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• A MOFs-derived bifunctional oxygen electrocatalyst was prepared. • The electron transfer from Ru to Co/Fe could improve the OER performance. • The porous carbon structure caused by Zn evaporation could promote both the ORR and OER activity. • A quasi in-situ electrochemical test in the battery cell was used to observe the surface passivation of transition metal nanoparticles. Prolonging the lifespan of oxygen catalysts in Zn-air batteries was urgently required for the potential commercialization. Herein, two interactional active species were integrated into porous N-doped carbon microspheres (Co-Fe-Ru/PNCS) to act as bifunctional oxygen electrocatalysts. Due to the electron transfer from Ru to Co/Fe element, the high value state of Ru could promote OER performance and reduce the charge voltage of the battery. An extended cycle stability of 200 h was achieved in Co-Fe-Ru/PNCS-based battery. Moreover, the quasi in-situ potentiodynamic sweep of air-electrode in battery cell confirmed it was the incorporation of Ru that avoided the passivation of Co/Fe-based nanoparticles. Accordingly, this novel electrocatalyst may provide a new strategy of designing durable bifunctional oxygen electrocatalyst for Zn-air batteries. [ABSTRACT FROM AUTHOR]

Smooth and compact Cu(In, Ga)Se2(CIGSe) thin film is critical to prepare high-quality solar cells. However, the ”dendritic” morphology of Cu tends to form on Mo leading to a nonuniform Cu distribution during the electrodeposition process, which affects the uniformity of CIGSe and device performance. In this work, Ag was used as the underlying buffer layer and Cu was electrodeposited on Ag film instead of Mo film. By adjusting deposition parameters, smooth and compact Ag layer was obtained on the Mo surface. With the Ag buffer layer, the ”dendritic” Cu on Mo was successfully eliminated. The electrodeposited Ag/Cu/In/Ga metal precursors were annealed in Se-containing atmosphere at 450 °C∼550 °C for 15min to prepare (Ag, Cu)(In, Ga)Se2(ACIGSe) absorbers. Compared with the CIGSe absorber, the crystallinity of the ACIGSe absorber was improved. The VOC, JSC, FFand efficiency of ACIGSe solar cells were improved compared with CIGSe solar cells. Ultimately, an 11.73% efficiency of ACIGSe thin-film solar cells was obtained.

A core–shell molecularly imprinted polymer nanoparticle with biological enzyme functional characteristics was developed by oxidative polymerization of template protein and polydopamine on the surface of protease–copper phosphate hybrid nanoflowers by molecular imprinting technology and enzyme immobilization technology. The obtained molecularly imprinted polymer showed specific binding characteristics with the template protein. It recognized and enriched the target molecules through the surface molecularly imprinted sites of the shell structure. In addition, the bound target molecules were further degraded into fragments by nanozymes with biological enzyme characteristics in the core. In this study, molecular imprinting technology and biotechnology were combined to obtain bifunctional molecularly imprinted polymer nanoparticles that can not only enrich template molecules but also degrade them into fragments. Herein, we selected interleukin 6 (IL-6), the target molecule of cytokine release syndrome (CRS), as a template molecule, and reported a molecularly imprinted polymer with degrading enzyme properties that can rapidly reduce IL-6 levels in vivo, including a molecularly imprinted layer that can recognize and bind IL-6 and nanozymes that can degrade IL-6 and deactivate it. It is used to clear the excessive secretion of IL-6 in CRS and reduce the level of IL-6 in the body to achieve the purpose of adjuvant treatment of CRS.

