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Compressed CO2energy storage (CCES) technology has the advantages of high energy storage density, low economic cost, low carbon emission, which is suitable for the construction of large-scale and long-time energy storage system. Besides, as a scene with massive heat, the electricity consumption of servers in data center is mostly converted into heat. Thus, the purpose of this work is to integrate a trans-critical compressed CO2energy storage system with the waste heat of data centers, so as to improve the system performance and reduce the operating cost of data center. Based on different operating principles of compressors, a single-stage compression system (System-CP) and a double-stage compression system (System-VP) are constructed. To analyze and compare the energy and exergy performance of these two systems under design conditions, a quasi-dynamic model is developed by considering the variations of pressure and temperature in the storage tank. On this basis, an economic model is developed to obtain the economy performance for the systems. The obtained results show that the round-trip efficiency (RTE) of System-CP and System-VP are 64.67 % and 67.41 %, respectively. For the energy storage capacity 15 MW × 5 h, volumes of high-pressure S-CO2storage tank are 314,387.51 m3and 287,982.91 m3for System-CP and System-VP, respectively. Thereby, the energy storage density (ESD) of System-CP and System-VP are 0.24 kW·h/m3and 0.26 kW·h/m3, respectively. Meanwhile, the total capital cost (TCC) is $477.84 × 106for System-CP, and $437.41 × 106for System-VP, and the corresponding payback period (PBP) are 14.76 years and 12.39 years respectively. Further, the effect of key parameters on systems performance is revealed. The results show that with the decrease of slip-pressure range decreases, RTE, TCC and the volume of storage tanks increase linearly.

The sonic hedgehog (SHH) signaling pathway exhibits aberrant activation in triple-negative breast cancer (TNBC), wherein it regulates several malignant phenotypes related to tumor metastasis. GANT61, an inhibitor of the SHH signaling pathway, may offer promise when administered in combination with conventional chemotherapy to treat metastatic TNBC. However, poor bioavailability and substantial off-target toxicity limit its clinical application. To address these limitations, we designed a peptide-functionalized dual-targeting delivery system encapsulating paclitaxel and GANT61 in tLyP-1 peptide-modified reconstituted high-density lipoprotein nanoparticle (tLyP-1-rHDL-PTX/GANT61 NP) for metastatic TNBC treatment. The apolipoprotein A-1 and tLyP-1 peptide modified on the surface of nanoparticles enable the delivery system to target tumor cells by binding to the overexpressed scavenger receptor B type I and neuropilin-1 receptor. Moreover, the tLyP-1 peptide also enables the deep tumor penetration of nanoparticles further facilitating paclitaxel and GANT61 delivery. Increased cellular uptake of the nanoparticles was observed in both MDA-MB-231, BT-549 tumor cells, and their 3D tumor spheroids. A series of in vitroexperiments reveal that GANT61 was able to suppress key metastasis-related tumor cell activities including angiogenesis, migration, invasion, and stemness. Owing to more effective drug administration, the metastasis suppression efficiency of GANT61 was significantly enhanced by the dual-targeting tLyP-1-rHDL delivery system. Meanwhile, the codelivery of paclitaxel and GANT61 by dual-targeting tLyP-1-rHDL nanoparticles demonstrated superior efficiency of disrupting proliferation and inducing apoptosis in tumor cells compared with drug solutions. In a spontaneous metastasis breast cancer NCG mice model, the tLyP-1-rHDL-PTX/GANT61 nanoparticles exhibited highly tumor-specific distribution and result in significant inhibition of the primary tumor growth and dramatic reduction of lung metastasis without obvious side effects. The present work suggests that a combination of the SHH signaling pathway suppression and chemotherapy assisted by peptide-functionalized targeting tLyP-1-rHDL nanoparticles may provide a promising strategy for metastatic TNBC treatment.

This study assessed the effectiveness and safety of percutaneous mechanical thrombectomy and catheter-directed thrombolysis combined with stent placement in the management of iliac vein compression syndrome with acute iliofemoral deep venous thrombosis (DVT).

Aiming at the characteristics of high power consumption and abundant waste heat resources in data centers, the integrated energy systems of data center are constructed by combining CO2heat pump and compressed CO2energy storage. Considering different stages of compression and expansion in energy storage, System I and System II are proposed. The systems can continuously provide cooling to data center through the CO2heat pump, and can also store the low-cost electricity so as to supply power to data center during the peak electricity consumption period. Meanwhile, hot water can also be provided by fully extracting the residual heat from the systems. Furthermore, to investigate system performances, the thermal and economic models are developed. On this basis, the thermal and economic performances for the two systems are analyzed in detail under design conditions. The results indicate that when providing cooling capacity of 5000 kW for data center, the Coefficient of Performance (COP) of heat pump is 7.22, and Round-Trip Efficiency (RTE) of System I and System II are 56.94 % and 55.85 % respectively. Systems I and System II can provide 879.26 tons and 1158.73 tons of domestic hot water, respectively. The total system capital cost is 234.35 × 104$ for System I, and 344.45 × 104$ for System II. Accordingly, the payback periods are 12.71 years and 11.19 years respectively. Furthermore, the effects of pressures on the system performances are also analyzed. The results show that every 0.5 MPa increase for heat pump outlet pressure, RTE of System II increases by 0.6 %, but the effect on System I is not significant.