1. Sulfur-Vacancy-Engineered Two-Dimensional Cu@SnS2–xNanosheets Constructed via Heterovalent Substitution for High-Efficiency Piezocatalytic Tumor Therapy
- Author
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Ma, Xinyu, Ding, Binbin, Yang, Zhuang, Liu, Sainan, Liu, Zhendong, Meng, Qi, Chen, Hao, Li, Jing, Li, Ziyao, Ma, Ping’an, and Lin, Jun
- Abstract
Ultrasound (US)-mediated piezocatalytic tumor therapy has attracted much attention due to its notable tissue-penetration capabilities, noninvasiveness, and low oxygen dependency. Nevertheless, the efficiency of piezocatalytic therapy is limited due to an inadequate piezoelectric response, low separation of electron–hole (e––h+) pairs, and complex tumor microenvironment (TME). Herein, an ultrathin two-dimensional (2D) sulfur-vacancy-engineered (Sv-engineered) Cu@SnS2–xnanosheet (NS) with an enhanced piezoelectric effect was constructed via the heterovalent substitution strategy of Sn4+by Cu2+. The introduction of Cu2+ion not only causes changes in the crystal structure to increase polarization but also generates rich Svto decrease band gap from 2.16 to 1.62 eV and inhibit e––h+pairs recombination, collectively leading to the highly efficient generation of reactive oxygen species under US irradiation. Moreover, Cu@SnS2–xshows US-enhanced TME-responsive Fenton-like catalytic activity and glutathione depletion ability, further aggravating the oxidative stress. Both in vitro and in vivo results prove that the Sv-engineered Cu@SnS2–xNSs can significantly kill tumor cells and achieve high-efficiency piezocatalytic tumor therapy in a biocompatible manner. Overall, this study provides a new avenue for sonocatalytic therapy and broadens the application of 2D piezoelectric materials.
- Published
- 2024
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