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To preliminarily explore the diagnostic potential of ultrasound (US) in detecting calcium pyrophosphate (CPP) crystal deposits at the hip joint in a cohort of patients with CPPdeposition disease (CPPD) who were previously evaluated by conventional radiography (CR) and to assess the sensitivity and specificity as well as the agreement between USand CRin the evaluation of hip CPPcrystal deposits. Fifty consecutive patients with definite CPPDand 40 age/sex/body mass index–matched disease control subjects who had undergone hip CRwithin the previous 6 months were enrolled. Bilateral hip USexamination was carried out to assess the presence of CCPcrystal deposits at the acetabular labrum fibrocartilage and at the femoral head's hyaline cartilage. Two independent radiologists evaluated the presence of hip CPPcrystal deposits on CRin both groups. USfindings indicative of CPPcrystal deposits were found in at least 1 hip in 45 of 50 patients with CPPD(90.0%) and in 73 of 100 hips (73.0%). CPPcrystal deposits were more frequently found at the acetabular labrum fibrocartilage than at the femoral head's hyaline cartilage (72% and 17% of the hips in patients with CPPD, respectively). USand CRsensitivity was 90% and 86%, whereas USand CRspecificity was 85% and 90%, respectively. Total agreement between the USand CRfindings was 77.8%. Our results provide new evidence supporting USas a first‐line, sensitive, safe, and reliable imaging technique in detecting CPPcrystal deposits at the hip level.