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Résumé: Le chondrosarcome myxoïde extrasquelettique (CME) est une entité rare, distincte sur le plan clinique, histologique, immunohistochimique, cytogénétique et évolutive. C’est un sarcome classé par l’OMS comme un sarcome de bas grade et qui représente 2,5 % des sarcomes des tissus mous. Son individualisation est importante, car elle est caractérisée par une agressivité essentiellement locale et une survie prolongée. La clé diagnostique est morphologique, aidée par l’immunohistochimie et l’étude génétique qui permettent de la différencier des autres tumeurs à stroma myxoïde et des chordomes. Nous en rapporterons un cas localisé au niveau du genou.

L’hyperméthylation de l’ADN des promoteurs joue un rôle important dans la carcinogenèse de tumeur de vessie et sa progression. L’objectif de cette étude est d’évaluer la méthylation des promoteurs des 4 gènes hTERT, TWIST1, VIM et NID2 chez une population suivie pour tumeur de vessie.

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Around the world, prostate cancer is one of the leading types of cancer in men. Indeed, according to the most recent reports, approximately 1.27 (7.1%) million new cases were diagnosed with an estimated 358,989 (3.8%) deaths. Prostate cancer manifests in a varied incidence according to the ethnic-geographic origin of patients. In Morocco, it is a public health issue regarding its frequency and severity, being the second most common male cancer with 3990 (15.8%) new cases recorded in 2018. This work aims at depicting the pattern of prostate cancer presentation in the Moroccan population for the first time, in regard to some clinical and pathological features along with aggressiveness nature in patients followed up in Mohammed V military hospital of Rabat which is a referral center.

Rosai-Dorfman disease (RDD), also known as sinus histocytosis with massive lymphadenopathy, is a rare idiopathic histioproliferative disease affecting the lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system manifestations, particularly in the absence of nodal disease with clinical and radiological findings suggestive of meningioma, are extremely rare. Histopathology and immunohistochemistry are essential for a positive diagnosis. We report a case of RDD in a patient presenting multiple meningeal nodules with a review of the literature and discussion of differential diagnosis.