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Molecular characterization is transforming research on novel therapeutics in breast cancer. High-throughput methodologies are unbiased to hypotheses; thus, data produced are relevant to address unlimited questions and provide resources for the experimental design process. However, the opportunity is often overlooked because data are not readily accessed or analyzed. Herein, the Breast Cancer Proteome Portal, the only online tool for analyzing protein and transcript abundances across the three breast cancer proteomics studies, is presented. The tool is applied to demonstrate that cofunctioning protein abundances are highly correlated and, conversely, high abundance correlation may be an indicator of cofunction. Furthermore, the cofunction–correlation relationship is less resolved at the transcript level. By applying analysis and visualization tools within the Breast Cancer Proteome Portal, insights are garnered about serine synthesis and the compartmentalization of one-carbon metabolism in breast cancer, and a transcription factor tumorigenic regulatory network of glutamine deamination and oxidation is proposed, illustrating that the Breast Cancer Proteome Portal provides an interface for garnering insights from the information-rich studies of the breast cancer proteome.

Based on the real sense of the time-of-flight , we demonstrate an alternative method of measuring the temperature of cold atoms in magneto-optical traps (MOTs) using a high-finesse optical microcavity, which acts as a pointlike single-atom counter. A cloud of atoms trapped in magneto-optical traps is positioned about 5?mm above the cavity, and the atoms fall freely down through the cavity. The temperature of the cold atoms in the MOT is determined by counting the exact arrival times of the single atoms. A theoretical model based on a ballistic expansion of a cloud of trapped atoms falling in the earth’s gravitational field is used to fit the probability distribution of atom arrivals, and the fittings agree very well with the experimental results. This method could be used for systems with little room, where an extra probe beam is hard to involve, or with fewer atoms initially.