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A recent report from Jilin University in Changchun, China discusses the use of nanoprobes to identify the molecular profile of cell membranes. The researchers focused on the chemical signature profiles of cell membranes as biomarkers for cancer cells using label-free surface-enhanced Raman scattering (SERS). They developed a magnetic plasmonic nanoprobe that allowed for targeted accumulation within 5 minutes and achieved successful classification of breast cancer subtypes. The study presents a practical and user-friendly approach for analyzing cell membranes, which could be used for early tumor screening and treatment assessment. The method can also be applied to explore cell membrane components of other cells, assisting in the Human Cell Atlas project. [Extracted from the article]

A patent application titled "Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)-Targeted Nanoprobe For Integrated Diagnosis And Treatment, And Preparation Method And Use Thereof" has been published online. The patent application describes a PECAM-1-targeted nanoprobe for integrated diagnosis and treatment, as well as its preparation method and use. The nanoprobe aims to address the challenges in classifying and visually detecting early molecular markers related to cytokine release syndrome (CRS), a serious adverse reaction of chimeric antigen receptor T-cell immunotherapy (CAR-T). The nanoprobe can be used to detect and monitor CRS in CAR-T and inhibit its occurrence. It has potential clinical translation value in promoting endothelial reconstruction and alleviating CRS. [Extracted from the article]

A study conducted at Fudan University in Shanghai, China has developed a non-invasive method for diagnosing liver fibrosis using targeted gadolinium-based nanoparticles. Liver fibrosis is a condition that can lead to cirrhosis and liver tumors, so accurate diagnosis is crucial. The researchers created hyaluronic acid-coated nanoprobes that specifically target hepatic stellate cells with elevated CD44 expression, which are associated with liver fibrosis. These nanoprobes were found to effectively target the cells and produce high-quality MRI images, allowing for efficient diagnosis of liver fibrosis. [Extracted from the article]

A study conducted at Sun Yat-Sen University has developed a new method for personalized treatment of hypertension. The researchers created activatable renin nanoprobes (ARNs) that can detect renin activity in the body, allowing for accurate profiling and guiding of antihypertensive therapy. The ARNs were found to outperform the gold standard radioimmunoassay in detecting renin levels. The researchers believe that this nanoprobe platform has the potential to improve outcomes for hypertensive patients by assisting clinicians in rapidly and accurately classifying patients and selecting tailored treatments. [Extracted from the article]

A report from Qinghai University in Xining, China discusses a new method for detecting tetracyclines (TCs) using europium (III)-functionalized polymer nanodots. The researchers synthesized the nanodots through a one-pot one-step reaction and found that they exhibited good detection limits for various TCs. The nanoprobe showed low cost, easy preparation, and desirable specificity and sensitivity, making it a promising tool for detecting TCs in food safety control and human health protection. The research was supported by the Natural Science Foundation of Qinghai Province. [Extracted from the article]

A study conducted by researchers from Jilin University in Changchun, China, has found that biochar nanoparticles derived from bagasse, a byproduct of sugarcane, can effectively quench the fluorescence of 6-carboxyfluorescein. These nanoparticles, known as bagasse-derived quencher nanoparticles (BQNPs), have various beneficial properties such as low cost, environmental friendliness, high dispersibility, and versatile molecular modification. The researchers demonstrated that BQNPs can be used to construct fluorescence nanoprobes for the detection of single-stranded DNA and 17 beta-estradiol (E2). The BQNPs showed high precision, selectivity, and sensitivity in detecting these substances, making them potential candidates for the development of cost-effective and sensitive fluorescence sensors. [Extracted from the article]

Researchers from Fudan University have developed a new method for grading liver fibrosis using molecular imaging. They discovered that the fibroblast activation protein alpha (FAPa) is strongly correlated with fibrosis grade. They created a FAPa-responsive MRI nanoprobe that can accurately grade liver fibrosis by measuring the T1-MRI signal of gadoteric acid. The nanoprobe was able to identify different stages of fibrosis with high accuracy. This research shows promise for the early detection and grading of liver fibrosis in clinical settings. [Extracted from the article]

Researchers at Peking University have made new findings in the field of cancer gene therapy. They have developed hydrophobic core-tunable ultra-pH-sensitive nanoprobes (HUNPs) that can amplify tumour microenvironmental signals, allowing for precise tumour detection and imaging. By tuning the hydrophobicity of the nanoparticle core composition, the researchers achieved high cellular internalization efficiency and fluorescence signals, resulting in improved contrast and resolution for locating malignant lesions. This study provides important strategies for designing nanomedicines for cancer detection, drug/gene delivery, and therapy. [Extracted from the article]

