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A feed-forward photonic neural network (PNN) is tested for chromatic dispersion compensation in Intensity Modulation/Direct Detection optical links. The PNN is based on a sequence of linear and nonlinear transformations. The linear stage is constituted by an 8-tap time-delayed complex perceptron implemented on a Silicon-On-insulator platform and acting as a tunable optical filter. The nonlinear stage is provided by the square modulus of the electrical field applied at the end-of-line photodetector. The training maximizes the separation between the optical levels (i.e. the eye diagram aperture), with consequent reduction of the Bit Error Rate. Effective equalization is experimentally demonstrated for 20Gbps 4-level Pulse Amplitude Modulated signal up to 125 km. An evolutionary algorithm and a gradient-based approach are tested for the training and then compared in terms of repeatability and convergence time. The optimal weights resulting from the training are interpreted in light of the theoretical transfer function of the optical fiber. Finally, a simulative study proves the scalability of the layout to larger bandwidths, up to 100 Gbps.

Epilepsy is a chronic neurological disorder associated with various symptoms, contingent upon the specific brain region involved. Unpredictable seizures characterize epilepsy, significantly influencing the quality of the patient’s life. Globally, epilepsy affects 1% of the population, with 30% of individuals developing drug resistant epilepsy despite anti-epileptic pharmacological treatment. While several anticonvulsant drugs alleviate epilepsy symptoms, there is currently no effective medication to cure this neurological disorder. Therefore, overcoming the challenges of predicting and controlling drug-resistant seizures requires further knowledge of the pathophysiology of epilepsy at the molecular and cellular levels. In this review, we delve into in vitro experiments that prove valuable in elucidating the mechanisms of drug-resistant epilepsy, as well as in the development and testing of novel therapeutic approaches prior to extensive animal-based trials. Specifically, our focus is on the utility of multi-electrode array (MEA) recording as an in vitro technique for evaluating aberrant electrical activity within neural networks. Real-time MEA recording from neuronal cultures facilitates monitoring of neurotoxicity, dose response, and the efficacy of newly-designed drugs. Additionally, when coupled with emerging techniques such as optogenetics, MEA enables the creation of closed-loop systems for seizure prediction and modulation. These integrated systems contribute to both prospective therapy and the study of intracellular pathways in drug-resistant seizures, shedding light on their impact on neuronal network activity.

The recording of epileptiform discharges from bottom‐of‐sulcus focal cortical dysplasia (BOSD) is often difficult during intraoperative electrocorticography (ECoG) due to the deep localization. We describe the use in this scenario of a new‐generation electrode strip with high flexibility, easily adapted to cortical gyri and sulci. A right‐handed 20‐year‐old male with drug‐resistant focal epilepsy due to BOSD of the inferior frontal gyrus and daily focal aware seizures was evaluated for epilepsy surgery. Based on electroclinical and neuroimaging results, a focal cortectomy guided by ECoG was proposed. ECoG recordings were performed with new‐generation cortical strips (Wise Cortical Strip; WCS®) and standard cortical strips. ECoG, performed on the convexity of the frontal cortical surface, recorded only sporadic spikes with both types of strips. Then, after microsurgical trans‐sulcal dissection, WCS was molded along the sulcal surface of the suspected BOSD based on 3D‐imaging reconstruction, showing continuous/subcontinuous 3–4‐Hz rhythmic spike activity from the deepest electrode. Registration after resection of the BOSD did not show any epileptiform activity. Pathology showed dysmorphic neurons and gliosis. No surgical complications occurred. The patient is seizure‐free after 12 months. This single case experience shows that highly flexible electrode strips with adaptability to cortical gyrations can identify IEDs originating from deep location and could therefore be useful in cases of bottom of the sulcus dysplasia. Content available : Video

ObjectiveTargeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in models of cirrhosis and acute-on-chronic liver failure (ACLF) and, its safety and tolerability in a clinical trial in cirrhosis.DesignPerformance of Yaq-001 was evaluated in vitro. Two-rat models of cirrhosis and ACLF, (4 weeks, bile duct ligation with or without lipopolysaccharide), receiving Yaq-001 for 2 weeks; and two-mouse models of cirrhosis (6-week and 12-week carbon tetrachloride (CCl4)) receiving Yaq-001 for 6 weeks were studied. Organ and immune function, gut permeability, transcriptomics, microbiome composition and metabolomics were analysed. The effect of faecal water on gut permeability from animal models was evaluated on intestinal organoids. A multicentre, double-blind, randomised, placebo-controlled clinical trial in 28 patients with cirrhosis, administered 4 gr/day Yaq-001 for 3 months was performed.ResultsYaq-001 exhibited rapid adsorption kinetics for endotoxin. In vivo, Yaq-001 reduced liver injury, progression of fibrosis, portal hypertension, renal dysfunction and mortality of ACLF animals significantly. Significant impact on severity of endotoxaemia, hyperammonaemia, liver cell death, systemic inflammation and organ transcriptomics with variable modulation of inflammation, cell death and senescence in the liver, kidneys, brain and colon was observed. Yaq-001 reduced gut permeability in the organoids and impacted positively on the microbiome composition and metabolism. Yaq-001 regulated as a device met its primary endpoint of safety and tolerability in the clinical trial.ConclusionsThis study provides strong preclinical rationale and safety in patients with cirrhosis to allow clinical translation.Trial registration numberNCT03202498.

Purpose: PTENhamartoma tumor syndrome (PHTS) comprises a group of rare genetic conditions caused by germline mutations in PTENgene and characterized by development of both benign and malignant lesions in many body tissues. In this study, we aimed to evaluate the incidence of thyroid findings in both adult and pediatric PHTS patients. Methods: A retrospectively analysis conducted in 19 (13 adult and 6 pediatric) patients with PHTS, all confirmed with genetic testing, observed from 2015 to 2021 at the Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico. Results: We found a thyroid involvement in 12 adult patients (92%): 11 patients had benign lesions (85%) and the remaining developed a follicular thyroid carcinoma (8.3%). The median age at time of the first available record was 30 years. Among benign lesions, multinodular goiter was the most observed finding (10/11, 91%). Only 1 out of 6 (16%) pediatric patients was diagnosed with a thyroid lesion (unifocal lesion in mild lymphocytic thyroiditis) at the age of 8 years. Conclusions: Thyroid disorders affected nearly all adult PHTS patients, but a much lower proportion of pediatric patients. We discuss about the natural history of thyroid involvement, age of PHTS clinical onset, and optimized surveillance.

Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation.

•Inappropriate use of antibiotics leads to the occurrence of their residues in milk.•High prevalence of antibiotic residues in raw milk in African continent.•Screening tests are commonly used to detect antibiotic residues in dairy milk.•The β-lactams, sulfonamides, and tetracycline are the most commonly detected.•Africa does not have specific legislation to control antibiotic residues in milk.

To reduce the energy consumption of large centrifugal pumps, modified heuristic intelligent algorithms are used to directly optimize the diffuser of centrifugal pumps. Considering the hydraulic efficiency under the design condition as the optimization target, in this study, 14 geometric parameters such as the inlet diameter, outlet diameter, and leading and trailing vane angles of the diffuser are selected as design variables, and the modified particle swam optimization and gravitational search algorithm are used to directly search for optimization in the design space. The performance and loss of internal entropy production of the different models before and after optimization are compared and analyzed in detail. The results show that the global optimization ability of the modified algorithm is improved. The diffuser model changes from cylindrical to twisted, the vane wrap angle increases, and the thickness of the leading edge decreases. Under the design condition, the efficiency of modified particle swarm optimization algorithm solution is increased by 2.75% and modified gravitational search algorithm solution by 2.21%, while the power remains unchanged. Furthermore, the optimization solution has the largest lift efficiency improvement under part-load conditions. After optimization, the unstable flow in the model is improved and internal entropy production loss is reduced significantly. The interior of the diffuser is dominated by turbulent entropy production and direct entropy production under different operating conditions, and the wall entropy production accounts for the smallest proportion.Graphical Abstract

Cycle tourism is a form of sustainable itinerant tourism expanding in Italy and the rest of the world, with prospects for growth in coming years. Europe and North America have already developed a wide range of cycling infrastructures tied to tourism experiences. Benefits induced are generally recognised: first, it is a sustainable solution that increases local economics while conserving the environment; second, it guarantees advantages on social connections, amusement, and physical and mental health. However, it requires an adequate network to enjoy destinations as historical and landscape peculiarities. Currently, literature provides some methods for planning itineraries dedicated to cycle tourism. Despite that, there is less attention on how evaluating existing or already planned tourist itineraries.

