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Although up to 15% of patients with whiplash injury develop chronic headache, the basis and mechanisms of this posttraumatic headache are not well understood.

The layout problem is of importance to ergonomists, vehicle/cockpit packaging engineers, designers of manufacturing assembly lines, designers concerned with the placement of levers, knobs, controls, etc. in the reachable workspace of a human, and also to users of digital human modeling code, where digital prototyping has become a valuable tool. This paper proposes a hybrid optimization method (gradient-based optimization and simulated annealing) to obtain the layout design. We implemented the proposed algorithm for a project at Oral-B Laboratories, where a manufacturing cell involves an operator who handles three objects, some with the left hand, others with the right hand.

The layout problem is of importance to ergonomists, vehicle/cockpit packaging engineers, designers of manufacturing assembly lines, designers concerned with the placement of levers, knobs, controls, etc. in the reachable workspace of a human, and also to users of digital human modeling code, where digital prototyping has become a valuable tool. This paper proposes a hybrid optimization method (gradient-based optimization and simulated annealing) to obtain the layout design. We implemented the proposed algorithm for a project at Oral-B Laboratories, where a manufacturing cell involves an operator who handles three objects, some with the left hand, others with the right hand.

The synthesis of the title compound (IV) (as hydrochloride) can be accomplished by hydrolysis of the ethylation product (III) from the oxazoline (I) which, in turn, is accessible from D‐alanine.