A recent study conducted at Fuzhou University in China has developed a biosensor that can quantitatively monitor the levels of microRNA-21 (miR-21) in vivo during cancer initiation and progression. MiR-21 is known to be upregulated in tumors and is closely associated with tumor occurrence. Traditional imaging methods for miR-21 are limited to qualitative imaging, but this new biosensor, called DCNP@DNA2@IR806, utilizes a ratiometric fluorescent nanoprobe to provide real-time monitoring of miR-21 levels. This research has the potential to enhance our understanding of microRNA-based molecular mechanisms in cancer and lay the foundation for early diagnosis of microRNA-related diseases. [Extracted from the article]

Researchers from Federal University Pernambuco in Recife, Brazil have developed bimodal nanoprobes for imaging techniques by combining quantum dots (QDs) with paramagnetic complexes (GdDOTA). These nanoprobes showed enhanced emission intensity compared to bare QDs and exhibited higher r1 values than clinical GdDOTA. The bimodal systems demonstrated promising performance for both optical and magnetic resonance imaging, making them potential contrast agents. This research was funded by various organizations and has been peer-reviewed. [Extracted from the article]

Researchers at the University of Calcutta have developed a new method for detecting the presence of amoxicillin (AMX) and chromium (Cr3+) using a smart pH-switchable ZnO quantum dot (QD) nanoprobe. The researchers synthesized the ZnO QDs using tetraethyl orthosilicate (TEOS) as a capping agent through a low-temperature base-hydrolysis reaction. The TEOS-capped ZnO QDs exhibited strong fluorescence and showed selective fluorescence quenching and enhancement in the presence of Cr3+ and AMX, respectively. The estimated limit of detection for Cr3+ was 15.94 nM and for AMX was 77.86 nM. The researchers suggest that this nanoprobe could be used in the fabrication of pH sensors and capacitive sensors. [Extracted from the article]

A study conducted at the University of Birmingham in the United Kingdom has explored the use of osmium-labelled gold nanoparticles for cellular imaging and singlet oxygen generation in cancer cells. The researchers developed gold nanoparticles decorated with an osmium complex, which exhibited near-infrared luminescence and localized in the cytoplasmic and perinuclear compartments of lung cancer and breast carcinoma cells. The nanoparticles also demonstrated the ability to generate reactive oxygen species and singlet oxygen, making them potentially useful for both imaging and therapy. This research offers new possibilities for localized therapy approaches using dual modality nanoprobes. [Extracted from the article]

A recent study conducted in Anhui, People's Republic of China, explored the use of deformed organosilica nanoprobes in personalized medicine for cancer treatment. The study found that these nanoprobes exhibited excellent biocompatibility and showed a direct correlation between tumor size and nanoprobe accumulation, with larger tumors having higher uptake. The researchers also identified vascular density and extracellular matrix remodeling as key factors in nanoprobe accumulation. The study suggests that deformed organosilica nanocapsules could be promising vehicles for targeted cancer therapy. [Extracted from the article]

A study conducted at Rhodes University in Grahamstown, South Africa, has explored the use of biocompatible liposomes and chitosan-coated CdTe/CdSe/ZnSe multi-core-multi-shell quantum dots (QDs) for biomedical applications. The researchers investigated the optical, morphological, and physicochemical properties of these nanocomposites and found that liposome-coated QDs demonstrated better optical properties, photostability, and biocompatibility compared to QDs with chitosan coating. The study concluded that these particles show promise for cell labeling and drug delivery studies. The research has been peer-reviewed and published in the Journal of Photochemistry and Photobiology A-Chemistry. [Extracted from the article]

Researchers at Soochow University in Suzhou, China have developed a new method to target and induce ferroptosis in myeloid-derived suppressor cells (MDSCs) using nanoprobes. MDSCs can hinder the immune response to tumor radiotherapy, leading to poor clinical outcomes. The researchers created an anti-PD-L1 antibody-conjugated iron oxide nanoprobe to track the movement of MDSCs and induce ferroptosis, which reprograms the immunosuppressive environment within the tumor. This study offers a strategy for monitoring and regulating the fate of MDSCs to improve treatment outcomes. [Extracted from the article]

