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Abstract: X-ray photoelectron spectroscopy (XPS), magnetization and magnetic susceptibility of Mn1−xAlxNi3 (x = 0.0, 0.2, 0.4, 0.5, 0.6, 0.7) alloys are reported. X-ray diffraction measurements showed that all investigated samples have the same crystallographic structure as the parent compound (AuCu3-structure type). The alloys are disordered for x ≤ 0.5, but become almost crystallographically ordered for higher Al concentration. This change in the crystallographic order is reflected both in the magnetization and Curie temperature values. The exchange interaction is ferromagnetic between the pairs of the near-neighbour Mn-Ni and Ni-Ni magnetic moments and antiferromagnetic for Mn-Mn pairs. The last one is present only in the disordered alloys, which leads to smaller values of the magnetization of these alloys in comparison with the ordered ones. The Mn magnetic moment has the fully ordered value of 3.2 μB in all investigated alloys. The decrease of the Ni magnetic moment as the Al concentration increases may be explained by the hybridization of the Ni 3d and Al 3sp states, which leads to a partial filling of the Ni 3d band. The magnetic susceptibility measurements pointed out the existence of spin fluctuations on Ni sites.

Literature so far illustrates different approaches to achieving circular economy (CE). It is increasingly important that every industry explores opportunities to transitioning towards CE doing it through process streamlining or via uses of technology to transform/exchange the resources. We recognize the difficulties faced by researchers in consolidating key aspects to CE, due to still fragmented knowledge base. To clearly identify these aspects is somewhat difficult due to the fragmented knowledge over applications of circular economy. However, any holistic approach is possible by considering the performance of the growth (in our temporal visible world) and that of innovation and creation as a result of the introspection of the temporal invisible world (thought and inspiration), in terms of three fundamental scalars in nature, mass, energy, and time transformed by natural action and human action, in order to define the circularity for any group, category, and type of product. We consider that the effect of any action should be evaluated by determining the most probable results and the dynamic of any process (using statistics), by considering the transformation of the three fundamental scalars. This article presents a consonant approach of the economy, aiming to optimize the intervention of humans in the natural environment and its performance and having the scope of the integration of the human actions in the natural cycles, to secure sustainability.

IMPORTANCE: Peripheral neuropathy has been associated with systemic fluoroquinolone exposure, but risk has been poorly quantified. OBJECTIVE: To calculate relative and absolute risk estimates for the association of fluoroquinolone exposure with peripheral neuropathy and to examine how risk may be affected by timing of fluoroquinolone exposure and by other risk factors. DESIGN, SETTING, AND PARTICIPANTS: This nested case-control study used anonymized data from all patients routinely registered with general practices in The Health Improvement Network database, a large primary care population database in the United Kingdom, from January 1, 1999, to December 31, 2015. Data analyses were conducted January 8, 2018. The cohort consisted of 1 338 900 adults issued 1 or more prescriptions of fluoroquinolone (34.3%) or amoxicillin-clavulanate (65.7%) antibiotics. Adults with incident peripheral neuropathy were matched (on age, sex, general practice, and calendar time) with up to 4 controls by using incidence density sampling selected from a cohort prescribed oral fluoroquinolone or amoxicillin-clavulanate antibiotics. Incidence rate ratios of peripheral neuropathy were calculated for fluoroquinolone and for amoxicillin-clavulanate exposure and compared with nonexposure among patients without diabetes, with sensitivity analyses testing the consistency of the results. Population mean–adjusted rate differences were then estimated, including the number needed to harm for various durations of fluoroquinolone therapy. EXPOSURES: Current and cumulative exposure to oral fluoroquinolone or amoxicillin-clavulanate antibiotics. MAIN OUTCOMES AND MEASURES: Incident peripheral neuropathy cases recorded in electronic medical records. RESULTS: In total, 5357 patients with incident peripheral neuropathy (mean [SD] age, 65.6 [14.7] years; 2809 women [52.4%]) were matched to 17 285 controls (mean [SD] age, 64.4 [15.2] years; 9485 women [54.9%]) without diabetes. Current oral fluoroquinolone exposure was associated with an increased relative incidence of peripheral neuropathy compared with nonexposure (adjusted incident rate ratio, 1.47; 95% CI, 1.13-1.92). Risk increased by approximately 3% for each additional day of current fluoroquinolone exposure and persisted for up to 180 days following exposure. No significant increased risk was observed with oral amoxicillin-clavulanate exposure. The absolute risk with current oral fluoroquinolone exposure was 2.4 (95% CI, 1.8-3.1) per 10 000 patients per year of current use. The number needed to harm for a 10-day course was 152 083 patients (95% CI, 117 742-202 778) and was greatest among men and among patients older than 60 years. CONCLUSIONS AND RELEVANCE: The results of the present study suggested that oral fluoroquinolone therapy was associated with an increased risk of incident peripheral neuropathy that may depend on the timing of the exposure and the cumulative dose. Health care professionals should consider these potential risks when prescribing fluoroquinolone antibiotics.

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