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A new cobalt(II) compound with the formula [Co(5-Br-pyc)(2,2′-bipy)(H2O)(Cl)]·2H2O (1·H2O) (5-Br-Hpyc = 5-bromo-pyridine-2-carboxylic acid, 2,2′-bipy = 2,2′-bipyridine) has been hydrothermally synthesized and well characterized. The X-ray single-crystal diffraction analysis showed that 1⋅2H2O has crystallizes in the monoclinic system, space group P21/c(no. 14). The Co(II) center was octahedrally bonded by one bidentate chelate 5-Br-pyc anion and one 2,2′-bipy, one water molecule as well as one chloride anion to form the mononuclear structure of 1⋅2H2O. Complex1⋅2H2O forms a 3D network through abundant O–H⋅⋅⋅O hydrogen bonds and π⋅⋅⋅π stacking interactions. Notably, the 5-Br-Hpyc ligand was in situgenerated by decarboxylation of the 3-bromo-pyridine-2,6-dicarboxylic acid (3-Br-H2pydc) precursor selectively on 2-position under hydrothermal conditions. The magnetic properties, the Hirshfeld surface structure and the synthetic process for 1⋅2H2O have been carefully described and discussed.

Objective: Isocitrate dehydrogenase gene (IDH) mutations are associated with tumor angiogenesis and therefore play an important role in glioma management. This study compared the performance of tumor blood vessels counted from contrast-enhanced 3D brain volume (3D-BRAVO) sequence and dynamic contrast-enhanced (DCE) MRI in differentiating IDH1 status in gliomas. Methods: Forty-four glioma patients [16 with IDH1 mutant-type (IDH1-MT), 28 with IDH1 wild-type (IDH1-WT)] were retrospectively analyzed. A blood vessel entering a tumor was defined as an intratumoral vessel; a blood vessel adjacent to the edge of a tumor was defined as a peritumoral vessel. Combined vessels were defined as the sum of the intratumoral and peritumoral vessels. DCE-derived metrics of tumor were normalized to the contralateral normal-appearing white matter. Results: Intratumoral, peritumoral, and combined tumor blood vessels were all significantly different between IDH1-MT and IDH1-WT gliomas, and the range of area under curves (AUCs) was 0.816–0.855. For DCE-derived parameters, cerebral blood volume, cerebral blood flow, mean transit time, and volume transfer constant were significantly different between IDH1-MT and IDH1-WT gliomas, and the range of AUCs was 0.703–0.756. Combined vessels possessed the best performance for identifying IDH1 mutations in gliomas (AUC: 0.855, sensitivity: 0.857, specificity: 0.812, P<0.001). Conclusion: The number of tumor blood vessels has comparable diagnostic performance with DCE-derived parameters for differentiating IDH1 mutations and can serve as a potential imaging biomarker to reflect IDH1 mutations in gliomas.

C20H20NO7Cd, triclinic, P1‾$P‾{1}$(no. 2), a= 9.9506(8) Å, b= 10.1867(11) Å, c= 11.2774(11) Å, α= 110.528(9)°, β= 93.830(7)°, γ= 107.307(8)°, V= 1003.18(17) Å3, Z= 2, Rgt(F) = 0.0775, wRref(F2) = 0.2051, T = 293(2) K.

C60H40N4O9Cu, triclinic, P1̄ (no. 2), a= 9.6569(8) Å, b= 10.3941(7) Å, c= 24.9421(16) Å, α= 97.162(5)°, β= 90.953(6)°, γ= 107.788(7)°, V= 2361.3(3) Å3, Z= 2, Rgt(F) = 0.0729, wRref(F2) = 0.1609, T= 293(2) K.

C25H22N3O8Cd, triclinic, P1̄ (no. 2), a= 10.2722(10) Å, b= 10.6897(11) Å, c= 12.5667(13) Å, α= 79.698(9)°, β= 72.168(9)°, γ= 63.166(10)°, V= 1170.8(2) Å3, Z= 2, Rgt(F) = 0.0618, wRref(F2) = 0.1078, T= 293(2) K.

