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Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1 diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty acids (SCFAs) mainly produced by gut microbiota, which plays key roles in maintaining intestinal homeostasis. In this study, we investigated the role of GPR41 in the progression of T1D. In non-obese diabetic (NOD) mice, we found that aberrant reduction of GPR41 expression in the pancreas and colons was associated with the development of T1D. GPR41-deficient (Gpr41−/−) mice displayed significantly exacerbated streptozotocin (STZ)-induced T1D compared to wild-type mice. Furthermore, Gpr41−/−mice showed enhanced gut immune dysregulation and increased migration of gut-primed IFN-γ+T cells to the pancreas. In bone marrow-derived dendritic cells from Gpr41−/−mice, the expression of suppressor of cytokine signaling 3 (SOCS) was significantly inhibited, while the phosphorylation of STAT3 was significantly increased, thus promoting dendritic cell (DC) maturation. Furthermore, adoptive transfer of bone marrow-derived dendritic cells (BMDC) from Gpr41−/−mice accelerated T1D in irradiated NOD mice. We conclude that GPR41 is essential for maintaining intestinal and pancreatic immune homeostasis and acts as a negative regulator of DC maturation in T1D. GPR41 may be a potential therapeutic target for T1D.

The biorelevant sulfur-containing Euphorbiaditerpenes with scarce 5/7/6/3 premyrsinane- and 5/7/6 myrsinane-type backbones were easily constructed from naturally abundant lathyrane-type Euphorbiafactor L3by visible-light-triggered tandem thiol–ene click reaction/transannular cyclization and regioselective cyclopropane ring-opening. The selenide diterpene was also successfully obtained to verify the system universality. This concise synthesis route gives an efficient strategy for obtaining structurally diverse Euphorbiaditerpenes under very mild conditions and provides a promising anti-HIV bioactive premyrsinane diterpene 3h.

This study focused on the improvement of Schisandra polysaccharide on the learning and memory in D-galactose-induced brain aging mice, to lay the foundation for the prevention and treatment of brain aging and related diseases. D-galactose was used to establish a mice brain aging model, Morris water maze and passive avoidance test were used to observe effects of Schisandra polysaccharide on the learning and memory ability of D- galactose-induced brain aging mice. The results showed that Schisandra polysaccharide could prolong the time of target qundrant, increase the number to cross the original platform in the Morris water maze test, and prolong the latency and reduce the number of errors of mice in the passive avoidance test. It is believed that Schisandra polysaccharide could improve the learning and memory ability of mice with brain aging.

Image authentication must be able to verify the origin and the integrity of digital images, and some research has made efforts in that. In this paper, we reveal a new type of malicious alteration which we call the “Tattooing Attack”. It can successfully alter the protected image if the collision of the authentication bits corresponding to the altered image and the original watermarking image can be found. To make our point, we chose Chang et al.'s image authentication scheme based on watermarking techniques for tampering detection as an example. The authors will analyze the reasons why the attack is successful, and then they delineate the conditions making the attack possible. Since the result can be generally applied into other schemes, the authors evaluate such schemes to examine the soundness of these conditions. Finally, a solution is provided for all tamper detection schemes suffering from the Tattooing Attack.

A secret sharing model can secure a secret over multiple noise-like shadows and remain recoverable despite multiple shadow failures. Even if some of the shadows are compromised, the secret will not be revealed as long as the number of the compromised shadows is smaller than a pre-determined threshold. Moreover, there are some necessary details of concerns: the malicious tampering on shadows must be detectable; the shadows must be concealed in a camouflage image with adequate quality to reduce suspicion and possible attack; color image properties must be considered. In addition to these concerns, in this paper, an adaptable mechanism is further designed to balance the hiding quantity and the quality of camouflage image depending on different applications. This is an important and interesting aspect that has never been discussed in previous research.

A secret sharing model can secure a secret over multiple noise-like shadows and remain recoverable despite multiple shadow failures. Even if some of the shadows are compromised, the secret will not be revealed as long as the number of the compromised shadows is smaller than a pre-determined threshold. Moreover, there are some necessary details of concerns: the malicious tampering on shadows must be detectable; the shadows must be concealed in a camouflage image with adequate quality to reduce suspicion and possible attack; color image properties must be considered. In addition to these concerns, in this paper, an adaptable mechanism is further designed to balance the hiding quantity and the quality of camouflage image depending on different applications. This is an important and interesting aspect that has never been discussed in previous research.