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Among gynecologic cancers, uterine serous carcinoma (USC) has been shown to be human epidermal growth factor receptor 2 (HER2) amplified and trastuzumab has been included in the recent National Comprehensive Cancer Network (NCCN) guidelines for treatment of advanced stage or recurrent USC with HER2 overexpression/amplification. There is limited literature suggesting that a subset of high-grade endometrioid carcinomas with aberrant p53 expression may also be HER2amplified and these patients could benefit from the addition of targeted therapy. We identified 59 p53-aberrant (mismatch repair proficient) FIGO 3 endometrioid carcinomas of the uterus. HER2 immunohistochemistry was performed in all 59 tumors and HER2fluorescence in situ hybridization (FISH) was performed in 52 of the 59 cases. Four of the 59 cases were HER2 3+ by immunohistochemistry (6.7%), using the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) 2007, 2013, and 2018 criteria. HER2FISH was performed in 3 of the 4 cases and was amplified in all 3. Nine, 8, and 7 tumors showed 2+ HER2 staining when applying 2018, 2013, and 2007 criteria, respectively, FISH was performed in 7 tumors and none were amplified. An additional 4 cases did not perfectly meet the 2018 ASCO/CAP criteria but were assigned a score of 2+, none were amplified by HER2FISH. The remaining 42 cases showed 1+ or no staining for HER2, FISH was successfully performed in 38 tumors and none showed amplification. Approximately half of the tumors fulfilled criteria for HER2-low or HER2-very low (10 HER2-low and 20 HER2-very low). Our data shows that a subset of p53-aberrant high-grade endometrial endometrioid carcinoma express HER2 and these patients may benefit from the addition of targeted therapy. The role of targeted therapy in HER2-low gynecologic carcinoma is currently unexplored.

During the twenty-first century, the professional athlete's net worth has increased as salaries have skyrocketed. (1) For those talented enough to earn million-dollar salaries each year, there is also the [...]

As customer centricity becomes widespread throughout the organization, teams can avoid unnecessary missteps and dismantle organizational bureaucracy. An effective, empowered team has members who are comfortable seeking qualitative and quantitative feedback from one another, leadership, and customers on how well they are doing against the organization's product vision and product strategy. As teams and the broader organization adopt an open culture and feel empowered at the individual and team level, teams feel a core element of engagement: purpose. As we look at performance outcomes, we typically see teams improve I effectiveness i (delivery predictability, value realization, and team engagement) early on. [Extracted from the article]

The article focuses on the wrongful death lawsuit case Diniro v. Aspen Athletic Club filed by the victim's widow against Aspen Athletic Club. It is mentioned that Ronald Pelligra suffered cardiac arrest while working out at an Aspen Athletic Club in DeWitt, New York and the Automated external defibrillation (AED) at the club was not working properly. It is noted that the extensive delay in Pelligra's treatment and the failure of AEDs subsequently resulted in his death.

We've leveraged data from more than 1,700 teams to understand the relationship between capabilities and performance outcomes. I Team processes: i It is intuitive that I harmonized team processes i (including effective agile ceremonies, a strong product roadmap, and a single backlog), coupled with an ingrained culture of continuous improvement and sharing best practices, support team productivity. I Resourcing: Dynamic resourcing i supports effective teams not only by ensuring that individuals are aligned with teams based on organizational goals but also by allowing the organization to optimize team composition more easily. I Reporting structure: i Creating a I reporting structure i that supports team autonomy, organizes teams around user journeys, ensures teams have the required skills within their group, and fosters strong communities of practice minimizes cross-team dependencies and enables teams to work toward their objectives with less administrative effort. [Extracted from the article]

