1. Future Research Goals in Immunotherapy
- Author
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Hulett, Tyler W., Fox, Bernard A., Messenheimer, David J., Marwitz, Sebastian, Moudgil, Tarsem, Afentoulis, Michael E., Wegman, Keith W., Ballesteros-Merino, Carmen, and Jensen, Shawn M.
- Abstract
In our opinion the most urgent needs to improve patient outcomes are: 1) a deeper ability to measure cancer immunobiology, and 2) increased availability of agents that, coupled with predictive biomarkers, will be used to tailor anti-cancer immunity. Tailoring effective immunotherapy will entail combinations of immunotherapeutics that augment priming of anti-cancer immunity, boost expansion of effector and memory cells of the T, B and NK lineage, amplify innate immunity and relieve checkpoint inhibition. Alternatives to inducing adaptive immunity to cancer include synthetic immunology that incorporate bi-specifics that target T cells to cancer or adoptive immunotherapy with gene-modified immune cells.
- Published
- 2019
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