The integration of reactive oxygen species (ROS)-involved molecular dynamic therapy (MDT) and photodynamic therapy (PDT) holds great promise for enhanced anticancer effects. Herein, we report a biodegradable tumor microenvironment-responsive nanoplatform composed of sinoporphyrin sodium (SPS) photosensitizer-loaded zinc peroxide nanoparticles (SPS@ZnO2NPs), which can enhance the action of ROS through the production of hydrogen peroxide (H2O2) and singlet oxygen (1O2) for MDT and PDT, respectively, and the depletion of glutathione (GSH). Under these conditions, SPS@ZnO2NPs show excellent MDT/PDT synergistic therapeutic effects. We demonstrate that the SPS@ZnO2NPs quickly degrade to H2O2and endogenous Zn2+in an acidic tumor environment and produce toxic 1O2with 630 nm laser irradiation both in vitroand in vivo. Anticancer mechanistic studies show that excessive production of ROS damages lysosomes and mitochondria and induces cellular apoptosis. We show that SPS@ZnO2NPs increase the uptake and penetration depth of photosensitizers in cells. In addition, the fluorescence of SPS is a powerful diagnostic tool for the treatment of tumors. The depletion of intracellular GSH through H2O2production and the release of cathepsin B enhance the effectiveness of PDT. This theranostic nanoplatform provides a new avenue for tumor microenvironment-responsive and ROS-involved therapeutic strategies with synergistic enhancement of antitumor activity.

Combinational administration of photothermal therapy (PTT) and chemotherapy (CT) shows great potential in improving the efficiency of tumor treatment. Herein, we designed a novel nanocomposite Pt@Bi2Te3composed of bismuth telluride (Bi2Te3) nanoparticles and platinum(IV) prodrugs (Pt) for PTT–CT combination therapy. The obtained Bi2Te3was synthesized by a simple solvothermal method and modified by polyethylene glycol, which exhibited excellent photothermal (PT) efficiency and stability and could also serve as a bimodal bioimaging contrast agent in PT and photoacoustic (PA) imaging. In vitroexperiment results showed that the nanocomposite Pt@Bi2Te3could effectively increase the uptake of platinum in cancer cells, which could kill tumor cells through the combined effect of PTT and CT. Furthermore, combination therapy of cancer in vivowas achieved with obvious tumor-growth inhibition without inducing observed side effects. We revealed the great potential of Bi2Te3nanocomposites in increasing therapeutic efficiency by PTT–CT therapy and PA–PT imaging.

Objective:To observe the effect of moxibustion on the mRNA and protein expressions of heat-shock protein 70 (HSP70) in gastric cancer-bearing rats.