CRISPR/Cas9 technology is a powerful genome manipulation tool in insects. However, little is known about whether mRNA and protein of a target gene are completely cleared in homozygous mutants. This study generated homozygous mutants of the insulin receptor gene 2 (NlInR2) in the brown planthopper (Nilaparvata lugens) using CRISPR/Cas9 genome editing. Both frameshift mutants, E5_D17 and E6_I7, differentiated towards long wings, but there were differences in wing morphology, with E5_D17 showing wing deformities. Subsequent investigations revealed the presence of residual expression of NlInR2mRNA in both mutants, as well as the occurrence of spliceosomes featuring exon skipping splicing in E5_D17. Additionally, the E5_D17 exhibited the detection of N-terminally truncated NlInR2 protein. RNA interference experiments indicated that the knockdown of NlInR2expression in the E5_D17 mutant line increased the proportion of wing deformities from 11.1 to 65.6%, suggesting that the residual NlInR2mRNA of the E5_D17 mutant might have retained some genetic functions. Our results imply that systematic characterization of residual protein expression or function in CRISPR/Cas9-generated mutant lines is necessary for phenotypic interpretation.

C52H40N2O10Mn2, monoclinic, I2/a(no. 15), a= 8.6162(4) Å, b= 11.0217(5) Å, c= 45.266(2) Å, β= 92.828(4)°, V= 4293.5(3) Å3, Z= 4, Rgt(F) = 0.0476, wRref(F2) = 0.0988, T= 293(2) K.

C26H18N2O9Sm, monoclinic P21/n(no. 14), a= 8.9665(3) Å, b= 9.3617(3) Å, c= 28.3925(9) Å, β= 95.134(3)°, V= 2373.76(12) Å3, Z= 4, Rgt(F) = 0.0317, wRref(F2) = 0.0637, T= 293(2) K.

C44H32N4O4Cl4Zn, triclinic, P1̅ (no. 2), a= 7.3158(2) Å, b= 13.6944(5) Å, c= 20.4081(6) Å, α= 82.930(3)°, β= 89.667(2)°, γ= 88.034(3)°, V= 2027.85(11) Å3, Z= 2, Rgt(F) = 0.0430, wRref(F2) = 0.1141, T= 293(2) K.

C20H28N4NiO7, monoclinic, P21/c(no. 14), a= 8.6404(5) Å, b= 21.0392(12) Å, c= 12.2580(6) Å, β= 96.839(5)°, V= 2212.5(2) Å3, Z= 4, Rgt(F) = 0.0476, wRref(F2) = 0.1092, T= 293(2) K.

C56H48N4Ca2Cl8O12, monoclinic, P21/c, a= 16.776(8) Å, b= 24.193(12) Å, c= 7.657(4) Å, β= 101.110(7)°, V= 3050(3) Å3, Z= 2, Rgt(F) = 0.0685, wRref(F2) = 0.1663, T= 296(2) K.

C52H40N2O9Pb, triclinic, P1̅ (no. 2), a= 10.3025(4) Å, b= 14.1740(9) Å, c= 16.0428(9) Å, α= 115.835(6)°, β= 97.680(4)°, γ= 90.493(4)°, V= 2083.7(2) Å3, Z= 2, Rgt(F) = 0.0342, wRref(F2) = 0.0612, T= 293(2) K.

C48H42O22N2Ca, triclinic, P1̅ (no. 2), a= 7.2548(2) Å, b= 11.7056(4) Å, c= 14.6024(4) Å, α= 72.687(3)°, β= 82.667(2)°, γ= 73.303(3)°, V= 1132.76(6) Å3, Z= 1, Rgt(F) = 0.0403, wRref(F2) = 0.0993, T= 293(2) K.

C28H20N2Cl4O4Cd, monoclinic, P21/c(no. 14), a= 12.5272(4) Å, b= 28.7754(10) Å, c= 7.7485(3) Å, β= 96.627(1)°, V= 2774.48(17) Å3, Z= 4, Rgt(F) = 0.0341, wRref(F2) = 0.0787, T= 296(2) K.

C38H28Cl4N4O4Zn, monoclinic, C2/c(no. 19), a= 33.2980(15) Å, b= 7.8254(3) Å, c= 13.8939(9) Å, β= 92.506(5)°, V= 3616.9(3) Å3, Z= 4, Rgt(F) = 0.0702, wRref(F2) = 0.1774, T= 293(2) K.

C24H28O6N10Ni, monoclinic, P21/c(no. 14), a= 7.3274(4) Å, b= 15.6403(5) Å, c= 11.8035(6) Å, β= 106.966(5)°, V= 1293.85(10) Å3, Z= 2, Rgt(F) = 0.0397, wRref(F2) = 0.1002, T= 293(2) K.