Complete elimination of B-cell acute lymphoblastic leukemia (B-ALL) by a risk-adapted primary treatment approach remains a clinical key objective, which fails in up to a third of patients. Recent evidence has implicated subpopulations of B-ALL cells with stem-like features in disease persistence. We hypothesized that microRNA-126, a core regulator of hematopoietic and leukemic stem cells, may resolve intratumor heterogeneity in B-ALL and uncover therapy-resistant subpopulations. We exploited patient-derived xenograft (PDX) models with B-ALL cells transduced with a miR-126 reporter allowing the prospective isolation of miR-126(high) cells for their functional and transcriptional characterization. Discrete miR-126(high) populations, often characterized by MIR126locus demethylation, were identified in 8/9 PDX models and showed increased repopulation potential, in vivo chemotherapy resistance and hallmarks of quiescence, inflammation and stress-response pathway activation. Cells with a miR-126(high) transcriptional profile were identified as distinct disease subpopulations by single-cell RNA sequencing in diagnosis samples from adult and pediatric B-ALL. Expression of miR-126 and locus methylation were tested in several pediatric and adult B-ALL cohorts, which received standardized treatment. High microRNA-126 levels and locus demethylation at diagnosis associate with suboptimal response to induction chemotherapy (MRD > 0.05% at day +33 or MRD+ at day +78).

Energy consumption around the world is growing at an alarming rate. That brings enormous pressure on energy production and environmental issues. Nowadays, energy efficiency enhancement strategies are considered the crucial approaches to release this problem. The pumps accounts for nearly 21% of the world electricity consumption of industrial motor-driven systems. Hence, much research focused on improving the energy efficiency of the pumps and their systems. According to the works of literature, the level of design of pumps for most applications is already extremely high while the system performance could be further improved by regulations, and the average energy savings potential achievable through pump system adjustments is about 30%. This paper focuses on the advanced characteristic modeling methods, and energy efficiency enhancement regulation approaches for the parallel pumping system. A comprehensive summary of traditional scheduling methods and advanced regulation methods based on computational intelligence has been made to provide insight for future research.

The cavitation has received considerable attention for decades because of its negative influence on the performance and the safety of the hydraulic machinery. In this study, a large eddy simulation is carried out to numerically investigate the unsteady cavitating flow around a trailing-truncated NACA 0009 hydrofoil for determining the underlying physical mechanisms. Two types of cavitation morphologies are identified: The large-scale bubble cluster and the von Kármán vortex cavity, named as the cloud cavitation and the wake vortex cavitation, respectively. It is shown that the velocity profiles obtained over the hydrofoil suction surface are in good agreement with the experimental data, indicating the accuracy of the current simulation. The dynamic evolution of the sheet/cloud cavity is also well reproduced, covering the sheet cavity breakup, the sheet/cloud transformation, and the collapse of the cloudy bubble cluster. The wake-vortex cavitation is caused by the blunt geometry at the hydrofoil trailing edge, where pairs of vortex cavities are induced. Both the cloud and vortex cavities significantly affect the lift oscillation, which makes it difficult to decompose the components. The fundamental shedding mechanisms of the wake vortex cavitation are discussed based on the finite-time Lyapunov exponent field. Specifically, the suction-side bubble grows and squeezes the giant pressure bubble away from the trailing edge. After the pressure bubble detaches, a new counterclockwise vortex or a new bubble appears at the pressure side, thus lifting the ridge towards the suction trailing edge and generating a strong vortex eye that pinches off the trailing portion of the suction-side bubble.

In the context of achieving the goal of carbon neutrality, multi-functional pump stations (MFPS) have been greatly developed as a new energy system in recent years. The MFPS can operate in forward direction in pump mode to pump water and in turbine mode in reverse direction to generate electricity. At present, the instability of the MFPS during start-up process (SUP) in pump mode has become the key to restricting the operating life and further development of MFPS. In this paper, based on the motion characteristics of the pump and the cut-off facility (COF), the SUP of the MFPS in pump mode is clearly classified. In order to reveal the transient effect during the SUP, the steady-state full characteristic experiment (SFCE) of the pump was carried out. The occurrence phase of the transient effect during the SUP is analyzed, and the deviation between the steady-state external characteristics and the transient characteristics is revealed. In this study, the evaluation formula of the start-up completion degree (SUCD) of the MFPS in pump mode is proposed for the first time, and the evaluation and identification of the start-up progress at different phases are completed. The results show that the water flow in the system is in a reverse flow state in the Phase I. The SUCD of Phase I is 17 %. In the Phase II, The high-speed jet flow in the pump flows to the inlet of the guide vane (GV), which gradually changes the mainstream direction in the GV. A certain vortex structure can be observed at the exit of the flap gate (FG). The SUCD of Phase II is 61 %. In the Phase I and II, the dimensionless head of transient simulation is much larger than that of SFCE. In the Phase III, the flow state in the impeller will gradually stabilize. The transient effect disappears and the pressure fluctuation intensity decreases. The SUCD of Phase III is 93 %. In the Phase IV, the separation vortex that persists from Phase I-III at the tail of the GV blades disappears. The diversion capacity at the gate increases, and significant annular flow can be observed near the FG.

