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To study the effects of different stress gradient on rockburst hazards, a novel experimental technique was proposed and a series of tests under different stress gradient paths were conducted on specimens (400 mm × 600 mm × 1000 mm) by using a true-triaxial gradient and hydraulic-pneumatic combined test device. The damage phenomena, force characteristics and acoustic emission (AE) signals of the specimen during rockbursts were systematically analyzed. The experimental results indicated that different stress gradient distributions not only affect the failure mechanism of the specimen, but also affect the energy conversion characteristics. With the stress gradient increasing from 0 to 6, the index rdecreasing from 0.93 to 0.37, and the power law growth characteristics of the energy acceleration tends to be obvious. The energy released after rockburst accounts for 31.1%, 41%, 77.7%, and 87.5% of the total energy, respectively, which is an important reason for the severe damage tendency of rockburst. Rockburst intensity can be judged according to the stress/strength ratio corresponding to the inflection point of the AE energy fitting curve under different stress gradients, which can be used as an important precursor of rockburst.

To investigate the fracture mechanical behavior and failure mechanism of jointed rock mass under compression and shear load. Conventional shear tests and shear tests under normal disturbances were conducted using an electro-hydraulic servo-motor loading system. Meanwhile, the discrete-element program particle flow code was adopted to establish a numerical shear model, and to discuss the microscopic deterioration characteristics and energy dissipation mechanism during shear fracture of rocks with discontinuous joints under joint action of normal static loads and dynamic disturbance. Compared with the conventional shear tests, shear test results under normal disturbances show the following specificities in terms of their macroscopic and microscopic mechanical properties as well as energy evolution: (1) frequent dynamic disturbances accelerate the non-steady fracture process of jointed rock samples and promote occurrence of the weakening effect of shear fracture. (2) The step-like abrupt increase in micro-cracks becomes more obvious before reaching the peak shear stress. (3) The energy-storage capacity and failure resistance of the rocks are weakened. The research results are of great significance for further understanding the dynamic catastrophe effect of deep rock mass.

Background. Parkinson’s disease is a neurodegenerative disease in elder people, pathophysiologic basis of which is the severe deficiency of dopamine in the striatum. The purpose of the present study was to evaluate the neuroprotective effect of low-frequency rTMS on Parkinson’s disease in model mice. Methods. The effects of low-frequency rTMS on the motor function, cortex excitability, neurochemistry, and neurohistopathology of MPTP-induced Parkinson’s disease mice were investigated through behavioral detection, electrophysiologic technique, high performance liquid chromatography-electrochemical detection, immunohistochemical staining, and western blot. Results. Low-frequency rTMS could improve the motor coordination impairment of Parkinson’s disease mice: the resting motor threshold significantly decreased in the Parkinson’s disease mice; the degeneration of nigral dopaminergic neuron and the expression of tyrosine hydroxylase were significantly improved by low-frequency rTMS; moreover, the expressions of brain derived neurotrophic factor and glial cell line derived neurotrophic factor were also improved by low-frequency rTMS. Conclusions. Low-frequency rTMS had a neuroprotective effect on the nigral dopaminergic neuron which might be due to the improved expressions of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor. The present study provided a theoretical basis for the application of low-frequency rTMS in the clinical treatment and recovery of Parkinson’s disease.