1. Biosilicate® Ototoxicity and Vestibulotoxicity evaluation in guinea-pigs
- Author
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Massuda, Eduardo Tanaka, Maldonado, Lucas Lisboa, de Lima, Jessé Teixeira, Peitl, Oscar, Hyppolito, Miguel Ângelo, and Apparecido de Oliveira, José Antonio
- Abstract
Changes, destructions and interruptions in middle ear ossicular chain architecture may be caused by infection, trauma, tumors, congenital alterations or prior surgeries. Nonetheless, infectious and inflammatory processes, focal or generalized which affect the middle ear are the most prevalent, causing a great demand for ossiculoplasty. Biosilicato® is a new material which can be used in the middle ear with the goal of reconstructing the ossicular chain. It is a bioactive type A vitroceramic, in other words, it binds to bone or soft tissue in a matter of a few hours, thanks to the formation of hydroxy-carbonateapatatie in its contact surface when in contact with body fluids.
- Published
- 2009
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