Amyotrophic lateral sclerosis (ALS) is known to represent a collection of overlapping syndromes. Various classification systems based on empirical observations have been proposed, but it is unclear to what extent they reflect ALS population substructures. We aimed to use machine-learning techniques to identify the number and nature of ALS subtypes to obtain a better understanding of this heterogeneity, enhance our understanding of the disease, and improve clinical care.

Huntington’s disease is caused by a pathologically long (>35) CAG repeat located in the first exon of the Huntingtin gene (HTT). While pathologically expanded CAG repeats are the focus of extensive investigations, non-pathogenic CAG tracts in protein-coding genes are less well characterized. Here, we investigated the function and evolution of the physiological CAG tract in the HTTgene. We show that the poly-glutamine (polyQ) tract encoded by CAGs in the huntingtin protein (HTT) is under purifying selection and subjected to stronger selective pressures than CAG-encoded polyQ tracts in other proteins. For natural selection to operate, the polyQ must perform a function. By combining genome-edited mouse embryonic stem cells and cell assays, we show that small variations in HTT polyQ lengths significantly correlate with cells’ neurogenic potential and with changes in the gene transcription network governing neuronal function. We conclude that during evolution natural selection promotes the conservation and purity of the CAG-encoded polyQ tract and that small increases in its physiological length influence neural functions of HTT. We propose that these changes in HTT polyQ length contribute to evolutionary fitness including potentially to the development of a more complex nervous system.

BackgroundNatural history of spinal muscular atrophy (SMA) in adult age has not been fully elucidated yet, including factors predicting disease progression and response to treatments. Aim of this retrospective, cross-sectional study, is to investigate motor function across different ages, disease patterns and gender in adult SMA untreated patients.MethodsInclusion criteria were as follows: (1) clinical and molecular diagnosis of SMA2, SMA3 or SMA4 and (2) clinical assessments performed in adult age (>18 years).ResultsWe included 64 (38.8%) females and 101 (61.2%) males (p=0.0025), among which 21 (12.7%) SMA2, 141 (85.5%) SMA3 and 3 (1.8%) SMA4. Ratio of sitters/walkers within the SMA3 subgroup was significantly (p=0.016) higher in males (46/38) than in females (19/38). Median age at onset was significantly (p=0.0071) earlier in females (3 years; range 0–16) than in males (4 years; range 0.3–28), especially in patients carrying 4 SMN2copies. Median Hammersmith Functional Rating Scale Expanded scores were significantly (p=0.0040) lower in males (16, range 0–64) than in females (40, range 0–62); median revised upper limb module scores were not significantly (p=0.059) different between males (24, 0-38) and females (33, range 0–38), although a trend towards worse performance in males was observed. In SMA3 patients carrying three or four SMN2 copies, an effect of female sex in prolonging ambulation was statistically significant (p=0.034).ConclusionsOur data showed a relevant gender effect on SMA motor function with higher disease severity in males especially in the young adult age and in SMA3 patients.

•Babies could be exposed to neurotoxic metals during a mother’s pregnancy and breastfeeding.•Aluminium was found in several infant formulas.•The evaluation of Aluminium bioaccessibility in baby foods is important to estimate its absorption and assess exposure.

