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Your search keyword '"Poggioli, Gilberto"' showing total 30 results
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30 results on '"Poggioli, Gilberto"'

4. Contemporary snapshot of tumor regression grade (TRG) distribution in locally advanced rectal cancer: a cross sectional multicentric experience

Author

Germani, Paola, Di Candido, Francesca, Léonard, Daniel, Cuicchi, Dajana, Elmore, Ugo, Allaix, Marco Ettore, Barbieri, Vittoria Pia, D’Allens, Laura, Faes, Seraina, Milani, Marika, Caputo, Damiano, Martinez, Carmen, Grosek, Jan, Caracino, Valerio, Christou, Niki, Roodbeen, Sapho X., Bracale, Umberto, Wildeboer, Aurelia, Usai, Antonella, Benedetti, Michele, Balani, Alessandro, Piccinni, Giuseppe, Catarci, Marco, Millo, Paolo, Bouvy, Nicole, Corcione, Francesco, Hompes, Roel, Ris, Frédéric, Basti, Massimo, Tomazic, Ales, Targarona, Eduardo, Coppola, Alessandro, Pietrabissa, Andrea, Hahnloser, Dieter, Adamina, Michel, Viola, Massimo, Morino, Mario, Rosati, Riccardo, Poggioli, Gilberto, Kartheuser, Alex, Spinelli, Antonino, and de Manzini, Nicolò

Abstract

Pre-operative chemoradiotherapy (CRT) followed by surgical resection is still the standard treatment for locally advanced low rectal cancer. Nowadays new strategies are emerging to treat patients with a complete response to pre-operative treatment, rendering the optimal management still controversial and under debate. The primary aim of this study was to obtain a snapshot of tumor regression grade (TRG) distribution after standard CRT. Second, we aimed to identify a correlation between clinical tumor stage (cT) and TRG, and to define the accuracy of magnetic resonance imaging (MRI) in the restaging setting. Between January 2017 and June 2019, a cross sectional multicentric study was performed in 22 referral centers of colon-rectal surgery including all patients with cT3-4Nx/cTxN1-2 rectal cancer who underwent pre-operative CRT. Shapiro–Wilk test was used for continuous data. Categorical variables were compared with Chi-squared test or Fisher’s exact test, where appropriate. Accuracy of restaging MRI in the identification of pathologic complete response (pCR) was determined evaluating the correspondence with the histopathological examination of surgical specimens.

Published
2021
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5. Functional outcome in handsewn versus stapled ileal pouch-anal anastomosis

Author

Gozzetti, Giuseppe, Poggioli, Gilberto, Marchetti, Floriano, Laureti, Silvio, Grazi, Gian Luca, Mastrorilli, Mario, Selleri, Simonetta, Stocchi, Luca, and Di Simone, Massimo

Subjects
Surgical anastomosis -- Evaluation, Ulcerative colitis, Ileum, Anus, Health
Abstract

Eighty-eight of 119 patients who underwent ileal pouch-anal anastomosis for ulcerative colitis were evaluated. Forty patients had a handsewn anastomosis (Hs) with mucosectomy, and 48 had a stapled anastomosis (St). In each patient, we evaluated operative, morphologic, functional, and manometric features. The results in the Hs and St groups were similar when the anastomosis was within 1 cm of the dentate line. In particular, there was no correlation between the type of anastomosis and the number of bowel movements in a 24-hour period, the presence of the urge to defecate, and the use of antidiarrheal drugs. Leakage was significantly higher in the Hs group, even when the anastomosis was less than 1 cm from the dentate fine. Ponchitis was more frequent in the Hs group, and, within this group, among those with a short distance between the anastomosis and the dentate line. No correlations were found between the presence of columnar epithelium or active colitis in the mucosa below the anastomosis, the functional outcomes, and the incidence of pouchitis.

Published
1994

6. Anastomosis configuration and technique following ileocaecal resection for Crohn’s disease: a multicentre study

Author

Celentano, Valerio, Pellino, Gianluca, Spinelli, Antonino, Selvaggi, Francesco, Celentano, Valerio, Pellino, Gianluca, Rottoli, Matteo, Poggioli, Gilberto, Sica, Giuseppe, Giglio, Mariano Cesare, Campanelli, Michela, Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, Francesco, Sampietro, Gianluca, Lamperti, Giulia, Foschi, Diego, Ficari, Ferdinando, Vacca, Ludovica, Cricchio, Marta, Giudici, Francesco, Selvaggi, Lucio, Sciaudone, Guido, Peltrini, Roberto, Manfreda, Andrea, Bucci, Luigi, Galleano, Raffaele, Ghazouani, Omar, Zorcolo, Luigi, Deidda, Simona, Restivo, Angelo, Braini, Andrea, Di Candido, Francesca, Sacchi, Matteo, Carvello, Michele, Martorana, Stefania, Bordignon, Giovanni, Angriman, Imerio, Variola, Angela, Di Ruscio, Mirko, Barugola, Giuliano, Geccherle, Andrea, Tropeano, Francesca Paola, Luglio, Gaetano, Tanzanu, Marta, Sasia, Diego, Migliore, Marco, Giuffrida, Maria Carmela, Marrano, Enrico, Moretto, Gianluigi, Impellizzeri, Harmony, Gallo, Gaetano, Vescio, Giuseppina, Sammarco, Giuseppe, Terrosu, Giovanni, Calini, Giacomo, Bondurri, Andrea, Maffioli, Anna, Zaffaroni, Gloria, Resegotti, Andrea, Mistrangelo, Massimiliano, Allaix, Marco Ettore, Botti, Fiorenzo, Prati, Matteo, Boni, Luigi, Perotti, Serena, Mineccia, Michela, Giuliani, Antonio, Romano, Lucia, Graziano, Giorgio Maria Paolo, Pugliese, Luigi, Pietrabissa, Andrea, Delaini, GianGaetano, Spinelli, Antonino, and Selvaggi, Francesco

Abstract

A limited ileocaecal resection is the most frequently performed procedure for ileocaecal CD and different anastomotic configurations and techniques have been described. This manuscript audited the different anastomotic techniques used in a national study and evaluated their influence on postoperative outcomes following ileocaecal resection for primary CD. This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing elective ileocaecal resection for primary CD from June 2018 May 2019. Postoperative morbidity within 30 days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. 427 patients were included. The side to side anastomosis was the chosen configuration in 380 patients (89%). The stapled anastomotic (n= 286; 67%), techniques were preferred to hand-sewn (n= 141; 33%). Postoperative morbidity was 20.3% and anastomotic leak 3.7%. Anastomotic leak was independent of the type of anastomosis performed, while was associated with an ASA grade ≥ 3, presence of perianal disease and ileocolonic localization of disease. Four predictors of LOS were identified after multivariate analysis. The laparoscopic approach was the only associated with a reduced LOS (p= 0.017), while age, ASA grade ≥ 3 or administration of preoperative TPN were associated with increased LOS. The side to side was the most commonly used anastomotic configuration for ileocolic reconstruction following primary CD resection. There was no difference in postoperative morbidity according to anastomotic technique and configuration. Anastomotic leak was associated with ASA grade ≥ 3, a penetrating phenotype of disease and ileo-colonic distribution of CD.

