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Introduction The construction of a medical emergency response system for disasters, which plays an important role in medical emergency response to multiple catastrophic events, has been sped up in China since the 2008 Wenchuan earthquake. However, the implementation process has also exposed some problems, particularly the disaster relief system.Methods In this review, we summarised and analysed emergency medical rescue efforts after major disasters in China in recent years, including 2008 Wenchuan earthquake, 2010 Yushu earthquake, ‘7.23’ Yongwen major railway line accident and 2013 Lushan earthquake.Results Critically wounded persons after Wenchuan and Lushan earthquake were managed according to the “four centralised strategies of care”, namely casualties, experts, resources and patients, which were designed to make the best use of limited resources. The collection of disaster response resources was not the sooner the better. The vulnerability and anti-disaster capacity of quake-hit zone and the degree of matching between critical elements of a response system and its supporting systems should be considered. The training of rescue teams in rural and high-altitude areas should be strengthened. Non-government organisations, the government and the public should join together to deal with the disaster.Conclusions In this paper, we evaluate the disaster relief systems in China through a retrospective analysis of medical practice of catastrophic events in recent years. This review suggests that there are a lot of experiences and lessons on how to prepare and respond to disasters in China, especially those in plateau mountain region and those considering emergency responses to catastrophic events. (Hong Kong j.emerg.med. 2015;22:270-280)

The construction of a medical emergency response system for disasters, which plays an important role in medical emergency response to multiple catastrophic events, has been sped up in China since the 2008 Wenchuan earthquake. However, the implementation process has also exposed some problems, particularly the disaster relief system. In this review, we summarised and analysed emergency medical rescue efforts after major disasters in China in recent years, including 2008 Wenchuan earthquake, 2010 Yushu earthquake, ‘7.23’ Yongwen major railway line accident and 2013 Lushan earthquake. Critically wounded persons after Wenchuan and Lushan earthquake were managed according to the “four centralised strategies of care”, namely casualties, experts, resources and patients, which were designed to make the best use of limited resources. The collection of disaster response resources was not the sooner the better. The vulnerability and anti-disaster capacity of quake-hit zone and the degree of matching between critical elements of a response system and its supporting systems should be considered. The training of rescue teams in rural and high-altitude areas should be strengthened. Non-government organisations, the government and the public should join together to deal with the disaster. In this paper, we evaluate the disaster relief systems in China through a retrospective analysis of medical practice of catastrophic events in recent years. This review suggests that there are a lot of experiences and lessons on how to prepare and respond to disasters in China, especially those in plateau mountain region and those considering emergency responses to catastrophic events. (Hong Kong j.emerg.med. 2015;22:270-280)

Introduction The revised trauma score (RTS) was developed more than 20 years ago. Few studies investigated its usefulness in predicting trauma outcomes. This is especially true for the weighted version of RTS (RTS-w). The aim of this study was to test the predicting power of RTS-w for the trauma outcomes including mortality, admission to intensive care unit (ICU), hospital length of stay and ICU length of stay through a comparison with Injury Severity Score (ISS).Methods Descriptive data, variables related to the trauma scores and outcomes were collected. The statistical performance of RTS-w and ISS in predicting the trauma outcomes using receiver operating characteristics (ROC) curves and the area under the curve (AUC) with 95% confidence interval and p value were calculated. The Hosmer-Lemeshow chi-squared statistic was performed to measure its calibration.Results A total of 3323 patients were enrolled in the study. RTS-w was significantly better than ISS in predicting mortality of trauma patients (AUC: 0.934 vs.0.880, p<0.0001). However, for the other three outcomes, i.e. admission to ICU, hospital length of stay and intensive care unit length of stay, the performance of RTS-w was inferior to ISS.Conclusions The RTS-w is a better predictor of mortality than ISS. But its ability to predict other trauma outcomes is not as good as ISS. More studies are needed to identify the predictive ability of RTS-w for the outcomes other than mortality. Besides, updating the coefficients of the formula may make RTS-w more accurate.