To explore the inhibitory effect of moxibustion on tumor growth and metastasis, and also its possible mechanism, in gastric tumor-bearing rats by investigating the expressions of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF). Fifty healthy Sprague-Dawley (SD) rats (half male and half female) were routinely housed for 1 week. A total of 20 rats were randomly divided into a blank group and a sham operation group, with 10 rats in each group. The remaining 30 rats were used to make gastric cancer models by implantation of ascites-type Walker-256 cancer cells. After successful modeling, rats were randomly divided into a model group, a moxibustion group and an infrared group, with 10 rats in each group. From the day of modeling, the body weight of each group was weighed every 4 days. Warm moxibustion was alternately performed at two-group acupoints [Zhongwan (CV 12), Guanyuan (CV 4) and bilateral Zusanli (ST 36) in one group, and bilateral Pishu (BL 20) and Weishu (BL 21) in another group] in the moxibustion group. The body surface projection area of the stomach was irradiated with short-wave infrared rays in the infrared group, once a day, 20 min per time for 21 d. At the end of the treatment, the gastric tumor was completely dissected, and the tumor volume and tumor growth inhibition rate were calculated. Then the gastric tumor cell metastasis was recorded. The levels of VEGF and EGF in rat gastric tumor tissues were determined by enzyme-linked immunosorbent assay (ELISA). Compared with the blank group, the body weight of the model group decreased significantly after modeling (P<0.05); compared with the model group, the rats in the moxibustion group had increased body weight during the middle and late stages (both P<0.05). The tumor volumes of rats in the moxibustion group and the infrared group were smaller than the volume in the model group (both P<0.05). The tumor growth inhibition rate in the moxibustion group was significantly higher than that in the infrared group (P<0.05). The case number of tumor metastasis in the moxibustion group was smaller than that in the model group and the infrared group. The VEGF level in the tumor tissues of the model group was statistically significantly higher than that in the blank group (P<0.05). Compared with the model group, the VEGF levels in the moxibustion group and the infrared group were statistically significantly lower (both P<0.05). The EGF levels in the tumor tissues of the model group was statistically significantly lower than that in the blank group (P<0.05); compared with the model group, the EGF levels in the moxibustion group and the infrared group were statistically significantly increased (both P<0.05). Moxibustion can increase the body weight, inhibit the tumor growth, invasion and metastasis in gastric tumor-bearing rats, which may be related to the regulation of VEGF and EGF expressions in tumor tissues. 通过观察艾灸对胃荷瘤大鼠肿瘤组织中血管内皮生长因子(VEGF)和表皮细胞生子因子(EGF)表达量的影响, 探讨艾灸对胃荷瘤大鼠肿瘤生长、转移的抑制情况及其可能的作用机制。 将50 只健康Sprague-Dawley (SD)大鼠(雌雄各半)常规饲养1 周后, 随机选取20 只分为空白组和假手术组, 每组10 只。剩余30 只种植腹水型Walker-256 癌细胞制作胃癌模型, 造模成功后随机分为模型组、艾灸组和红外组, 每组10 只. 自造模当日开始, 每隔4 d 称量各组大鼠体质量. 艾灸组在两组穴位(中脘、关元和双侧足三里为一组, 双侧脾俞和胃俞为一组)上交替施以温和灸, 红外组在腹背部胃体表投影区域用短波红外线照射, 两组均每日治疗1 次, 每次20 min,连续治疗21 d。治疗结束后, 完整剥离胃肿瘤, 并计算肿瘤体积及肿瘤生长抑制率, 记录大鼠胃肿瘤细胞转移情 况. 用酶联免疫吸附法(ELISA)测定大鼠胃肿瘤组织中VEGF 和EGF 含量。 与空白组比较, 模型组大鼠造模后体质量明显降低(P<0.05); 与模型组比较, 艾灸组大鼠干预中、后期体质量增加(均P<0.05). 艾灸组和红外组瘤体体积均较模型组缩小(均P<0.05); 艾灸组肿瘤生长抑制率高于红外组, 差异有统计学意义(P<0.05); 艾灸组肿瘤转移例数少于模型组和红外组. 模型组大鼠肿瘤组织中VEGF 含量明显高于空白组, 差异有统计学意义(P<0.05); 与模型组相比, 艾灸组和红外组肿瘤组织中VEGF 均明显降低, 差异有统计学意义(均P<0.05). 模型组大鼠肿瘤组织中EGF 含量较空白组低, 差异有统计学意义(P<0.05); 与模型组比较, 艾灸组和红外组肿瘤组织中EGF 含量均明显升高, 差异有统计学意义(均P<0.05)。 艾灸能增加胃荷瘤大鼠体质量, 并有抑制胃荷瘤大鼠肿瘤生长及浸润转移的作用, 其抑制作用可能与调整胃荷瘤大鼠肿瘤组织中VEGF 和EGF 表达量有关。