Published
2021
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7. The Association among Pyoderma Gangrenosum, Ulcerative Colitis, and Hidradenitis Suppurativa and the Syndromic Hidradenitis Suppurativa Network: A Case Report

Author

Bettoli, Vincenzo, Schettini, Natale, Libanore, Marco, Scuderi, Valeria, Zedde, Pierantonia, Forconi, Riccardo, Pacetti, Lucrezia, Ceccherini, Isabella, Gattorno, Marco, Poggioli, Gilberto, and Corazza, Monica

Abstract

Hidradenitis suppurativa (HS), together with other inflammatory diseases, is involved in a syndromic network where different combinations of signs and symptoms characterize the definition. The observation of the concurrent occurrence of HS, pyoderma gangrenosum (PG), and inflammatory bowel disease (IBD), in detail ulcerative colitis (UC), led the authors to describe a new association. The patient, a 36-year-old woman, who saw IBD as the first appearing condition, shortly followed by HS and PG, was referred because of a clinical situation quickly worsening. A severe aggravation of both GI symptoms and general systemic situation total led to total colectomy. Surprisingly, shortly after the radical surgical treatment of UC, the cutaneous manifestations of HS and PG with no specific treatment almost completely disappeared suggesting the existence of a common etiopathogenetic mechanism and possibly an inductor role of UC on the other disorders. The presentation of this case offers the opportunity to deal with the fact that the resolution of one of the associated conditions may lead to the clearance of one or more of the others. It confirms a pathogenetic link between them and the pivotal role of one of them, in this case colitis.

Published
2021
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8. Inflammatory bowel disease patients requiring surgery can be treated in referral centres regardless of the COVID-19 status of the hospital: results of a multicentric European study during the first COVID-19 outbreak (COVID-Surg)

Author

Rottoli, Matteo, Pellino, Gianluca, Tanzanu, Marta, Baldi, Caterina, Frontali, Alice, Carvello, Michele, Foppa, Caterina, Kontovounisios, Christos, Tekkis, Paris, Colombo, Francesco, Sancho-Muriel, Jorge, Frasson, Matteo, Danelli, Piergiorgio, Celentano, Valerio, Spinelli, Antonino, Panis, Yves, Sampietro, Gianluca M., and Poggioli, Gilberto

Abstract

Outcomes of inflammatory bowel disease (IBD) patients requiring surgery during the outbreak of Coronavirus disease 19 (COVID-19) are unknown. Aim of this study was to analyse the outcomes depending on the COVID-19 status of the centre. Patients undergoing surgery in six COVID-19 treatment and one COVID-free hospitals (five countries) during the first COVID-19 peak were included. Variables associated with risk of moderate-to-severe complications were identified using logistic regression analysis. A total of 91 patients with Crohn’s disease (54, 59.3%) or ulcerative colitis (37, 40.7%), 66 (72.5%) had surgery in one of the COVID-19-treatment hospitals, while 25 (27.5%) in the COVID-19-free centre. More COVID-19-treatment patients required urgent surgery (48.4% vs. 24%, p= 0.035), did not discontinue biologic therapy (15.1% vs. 0%, p= 0.039), underwent surgery without a SARS-CoV-2 test (19.7% vs. 0%, p= 0.0033), and required intensive care admission (10.6% vs. 0%, p= 0.032). Three patients (4.6%) had a SARS-CoV-2 infection postoperatively. Postoperative complications were associated with the use of steroids at surgery (Odds ratio [OR] = 4.10, 95% CI 1.14–15.3, p= 0.03), presence of comorbidities (OR = 3.33, 95% CI 1.08–11, p= 0.035), and Crohn’s disease (vs. ulcerative colitis, OR = 3.82, 95% CI 1.14–15.4, p= 0.028). IBD patients can undergo surgery regardless of the COVID-19 status of the referral centre. The risk of SARS-CoV-2 infection should be taken into account.

Published
2021
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10. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Author

Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Li, Elizabeth, Omar, Omar M, Simoes, Joana FF, Abbott, Tom EF, Alser, Osaid, Arnaud, Alexis P, Bankhead-Kendall, Brittany K, Breen, Kerry A, Cunha, Miguel F, Davidson, Giana H, Di Saverio, Salomone, Gallo, Gaetano, Griffiths, Ewen A, Gujjuri, Rohan R, Hutchinson, Peter J, Kaafarani, Haytham MA, Lederhuber, Hans, Löffler, Markus W, Mashbari, Hassan N, Minaya-Bravo, Ana, Morton, Dion G, Moszkowicz, David, Pata, Francesco, Tsoulfas, George, Venn, Mary L, Cox, Daniel, Roslani, April C, Alakaloko, Felix, de Vries, Jean-Paul PM, Aaraj, Mahmoud A, Abbott, Tom EF, Abbott, Sarah J, Abdalla, Mutwakil OM, Abdelaal, Ahmed S, Ademuyiwa, Adesoji O, Aherne, Thomas M, Ali, Osman M, Alkadeeki, Ghadah Z, Almeida, Ana C, Alrahawy, Mahmoud M, Ambler, Graeme K, Alameer, Ehab, Andreani, Stefano M, De Andrés-Asenjo, Beatriz, Antonanzas, Leyre Lopez, Aoun, Salah G, Ashoush, Fouad M, Augestad, Knut Magne, Avellana, Rocio B, Ayeni, Funbi A, Ayorinde, John OO, Babu, Bheemanakone H, Baig, Mirza MAS, Bajomo, Oreoluwa M, Baker, Olivia J, Baker, Markus P, Baldwin, Alexander J, Ban, Vin Shen, Baron, Ryan D, Barranquero, Alberto G, Barry, Conor P, DI Bartolomeo, Alessandro, Bass, Gary A, Bath, Michael F, Batjer, H Hunt, Beamish, Andrew J, Belgaumkar, Ajay P, Bence, Matthew N, Benson, Ruth A, Bernal-Sprekelsen, Juan Carlos, Bhama, Anuradha R, Bhavaraju, Avi V, Biffl, Walter L, Blundell, Chris M, Boddy, Alexander P, Borgstein, Alexander BJ, Bosanquet, David C, Bosch, Karen D, Bouhuwaish, Ahmad EM, Bozkurt, Mehmet A, Brathwaite, Collin EM, Brown, Benjamin C, Brown, Oliver D, Brown, Allison K, Buarque, Igor Lima, Bueno-Cañones, Alejandro D, Bulugma, Mustafa R, Burke, Joshua R, Byrne, Matthew HV, Cagigal-Ortega, Elima P, Callcut, Rachael A, DI Candido, Francesca, Canova, Michaela E, Carlos, William J, Caruana, Edward J, Cato, Liam D, Catton, Andrew B, Ceretti, Andrea Pisani, Chase, Thomas JG, Chiara, Francesco Di, Chowdhury, Abeed H, Chung, Eric A, Cicerchia, Pierfranco M, Clough, Ethan CS, Coleman, Natasha L, Collins, Chris G, Collins, Michelle L, Colonna, Emily T, Comini, Lara V, Coughlin, Patrick A, Cruzado, Laura Fernández-Gomez, Davidson, Brian R, Davies, Richard J, Davies, Emma J, Davis, Niall F, Dawson, Brett E, Dean, Benjamin JF, Delgado, Maria Garcia-Conde, Diaz, Jose J, Dickson, Kathryn E, Diez-Alonso, Manuel M, Dixon, Jan R, Doe, Matthew J, Drake, Thomas D, Drake, Frederick T, Duffy, John P, Dunne, Declan FJ, Dunne, Naomi JM, Durán-Muñoz-Cruzado, Virginia M, Durst, Alexander ZE, Eardley, Nicola J, Edwards, John G, Elfallal, Ahmed H, Elfiky, Mahmoud MA, Elliott, Jessie A, Emile, Sameh H, Emslie, Katy M, Endorf, Frederick W, Engel, Jamie L, Enjuto, Diego T, Etchill, Eric W, Evans, Jonathan P, Fahey, Brian A, Faria, Carlos S, Feo, Carlo V, Ferguson, Henry JM, Fernandez, Beatriz Dieguez, Fernandez, Andres Garcia, Fernández, Antonio J, Fernández-Pacheco, Borja Camacho, Fitzgerald, J Edward, Fonsi, Giovanni B, Font, Roser Farré, Fowler, Amy L, Fretwell, Kenneth R, Fructuoso, Lorena Sanchon, Fusai, Giuseppe K, Garcia, Miguel Hernandez, Garcia-Ureña, Miguel Angel, Gill, Charn K, Gisbertz, Suzanne S, Del Giudice, Roberto, Giuffrida, Maria Carmela, Di Giuseppe, Matteo, Gómez, María Fanjul, Griffiths, Ewen A, Guariglia, Claudio A, Hainsworth, Alison J, Hall, Bria J, Hall, James RW, Hammond, John S, Haqqani, Maha H, Harrison, Ewen M, Hazelton, Joshua P, van Heinsbergen, Maarten, Hill, Arnold DK, Hing, Caroline B, Hirji, Sameer A, Ho, Michael WS, Holbrook, Charlotte M, Holme, Thomas J, Hopkins, James C, Hopkinson, David N, Hossain, Fahad S, Hudson, Victoria E, Hughes, Jane L, Hwang, E. Shelley, Ibrahim, Mohamed AH, Isolani, Simone M, Jenkinson, Michael D, Jenny, Hillary E, Jeyaretna, Deva S, Jones, Robert P, Jones, Andrew P, Jonker, Pascal KC, Jönsson, Maria L, Joyce, Doireann P, Kalkwarf, Kyle J, Kamarajah, Sivesh K, El Kassas, Mohamed, Kavanagh, Dara O, Keatley, James M, Khalefa, Mohamed A, Khan, Jim S, Kirmani, Bilal H, Kisiel, Aaron P, Kouris, Spyros Marinos, Kowal, Mikolaj R, Labib, Peter L, Larkin, John O, Lauscher, Johannes C, Leclercq, Wouter KG, Ledesma, Frances SJ, Leite-Moreira, André M, Leung, Elaine YL, Lewis, Sophia E, Lima, Maria João, Lin, Daniel J, Liu, Helen H, Lowery, Aoife J, Lozano, Saida Martel, Luney, Catriona R, Maia, Mariana Magalhães, Mariani, Nicolò M, Marino, Marco V, Marra, Angelo A, Marsh, Christopher L, Martin, Robert CG, McCluney, Simon J, McIntyre, Robert C, Mckay, Siobhan C, McKevitt, Kevin L, Meagher, Ashley D, Mehdi, Mohammad Q, Mehigan, Brian J, Gonzalez-De Miguel, Melania, De Miguel-Ardevines, Maria-Carmen, Mills, Sarah J, Mohan, Helen M, Moir, John AG, Monson, John RT, Monteiro, Joana M, Montella, Maria T, Montesinos, Cristina Soto, Morgom, Marwa M, Moura, Francisco S, Muguerza, Jose M, Murphy, Suzanne H, De Nardi, Paola, Naumann, David N, Neary, Paul C, Neely, David TA, Ng-Kamstra, Joshua S, Ngu, Albert WT, Nguyen, Truong A, Nita, George E, Nunes, Quentin M, Nygaard, Rachel M, O'Meara, Lindsay B, O'Neill, John R, Okafor, Barbara U, Olson, Steven A, Oo, Aung Y, Ormazabal, Pablo Collera, Osorio, Alexander L, Pachl, Max J, Parry, James T, Patel, Panna K, Pérez-Sánchez, Luis E, Pevidal, Ana Nogues, Pezzuto, Anna P, Philp, Matthew M, Pinkney, Thomas D, Pollok, Joerg M, Povey, Meical G, Poza, Alfredo Alonso, Rajgor, Amarkumar D, Rao, Jagan N, Raptis, Dimitri A, Rice, Henry E, Ridgway, Paul F, Rivas, Ana Munoz, Rodriguez-Sanjuan, Juan C, Rogers, Luke J, Da Roit, Anna, Rollett, Rebecca A, Romera, Jose L, Rooney, Siobhan M, Roxo, Vanessa I, Le Roy, Bertrand, Rubio, Eduardo E, Ruiz, Carolina Castro, Ruiz, Manuel Losada, Ryan, Éanna J, Saad, Abdel Rahman, Saeed, Samerah A, Salama, Hiba A, Salamah, Abdulrauf A, Sampietro, Gianluca M, Sarma, Diwakar R, Schaffer, Kathryn B, Schnitzbauer, Andreas A, Scurrah, Rachel J, Serevina, Olivia L, Serralheiro, Pedro A, Sewards, Joseph M, Shackcloth, Michael J, Shaw, Abigail V, Sheel, Andrea RG, Sica, Giuseppe S, De Simone, Veronica, Singh, Aminder A, Singh, Rabindra P, Skelly, Brendan L, Smith, Henry G, Sohail, Amir H, Spalding, Duncan R, Springford, Laurie R, Ssentongo, Anna E, Steinkamp, Pieter J, Stevens, Kent A, Stewart, Grant D, Stylianides, Nicholas A, Sullivan, Tom BB, Taher, Ahmed SA, Tamimy, Muhammad S, Tang, Alethea M, Tebala, Giovanni D, Tejero-Pintor, Francisco J, Thaha, Mohamed A, Thomas, Amy J, De Toma, Giorgio, La Torre, Filippo, Torres, Antonio J, Townshend, David N, Trout, Isobel M, Tucker, Sarah C, Ubhi, Harmony K, Vega, Viviana A, Velmahos, George C, Velopulos, Catherine G, Viswanath, Yirupaiahgari KS, Vivas, Alfredo A, Wade, Ryckie G, Wadley, Martin S, Wall, Joshua JS, Walters, Andrew M, Warren, Oliver J, Weerasinghe, Chamindri K, Wilkin, Richard JW, Williams, Katherine J, Winter, Stuart C, Wormald, Justin CR, Wright, Franklin L, Xyda, Souzana E, Young, Alastair L, Youssef, Mina MG, Yousuf, Farhat B, El Youzouri, Hanan, Zappa, Marco A, Abate, Emmanuele, Abdalaziz, Hossam, Abdelkarim, Mostafa, Abdou, Hossam, Aboelkassem-Ibrahim, Ahmad, Abuown, Ala, Acebes-Garcia, Fernando, Acharya, Metesh, Adamina, Michel, Addae-Boateng, Emmanuel, Aftab, Raiyyan, Agarwal, Arnav, Aguilar, José, Ahmed, Yousra, Aitken, Emma, Al-Azzawi, Marwa, Al-Embideen, Somya, Al-Masri, Mahmoud, Al-Najjar, Hani, Al-Sukaini, Ahmad, Alam, Ruhina, Alderson, Derek, Aliyeva, Zumrud, Aljanadi, Firas, Almasri, Murad, Alonso-Ortuño, Paula, Altintoprak, Fatih, Amira, Gamal, Amjad, Rabbia, Anania, Gabriele, Andabaka, Tatjana, Angelou, Dimitrios, Annamalai, Seethalakshmi, Annessi, Valerio, Anthoney, James, Anwar, Sibtain, Anwer, Mariyah, Aragon-Chamizo, Juan, Ardito, Antonella, Arigoni, Michele, Armao, Teodora, Arminio, Armando, Armstrong, Lara, Arnaud, Alexis, Asaad, Peter, Ashcroft, James, Ashmore, Christopher, Asqalan, Ahmad, Asti, Emanuele, Aubry, Emmanuelle, Aytac, Erman, Ayuso-Herrera, Esther, Baeza, Melody, Bailon-Cuadrado, Martin, Bakmaz, Bernarda, Baldi, Caterina, Baldini, Edoardo, Baldo, Stefano, Ballabio, Michele, Baloyiannis, Ioannis, Baltazar, Gerard, Bàmbina, Fabrizio, Bandiera, Alessandro, Barlow, Emma, Barmasse, Roberto, Barmpagianni, Christina, Baronio, Gianluca, Barra, Fabio, Bartsch, Anne-Marie, Basgaran, Amedra, Basha, Amr, Bashkirova, Varvara, Bastazza, Marco, Baumber, Rachel, Belcher, Elizabeth, Belvedere, Angela, Benítez-Linero, Inmaculada, Bergeat, Damien, Bernasconi, Matteo, Bhalla, Ashish, Bhutiani, Neal, Bianco, Federica, Bisagni, Pietro, Blake, Iain, Blanco-Colino, Ruth, Blazquez-Martin, Alma, Boal, Matthew, Bonavina, Luigi, Bonavina, Giulia, Bond-Smith, Giles, Booth, Karen, Borges, Filipe, Borghi, Felice, Bouchagier, Konstantinos, Bourke, Grainne, Boyle, Emily, Brachini, Gioia, Brain, Jessie, Brar, Amanpreet, Breckles, Lisa, Bretagnol, Frédéric, Brixton, Genevieve, Bruzzaniti, Placido, Bueser, Teofila, Burnside, Nathan, Caballero, Albert, Calcerrada-Alises, Enrique, Callahan, Miriam, Camarero, Enrique, Campagnaro, Tommaso, Campanelli, Michela, Candiani, Massimo, Cantalejo-Diaz, Miguel, Cao, Han, Capelli, Patrizio, Capizzi, Vita, Carcano, Giulio, Carissimi, Francesca, Carlini, Massimo, Carlucci, Michele, Carmichael, Heather, Carrasco, Milagros, Carrillo, Mariana, Carvello, Michele, Casati, Massimiliano, Castoro, Carlo, Catalan, Vanesa, Cavaleiro, Salomé, Cellerino, Paola, Centinaio, Giovanna, Cernei, Cristina, Cerro, Cristina, Cervellera, Maurizio, Chakrabortee, Sohini, Chamberlain, Stephanie, Chan, Jeffrey, Chang, Grace, Chaudhry, Dauod, Chebaro, Alexandre, Chen, David, Chetty, Govind, Chia, Zoe, Chiappini, Ambra, Chiarugi, Massimo, Chidambaram, Swathikan, Chiozza, Matteo, Cholewa, Hanna, Chong, Clara, Choolani-Bhojwani, Ekta, Christoforidis, Dimitri, Chui, Karen, Chung, Choyin, Cirillo, Bruno, Citterio, Davide, Clermidi, Pauline, Coccolini, Federico, Colletti, Gaia, Compagnoni, Bruno, Concepción-Martín, Vanesa, Confalonieri, Marco, Connolly, Hannah, Conso, Christel, Conti, Luigi, Cooper, Zara, Cordera, Fernando, Corral, Javier, Costa, Marta, Costanzi, Andrea, Cotsoglou, Christian, Cozza, Valerio, Cuming, Tamzin, Curtis, Miles, Cuschieri, Joseph, D'Agruma, Michele, D'Andrea, Giancarlo, Daliya, Prita, Dare, Oliver, Darko, Ebenezer, Day, Andrew, Dehal, Ahmed, Dehart, Dustin, Delgado-Oliver, Eduardo, Denning, Max, Desai, Anant, Desender, Liesbeth, Dester, Sara, Díaz-García, Alberto, Diaz-Peña, Patricia, Dousset, Bertrand, Doussot, Alexandre, Duchateau, Nicolas, Duff, Sarah, Dunning, Joel, Duque-Mallen, Victoria, Dziakova, Jana, Egan, Bridget, Egan, Richard, El-Ali, Abess, Elfeki, Hossam, Elhadi, Muhammed, Eljareh, Mohammed, Elkady, Ramy, Elkhafeefi, Fatimah, Elmore, Ugo, Elmoslemany, Tarek, Emmerson, Oliver, Enemosah, Ibrahim, English, Camilla, English, William, Escartin, Jorge, Estaire-Gomez, Mercedes, Evans, Luke, Evans, Jessica, Exley, Rebecca, Fabbri, Nicoló, Falco, Giuseppe, Familiari, Pietro, Fancellu, Alessandro, Farik, Shebani, Farrell, Tony, Fehervari, Matyas, Fell, Adam, Fernandez-Camuñas, Angel, Fernández-Marín, Reyes, Fernández-Martínez, María, Ferrara, Francesco, Ferrari, Guglielmo, Ferrero, Simone, Findlay, Laura, Fiore, Marco, Fiori, Enrico, Flatman, Michael, Flindall, Ian, Flor, Blas, Fontana, Tommaso, Ford, Samuel, Ford, David, Forlani, Stefano, Francone, Elisa, Frattaruolo, Colomba, Frio, Federico, Gagliano, Annalisa, Gagliardi, Filippo, Gahunia, Sukhpreet, Gaino, Francesca, Gala, Tanzeela, Galfrascoli, Elisa, Galimberti, Luca, Gallagher, Phoebe, Galleano, Raffaele, Galván-Pérez, Armando, Gammeri, Emanuele, Ganau, Mario, Garcés-García, Raúl, Garulli, Gianluca, Gascon-Ferrer, Isabel, Gattolin, Andrea, Gaujoux, Sebastien, Gentilli, Sergio, Georgiades, Fanourios, Ghanbari, Amir, Ghosh, Dhruv, Giacometti, Marco, Giblin, Anna-Victoria, Gilbert, Catherine, Giménez, Clara, Giorgakis, Emmanouil, Gipponi, Manuel, Glen, Paul, Goatly, Giles, Gobatti, Davide, Godbole, Chintamani, Gohil, Kajal, Gómez, Marcos, Gomez-Rosado, Juan-Carlos, Gonullu, Emre, Gonzalez-Gonzalez, Enrique, Gordini, Luca, Gracia, Isabel, Gracia-Roche, Carlos, Granieri, Stefano, Green, Susanna, Grivon, Manuela, Grove, Thomas, Guaglio, Marcello, Guaitoli, Eleonora, Guglielmi, Alfredo, Guha, Soumya, Gustavino, Claudio, Habeeb, Amir, Hagger, Robert, Hakmi, Hazim, Halkias, Constantine, Hall, Claire, Hampton, Matthew, Handa, Siddhartha, Hansen, Laura, Haq, Iram, Harky, Amer, Harries, Rhiannon, Harrison, Joseph, Hasan, Raashad, Hawari, Mohammad, Hawkin, Paul, Hebblethwaite, Bethany, Henriques, Susana, Heritage, Emily, Hernandez-Juara, Pilar, Herrero-Lopez, Maria, Hervieux, Erik, Heyd, Bruno, Higgs, Simon, Hitchman, Louise, Ho, Beatrice, Hogan, Aisling, Hölzle, Frank, Hossain, Tanvir, Hurt, Libor, Hutchinson, Peter, Iacob, Giulio, Iannone, Immacolata, Ibrahim, Sherif, Iovino, Domenico, Isik, Arda, Jafarova, Sevda, Jamil, Tahir, Jayaraju, Ullas, Jenner, Edward, Jimenez-Higuera, Elisa, Jimeno, Jaime, Jones, Mark, Judkins, Nicholas, Kalavrezos, Nicholas, Kalidindi, Venugopala, Kalkat, Maninder, Kamal, Mona, Kamphues, Carsten, Kang, Chong, Kara, Yasin, Karam, Edward, Karim, Ahmed, Kashora, Florence, Kearney, David, Khajuria, Apoorva, Khan, Umul, Khan, Azam, Khatri, Chetan, Kinnaman, Gabriel, Kinross, James, Kler, Aaron, Klimopoulos, Serafeim, Kocataş, Ali, Kolias, Angelos, Königsrainer, Alfred, Konsten, Joop, Kontovounisios, Christos, Kourdouli, Amar, Krishnan, Emily, Kristinsson, Sverrir, Kruijff, Schelto, Kudsk-Iversen, Søren, Kufeji, Dorothy, Kugler, Nadav, Kulkarni, Rugved, Kurihara, Hayato, Laface, Letizia, Lakkis, Zaher, Lami, Mariam, Landaluce-Olavarria, Aitor, Lapolla, Pierfrancesco, Lawani, Ismail, Lawday, Samuel, Lázaro, André, Lecolle, Katia, Leventoglu, Sezai, Li, Zoe, Liew, Ignatius, Lisi, Giorgio, Lizzi, Vincenzo, Lo, Terence, Lomiento, Daniele, Longhi, Marco, Lostis, Emilie, Lostoridis, Eftychios, Loubani, Mahmoud, Lowy-Benoliel, Alejandro, Lucianetti, Alessandro, Luke, Louis, Lunevicius, Raimundas, Luraghi, Marco, Lye, George, Mabrouk, Islam, Macchi, Alberto, MacDonald, Luisa, Machairas, Nikolaos, Madonini, Marco, Magowan, Drew, Maisonneuve, Emeline, Majkowska, Agata, Majkowski, Lawrence, Mak, Jason, Malabarba, Stefano, Malerba, Michele, Mannan, Syed, Manson, Joanna, Mansuri, Ahmer, Mantoglu, Baris, Manu, Nichola, Maqsood, Afnan, Marano, Alessandra, Marchbank, Adrian, Marcos-Santos, Pablo, Marrano, Enrico, Martin, Janet, Martin, Emmeline, Martin, Guy, Martin-Albo, Lorena, Martín-Román, Lorena, Martinelli, Fabio, Martínez-dePaz, Fernando, Martinez-German, Antonio, Martinez-Pinedo, Carlos, Martins, Ricardo, Marwan, Hisham, Marzi, Federica, Mathieu, Pierre, Matute-Najarro, Maria-Soledad, Maw, Andrew, Mazingi, Dennis, Mazzaferro, Vincenzo, McCanny, Andrew, McKenzie, Katherine, McLarty, Nicola, McPherson, Iain, Medina, Esther, Mediratta, Saniya, Medone, Marzia, Mehra, Gautam, Mele, Simone, Melero-Cortés, Lidia, Mendoza-Moreno, Fernando, Meneghini, Simona, Mercante, Giuseppe, Merdrignac, Aude, Merola, Stephen, Metallidis, Symeon, Michel, Martin, Migliore, Marco, Mihanovic, Jakov, Miller, Douglas, Mingoli, Andrea, Minto, Gary, Mirabella, Antonello, Misra, Nikhil, Mitrasinovic, Stefan, Miu, Victor, Moawad, Nader, Mochet, Sylvie, Modabber, Ali, Mohammad, Adam, Mohan, Midhun, Moliner-Sánchez, Carmen, Mongelli, Francesco, Monteleone, Michela, Montuori, Mauro, Moore, Rachel, Mora-Guzmán, Ismael, Morales, Xavier, Morales, Dieter, Morelli, Luca, Morelli, Lucia, Morgan, Richard, Morris, Chris, Mortini, Pietro, Mosca, Angelo, Motter, Dema, Moug, Susan, Mukherjee, Samrat, Najdy, Manhal, Nakas, Apostolos, Namazov, Ilgar, Naredla, Pradyumna, Nasef, Emmhamed, Nassa, Heeam, Nath, Rahul, Navarro-Sánchez, Antonio, Nazarian, Scarlet, Negri, Giampiero, Nehra, Deepika, Neil-Dwyer, Jason, Neri, Jacopo, Newton, Katy, Nikaj, Herald, Niquen, Milagros, Nobile, Sara, Nogueiro, Jorge, Ntirenganya, Faustin, Nugent, Michael, Núñez, Jordi, Ocaña, Juan, Okechukwu, Valentine, Oliva-Mompean, Fernando, Oliveira, Ana, Ollat, Didier, Onos, Lavinia, Osagie-Clouard, Liza, Osman, Khabab, Ottolina, Jessica, Ourieff, Jared, Outani, Oumaima, Oyewole, Bankole, Ozben, Volkan, Pacheco-Sanchez, David, Padilla-Valverde, David, Pai, Madhava, Paiella, Salvatore, Paisley, Samuel, Palini, Gianmarco, Palmeri, Matteo, Panahi, Pedram, Parente, Alessandro, Parlanti, Daniele, Parmar, Chetan, Pascual, Angela, Patel, Mahul, Pathak, Abhijit, Patil, Sangram, Pattyn, Piet, Peckham-Cooper, Adam, Pedrazzani, Corrado, Pellino, Gianluca, Peluso, Chiara, Pereira, André, Pereira-Neves, António, Perez-Diaz, MD, Pérez-González, Marta, Pérez-Saborido, Baltasar, Perivoliotis, Konstantinos, Perkins, Clare, Peros, Georgios, Perotto, Ornella, Perra, Teresa, Petrone, Patrizio, Phenix, George, Picazo, Sara, Picon-Rodriguez, Rafael, Piloni, Martina, Pingarrón-Martín, Lorena, Pinotti, Enrico, Pisanu, Adolfo, Pizzini, Paolo, Pockney, Peter, Podda, Mauro, Podolsky, Dina, Poggioli, Gilberto, Pompili, Cecilia, Pontari, Michael, Porcu, Alberto, Potter, Ryan, Price, Claire, Pruvot, François-René, Pujol-Muncunill, Roger, Puppo, Andrea, Quante, Markus, Quintana-Villamandos, Begoña, Qureshi, Ali, Radenkovic, Dejan, Rakvin, Ivan, Ramallo-Solís, Irene, Ramcharan, Sean, Ramos, Diego, Ramos-Bonilla, Antonio, Ramzi, Joussi, Rathinam, Sridhar, Rausa, Emanuele, Ravaioli, Matteo, Ravindran, Sharanya, Raymond, Thomas, Razik, Aisha, Redfern, Jennifer, Reguera-Rosal, Julio, Rela, Mariam, Rey-Biel, Juan, Rey-Valcarcel, Cristina, Ribolla, Marta, Richards, Tomos, Richmond, Michael, Righini, Erminio, Rio-Gomez, Javier, Riyat, Harjoat, Rizvi, Sana, Roberts, Keith, Roberts, Matthew, Robertson, Stuart, Robertson, Ronald, Robin-Valle, Alvaro, Rochon, Melissa, Rojo, Mikel, Rolli, Luigi, Romano, Silvio, Ross, Elizabeth, Ross, Howard, Rossborough, Catherine, Rottoli, Matteo, Ruiz-Grande, Fernando, Ruiz-Martin, Irene, Ruiz-Soriano, María, Ruzzenente, Andrea, Ryska, Ondrej, Saez, Carlos, Sagnotta, Andrea, Sahnan, Kapil, Sahni, Arun, Salim, Ali, Sallam, Ibrahim, Salvia, Roberto, Samadov, Elgun, Sammarco, Giuseppe, Sampaio-Alves, Mafalda, Sánchez-Arteaga, Alejandro, Sanchez-Fuentes, Maria-Nieves, Sanchez-Pelaez, Daniel, Sanchez-Perez, Coral, Sanchez-Rubio, Maria, Sancho-Muriel, Jorge, Sanders, Julie, Santero-Ramirez, Maria-Pilar, Santora, Thomas, Santoro, Antonio, Santos, Irene, Santos-Sousa, Hugo, Sapienza, Paolo, Sartarelli, Lodovico, Sarveswaran, Janahan, Sasia, Diego, Saudemont, Alain, Saudi-Moro, Sef, Saxena, Shobhit, Saxena, Dolly, Sayasneh, Ahmad, Scalabre, Aurelien, Schache, Andrew, Schiavina, Riccardo, Schineis, Christian, Schreckenbach, Teresa, Scorza, Antonella, Scott, Lucy, Seegert, Sara, Seguin-Givelet, Agathe, Senent-Boza, Ana, Seymour, Keith, Shabana, Amanda, Shah, Karishma, Shah, Jigar, Shah, Preena, Shah, Sujay, Shakir, Taner, Shalaby, Mostafa, Shankar, Sushma, Shaw, Richard, Shehata, Sameh, Shenfine, Amy, Sheridan, Kelda, Sherief, Ahmed, Sherief, Mohamed, Sherif, Mohamed, Shinkwin, Michael, Shu, Sebastian, Siaw-Acheampong, Kwabena, Sileri, Pierpaolo, Singh, Abhinav, Singh, Shailendra, Sinha, Sanjay, Sinha, Deepti, Siragusa, Leandro, Sivaprakasam, Rajesh, Sivayoganathan, Sriharan, Smillie, Robert, Smith, Claire, Smith, Andrew, Smith, Christopher, Sochorova, Dana, Soggiu, Fiammetta, Sohrabi, Catrin, Sohrabi, Catrin, Sohrabi, Catrin, Solari, Francesca, Solli, Piergiorgio, Soreide, Kjetil, Spinelli, Antonino, Spoletini, Domenico, Spriano, Giuseppe, Sravanam, Sanskrithi, Ssentongo, Paddy, Stanger, Sophie, Stavroulias, Dionisios, Steel, Ben, Stella, Marco, Stewart, Robbie, Stringer, Sally, Sulen, Nina, Sundar, Sudha, Sundhu, Matthew, Suri, Avni, Syed, Arooj, Szatmary, Peter, Tabiri, Stephen, Tadross, Daniel, Taglietti, Lucio, Tansey, Rosamond, Tartaglia, Dario, Tawheed, Ahmed, Tayeh, Salim, Teles, Tobias, Testa, Valentina, Tewari, Nilanjana, Thoenissen, Philipp, Thomas, Kane, Thomin, Anne, Thrush, Jessica, Tierney, Sean, Tiwari, Abhinav, Toh, Simon, Toledo, Enrique, Tonini, Valeria, Torkington, Jared, Torquati, Alfonso, Torzilli, Guido, Totty, Joshua, Tourountzi, Paraskevi, Tousidonis, Manuel, Townend, Philip, Townsend, Catherine, Trompeter, Alex, Trotta, Francesco, Truant, Stéphanie, Trujillo-Díaz, Jeancarlos, Tsoulfas, Georgios, Turco, Celia, Turrado-Rodriguez, Victor, Turri, Giulia, Tustin, Harry, Tyler, Jayne, Tzedakis, Stylianos, Tzovaras, George, Uittenbogaart, Martine, Ullah, Ramzan, Urban, Shane, Urbani, Alessia, Usai, Antonella, Vaccarella, Gianpaolo, Valdes-Hernandez, Javier, Valsecchi, Luca, Vashisht, Rajiv, Vázquez-Fernández, Andrea, Venn, Mary, Vera-Mansilla, Cristina, Vergari, Roberto, Vescio, Giuseppina, Vidya, Raghavan, Vieira, Paula, Vijay, Vardhini, Vimalachandran, Dale, Violante, Tommaso, Volpe, Anita, Vovola, Fernanda, Vulliamy, Paul, Wall, Rosemary, Wallwork, Kate, Ward, Alex, Warwick, David, Waseem, Saima, Weaver, Helen, Wells, Fiona, Wen, Jiaxin, West, Raha, Whitehall, Emma, Wild, Laura, Wilkins, Alex, Williams, Gethin, Williams, Matthew, Winnand, Philipp, Wong, Ken, Worku, Dawit, Wright, Naomi, Yalamanchili, Seema, Yershov, Danylo, Yildiz, Alp, Young, Richard, Yurttas, Can, Zadegan, Frederic, Zafar, Noman, Zakaria, Rasheed, Zambon, Martina, Zanini, Nicola, Zarate, Alba, Zerbib, Philippe, Zizzo, Maurizio, Zmora, Oded, Zonta, Sandro, van Berge Henegouwen, Mark I, van der Plas, Willemijn Y, Ali, Inthekab Ali Mohamed, Bakri, Nur Amalina Che, Bauset, Juan Carlos Catalá, Abou Chaar, Mohamad K, Marino Cosentino, Luigi MP, Gómez Díaz, Carlos J, Garcia Galocha, Jose L, de Gheldere, Charles A, Ataíde Gomes, Gustavo Mendonça, Beltrán de Heredia, Juan, Blazer III, Dan G, Nugent III, William C, Ali karar, Ali A, Borja De Lacy, F, Blas Laina, Juan luis, Shane Lester, Madan Jha, Liyanage, Aloka S D, Al Maadany, Faraj S, De Marchi, Joshua A, Ramos-De la Medina, Antonio, Mithany, Reda H M, Sanchez del Pueblo, Cristina, van Ramshorst, Gabrielle H, De Salas, Maria Marqueta, De Souza, Anthony C, Dolores Del Toro, M, Archer, James E, Odeh, Abdulrahman, Erridge, Simon, Salem, Hosni Khairy, Jones, Gareth P, Gardner, Anne, Tripathi, Shiva S, Gregg, Anne, Jeganathan, Reuben, Siddique, Muhammad Harris, Lombardi, Celestino P, Martin, Benjamin, Leo, Cosimo Alex, Dass, Debashis, Di Franco, Gregorio, Jiao, Long R, Mari, Giulio Maria, Capitan-Morales, Luis-Cristobal, Connelly, Tara M, Alanbuki, Ammar, De Virgilio, Armando, Schilling, Clare, San Miguel Mendez, Carlos, Kulkarni, Gauri, Nizami, Kulsoom, Walsh, Stewart, Dean, Harry, Ruiz-Marin, Miguel, Houston, Rory, Trompetto, Mario, Chrastek, David, Kouritas, Vasileios, Cannoletta, Maria, Rosato, Francesco, Kaushal, Manish V, Costa, Paulo Matos, Elkadi, Hannah H, Johnstone, Jack R, Irvine, Esmee, Alvarez, Maria R, Corbellini, Carlo, Venkatesan, Gowtham S, Mateo-Sierra, Olga, Martínez-Pérez, Carolina, Serrano González, Javier, Hernández Bartolomé, Miguel Ángel, Díaz Pérez, David, Gutiérrez Samaniego, María, Galindo Jara, Pablo, Sharma, Neil, Smart, Neil J, and Keller, Deborah S