A recent report from Shanghai Jiao Tong University discusses the development of dual-modal nanoprobes for the detection of triple negative breast cancer (TNBC). The researchers synthesized a nanoprobe that combines near infrared II (NIR II) luminescence imaging and magnetic resonance imaging (MRI) capabilities. The nanoprobe showed effective recognition of TNBC cells in vitro and concentrated more efficiently in metastatic TNBC tumors compared to other probes. The researchers concluded that this nanocomposite could serve as a non-invasive diagnostic tool for TNBC detection in clinical settings. [Extracted from the article]

Researchers from Tanta University in Egypt have developed a new fluorescent nanoprobe sensor using a luminescent metal-organic framework (LMOF) composite for the selective determination of monosodium glutamate (MSG) in instant noodles. The sensor was characterized using various techniques and was found to be successful in detecting MSG in food samples. The method was validated according to international guidelines and showed good accuracy and precision. The researchers concluded that the nanoprobe was selective and accurate in determining MSG in instant noodle seasonings, with a reduced environmental impact. [Extracted from the article]

A study conducted by researchers at East China University of Science and Technology in Shanghai, China, has explored the functionalization of nanoscale hierarchically mesoporous metal-organic frameworks (HMMOFs) for the specific detection of cancer cells. By modifying the microporous and mesoporous spaces, as well as the external surface of the HMMOFs, the researchers were able to enhance the functionalities of the nanoprobes. The developed nanoprobe demonstrated the ability to specifically identify cancer cells through colorimetric and visible means. This research provides a potential guideline for the design of multi-functional diagnostic platforms for the detection of various cancers. [Extracted from the article]

Researchers from Dankook University in Yongin, South Korea have developed a new method for diagnosing pancreatic cancer using top-down-based optical fiber nanoprobes. The researchers used gold nanostructures patterned onto optical fibers to improve the sensitivity of the sensors. By incorporating a sandwich assay, they were able to achieve a detection limit of 0.25 U/mL, which is approximately 700 times lower than the reference value. The researchers believe that these fiber-optic sensors could be commercially viable as reliable and cost-effective devices for diagnosing pancreatic cancer. [Extracted from the article]

The article focuses on a new nanoplatform designed for diagnosing and treating non-small-cell lung cancer (NSCLC). Topics include the integration of gold nanoparticles, DNAzyme, and siRNA for detecting CEACAM6 RNA in cerebrospinal fluid, the enhancement of siRNA delivery to tumor cells for gene therapy, and the effectiveness of this system in in-situ fluorescence imaging and tumor growth inhibition in mouse models.

The article focuses on a Phase 2 multicenter trial conducted at the University of Pennsylvania, evaluating the use of a pH-activatable nanoprobe for intraoperative molecular imaging of lung cancer. Topics include the efficacy of the nanoprobe in detecting tumors during surgery, the comparison of imaging results with traditional methods, and the safety and clinical impact of the technology.

A recent report from researchers at Xiangya Hospital 2 in Changsha, People's Republic of China, details the development of a three-in-one multimodal lateral flow immunoassay (LFIA) for the detection of Staphylococcus aureus (S. aureus). S. aureus is a prevalent bacterium that can cause postoperative complications, so detecting it in clinical settings is crucial for patient well-being. The LFIA utilizes nanoprobes and offers a visual detection mode with a limit of detection of 103 CFU/mL, as well as colorimetric analysis with a detection range from 102 to 107 CFU/mL. The LFIA demonstrates promising results for quantitative analysis of bacteria in clinical samples and can be used as a point-of-care testing platform. [Extracted from the article]

A patent application titled "Nucleic Acid Functionalized Metal Nanoprobe And Preparation Method Therefor" has been published online. The inventors discuss the challenges of detecting and treating pathogenic microorganisms and propose a new detection technology using metal nanoprobes synthesized through in-situ self-assembly. The patent application also describes a method for detecting food-borne pathogenic bacteria using a metal-organic framework material-nucleic acid aptamer fluorescence sensor. The inventors aim to develop a simple, sensitive, and reliable detection technology and a safe and effective treatment strategy for pathogenic microorganisms. The patent application describes the process of creating the nucleic acid functionalized metal nanoprobe and the method for preparing it, which involves mixing nucleic acid fragments with a nucleic acid intercalator and a metal soluble salt solution, incubating the mixture with pathogenic microorganisms, and activating the cells with a laser confocal fluorescence microscope. The nanoprobe has advantages such as high specificity, simplicity, and convenience, and it has potential applications in infectious disease intervention. [Extracted from the article]

