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Alzheimer’s disease (AD) is characterized by deposition of amyloid-β protein aggregates and an appropriate treatment strategy is urgently needed, as the number of diagnosed cases continues to increase. The management of AD and other brain-associated diseases is limited by the blood brain barrier and its selective control of drug passage. In fact, most of the promising drugs have restricted curative effects on AD owing to their lower bioavailability. Gold nanoparticles (AuNPs) have emerged as attractive therapeutic agents and have distinctive properties that could contribute to the development of a novel treatment strategy for neurodegenerative disorders. In this review article, we attempt to identify promising ways of developing competent AD therapeutic agents from anti-amyloid aggregating AuNPs. Initially, we discuss the current status of anti-amyloid inhibitors, the abilities of AuNPs to inhibit amyloid aggregation, and mechanistic aspects, and then describe plausible modifications that could aid the translation of AuNP-based therapeutics into neuromedicines. The review highlights some interesting characteristics that might effectively bridge the gap between laboratory and bedside treatments.

The aim of this study was to evaluate possible genotoxic damage of dichlorophene stress in rats by chromosomal aberration (CA), micronucleus (MN) and mitotic index (MI) assays in bone marrow cells. The study was carried out in vivousing three sublethal concentrations, 66.9 mg, 133.8 mg and 200.7 mg kg–1body weight of rat of dichlorophene administered intraperitoneally. The bone marrow cells were evaluated in each of the three treated groups at multiple durations. The MN and CA frequencies were increased significantly. A positive time- and dose-response relationship in all exposures was observed. However, the MI significantly decreased at each concentration compared to normal control. The results confirm the cytotoxic and genotoxic damage in Rattus norvegicus, and the suitability of the parameters for the screening of the genotoxicant is further discussed.