Abstract

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection.

Published
2020
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11. PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability

Author

Giuffrida, Paolo, Arpa, Giovanni, Grillo, Federica, Klersy, Catherine, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D’Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Ferrero, Stefano, Furlan, Daniela, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C., Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D’Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada M., Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D’Incà, Renata, Zingone, Fabiana, D’Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Reggiani Bonetti, Luca, Astegiano, Marco, Biletta, Elena, Cantoro, Laura, Giannone, Antonino G., Orlandi, Augusto, Papi, Claudio, Perfetti, Vittorio, Quaquarini, Erica, Sandri, Giancarlo, Silano, Marco, Usai, Paolo, Barresi, Valeria, Ciccocioppo, Rachele, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Viglio, Alessandra, Paulli, Marco, Corazza, Gino R., Solcia, Enrico, Vanoli, Alessandro, and Di Sabatino, Antonio

Abstract

Small bowel adenocarcinomas (SBAs) are often associated with poor prognosis and have limited therapeutic options. Programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway blockade is an effective treatment in many microsatellite instability-high (MSI-H) solid tumors. We aimed at investigating PD-L1 and PD-1 expression in non-hereditary, non-ampullary SBAs, associated with celiac disease (CeD), Crohn’s disease (CrD), or sporadic, recruited through the Small Bowel Cancer Italian Consortium. We assessed PD-L1 and PD-1 by immunohistochemistry in a series of 121 surgically resected SBAs, including 34 CeD-SBAs, 49 CrD-SBAs, and 38 sporadic SBAs. PD-L1 and PD-1 expression was correlated with several clinico-pathological features, such as the etiology, microsatellite instability status, and tumor-infiltrating lymphocyte (TIL) density. The prevalence of PD-L1 positivity according to combined positive score (CPS) was 26% in the whole cohort of SBAs, with significantly (p= 0.001) higher percentage (35%) in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs (5%). CPS ≥ 1 SBAs were significantly (p= 0.013) more frequent in MSI-H cases (41%) than in non-MSI-H ones (18%); however, 15 CPS ≥ 1 microsatellite stable SBAs were also identified. CPS ≥ 1 SBAs showed higher TIL and PD-1+immune cell density, more frequently medullary histotype, as well as a better outcome in comparison with CPS < 1 cases. This study demonstrates an increased proportion of PD-L1+cases in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs. In addition, the identification of a subset of PD-L1+microsatellite stable SBAs supports the need to ascertain additional biomarkers of response to immune checkpoint inhibitors along with MSI-H.

Published
2020
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12. Morbidity associated with closure of ileostomy after a three-stage ileal pouch-anal anastomosis

Author

Rottoli, Matteo, Casadei, Benedetta, Vallicelli, Carlo, Vitali, Giulia, Ghignone, Federico, Melina, Marica, Tanzanu, Marta, and Poggioli, Gilberto

Abstract

The aim of the study was to compare the perioperative outcomes of patients undergoing ileostomy closure after a three-stage ileal pouch-anal anastomosis to a control group of patients who had elective colorectal resections and stoma, and to analyse the differences based on the technique of closure. The cases were retrospectively compared for demographic characteristics and postoperative outcomes. Chi-square, Fisher’s exact and Wilcoxon rank sum tests were used as appropriate. Between 2011 and 2016, 338 patients having their stoma reversed after three-stage IPAA were compared to 158 patients in the control group. A younger age (43.2 vs 60.6 years, p< 0.0001), a lower body mass index (22 vs 24.4 kg/m2, p< 0.0001), a higher rate of hand-sewn anastomosis (84.3 vs 15.7%, p< 0.0001), a lower rate of intraoperative complications (0 vs 1.2%, p= 0.038), a shorter operative time (91.5 vs 99.4 min, p= 0.0046) and length of hospital stay (6.6 vs 7.6 days, p= 0.045) were seen in the IPAA group. The 30-day rate of wound infection, anastomotic leak (0.6 vs 0.6%), small bowel obstruction (SBO, 8 vs 11.4%) and reoperation (1.8 vs 1.3%) was similar. Among IPAA patients, the hand-sewn anastomosis was correlated with a higher chance of developing SBO (9.1 vs 1.9%, p= 0.03). Closure of ileostomy after three-stage IPAA is associated with low rate of serious complications, despite the higher number of previous abdominal surgeries. This supports the construction of routine ileostomy during IPAA to reduce the risk of pelvic sepsis.

Published
2019
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13. TAMIS-Flap Technique: Full-thickness Advancement Rectal Flap for High Perianal Fistulae Performed Through Transanal Minimally Invasive Surgery

Author

Rottoli, Matteo, Di Simone, Massimo P., and Poggioli, Gilberto

Abstract

Supplemental Digital Content is available in the text.The formation of an advancement rectal flap could be technically demanding in the presence of high perianal of rectovaginal fistula, and the outcomes could be frustrated by the inadequate view, bleeding and a poor exposure through the standard transanal approach. The application of the transanal minimally invasive surgery (TAMIS) to the advancement rectal flap procedure could overcome these difficulties. In the lithotomy position, a partial fistulectomy was performed and the internal opening was closed. A full-thickness flap was mobilized initially through the classic transanal approach. Subsequently, the TAMIS port was inserted and the mobilization of the flap was carried on proximally for as long as required. The laparoscopic visualization allowed a perfect view, a proper orientation of the flap and accurate hemostasis. The TAMIS-flap procedure seems a promising technique to perform a long advancement rectal flap to treat high perianal or rectovaginal fistulae (Video, Supplemental Digital Content 1, http://links.lww.com/SLE/A208).

Published
2019
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14. Burnout and psychological distress between surgical and non-surgical residents

Author

Serenari, Matteo, Cucchetti, Alessandro, Russo, Paolo, Fallani, Guido, Mattarozzi, Katia, Pinna, Antonio, Colonnello, Valentina, Poggioli, Gilberto, and Cescon, Matteo

Abstract

Surgical training is considered to be very stressful among residents and medical students choose less often surgery for their career. Our aim was to assess the prevalence of burnout and psychological distress in residents attending surgical specialties (SS) compared to non-surgical specialties (NSS). Residents from the University of Bologna were asked to participate in an anonymous online survey. The residents completed a set of questions regarding their training schedule and three standardized questionnaires: (1) the Maslach Burnout Inventory, assessing the three dimensions of burnout: emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA); (2) the Zung Self-Rating Depression Scale; (3) the Psychosomatic Problems Scale. One-hundred and ninety residents completed the survey. Overall, the prevalence of burnout was 73% in the SS group and 56.3% in the NSS group (P= 0.026). More specifically, SS reported higher levels of EE and DP compared to NSS. No significant differences between SS and NSS emerged for PA, depression, or somatic problems. The present findings indicate that burnout is more prevalent in surgical residents than in residents attending non-surgical specialties. ClinicalTrials.gov identifier: NCT03668080.

Published
2019
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15. Gracilis muscle transposition for the treatment of recurrent rectovaginal and pouch-vaginal fistula: is Crohn’s disease a risk factor for failure? A prospective cohort study

Author

Rottoli, Matteo, Vallicelli, Carlo, Boschi, Luca, Cipriani, Riccardo, and Poggioli, Gilberto

Abstract

The surgical management of rectovaginal fistulae associated with Crohn’s disease is often frustrated by poor results regardless of the different techniques. The outcomes of the gracilis muscle transposition (GMT) for the treatment of recurrent Crohn’s-associated fistulae are still debated. The aim of the study is to determine whether the success rate of GMT is similar in Crohn’s disease patients and in a control group. All patients undergoing GMT for rectovaginal or pouch-vaginal fistula were collected from a prospectively maintained database (2005–2016). The primary study outcome was the comparison of the success rate of GMT in Crohn’s disease and control group patients. Twenty-one patients with a rectovaginal fistula due to Crohn’s disease (8, 38.1%) or other etiologies (13, 61.9%) were included. The groups had similar characteristics and postoperative outcomes. After a median follow-up time of 81 and 57 months (p0.34), the success rate of GMT was 75% in patients with Crohn’s disease and 68.4% in control group (p0.6). The median time to recurrence was 3.5 months (1–12). The success rate in patients who had more than two previous attempts of repair was lower regardless of the etiology (50 vs 79.4%, p0.1). GMT is associated with a high success rate, especially in Crohn’s disease-related rectovaginal fistula. In consideration of the low morbidity rate and the fact that an increasing number of previous local operations might be associated with failure, the procedure should be considered as a first line of treatment for recurrent rectovaginal fistulae.