A recent report from Nanchang University in China discusses the development of a nuclear magnetic resonance biosensor for detecting Salmonella in milk. The researchers used a gadolinium-targeting molecular probe to create a magnetic complex that could capture Salmonella. The sensor was able to detect Salmonella within 1.5 hours, with a detection limit of 7.1 x 10(3) cfu mL(-1). This research provides new insights into the detection of harmful pathogens in food and has potential implications for food quality management and public health. [Extracted from the article]

Researchers at Soochow University in Suzhou, China have developed a multifunctional nanoagent for bladder cancer downstaging and bladder-preserving therapy. The nanoagent, which is a nanoprobe labeled with Lu-177, was able to target and image both nonmuscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) after being instilled into the bladder. The study showed that the nanoprobe was effective in downstaging the cancer and inhibiting metastasis, demonstrating its potential for bladder preservation in bladder cancer treatment. The research was supported by the National Natural Science Foundation of China and the National Key Research and Development Program of China. [Extracted from the article]

Researchers from Xi'an Jiaotong University in China have developed a new nitroreductase-responsive nanoprobe called NanoBodipy for non-invasive tumor imaging and intraoperative guidance. The nanoprobe, which has a homogeneous composition and high loading capacity, can efficiently accumulate in tumors and be activated by overexpressed nitroreductase in tumor cells. The researchers successfully performed complete tumor resection surgery using the real-time fluorescence guidance provided by NanoBodipy. This research has been peer-reviewed and published in Chinese Chemical Letters. [Extracted from the article]

Researchers at Southwest University in Chongqing, China have developed a new nanotechnology called lanthanide-grafted covalent organic framework (COF) that can detect tetracycline (TC) in water and food samples. TC is an antibiotic commonly used for infection treatment, but its presence in potable water and food can have adverse health and environmental effects. The COF-Ce-Eu nanoprobes function as a colorimetric and luminescence dual-mode platform, providing precise, sensitive, rapid, and real-time TC determination. The nanoprobes exhibit excellent selectivity and sensitivity towards TC, with a wide linear range and low detection limits. This research provides a promising method for accurately tracing TC in food and water samples. [Extracted from the article]

A recent study conducted by researchers at the University of Kerala in India has developed a new nanocrystal probe that can detect bilirubin, a biomarker for jaundice. The researchers synthesized a lead-free, stable, and cost-effective perovskite nanocrystal that emits bright blue fluorescence when exposed to UV light. The sensor was able to selectively detect bilirubin, even in the presence of other interfering biomolecules, with a limit of detection of 26.10 nM. Additionally, the researchers designed a paper strip sensor for visual detection of bilirubin, making the sensor more economical and adaptable. This research provides new insights into the development of advanced materials for biological sensing applications. [Extracted from the article]

Researchers at the Federal University of Pernambuco in Brazil have developed bimodal nanoprobes for diagnostic magnetic resonance imaging (MRI) and optical imaging. The nanoprobes, which consist of AgInSe quantum dots and gadolinium complexes, showed good optical properties and higher relaxivity compared to clinically used contrast agents. The researchers concluded that these nanoprobes have the potential to be used as contrast agents for MRI and optical imaging. This information is available in a journal article published by MDPI AG. [Extracted from the article]

Researchers at Anhui Normal University in Wuhu, China have developed a new nanoprobe called LyNO-Pdots that can be used for ratiometric imaging of lysosomal nitric oxide (NO) variations in brain cells and tissues. The probe showed high specificity, stability, and good penetration through the blood-brain barrier. In their study, the researchers found that the NO content in the brains of mice with Alzheimer's disease was significantly higher than in normal mice. This research was supported by the National Natural Science Foundation of China and has been peer-reviewed. [Extracted from the article]

A report from Tumkur University in India discusses the synthesis of eco-friendly carbon quantum dots (PCQDs) from pistachio shells. These PCQDs have versatile applications, including as nano-probes for measuring Cu2+ ions, ink-free patterned substrates for detecting latent fingerprints, and in the fabrication of anti-counterfeiting films. The PCQDs also exhibit sustainability, flexibility, and foldability, expanding their potential applications in various fields. The research concludes that PCQDs are a highly efficient luminescent platform with a wide range of applications. [Extracted from the article]