To observe the effect of moxibustion on T lymphocyte subsets in peripheral blood of rats with gastric cancer. Sixty healthy Sprague-Dawley (SD) rats were adaptively fed for one week. By the random number table method, 10 rats were randomly selected as a blank group, and 12 rats were randomly selected to simulate the tumor transplantation process; after transplantation, 10 rats were randomly selected as a sham operation group. The remaining 38 rats were used to prepare gastric cancer models by gastric transplantation of the Walker-256 tumor tissue; 8 rats were randomly selected to verify the successful modeling after 7 d; the remaining 30 rats were randomly divided into a model group, a moxibustion group and an infrared group by the random number table method, with 10 rats in each group. From the first day of enrollment, the rats in the moxibustion group received mild moxibustion at Zhongwan (CV 12), Guanyuan (CV 4) and bilateral Zusanli (ST 36) (the first group) and bilateral Pishu (BL 20) and Weishu (BL 21) (the second group), and the two groups of acupoints were alternated every other day. The rats in the infrared group received infrared radiation on the stomach area and the area on the back between the T12-T13spinous processes, the two areas were alternated every other day. Rats in the moxibustion group and the infrared group were treated for 20 min each time, once a day for 21 d. Rats in the blank group, the sham operation group, and the model group were simultaneously grasped and fixed, and no other treatment was performed. After 21 d of intervention, the rats in each group were fasted for 12 h, and blood was collected from the orbits. The numbers of CD3+, CD3+CD4+, CD3+CD8+T lymphocytes in peripheral blood were determined by flow cytometry, and the ratio of CD3+CD4+/CD3+CD8+was calculated. The rats were sacrificed and the thymus was dissected under sterile conditions to calculate the thymus index. Compared with the blank group, the thymus index, peripheral blood CD3+, CD3+CD4+, CD3+CD8+and CD3+CD4+/CD3+CD8+ratio in the sham operation group did not change significantly (all P>0.05). Compared with the blank group, the thymus index of the model group was increased (P<0.05), the CD3+and CD3+CD8+T lymphocytes were increased (both P<0.01), and the CD3+CD4+/CD3+CD8+ratio was decreased (P<0.05). Compared with the model group, the thymus index of the moxibustion group was increased (P<0.01), and CD3+, CD3+CD4+and CD3+CD8+T lymphocytes and the ratio of CD3+CD4+/CD3+CD8+in peripheral blood were increased (all P<0.05). Compared with the infrared group, the thymus index of the moxibustion group was significantly increased (P<0.05), the CD3+and CD3+CD4+T lymphocytes in the peripheral blood were significantly increased (both P<0.01), and the CD3+CD8+was increased (P<0.05). Moxibustion can significantly increase the thymus index of gastric cancer-bearing rats and activate CD3+CD4+and CD3+CD8+T lymphocytes in peripheral blood. 观察艾灸对胃荷瘤大鼠外周血中T 淋巴细胞亚群的影响。 将60 只健康Sprague-Dawley (SD)大鼠适应性喂养一周后, 按随机数字表法随机选出10 只作为空白组, 时随机选出12 只通过手术模拟瘤体移植过程, 成功后, 随机将10 只作为假手术组. 剩余38 只采用Walker-256 瘤组织胃部移植制备胃荷瘤模型, 7 d 后随机选取8 只验证造模成功, 剩余30 只用随机数字表法依次分入模型组、艾灸组和红外组,每组10 只. 自入组第1 日起, 艾灸组接受温和灸中脘、关元和双侧足三里(第一组)以及双侧脾俞和胃俞(第二组)治疗, 两组穴位隔日交替使用. 红外组接受红外线照射胃脘部及背部T12-T13 棘突间两个区域, 两个区域隔日交替使用。 艾灸组、红外组每次干预20 min, 每日1 次, 连续21 d. 空白组、假手术组和模型组同时间抓取、固定, 不予其他处理. 干预21 d 后, 各组大鼠禁食不禁水12 h, 眼眶采血, 流式细胞仪测定外周血中CD3+、CD3+CD4+和CD3+CD8+T 淋巴细胞 含量, 计算CD3+CD4+/CD3+CD8+比值。处死动物, 无菌条件下剖取胸腺, 计算胸腺指数。 与空白组比较, 假手术组大鼠胸腺指数、外周血中CD3+、CD3+CD4+、CD3+CD8+及CD3+CD4+/CD3+CD8+比值均无显著变化(均P>0.05). 与空白组比较, 模型组大鼠胸腺指数增高(P<0.05), 外周血中CD3+、CD3+CD8+T淋巴细胞增多(均P<0.01), CD3+CD4+/CD3+CD8+比值下降(P<0.05). 与模型组比较, 艾灸组大鼠胸腺指数增高(P<0.01), 外周血中CD3+、CD3+CD4+和CD3+CD8+ T淋巴细胞以及CD3+CD4+/CD3+CD8+比值均增加(均P<;0.05). 与红外组比较, 艾灸组大鼠胸腺指数明显增高(P<0.05), 外周血中CD3+和CD3+CD4+T淋巴细胞显著增加(均P<0.01), CD3+CD8+稍有增加(P<;0.05)。 艾灸可明显提高胃荷瘤大鼠胸腺指数, 激活外周血中CD3+CD4+和CD3+CD8+T淋巴细胞。

