotherapy in the treatment of canine nasal tumours. DesignRetrospective clinical study ProcedureEight dogs with histologically confirmed nasal tumours were staged by means of complete blood count, serum biochemical analysis, cytological analysis of fine needle aspirate of the regional lymph nodes, thoracic radiographs and computed tomography scan of the nasal cavity. All dogs were treated with alternating doses of doxorubicin, carboplatin and oral piroxicam. All dogs were monitored for side effects of chemotherapy and evaluated for response to treatment by computed tomography scan of the nasal cavity after the first four treatments. ResultsComplete remission was achieved in four dogs, partial remission occurred in two dogs and two had stable disease on the basis of computed tomography evaluation. There was resolution of clinical signs after one to two doses of chemotherapy in all dogs. ConclusionsThis chemotherapy protocol was efficacious and well tolerated in this series of eight cases of canine nasal tumours.