The revised trauma score (RTS) was developed more than 20 years ago. Few studies investigated its usefulness in predicting trauma outcomes. This is especially true for the weighted version of RTS (RTS-w). The aim of this study was to test the predicting power of RTS-w for the trauma outcomes including mortality, admission to intensive care unit (ICU), hospital length of stay and ICU length of stay through a comparison with Injury Severity Score (ISS). Descriptive data, variables related to the trauma scores and outcomes were collected. The statistical performance of RTS-w and ISS in predicting the trauma outcomes using receiver operating characteristics (ROC) curves and the area under the curve (AUC) with 95% confidence interval and p value were calculated. The Hosmer-Lemeshow chi-squared statistic was performed to measure its calibration. A total of 3323 patients were enrolled in the study. RTS-w was significantly better than ISS in predicting mortality of trauma patients (AUC: 0.934 vs.0.880, p<0.0001). However, for the other three outcomes, i.e. admission to ICU, hospital length of stay and intensive care unit length of stay, the performance of RTS-w was inferior to ISS. The RTS-w is a better predictor of mortality than ISS. But its ability to predict other trauma outcomes is not as good as ISS. More studies are needed to identify the predictive ability of RTS-w for the outcomes other than mortality. Besides, updating the coefficients of the formula may make RTS-w more accurate.

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are different stages of the same disease, the aggravated stage of ALI leading to ARDS. Patients with ARDS have higher hospital mortality rates and reduced long-term pulmonary function and quality of life. It is, therefore, important to prevent ALI converting to ARDS. This study evaluated 17 risk factors potentially associated with the conversion from ALI to ARDS in severe multiple trauma. The results indicate that the impact of pulmonary contusion, APACHE II score, gastrointestinal haemorrhage and disseminated intravascular coagulation may help to predict conversion from ALI to ARDS in the early phase after multiple-trauma injury. Trauma duration, in particular, strongly impacted the short- and long-term development of ALI. Being elderly (aged ≥ 65 years) and undergoing multiple blood transfusions in the early phase were independent risk factors correlated with secondary sepsis, deterioration of pulmonary function and transfusion-related acute lung injury due to early multiple fluid resuscitation.

Skeletal effects of moexipril, an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide (HCTZ), a thiazide diuretic, were studied in ovariectomized (OVX) spontaneously hypertensive rats (SHR). Moexipril (10 mg/kg per day), HCTZ (10 mg/kg per day), alone or in combination, as well as 17 alpha-estradiol (30 micrograms/kg per day) were given to OVX SHR immediately after surgery and studied for short- and long-term effects (14 and 56 days respectively). All drugs were given orally. Histomorphometric data on the secondary spongiosa of proximal tibial metaphyses (cancellous bone) and tibiofibular junctions of tibial shafts (cortical bone) were analyzed. Ovariectomy induced cancellous bone loss in SHR by inducing negative bone balance. Estrogen prevented ovariectomy-induced cancellous bone loss in the SHR by reducing bone turnover and partially suppressing the coupling of bone formation to resorption on the endocortical surface. HCTZ reduced blood pressure after 1 week of treatment, yet this effect was no lower than that seen in controls after 3 weeks of treatment. Two weeks of HCTZ transiently prevented ovariectomy-induced increases in bone turnover rate and eroded surface. This delayed ovariectomy induced trabecular bone loss in the proximal tibial metaphysis, but had no effect on the tibial shaft. Like HCTZ, moexipril also reduced blood pressure after the first week of treatment but it had no apparent effect on either the proximal tibial metaphysis or the tibial shaft. A combination of moexipril and HCTZ exhibited a much more potent hypotensive effect and had the same effect on bone mass and dynamic end-points as HCTZ alone. Our data indicate that (1) HCTZ treatment has some transient beneficial effects on both antihypertension and osteoprotection in hypertensive osteopenic rats, (2) the combination of moexipril with HCTZ improved the antihypertensive effect but did not potentiate or hamper the osteoprotective effect of HCTZ, and (3) the skeletal effect of estrogen is not impacted by the hypertensive state. These findings are relevant for the use of ACE inhibitor and thiazide diuretics, alone or in combination, in antihypertensive therapy in postmenopausal women.