Post-transplantation cyclophosphamide (PTCy) has emerged as a promising graft-versus-host-disease (GVHD) prophylaxis in the setting of allogeneic hematopoietic stem cell transplantation (HSCT) from haploidentical donors and more recently in matched donor transplants. Herein, we describe our real-life experience on 249 adult patients undergoing allogeneic HSCT, from HLA-matched related (MRD), HLA-matched unrelated (MUD), or mismatched related donors (MMRD). Patients received unmanipulated peripheral blood stem cells (PBSCs), using a GVHD prophylaxis with PTCy and sirolimus. Mycophenolate mofetil was added in MUD or MMRD. In the HLA-matched donor group (MRD, n = 48, MUD, n = 50), the cumulative incidence of grades II-IV and III-IV acute GvHD was 23% and 9% at 100 days, respectively. The cumulative incidence of chronic GvHD was 25% at 2 years, severe only for 5% of the patients. The cumulative incidences of relapse and transplant-related mortality (TRM) were 31% and 9% at 2 years, respectively. The 2-year overall survival (OS) was 72% and progression-free survival (PFS) 60%; the composite endpoint of GvHD/relapse-free survival (GRFS) was 52% at 2 years. In the haploidentical donor group (n = 151), we documented a cumulative incidence of grades II-IV and III-IV acute GVHD of 35% and 20% at 100 days, respectively, and a cumulative incidence of chronic GvHD of 39% at 2 years. We observed severe chronic GVHD in 15% of the patients. The cumulative incidence of relapse and TRM was 32% and 25% at 2 years, respectively. The 2-year OS was 48%, whereas PFS was 43%; GRFS was 28% at 2 years. However, more patients in the haploidentical group presented high/very high disease risk index (DRI) and higher HCT-comorbidity index. In patients classified in the low-intermediate DRI, 2-year GRFS was 53% in MRD, 65% in MUD, and 46% in haploidentical HSCT (P = .33). Sirolimus-PTCy platform deserves further investigation as an alternative to calcineurin-inhibitor–based GVHD prophylaxis for all donor sources. In patients presenting a low-intermediate DRI, this strategy translates in relevant survival independently from the transplant source.

The Sox2 transcription factor is necessary for the long‐term self‐renewal of neural stem cells (NSCs). Its mechanism of action is still poorly defined. To identify molecules regulated by Sox2, and acting in mouse NSC maintenance, we transduced, into Sox2‐deleted NSC, genes whose expression is strongly downregulated following Sox2 loss (Fos, Jun, Egr2), individually or in combination. Fos alone rescued long‐term proliferation, as shown by in vitro cell growth and clonal analysis. Furthermore, pharmacological inhibition by T‐5224 of FOS/JUN AP1 complex binding to its targets decreased cell proliferation and expression of the putative target Suppressor of cytokine signaling 3 (Socs3). Additionally, Fos requirement for efficient long‐term proliferation was demonstrated by the reduction of NSC clones capable of long‐term expansion following CRISPR/Cas9‐mediated Fos inactivation. Previous work showed that the Socs3 gene is strongly downregulated following Sox2 deletion, and its re‐expression by lentiviral transduction rescues long‐term NSC proliferation. Fos appears to be an upstream regulator of Socs3, possibly together with Jun and Egr2; indeed, Sox2 re‐expression in Sox2‐deleted NSC progressively activates both Fos and Socs3 expression; in turn, Fos transduction activates Socs3 expression. Based on available SOX2 ChIPseq and ChIA‐PET data, we propose a model whereby Sox2 is a direct activator of both Socs3 and Fos, as well as possibly Jun and Egr2; furthermore, we provide direct evidence for FOS and JUN binding on Socs3promoter, suggesting direct transcriptional regulation. These results provide the basis for developing a model of a network of interactions, regulating critical effectors of NSC proliferation and long‐term maintenance. Sox2 is necessary for long‐term neural stem cell (NSC) self‐renewal and for Socs3, Fos, Jun, and Egr2 gene expression. We previously showed that Socs3 overexpression rescues Sox2‐deleted NSC self‐renewal. Fos, Jun, and Egr2 transduction into Sox2‐deleted NSC rescues self‐renewal, Fos alone being both sufficient and necessary. Sox2 transduction upregulates Fos and Socs3 in Sox2‐deleted cells, and Fos upregulates Socs3, defining a Sox2‐dependent regulatory network.

The desmoplastic nature of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) prevents the infiltration of T cells and the penetration of chemotherapeutic drugs, posing a challenge to the validation of targeted therapies, including T cell immunotherapies. We present an in vitro3D PDAC-TME model to observe and quantify T cell infiltration across the vasculature. In a three-channel microfluidic device, PDAC cells are cultured in a collagen matrix in the central channel surrounded, on one side, by endothelial cells (ECs) to mimic a blood vessel and, on the opposite side, by pancreatic stellate cells (PSCs) to simulate exocrine pancreas. The migration of T cells toward the tumor is quantified based on their activation state and TME composition. The presence of EC-lining drastically reduces T cell infiltration, confirming the essential role of the vasculature in controlling T cell trafficking. We show that activated T cells migrate ∼50% more than the not-activated ones toward the cancer cells. Correspondingly, in the absence of cancer cells, both activated and not-activated T cells present similar migration toward the PSCs. The proposed approach could help researchers in testing and optimizing immunotherapies for pancreatic cancer.

