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The industrial adoption of low-carbon technologies and renewable electricity requires novel tools for electrifying unitary steps and efficient energy storage, such as the catalytic synthesis of valuable chemical carriers. The recently-discovered use of microwaves as an effective reducing agent of solid materials provides a novel framework to improve this chemical-conversion route, thanks to promoting oxygen-vacancy formation and O2-surface exchange at low temperatures. However, many efforts are still required to boost the redox properties and process efficiency. Here, we scrutinise the dynamics and the physicochemical dependencies governing microwave-induced redox transformations on solid-state ion-conducting materials. The reduction is triggered upon a material-dependent induction temperature, leading to a characteristically abrupt rise in electric conductivity. This work reveals that the released O2yield strongly depends on the material's composition and can be tuned by controlling the gas-environment composition and the intensity of the microwave power. The reduction effect prevails at the grain surface level and, thus, amplifies for fine-grained materials, and this is ascribed to limitations in oxygen-vacancy diffusion across the grain compared to a microwave-enhanced surface evacuation. The precise cyclability and stability of the redox process will enable multiple applications like gas depuration, energy storage, or hydrogen generation in several industrial applications.

The diagnosis of IgE-mediated cow's milk allergy (CMA) is often based on clinical history and on specific IgE levels and/or skin-prick tests (SPT), both of which are sensitive but not specific. The gold standard, oral food challenge (OFC), is expensive and time-consuming and involves a risk of severe allergic reactions. This study aimed to determine the value of specific IgEs, ratios of specific IgEs for cow's milk and its components to total IgE, and wheal size on SPT for predicting a positive OFC for CMA.

La displasia broncopulmonar (DBP) es la secuela más prevalente del recién nacido pretérmino, y sigue suponiendo un motivo frecuente de consulta en las unidades de Neumología Pediátrica. La decisión del alta de la unidad neonatal debe apoyarse en una valoración exhaustiva de la situación clínica del paciente y en el cumplimiento de unos requisitos, que incluyen la estabilidad respiratoria y nutricional, y la instrucción a los cuidadores en el manejo domiciliario. Para un control adecuado de la enfermedad, es necesario que quede establecido, previamente al alta, un calendario de visitas y de exploraciones complementarias, y deben aplicarse las pautas de prevención de exacerbaciones y el tratamiento apropiados. El concepto de DBP como enfermedad multisistémica es fundamental en el seguimiento de los pacientes y debe ser tenido en cuenta para un buen control de la enfermedad.

The present document offers an update on the recommendations for managing patients with cow's milk allergy – a disorder that manifests in the first year of life, with an estimated prevalence of 1.6–3% in this paediatric age group.

The anomalous aggregation of proteins into pathological filaments is a common feature of a many human diseases, often related to aging. In this context, neurodegenerative pathologies such as Alzheimers disease (AD) account for a major part of these protein misfolding diseases. AD is characterized by pathological aggregation of two proteins, tau and A-amyloid. The intracellular neurofibrillary tangles (NFTs) and neuropil threads consists of filaments of the modified microtubule-associated protein tau, while extracellular amyloid plaques consists of filaments of A-peptide. It is noteworthy that tau oligomers with a prefilamentous structure appear to play a role at early stages of AD and tauopathies, but also in asymptomatic patients with Braak-stage I neuropathology, where clinical symptoms of AD and NFTs in frontal cortex are absent. This suggests that an increase in tau oligomers levels occurs before individuals manifest clinical symptoms of AD. NFTs are one of the hallmarks of Alzheimer disease and other tauphaties. These aggregates are thought to be toxic to neurons, either by causing some neurotoxic signalling defects or by obstructing the cell function. Factors contributing to accumulation of tau aggregates include the increased rate of protein misfolding, generation of amyloidogenic oligomers, underactivity of repair systems such as chaperones and ubiquitin-proteasome system, or a failure of energy supply and antioxidant defense mechanisms. There is not clear evidence if the aggregated tau or oligomers cause cellular damage, but on the basis of the emergent need to have an early and effective treatment, lowering the production or removal of these aggregates appears as a pathway toward alleviating the disease. In the context of some of most relevant reports, we analyze why tau protein seems to be an interesting target for AD treatment, and the importance to understand the pathways of tau. aggregation. This knowledge will allow us to identify and optimize potential inhibitors that interact with aggregated forms of tau and hyperphosphorylated tau before the formation of the NFTs, offering a possible therapeutic route for AD treatment.

Research is reported probing the concern of some wheat producers that grazing of early sown, dual-purpose wheat for winter forage may accentuate the spread of Wheat streak mosaic virus(WSMV). In experiments with housed sheep, we investigated whether there were any grounds for this concern. In the first experiment, sheep were allowed to graze heavily virus-infected wheat in trays, followed over a period of 24h by a series of test trays of healthy wheat. The grazed plants were allowed to recover and new leaves were tested for symptoms and the presence of virus. In total, 2352 test plants were negative for WSMV, assessed through symptoms, ELISA, and RT-PCR. In the second experiment, no WSMV particles (assayed with ELISA) or RNA (assayed by RT-PCR) were detected in any saliva samples collected from sheep 0.5, 7.5, and 24.5h after being fed heavily virus-infected wheat. Furthermore, these saliva samples, when inoculated onto test wheat seedlings under optimal conditions, failed to transmit the virus. In a third experiment we showed that the urea concentration in sheep saliva is at least two orders of magnitude lower than that required to render WSMV non-infective, and therefore is not responsible for the failure of sheep to transmit the virus. Our data provide no support for the suggestion that grazing sheep spread the WSMV between plants in a grazed wheat crop as a consequence of the grazing process itself.

MnO2 samples have been prepared by the pyrolytic decomposition of manganese nitrate in different atmospheres: dry air and air saturated with water vapour. The influence of the atmosphere on the kinetics of the manganese nitrate decomposition and on several physical properties of the resulting MnO2, such as density, grain size, crystalline structure, resistivity and activation energy for electrical conduction, has been studied. The dielectric and breakdown properties of Ta-Ta2O5-MnO2 capacitive structures, using MnO2 as a solid electrolyte, are also strongly affected by the atmosphere in which the MnO2 layers are prepared. It has been found that the electrical conductivity of the MnO2 samples is greater when they are formed in a saturated water vapour atmosphere, resulting in substantially improved characteristics for the power losses and scintillation voltage of the corresponding tantalum capacitors.