1. Chromatin as an old and new anticancer target
- Author
-
Neefjes, Jacques, Gurova, Katerina, Sarthy, Jay, Szabó, Gábor, and Henikoff, Steven
- Abstract
Chromatin modifiers are among the most commonly mutated classes of genes in cancer.Chromatin-damaging activities disrupt histone–DNA interactions without damaging DNA.Chromatin damage may explain the efficacy of anthracyclines in a broad range of liquid and solid cancers.The chromatin-damaging anthracyclines tested in animals, or in the clinic, retain antineoplastic efficacy of DNA-damaging drugs without irreversible side effects.Understanding the molecular consequences of chromatin damage will maximize the impact of chromatin-damaging drugs in oncology.
- Published
- 2024
- Full Text
- View/download PDF