Salivary duct carcinoma (SDC) is aggressive with limited therapeutic options. A subset of SDC display human epidermal growth factor receptor 2 (HER2) protein overexpression by immunohistochemistry, and some show ERBB2gene amplification. Guidelines for HER2 scoring are not firmly established. Recent advances in breast carcinoma have established a role for anti-HER2 therapies in lesions with low HER2 expression lacking ERBB2amplification. Delineating HER2 staining patterns in SDC is critical for evaluating anti-HER2 treatments. 53 cases of SDC resected at our institution between 2004 and 2020 were identified. Androgen receptor (AR) and HER2 immunohistochemistry and ERBB2FISH were performed in all cases. AR expression was scored for percent positive cells and categorized as positive (>10% of cells), low positive (1-10%), or negative (<1%). HER2 staining levels and patterns were recorded, scored using 2018 ASCO/CAP guidelines, and categorized into HER2-positive (3+ or 2+ with ERBB2amplification), HER2-low (1+ or 2+ without ERBB2amplification), HER2-very low (faint staining in <10% of cells), or HER2-absent. Clinical parameters and vital status were recorded. Median age was 70 years with a male predominance. ERBB2-amplified tumors (11/53; 20.8%) presented at lower pT stages (pTis/pT1/pT2, p= 0.005, Fisher exact test) and more frequently had perineural invasion (p= 0.007, Fisher exact test) compared with ERBB2non-amplified tumors; no other pathologic features differed significantly by gene amplification status. 2+ HER2 staining by 2018 ASCO/CAP criteria was most common (26/53; 49%); only 4 cases (8%) were HER2-absent. 3+ HER2 staining was found in 9 tumors and all were ERBB2-amplified. 6 patients with HER2-expressing tumors received trastuzumab therapy, including 2 with ERBB2-amplified tumors. Overall survival and recurrence-free survival did not differ significantly based on ERBB2status. This work suggests that 2018 ASCO/CAP guidelines for HER2 evaluation in breast carcinoma could be applied to SDC. Our findings also show broad overexpression of HER2 in SDC raising the possibility that more patients may benefit from anti-HER2 directed therapies.

The article discusses why several athletes are creating nonprofit foundations these days and how an athlete can start his own foundation and make it successful. The article also gives certain examples of successful nonprofit organizations. It highlights the trademarks of a successful athlete-sponsored foundation. It suggests that an athlete must understand that running a nonprofit foundation is a time-consuming process and requires hard work. It also suggests hiring professionals with experience.

Schools and universities often struggle with the balance of education, prevention, and due process related to sexual assault claims on campus. With this struggle comes increased scrutiny, most of which focuses on athletics. A series of high profile incidents in recent years have involved student-athletes with many wondering if schools are protecting those individuals to safeguard the business of college sports. As the leading institution for college sport governance, the public looks to the NCAA to set an example. Their current silence related to sexual assault claims sets a difficult precedent. Should the NCAA intervene and enforce rules related to concerns that go beyond sport and into the courtroom? This article will address whether the NCAA should impose sanctions on universities related to the mishandling of sexual assault complaints. An examination of NCAA rules will be conducted to determine if the NCAA could potentially punish these systemic failures and how the NCAA would have to proceed to implement these sanctions. Finally, the article will address the success of those potential claims by highlighting the results of previous NCAA involvement in potential civil liability or criminal activity conducted by student-athletes or those employed by athletics. [ABSTRACT FROM AUTHOR]

The article discusses the reasons why the author chose Marquette University Law School to pursue a career in sports in Milwaukee, Wisconsin. The author explains the effect of the school's professional sports internships on students legal knowledge. She also notes the role of the faculty and staff in inspiring students to become successful.

Schools and universities often struggle with the balance of education, prevention, and due process related to sexual assault claims on campus. With this struggle comes increased scrutiny, most of which focuses on athletics. A series of high profile incidents in recent years have involved student-athletes with many wondering if schools are protecting those individuals to safeguard the business of college sports. As the leading institution for college sport governance, the public looks to the NCAA to set an example. Their current silence related to sexual assault claims sets a difficult precedent. Should the NCAA intervene and enforce rules related to concerns that go beyond sport and into the courtroom? This article will address whether the NCAA should impose sanctions on universities related to the mishandling of sexual assault complaints. An examination of NCAA rules will be conducted to determine if the NCAA could potentially punish these systemic failures and how the NCAA would have to proceed to implement these sanctions. Finally, the article will address the success of those potential claims by highlighting the results of previous NCAA involvement in potential civil liability or criminal activity conducted by student-athletes or those employed by athletics. [ABSTRACT FROM AUTHOR]