Search

La telangiectasia hemorrágica hereditaria (HHT, por sus siglas en inglés) es una enfermedad minoritaria con herencia autosómica dominante que provoca una afectación vascular sistémica.

Las enfermedades cardiovasculares heredadas representan un grupo heterogéneo de alteraciones que tiene como causa una variante genética con una expresión variable de la enfermedad y alta penetrancia, y se caracterizan por una presentación familiar. Incluyen miocardiopatías, canalopatías, aortopatías, así como hipertensión pulmonar familiar.

Background: Although exercise echocardiography (EE) has value for the diagnosis of coronary artery disease (CAD), it's not clear whether it may be useful for risk assessment in all categories of patients. To determine whether: 1) there is an incremental value of EE over clinical, exercise and resting echocardiographic variables for the prediction of events according to the pre-test probability of CAD; and 2) the number, location of the diseased territories, and nature of the disease affect the risk stratification, we studied 2436 patients referred for EE that were followed for 2.1 +/- 1.5 years. Methods: Based on a pre-test score, previous myocardial infarction (MI) or revascularizations, 1242 patients were considered as having high, 1038 moderate, and 156 low pre-test probability. Results: There were 89 hard events (myocardial infarction or cardiovascular death) in the 1203 patients with abnormal EE vs. 31 events in the 1233 with normal EE (p < 0.0001). Gender, Mets, heart rate x blood pressure, resting wall motion score index and number of involved territories at exercise were independently associated to hard events (final Chi-square = 170, incremental p value of exercise echo <0.0001). The incremental value of exercise echo over other variables was found in patients with the different pre-test probabilities. Conclusions: Exercise echocardiography has incremental value over clinical, exercise and resting echocardiographic variables in patients with different pre-test probabilities of CAD.

The objective of this study is to determine the effect of the ageing time on the quality characteristics of yearling calf meat under vacuum. Ninety-six Rubia Gallega yearling calves were used. Samples of the Longissimus thoracis at 1 day post slaughter as a control, and vacuum-packaged for 7, 14 and 21 days were analysed. Colour (lightness, L*, redness, a*, yellowness, b*, hue, Ho, chroma, C*, and pigment concentration), water-holding capacity (expressible juice and cooking losses), pH and toughness were measured. The statistical analysis showed an increase in a*, b*, Ho and C* and a decrease in expressible juice, cooking losses and toughness as the ageing time increased. Discriminant analysis divided the samples into two groups; i.e., 1-day post-slaughter samples and vacuum-packaged samples. Considering vacuum-packaged samples only, canonical discriminant analysis separated the long-ageing samples (21 days) from the short-ageing samples (7 days).

CHOP regimen is standard chemotherapy in patients with non-Hodgkin's lymphoma (NHL), but its use is limited by the risk of cardiotoxicity. Aim. To define new parameters, such as 4D echo (4DE) LV deformation or biomarkers, to diagnose early cardiac dysfunction and predict cardiotoxicity. Methods. 37 patients (13 men, 62 ± 12 years) with NHL, without cardiac disease, with EF>53%, scheduled to receive CHOP, were assessed at baseline, after the 2nd and 4th cycle. 4DE was used to assess EF and LV systolic deformation: longitudinal, radial, circumferential, area strain (LS, RS, CS, AS). Troponin I was measured. Cardiotoxicity was defined as a decrease of EF <53%, with >10% from the baseline. Results. After the 4th cycle of CHOP, 10 patients (27%) (group I) developed cardiotoxicity, while 27 patients (group II) didn't. There was a significant reduction of all LV systolic deformation parameters starting with the 2nd cycle, but group I had lower values than group II (Table). The reduction of the LS after the 2nd cycle was the best independent predictor for the decrease of EF after the 4th cycle (R2=0.44, p=0.0001); a decrease of LS with >30% after the 2nd cycle predicted the development of cardiotoxicity after the 4th cycle (sb 100%, sp 85%). Conclusion. Assessment of 4DE myocardial deformation parameters are able to detect early chemotherapy-induced cardiotoxicity and to predict further changes in the EF of patients with NHL. 4D deformation parameters CHOPGroup IGroup IIp value (Anova)LS (-%)Baseline22 ± 222 ± 20.00012nd cycle10 ± 116 ± 2*0.00014th cycle8 ± 1*12 ± 2*0.0001CS (-%)Baseline21 ± 2*21 ± 2*0.00012nd cycle15 ± 1*17 ± 2*0.054th cycle12 ± 3*15 ± 1*0.0001RS (%)Baseline56 ± 5*56 ± 5*0.00012nd cycle40 ± 5*46 ± 6*0.054th cycle33 ± 6*39 ± 6*0.0001AS(%)Baseline35 ± 4*36 ± 4*0.00012nd cycle22 ± 528 ± 4*0.00014th cycle17 ± 5*23 ± 40.01