A study conducted at Anhui Normal University in Wuhu, People's Republic of China, has developed a method for improving the accuracy and fidelity of artificial chemical reactions (ACRs) used in bioimaging within living cells. The researchers utilized metal-ion-dependent DNAzyme cleavage reactions as a model ACR and developed coordination-driven nanoprobes to enhance the stability and specificity of tumor imaging. This research has implications for cell biology, pathology studies, and the advancement of biomedical imaging and disease diagnostic technologies. The study was supported by various funding sources and has been peer-reviewed. [Extracted from the article]

Researchers at Nankai University in Tianjin, China have developed a new method for diagnosing and assessing the vulnerability of atherosclerotic plaques, which are associated with cardiovascular diseases. The researchers created a nanoprobe called FANP@RBCM, which accurately detects reactive oxygen species (ROS) levels at plaque sites. The nanoprobe has improved biocompatibility, increased immune escape capability, and enhanced accumulation at plaque sites. This research holds promise as a versatile tool for the diagnosis and risk assessment of atherosclerotic disease. [Extracted from the article]

A study conducted by researchers from Shanghai Jiao Tong University in China has explored the advancements and future development of second near-infrared (NIR-II) surface-enhanced Raman scattering (SERS) nanoprobes in biomedicine. The study discusses the principles of SERS nanoprobes and highlights the progress made in the NIR-II window, including reduced tissue attenuation, deep penetration, and improved photostability. It also examines the potential of artificial intelligence (AI) integration in nanoprobe design and the emergence of deep Raman techniques for through-tissue SERS detection. The article concludes by addressing biosafety, functionalization, compatibility, and the path to clinical translation. This review aims to provide insights into the innovative diagnostic and therapeutic approaches in biomedicine using NIR-II SERS nanoprobes. [Extracted from the article]

A new study conducted by investigators at Shandong Normal University in Jinan, People's Republic of China, has developed novel nanoprobes for the specific detection of biomarkers in nonsmall cell lung cancer (NSCLC). These nanoprobes demonstrated exceptional specificity and sensitivity, allowing for dual-color fluorescence imaging to effectively distinguish between NSCLC cells and normal lung cells. The researchers concluded that these nanoprobes show promise as a tool for early NSCLC diagnosis, potentially enhancing the accuracy of cancer detection. This research has been peer-reviewed and published in Analytical Chemistry. [Extracted from the article]

Researchers from Yangtze University in Jingzhou, China have developed a new electrochemical biosensor for the detection of foodborne pathogenic bacteria. The biosensor utilizes a bacterial imprinted polymer film (BIF) and metal-organic frameworks (MOF) to create signal nanoprobes with target recognition ability. The method demonstrates excellent analytical performance with a low limit of detection, a broad detection range, and high selectivity. This research has significant potential in areas related to food safety and public health. [Extracted from the article]

A recent study conducted at Sharda University in Uttar Pradesh, India, has explored the use of carbon dots (C-Dots) in nanotechnology. The researchers synthesized C-Dots using natural precursors and cysteamine, resulting in C-Dots with sulfenic acid functional groups that have potential applications in anti-cancer therapy. The study also investigated the use of these C-Dots as nanoprobes for metal ion detection, specifically for Cr(VI). The research concluded that the fluorescence quenching of C-Dots in the presence of Cr(VI) is due to the inner filter effect. This study provides valuable insights into the tunability and potential applications of C-Dots in various fields. [Extracted from the article]

Researchers from Kaneka Corporation have developed a method for measuring and visualizing aggregating proteins, specifically amyloid beta proteins (Ab), which are associated with Alzheimer's disease. The method involves using a solution to accelerate and visualize protein aggregation, allowing for the collection and quantification of aggregating proteins. By removing contaminants and using a solution with a surface-active substance, the researchers were able to visualize the aggregates. This method has the potential to improve screening techniques for potential treatments for Alzheimer's disease. The patent application also describes kits containing the necessary materials for the method. [Extracted from the article]

A study conducted by researchers at Xuzhou Medical University in China has developed a new intelligent nanoprobe called GHPSM that shows potential for monitoring and delaying the progression of osteoarthritis (OA). The nanoprobe is designed to target the OA microenvironment and reshape it by reducing inflammation and oxidative stress, increasing the expression of structural proteins, and reducing cartilage degradation and chondrocyte apoptosis. The researchers successfully tracked the progression of early OA disease using fluorescence/MR imaging and X-ray imaging of the knee joint. These findings provide novel ideas for future research in OA diagnosis and treatment. [Extracted from the article]

