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Background: Phencyclidine (PCP) as well as the analogues has indicated several pharmacological behaviors like analgesic, anticonvulsant, antianxiety, antidepressant depending on the dose and species examined. They interact with some neurotransmitter systems in the central nervous system like particular affinity for PCP sites in NMDA receptors or dopamine uptake blocking or both. Objective: Due to analgesic properties of aminobenzothiazoles family, piperidine ring of PCP was replaced with electron-donating and electron-withdrawing substituted aminobenzothiazoles (1-4) for obtaining new analogues (II-V) with more analgesic activities. Methods: Synthesis of new compounds (II-V) and measuring the acute and chronic pain properties of them were carried out through applying tail immersion tests on mice and the outcomes compared with control & PCP groups at dosage of 10 mg/kg. Results: III & V with substituted methoxy and methyl-aminobenzothiazoles indicated better activity to lessen acute and chronic (thermal and chemical) pains compared with unsubstituted & phencyclidine animal groups. Conclusion: Methoxy and methyl-aminobenzothiazole derivatives” of phencyclidine revealed more analgesic activities compared with other groups which may concern to close affinity for DA uptake blocking as well as NMDA receptors in this family.

Silver nanoparticle-decorated polyaniline nanorods (AgNPs-PANINRs) and silver nanoparticle-decorated polyaniline nanotubes (AgNPs-PANINTs) composites were prepared through a one-step modified methods by immobilizing a mixture of AgNO3, aniline and ammonium per sulfate (APS) as an oxidant without adding any extra acids, templates or surface modifiers. The composites were characterized by using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The reactivity of the prepared composites towards hydrogen peroxide (H2O2) was analyzed using cyclic voltammetry and chronoamperometry. The AgNPs-PANINRs composite exhibits better electrochemical performance than the AgNPs-PANINTs composite due to higher content of silver nanoparticle (AgNPs). The sensor has a fast amperometric response time which less than 3 s. The detection limit and limit of quantification (S/N = 3) of two linear range (low and high concentration of H2O2) are estimated as 0.13 uM and 0.45 uM and 0.33 uM and 1.12 uM, respectively.

Silver nanoparticle-decorated polyaniline nanorods (AgNPs-PANINRs) and silver nanoparticle-decorated polyaniline nanotubes (AgNPs-PANINTs) composites were prepared through a one-step modified methods by immobilizing a mixture of AgNO3, aniline and ammonium per sulfate (APS) as an oxidant without adding any extra acids, templates or surface modifiers. The composites were characterized by using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The reactivity of the prepared composites towards hydrogen peroxide (H2O2) was analyzed using cyclic voltammetry and chronoamperometry. The AgNPs-PANINRs composite exhibits better electrochemical performance than the AgNPs-PANINTs composite due to higher content of silver nanoparticle (AgNPs). The sensor has a fast amperometric response time which less than 3 s. The detection limit and limit of quantification (S/N = 3) of two linear range (low and high concentration of H2O2) are estimated as 0.13 μM and 0.45 μM and 0.33 μM and 1.12 μM, respectively.