Tumor targeting by genetically modified mesenchymal stromal/stem cells (MSCs) carrying anti-cancer molecules represents a promising cell-based strategy. We previously showed that the pro-apoptotic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can be successfully delivered by MSCs to cancer sites. While the interaction between TRAIL and its receptors is clear, more obscure is the way in which MSCs can selectively target tumors and their antigens. Several neuroectoderm-derived neoplasms, including glioblastoma (GBM), sarcomas, and neuroblastoma, express high levels of the tumor-associated antigen GD2. We have already challenged this cell surface disialoganglioside by a chimeric antigen receptor (CAR)-T cell approach against neuroblastoma. With the intent to maximize the therapeutic profile of MSCs delivering TRAIL, we here originally developed a bi-functional strategy where TRAIL is delivered by MSCs that are also gene modified with the truncated form of the anti-GD2 CAR (GD2 tCAR) to mediate an immunoselective recognition of GD2-positive tumors. These bi-functional MSCs expressed high levels of TRAIL and GD2 tCAR associated with a robust anti-tumor activity against GD2-positive GBM cells. Most importantly, the anti-cancer action was reinforced by the enhanced targeting potential of such bi-functional cells. Collectively, our results suggest that a truncated anti-GD2 CAR might be a powerful new tool to redirect MSCs carrying TRAIL against GD2-expressing tumors. This affinity-based dual targeting holds the promise to combine site-specific and prolonged retention of MSCs in GD2-expressing tumors, thereby providing a more effective delivery of TRAIL for still incurable cancers.

The World Health Organization (WHO) has declared coronavirus disease 2019 (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic. Global health care now faces unprecedented challenges with widespread and rapid human-to-human transmission of SARS-CoV-2 and high morbidity and mortality with COVID-19 worldwide. Across the world, medical care is hampered by a critical shortage of not only hand sanitizers, personal protective equipment, ventilators, and hospital beds, but also impediments to the blood supply. Blood donation centers in many areas around the globe have mostly closed. Donors, practicing social distancing, some either with illness or undergoing self-quarantine, are quickly diminishing. Drastic public health initiatives have focused on containment and “flattening the curve” while invaluable resources are being depleted. In some countries, the point has been reached at which the demand for such resources, including donor blood, outstrips the supply. Questions as to the safety of blood persist. Although it does not appear very likely that the virus can be transmitted through allogeneic blood transfusion, this still remains to be fully determined. As options dwindle, we must enact regional and national shortage plans worldwide and more vitally disseminate the knowledge of and immediately implement patient blood management (PBM). PBM is an evidence-based bundle of care to optimize medical and surgical patient outcomes by clinically managing and preserving a patient’s own blood. This multinational and diverse group of authors issue this “Call to Action” underscoring “The Essential Role of Patient Blood Management in the Management of Pandemics” and urging all stakeholders and providers to implement the practical and commonsense principles of PBM and its multiprofessional and multimodality approaches.

Electric-field-induced second-harmonic generation is demonstrated in silicon waveguides with reverse biased lateral p-i-n junctions. Phase matching is achieved by periodically poling the applied electric field. Two different poling configurations are compared: in the first, the p- and n-type doped regions of the junctions are on different sides of the waveguide (simple configuration), while in the second, they are alternated periodically across the waveguide sides (interdigitated configuration). Both simulations and experiments show that the generation efficiency is increased by 10 times comparing the interdigitated and simple configurations. The effective second-order susceptibility modulation obtained at a reverse bias voltage of 3.5 V is Δχeff,S(2)≃0.14pm/V for the simple configuration and Δχeff,I(2)≃0.64pm/V for the interdigitated one.

The article reviews the key components of mascara formulations, including waxes, film-formers, fillers and importantly, packaging. It mentions when trying to increase the eyelash volume by applying mascara, the increased weight of the eyelashes results in a reduction in their curl; and also mentions a combined strategy to select and assemble ingredients is crucial to developing a successful mascara.

WWD Women's Wear Daily ⢠Tuesday, November 30, 2010 CAPTION(S): Trim Fit According to Giorgio Armani, suits are the 'must-haves' for pre-fall, and he is providing a number of distinctive [...]