Samsung Electronics Co. Ltd has submitted a patent application for an electronic device with a three-dimensional (3D) nanoprobe device. The device is designed for use in bio-healthcare fields and can be implanted in the body to apply external stimuli and enable extracellular or intracellular recording. The 3D nanoprobe device includes a body portion with stacked layers, nanoprobes extending longitudinally from the body portion, and an electrode portion. The nanoprobes are spaced apart and can have various dimensions and aspect ratios. The device can be used to measure biosignals, biomaterials, and brain signals, and can be configured as an implantable device or for applying external stimuli. [Extracted from the article]

A recent study conducted by researchers at Shanghai Jiao Tong University in China has developed a new type of nanoprobes for ultra-high-field magnetic resonance imaging (MRI) of isolated tumor cells (ITCs). The conventional approach to diagnosing ITCs through invasive biopsies is risky and can lead to overdiagnosis and overtreatment. The new nanoprobes, called structural defect-enabled magnetic neutrality nanoprobe (MNN), have an exceptionally low magnetic susceptibility, which mitigates the T2-decaying effect and enhances the UHF T1 contrast. Under 9 T MRI, the MNNs demonstrated a high-performance imaging capability, allowing for the noninvasive visualization of ITCs with a detection threshold of approximately 0.16 mm. This advancement in UHF-MRI has significant implications for diagnostic purposes and metastasis research. [Extracted from the article]

A recent report from Guangxi University in the People's Republic of China discusses the development of a new fluorescent nanoprobe for the detection of hydrogen sulfide (H2S) in acute pancreatitis (AP). The nanoprobe, called LMOF-BR, utilizes a luminescent metal-organic framework (LMOF) and a fluorescent dye to accurately detect H2S in complex biological environments. The researchers successfully quantified H2S in serum samples and AP mouse plasma, demonstrating the potential of the nanoprobe for the timely and reliable diagnosis of AP. This research has been peer-reviewed and holds promise for advancing biosensing technology. [Extracted from the article]

Researchers at Tianjin University of Science and Technology in China have developed a new method for simultaneous detection of multiple targets in lateral flow immunoassays (LFA). The method uses nanoprobes that encode both color and Raman information, allowing for accurate and sensitive detection. The nanoprobes were successfully tested for the simultaneous detection of carbendazim and imidacloprid in both standard and real samples. This research has been peer-reviewed and shows promising potential for improving detection efficiency and reliability in various fields. [Extracted from the article]

Researchers at Minjiang University in Fujian, China have developed a new miRNA-based therapy using a three-dimensional (3D) DNA walker nanoprobe. The nanoprobe, called a cholesterol-conjugated multifunctional molecular beacon (Chol-MMB), can detect and image miRNA in cells. The nanoprobe has shown promising results in differentiating various cells based on specific miRNA and has a limit of detection of 0.326 fmol for miR-21. The researchers believe that further refinement of this method could lead to an effective platform for cell typing and liquid biopsy. [Extracted from the article]

A report from Shanghai Jiao Tong University discusses the use of nanotechnology in the diagnosis and monitoring of Inflammatory Bowel Disease (IBD). The researchers explain that nanomaterials can be used as contrast agents for imaging and targeted agents for endoscopy, allowing for enhanced detection of IBD. The review outlines existing IBD detection techniques, explores the use of nanoparticles in diagnosis, and discusses the potential of in vitro diagnostics. This research has been peer-reviewed and provides valuable insights into the future of IBD detection and monitoring. [Extracted from the article]

A study conducted by researchers at Hefei University of Technology in China has reported new findings in the field of nanoprobes. The study focuses on the preparation of near-infrared-II (NIR-II) polymer nanoprobes through twisted intramolecular charge transfer and Förster resonance energy transfer of NIR-I dye. The researchers synthesized stable small-sized polymer NIR-II fluoroprobes that enhance NIR-II emission and provide high-resolution angiography. The fluorophore shows potential applications in the prognosis of kidney diseases and can be rapidly excreted from the kidney. The study concludes that the probes with rapid renal clearance can be used for angiography, imaging of middle cerebral artery occlusion mice, and prognosis of acute kidney injury mice. [Extracted from the article]