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1. Evaluation of the Clinical Performance of the cobas 4800 HPV Test in Patients Referred for Colposcopy

Author

White, Christine, Keegan, Helen, Pilkington, Loretto, Ruttle, Carmel, Kerr, Patrick, Sharp, Linda, O'Toole, Sharon, Turner, Michael, Prendiville, Walter, D'Arcy, Tom, Fitzpatrick, Myra, Lenehan, Peter, Flannelly, Grainne, O'Leary, John J., and Martin, Cara M.

Abstract

ABSTRACTThe clinical performance of the cobas human papillomavirus (HPV) test for detection of high-grade disease in a colposcopy-referred population was compared with that of Hybrid Capture 2 (HC2). The overall agreement between the tests was 92.3%. Clinical sensitivity and specificity for detection of cervical intraepithelial neoplasia grade 2 or greater (CIN2+) were 90.0% and 55.5% for cobas and 90.5% and 50.2% for HC2, respectively. In conclusion, both tests showed comparable performance for detection of CIN2+.

Published
2013
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