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Background: The aim of this study was to evaluate the histological tolerance of medical cyanoacrylate adhesives (CAs), butyl‐CA and octyl‐CA, applied by two different methods in surgical skin incisions of T. scripta. Methods: A two‐trial controlled blind study each one including 12 female adult T. scriptaturtles. Two 1‐cm long full‐thickness surgical skin incisions were made on the dorsal aspect of each hind limb. In trial 1 CAs were applied superficially over the apposed wound edges; each animal's four wounds were closed using butyl‐CA, octyl‐CA and ethyl‐CA or absorbable suture as controls. In trial 2 adhesives were applied holding wound edges everted, and octyl‐CA was replaced by a non‐sutured control wound. At each time point (2, 7, 14 and 21 days) all wounds from three randomly chosen animals were biopsied. Results: Medical grade CAs did not induce any sign of tissue damage and/or inflammatory reaction attributable to histotoxicity independently of the method of application. Wound dehiscence rate was higher when CAs were applied superficially over the apposed wound edges. Conclusions: Octyl and butyl‐CA are well tolerated by turtles' soft skin but because of their high rate of dehiscence they are not recommended in high tension wounds; use in low tension wounds needs further investigation.