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1. Communication breakdown: protein dynamics and drug design.

Author

Peng JW

Subjects
Binding Sites, Nuclear Magnetic Resonance, Biomolecular, Structure-Activity Relationship, Tetrahydrofolate Dehydrogenase metabolism, Drug Design, Folic Acid Antagonists chemistry, Tetrahydrofolate Dehydrogenase chemistry
Abstract

Mauldin et al. (2009) use NMR to show that drug binding can break up collective protein motions necessary for function. We discuss their findings in the context of drug discovery in pharmaceutical research.

Published
2009
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