We herein report a novel type of chiral carbon nanotube nanomaterial (MCNTs–PNG–CD) based on smart polymer brush grafted magnetic carbon nanotubes (MCNTs) for highly efficient chiral recognition and separation of tryptophan enantiomers (dl-Trp). The grafted PNG–CD smart polymer brushes are composed of thermosensitive poly(N-isopropyl acrylamide-co-glycidyl methacrylate) (PNG) copolymer chains with numerous appended beta-cyclodextrin (β-CD) units, which play a crucial role in efficient chiral discrimination and separation of dl-Trp. PNG–CD was fabricated on Fe3O4nanoparticle-loaded carbon nanotubes (CNTs) by combining surface-initiated atom transfer radical polymerization (SI-ATRP) with a ring opening reaction. MCNTs–PNG–CD was systematically characterized by transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) and Raman spectroscopy, thermogravimetric analysis (TGA), vibrating sample magnetometry (VSM) and elemental analysis (EA). The prepared MCNTs–PNG–CD demonstrates highly thermosensitive chiral recognition and enantioselectivity toward dl-Trp, which is based on host–guest interactions between β-CD units and l-tryptophan (l-Trp) and the thermosensitive volume phase transition of poly(N-isopropylacrylamide) (PNIPAM) chains. The operating temperature and initial concentrations of AAs are two significant factors that affect the chiral recognition and separation of dl-Trp. Furthermore, the obtained MCNTs–PNG–CD also exhibits satisfactory reusability and excellent magnetic separability from enantiomeric solutions. Such a multifunctional CNT nanomaterial can serve as a high-performance nanoselector for direct enantioseparation of various chiral compounds.

Due to the large reserves, low cost, high security and high energy density, rechargeable multivalent batteries have attracted extensive research enthusiasm for a long time. Multivalent batteries are also supposed as the potential candidates to Li-ion batteries in portable electronic devices and large-scale energy storage units. Unfortunately, most commercial cathode materials in Li-ion batteries cannot be applied in multivalent batteries because of the intensive polarization problem of multivalent intercalated ions (Mg2+, Zn2+, Al3+). Choosing and synthesizing the appropriate cathode materials are the main issues in overcoming the intensive polarization problem. Vanadium-based materials often possess many kinds of oxidation states because of the mutable vanadium element, which can facilitate achieving local electroneutrality and relieve the polarization problem of multivalent ions. In this review, we summarize the researches about the vanadium-based cathode materials for multivalent batteries and highlight the intercalation mechanism of multivalent ions to vanadium-based materials. In addition, different kinds of optimizing strategies are extracted from the literatures. On the basis of our review, progresses and future challenges of vanadium-based cathode materials in rechargeable multivalent batteries are more explicit.

Pseudocapacitive charge storage has been regarded as a promising mechanism to achieve both high specific energy and power energy storage devices. Some pseudocapacitive anode materials show great high-rate performance, however, it remains a significant challenge to develop the cathode ones. Herein, for the first time, we report a layered iron vanadate (Fe5V15O39(OH)9⋅9H2O, named as kazakhstanite) nanosheets (FeVO NSs) with featuring ultrathin layer thickness (< 10 nm). The FeVO NSs are synthesized by a facile wet-chemical approach with a high yield. Compared to the FeVO nanoparticles, the crystalline layered FeVO NSs have additional interlayered Li+storage sites, leading to the enhanced capacity. Ex-situX-ray diffraction results demonstrate a non-phase change process and there is only ~ 1.1% layer expansion/shrinkage during lithiation and delithiation process. Based on detail kinetics analysis and ex-situX-ray photoelectron spectroscopy results, it is found that over 70% of total capacity is pseudocapacitive contribution, which contributes to the ultrahigh-rate capability (a high capacity of 350, 273 and 90 mAh g−1is achieved at 0.1, 1 and 20 A g−1, respectively) and excellent cycling stability over thousands of cycles. This work presents the high performance vanadate material that delivers highly pseudocapacitive behavior, and provides a promising direction to realize both high energy and high power lithium storage.

To adapt the contradiction between the increasing information quantity of highway traffic network monitoring and the limited network bandwidth resources, this paper proposes an object detection algorithm based on Bayesian compressed sensing. Video are sparse in a wavelet base, and a partial Hadamard measurement matrix is adopted to compress the video. The object detection method combines background difference and Bayesian compressed sensing of wavelet tree structure. To get more accurate foreground, an adaptive background model is proposed. Experiments results show the accuracy and effectiveness of the method, and can robustly detect the targets under changing light and reduce the price of video transmission.

