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CRE-319, a novel 1, 4-dihydropyridine derivative, produces a cathodic polarographic peak due to the reduction of its nitro group according to the following well-known general pathway for the nitro group: [image omitted] The electrode mechanism is strongly dependent on the pH of the solution and follows a similar behaviour to that previously reported for nitrobenzene.The peak current shows a linear dependence with CRE-319 concentrations. This behaviour is used for analytical purposes in determining CRE-319 content in solution. In order to obtain comparative results, we have also developed a spectrophotomebic and an HPLC method for quantifying CRE-3 19.