Ngo, Hien T.T., Hwang, Eunson, Seo, Seul A., Yang, Jung-Eun, Nguyen, Quynh T.N., Do, Nhung Quynh, and Yi, Tae Hoo
ABSTRACTAccording to the previously described anti-photoaging effect of the enzyme-processed Panax ginsengextract and Gastrodia elataextract, we hypothesized that the combination of the two extracts would have superior effect to protect human skin from UVB radiation. Besides, the mixture of active components isolated from herbal extracts, ginsenoside F2, and α-gastrodin was investigated on the photo-protective capability. The expression of aging-related markers including matrix metalloproteinase-1 (MMP-1), interleukin-6 (IL-6), and procollagen type 1 was evaluated using ELISA kits. It was reported that the herbal extract at a Panax ginsengextract to Gastrodia elataextract ratio of 1:10 (w/w) and the compound mixture with equal proportion of ginsenoside F2 and α-gastrodin exhibited significant inhibition of MMP-1 and IL-6 production, and marked upregulation of procollagen type 1 formation. Thus, the combination of either the enzyme-processed herbal extracts or their active components would enhance the properties of prevention and treatment of UVB-induced skin damage.