The indexing precision of power tool rest cutter head is the prima choice to judge the performance of the tool rest and the test of it is the premise of the tool rest quality. Considering the lack of an effective indexing precision detection method of power tool rest cutter head, the testing methods of the indexing precision of power tool rest cutter head are discussed and an indexing precision testing system based on photoelectric auto collimator is set up. The testing results can show the indexing error of every tool. The studied system of the indexing precision of power tool rest cutter head is suitable for various indexing device to realize dynamic indexing accuracy testing and the system has a high reliability and testing accuracy.

As the tool magazine and automatic tool changer (ATC) are the important function units to reserve and change tools for the machining center, the tool-changing rate affects their reliability life which directly influences the performance level of the machining center. However, the reliability of the tool magazine and ATC has not yet got a reasonable evaluation index. Directing at the features of the tool magazine and ATC system, the mean tool change numbers between failures evaluation index is proposed, which is used to calculate the mean time to repair and estimate the collected failure data of the chain-type tool magazine and ATC. It can be seen that the tool magazine with continuous tool-changing adopts the mean tool change numbers between failures as the reliability evaluation index.

The scarcity and imperfection of power tool rest noise detection method have seriously limited the development of the industry of CNC lathe, lathe and milling composite machining center. A noise detection system based on LabVIEW is developed. The developed system adopts a noise sensor as noise detection component to test the noise information of the power tool rest. To enhance the anti-interference ability of this system, the sampled signals are amplified and adjusted by the signal disposal instrument. Through the spectrum transformation and spectrum analysis of the sampled noise signals, the noise causes of the power tool rest can be inquired and the concerned measurements can be taken to reduce the noise effectively. Finally, the sampled data is stored by the data saving function.

Tool magazine and automatic tool changer is important parts to fulfill the machining center tool reserve and automatic changing of the spindle tool. The reliability of them directly affects the performance of the host. But recently there are no researches on the reliability evaluation methods, so considering this situation, the reliability evaluation researches on CNC machine tools and their main parts at home and abroad are analyzed and concluded. Combining the collected failure data of the circular tool magazine and automatic tool changer, use MTBF (Mean Time between Failures), MTTR (Mean Time To Repair) and the inherent availability index to realize the reliability evaluation of the circular tool magazine and automatic tool changer. Thus put forward a method to study the reliability evaluation of circular tool magazine and automatic tool changer.

According to the existing problems in production planning management mode and management processes of Chinese medium and small manufacture enterprise, referring to the advanced management concept of MRPII/ERP, a master production schedule system which is suitable for management state of Chinese medium and small manufacture enterprise is researched and developed. The operation process, data flow and ER model of the master production schedule system are discussed and researched. Finally, Microsoft vb.net is selected as the development tool of the master production schedule system and Microsoft SQL Server 2000 is used as the database management system, a master production schedule prototype system is designed and implemented.

In multi-objective particle swarm optimization (MOPSO), the selection of global guides for all partials is vital to improve the convergence and diversity of solutions. In this paper, the related work of global guides searching in MOPSO is introduced, and a new Pareto–based selecting strategy is proposed. Basing on the analysis of the structure and mapping relation of the particle swarm and the nondominated solutions archive, considering the density information, the global guides selecting frequency and other factors, a new gbest selecting strategy for each particle in the swam is presented. Experimental results of contrasting experiments of two typical MOPSO functions demonstrate that the proposed strategy is satisfying.

Objective: to probe the interference of Ruyanneixiao cream for hemorheology and mammary microcirculation of mammary precancer rats. Methods: 48 virginal female SD rats were randomly allocated into 6 groups, A: Blank control group (8); B: Mammary precancer model group (8); C: Tamoxifen (TAM) group (8); D: High dose group of Ruyanneixiao cream (8); E: Middle dose group of Ruyanneixiao cream (8); F: Low dose group of Ruyanneixiao cream (8). The changes of hemorheology and mammary microcirculation were recorded when the rats were executed after 60d. Result: compared with the Blank control group, the whole blood viscosity and plasma viscosity of mammary precancer model group was higher (P<0.05) and the perfusion of mammary microcirculation was lower (P<0.01). Compared with mammary precancer model group, the hemorheological parameters and perfusion of mammary microcirculation of each dose group of Ruyanneixiao cream were improved (P<0.05). Conclusion: Ruyanneixiao cream can improve the status of hemorheology, increase the perfusion of mammary microcirculation. And it may be one of mechanism to treat and prevent mammary precancer disease.