Hot metal ladle is an important part in continuous casting production line and its stress distribution has direct influence on its life. In the process of design and calibration of the large-sized hot metal ladle, it is of great significance to determine the stress distribution of each part of the ladle for safely and reliably running the device. Based on 100 t hot metal ladle which is designed by Baotou Iron and Steel Group, simulation of stress field was made by finite element software ANSYS 10. 0 from different dumping angles. Through modeling, loading, restricting and calculating, strain and stress field distribution of the hot metal ladle were acquired. Finally, an assessment of strength and stiffness was made on the hot metal ladle. The results show that in the process of tipping for the hot metal ladle, maximum stress is 132 MPa and maximum strain is only 0. 064%; maximum stress and strain have appeared in the stiffener plate which is located at the bottom of the trunnion, and strength and stiffness are qualified. The method, which is convenient and practical, reasonable and reliable, provides theoretical evidence for checking analysis and further optimal design of the hot metal ladle.

Hot metal ladle is an important part in continuous casting production line and its stress distribution has direct influence on its life. In the process of design and calibration of the large-sized hot metal ladle, it is of great significance to determine the stress distribution of each part of the ladle for safely and reliably running the device. Based on 100 t hot metal ladle which is designed by Baotou Iron and Steel Group, simulation of stress field was made by finite element software ANSYS 10.0 from different dumping angles. Through modeling, loading, restricting and calculating, strain and stress field distribution of the hot metal ladle were acquired. Finally, an assessment of strength and stiffness was made on the hot metal ladle. The results show that in the process of tipping for the hot metal ladle, maximum stress is 132 MPa and maximum strain is only 0.064%; maximum stress and strain have appeared in the stiffener plate which is located at the bottom of the trunnion, and strength and stiffness are qualified. The method, which is convenient and practical, reasonable and reliable, provides theoretical evidence for checking analysis and further optimal design of the hot metal ladle.

C44H54Cd2N4O12, monoclinic, C2/c, a= 22.818(5) Å, b= 10.714(2) Å, c= 19.163(4) Å, β= 102.43(3)°, V= 4575.2(16) Å3, Z= 2, Rgt(F)= 0.0381, wRref(F2) = 0.1077, T= 293(2) K.

C12H18O14S2Mn, Triclinic, P1̅, a= 6.5076(10) Å, b= 8.4923(13) Å, c= 9.8092(15) Å, α= 66.6180(10)°, β= 86.903(2)°, γ= 82.235(2)°, V= 493.02(13) Å3, Z= 1, Rgt(F)= 0.0569, wRref(F2)= 0.1756, T= 296(2) K.

C40H40N4O12Ni, triclinic, P1̅, a= 7.6612(6) Å, b= 8.0725(7) Å, c= 16.3021(10) Å, α= 89.394(6)°, β= 77.966(6)°, γ= 69.868(8)°, V= 923.75(12) Å3, Z= 1, Rgt(F)= 0.0492, wRref(F2)= 0.1309, T= 293(2) K.

C30H41CdN2O11, triclinic, P1̄ (no. 2), a = 10.266(2) Å, b = 11.907(2) Å, c = 14.989(2) Å, α = 104.822(1)°, β = 108.566(1)°, γ = 95.923(2)°, V = 1644.6 Å3, Z = 2, Rgt(F) = 0.0307, wRref(F2) = 0.0814, T = 296 K.

Porous mullite were prepared by coating Al(OH)3 on the surface of the particles of waste fly ash. The effects of content of urea on formation of mullite and sintering temperature on microstructure of mullite were investigated by XRD and SEM analysis. It was showed that two kind mullite were obtained, one was growing from original Needle-like mullite existing in original ashfly, and the other was formed through by the reaction between glassy phase and Al2O3 coated on spherical waste fly ash.

In the article, we present the best possible upper and lower bounds for the Sándor–Yang means in terms of the families of one-parameter geometric and quadratic means, and discover new bounds for the inverse tangent and inverse hyperbolic sine functions.

C100H60N12O16Cd4, monoclinic, I2/a(no. 15), a= 21.2654(5) Å, b= 11.1493(3) Å, c= 17.3039(4) Å, β= 97.774(2)°, V= 4064.96(18) Å3, Z= 2, Rgt(F) = 0.0213, wRref(F2) = 0.0559, T= 289.23(10) K.

C31H22N4O2Cl2Cu, orthorhombic, C2221(no. 20), a= 6.869(2) Å, b= 18.535(7) Å, c= 21.199(7) Å, V= 2698.9(16) Å3, Z= 4, Rgt(F) = 0.0385, wRref(F2) = 0.1036, T= 293 K.