Currently, the methods of establishing mammary precancer animal model is various, including hormones-induced precancerous lesions model, chemical carcinogen precancerous lesions model, precancerous lesions model induced by hormones combined with chemical carcinogen, MCF10AT cell lines transplantation model, transgenic model and disease and syndrome animal model. This paper aims to explore the establishing and applied research of animal models of mammary precancerous lesions. Showing it would play a critical role in studying the cause and pathogenesis of mammary precancerous lesions, effective prevention and improving treatment effect by a proper mammary precancerous lesion animal model.

lHierarchical porous Co9S8/NF nanowire arrays exhibit high electrical property.lIntroducing of ZIF offers large surface area and hierarchical porous structure.lZIF-derived Co9S8/NF curbs structural damage and volume expansion in cycle process.lGood conductivity and abundant redox sites of Co9S8improve ion/electron diffusion.lThe assembled Co9S8/NF//AC ASC shows excellent specific energy and specific power.

•The core-shell NiCo2O4@Ppy nanowire arrays were successfully synthesized.•Core-shell NiCo2O4@Ppy nanowires have large specific surface area of 132 m−2 g.•NiCo2O4@Ppy/CC has high stability with retention ratio of 71% after 8000 cycles.•All-solid-state asymmetric capacitor shows maximum energy density of 22.3 Wh kg−1.

Tripartite motif 8 (TRIM8) is a member of the TRIM protein family that has been found to be implicated in cardiovascular disease. However, the role of TRIM8 in myocardial ischemia/reperfusion (I/R) has not been investigated. We aimed to explore the effect of TRIM8 on cardiomyocyte H9c2 cells exposed to hypoxia/reoxygenation (H/R). We found that TRIM8 expression was markedly upregulated in H9c2 cells after stimulation with H/R. Gain- and loss-of-function assays proved that TRIM8 knockdown improved cell viability of H/R-stimulated H9c2 cells. In addition, TRIM8 knockdown suppressed reactive oxygen species production and elevated the levels of superoxide dismutase and glutathione peroxidase. Knockdown of TRIM8 suppressed the caspase-3 activity, as well as caused significant increase in bcl-2 expression and decrease in bax expression. Furthermore, TRIM8 overexpression exhibited apposite effects with knockdown of TRIM8. Finally, knockdown of TRIM8 enhanced the activation of PI3K/Akt signaling pathway in H/R-stimulated H9c2 cells. Inhibition of PI3K/Akt by LY294002 reversed the effects of TRIM8 knockdown on cell viability, oxidative stress, and apoptosis of H9c2 cells. These present findings defined TRIM8 as a therapeutic target for attenuating and preventing myocardial I/R injury.

Myocardial infarction (MI) is one of the most serious cardiovascular diseases associated with myocardial ischemia/reperfusion (I/R) injury. Glaucocalyxin A (GLA) is a biologically active ent-kauranoid diterpenoid that has been found to ameliorate myocardial I/R injury in mice. However, the mechanism has not been fully investigated. In the present study, we aimed to investigate the effect of GLA on rat cardiomyocytes H9c2 cells exposed to hypoxia/reoxygenation (H/R). The results showed that GLA treatment improved cell viability of H/R-stimulated H9c2 cells. Administration with GLA suppressed the H/R-stimulated reactive oxygen species (ROS) production in H9c2 cells. GLA also elevated the activities of antioxidant enzymes, including superoxide dismutase and glutathione peroxidase in H/R-stimulated H9c2 cells. Moreover, GLA prevented H/R-stimulated cell apoptosis in H9c2 cells, as evidenced by increased bcl-2 expression, decreased bax expression, as well as reduced caspase-3 activity. Furthermore, GLA enhanced the activation of protein kinase B (Akt)/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in H9c2 cells exposed to H/R. Additionally, treatment with LY294002 reserved the protective effects of GLA on H/R-stimulated oxidative injury in H9c2 cells. In conclusion, these findings suggested that GLA protected H9c2 cells from H/R-stimulated oxidative damage, which was mediated by the Akt/Nrf2/HO-1 signaling pathway. Thus, GLA might be a promising therapeutic agent for the prevention and treatment of myocardial I/R.

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