C7H7NO6Zn, monoclinic, C2/c(no. 15), a= 10.009(10) Å, b= 11.907(12) Å, c= 7.328(7) Å, β= 105.050(12)°, V= 843.3(15) Å3, Z= 2, Rgt(F) = 0.0681, wRref(F2) = 0.1757, T= 296(2) K.

C44H34N8CdCl4O4, monoclinic, P21/c(no. 14), a= 9.7056(2) Å, b= 14.3244(3) Å, c= 15.3626(3) Å, β= 99.7540(10)°, V= 2104.94(7) Å3, Z= 2, Rgt(F) = 0.0271, wRref(F2) = 0.0717, T = 296(2) K.

C13H11N1O5Cl2Cd, monoclinic, P21(no. 4), a= 8.036(4) Å, b= 7.113(3) Å, c= 13.556(6) Å, β= 104.725(5)°, V= 749.5(6) Å3, Z= 2, Rgt(F) = 0.0220, wRref(F2) = 0.0562, T= 296(2) K.

C10H13O9Ce, monoclinic, P21/c, a= 10.5139(13) Å, b= 12.5642(15) Å, c= 10.4197(13) Å, β= 93.813(1)°, V= 1373.4(3) Å3, Z= 4, Rgt(F)= 0.0197, wRref(F2)= 0.0505, T= 296(2) K.

C26H24N2O12Co, triclinic, P1̅, a= 6.892(3) Å, b= 8.469(4) Å, c= 11.306(5) Å, α= 86.963(6)°, β= 88.691(5)°, γ= 85.404(6)°, V= 694.14(15) Å3, Z= 1, Rgt(F)= 0.0561, wRref(F2)= 0.1319, T= 293(2) K.

C17H14N2O4, triclinic, P1̄ (no. 2), a = 7.025(1) Å, b = 9.607(2) Å, c = 10.749(2) Å, α = 97.47(3)°, β = 92.10(3)°, γ = 91.01(3)°, V = 718.6 Å3, Z = 2, Rgt(F) = 0.0564, wRref(F2) = 0.1251, T = 293 K.

C13H10N4S, monoclinic, P21/c (no. 14), a = 9.184(7) Å, b = 11.094(8) Å, c = 12.109(9) Å, β = 104.287(8)°, V = 1195.6 Å3, Z = 4, Rgt(F) = 0.0303, wRref(F2) = 0.0847, T = 296 K.

C40H44MnN6O6S2, monoclinic, P21/n (no. 14), a = 10.839(1) Å, b = 17.117(2) Å, c = 11.396(1) Å, β = 111.465(10)°, V = 1967.5 Å3, Z = 2, Rgt(F) = 0.0324, wRref(F2) = 0.0821, T = 296 K.

C19H15Br2ClO, orthorhombic, P212121(no. 19), a = 4.501(2) Å, b = 16.229(8) Å, c = 24.20(1) Å, V = 1767.4 Å3, Z = 4, Rgt(F) = 0.0350, wRref(F2) = 0.0637, T = 296 K.

C9H11CaNO6, orthorhombic, Pbca (no. 61), a = 15.9540(19) Å, b = 7.7489(9) Å, c = 17.811(2) Å, V = 2201.9 Å3, Z = 8, Rgt(F) = 0.0398, wRref(F2) = 0.1010, T = 296 K.

C42H34N4O12, monoclinic, P21/c (no. 14), a = 9.817(2) Å, b = 7.061(1) Å, c = 26.695(7) Å, ( = 106.99(3)°, V = 1769.8Å3, Z = 2, Rgt(F) = 0.0634, wRref(F2) = 0.1196, T = 293 K.

C17H15N4O, tetragonal, I41/a (no. 88), a = 16.2111(9) Å, c = 22.095(3) Å, V = 5806.6 Å3, Z = 16, Rgt(F) = 0.0479, wRref(F2) = 0.1476, T = 296 K.

C13H17CdN2O8, triclinic, P1̄ (no. 2), a = 9.230(1) Å, b = 10.191(1) Å, c = 10.248(1) Å, α = 65.699(1)°, β = 65.896(1)°, γ = 79.459(1)°, V = 801.8 Å3, Z = 2, Rgt(F) =` 0.0203, wRref(F2) = 0.0490, T = 296 K.