Published
2018
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16. Mucosa-associated microbiota dysbiosis in colitis associated cancer

Author

Richard, Mathias L., Liguori, Giuseppina, Lamas, Bruno, Brandi, Giovanni, da Costa, Gregory, Hoffmann, Thomas W., Pierluigi Di Simone, Massimo, Calabrese, Carlo, Poggioli, Gilberto, Langella, Philippe, Campieri, Massimo, and Sokol, Harry

Abstract

ABSTRACTGut microbiota dysbiosis has been associated with inflammatory bowel diseases (IBD). In colorectal cancer, the gut microbiota has also been recognized as potentially involved in aggravating or favoring the tumor development. However, very little is known on the structure and role of the microbiota in colitis associated cancer (CAC), an important complication of IBD in human. Here we analyzed the bacterial and fungal composition of the mucosa associated microbiota of patients suffering CAC, sporadic cancer (SC) and of healthy subjects (HS) by barcode sequences analysis on the following cohort: 7 CAC patients, 10 SC patients and 10 HS using 16S (MiSeq) and ITS2 (pyrosequencing) sequencing, for bacteria and fungi respectively. Mucosa-associated bacterial microbiota in CAC was significantly different from the ones in SC or in HS, while the fungal showed no differences. Comparison between mucosa-associated microbiota on the tumor site or in normal mucosa near the tumor showed very similar patterns. The global mucosa-associated bacterial microbiota in cancer patients was characterized by a restriction in biodiversity but no change for the fungal community. Compared to SC, CAC was characterized by an increase of Enterobacteriacae family and Sphingomonasgenus and a decrease of Fusobacteriumand Ruminococcusgenus. Our study confirms the alteration of the mucosa-associated bacterial microbiota in IBD and SC. Although the cohort is limited in number, this is the first evidence of the existence of an altered bacterial microbiota in CAC clearly different from the one in SC patients.

Published
2018
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17. Adenocarcinoma in Crohn’s disease: the pathologist’s experience in a tertiary referral centre of inflammatory bowel disease

Author

Malvi, Deborah, Vasuri, Francesco, Mattioli, Benedetta, Gruppioni, Elisa, Fiorentino, Michelangelo, Gionchetti, Paolo, Grigioni, Walter F., Poggioli, Gilberto, and D’Errico-Grigioni, Antonia

Abstract

The aim of the present study is to describe the histological and mutational characteristics of a series of both large and small bowel adenocarcinomas in patients with Crohn’s disease from a tertiary referral centre of inflammatory bowel disease. Bowel adenocarcinoma was diagnosed in 11 (1.7%) of 660 consecutive patients submitted to surgery for histologically proven Crohn’s disease in 5 years. The following data were collected: tumour site, stage and grade, intracellular/extra-cellular mucin, lymphovascular invasion, immunohistochem-istry for keratin 7, keratin 20 and CDX-2, mutation analyses of KRAS, B-RAF, PI3K and microsatellite instability. A strong predominance of male gender was observed (10/11). Four (36.4%) adenocarcinomas arose in the small bowel, five (45.4%) in the anus/rectum, and two (18.2%) in anastomosis. Furthermore, all cases of anorectal adenocarcinoma showed >50% of extracellular mucin, with associated KRAS mutations in three of five. No influence in cancer incidence by infliximab therapy was observed. Our series, one of the largest on the topic with immunomorphological and molecular deepening, showed that bowel adenocarcinomas in Crohn’s disease have an aggressive behaviour and a strong predominance of extracellular mucin. In surgical specimens from Crohn’s disease patients, mucinous-looking anal fistulas and ileal areas of adhesion/retraction should always be extensively sampled.

Published
2014
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18. Correction to: Inflammatory bowel disease patients requiring surgery can be treated in referral centres regardless of the COVID-19 status of the hospital: results of a multicentric European study during the first COVID-19 outbreak (COVIBD-Surg)

Author

Rottoli, Matteo, Pellino, Gianluca, Tanzanu, Marta, Baldi, Caterina, Frontali, Alice, Carvello, Michele, Foppa, Caterina, Kontovounisios, Christos, Tekkis, Paris, Colombo, Francesco, Sancho-Muriel, Jorge, Frasson, Matteo, Danelli, Piergiorgio, Celentano, Valerio, Spinelli, Antonino, Panis, Yves, Sampietro, Gianluca M., and Poggioli, Gilberto

Published
2022
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19. Diagnosis and treatment of pouchitis

Author

Gionchetti, Paolo, Amadini, Cristina, Rizzello, Fernando, Venturi, Alessandro, Poggioli, Gilberto, and Campieri, Massimo

Abstract

Total proctocolectomy with ileal pouch–anal anastomosis is the surgical procedure of choice for the management of ulcerative colitis. Pouchitis, a non-specific inflammation of the ileal reservoir, is the most frequent complication that patients experience in the long-term. Diagnosis should be made on the basis of clinical, endoscopic and histological aspects. The Pouchitis Disease Activity Index (PDAI) represents an objective and reproducible scoring system for pouchitis: active pouchitis is defined as a score⩾7 and remission as a score<7. About 15% of patients develop a chronic disease. Treatment of pouchitis is empirical, and very few controlled studies have been carried out. Antibiotics, particularly metronidazole and ciprofloxacin, are the treatment of choice. Chronic pouchitis may benefit from a prolonged course of a combination of antibiotics. Highly concentrated probiotics are effective for both prevention of relapses and prevention of pouchitis onset. There is no convincing evidence of the efficacy of other therapeutic agents.

Published
2003
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20. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

Author

Gionchetti, Paolo, Rizzello, Fernando, Venturi, Alessandro, Brigidi, Patrizia, Matteuzzi, Diego, Bazzocchi, Gabriele, Poggioli, Gilberto, Miglioli, Mario, and Campieri, Massimo

Abstract

Background & Aims:Pouchitis is the major long-term complication after ileal pouch–anal anastomosis for ulcerative colitis. Most patients have relapsing disease, and no maintenance treatment study has been performed. We evaluated the efficacy of a probiotic preparation (VSL#3) containing 5 × 1011per gram of viable lyophilized bacteria of 4 strains of lactobacilli, 3 strains of bifidobacteria, and 1 strain of Streptococcus salivariussubsp. thermophiluscompared with placebo in maintenance of remission of chronic pouchitis. Methods:Forty patients in clinical and endoscopic remission were randomized to receive either VSL#3, 6 g/day, or an identical placebo for 9 months. Patients were assessed clinically every month and endoscopically and histologically every 2 months or in the case of a relapse. Fecal samples were collected for stool culture before and after antibiotic treatment and each month during maintenance treatment. Results:Three patients (15%) in the VSL#3 group had relapses within the 9-month follow-up period, compared with 20 (100%) in the placebo group (P< 0.001). Fecal concentration of lactobacilli, bifidobacteria, and S. thermophilusincreased significantly from baseline levels only in the VSL#3-treated group (P< 0.01). Conclusions:These results suggest that oral administration of this new probiotic preparation is effective in preventing flare-ups of chronic pouchitis.

Published
2000
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21. Conservative surgical management of perforating Crohn's disease: Side-to-side enteroenteric neoileocolic anastomosis

Author

Poggioli, Gilberto, Selleri, Simonetta, Stocchi, Luca, Laureti, Silvio, Salone, Mariacristina, Marra, Claudio, DiSimone, Massimo, Ugolini, Federica, and Cavallari, Antonino

Abstract

Conservative surgical management of jejunoileal Crohn's disease is the first-choice treatment in plurioperated patients with high risk of small-bowel syndrome. Treatment is more controversial in patients with a limited disease and no previous surgery, especially in those with terminal ileitis. Even in those cases we advocate conservative surgical management because we have demonstrated regression of both symptoms and morphologic lesions. Contraindications to nonresectional surgery include the presence of abscesses and fistulas. Impending short-bowel syndrome represents a partial exception to this approach. In this article two cases of conservative surgery performed in plurioperated patients with perianastomotic perforating recurrent disease are presented. We have named this procedure “side-to-side enteroenteric neoileocolic anastomosis,” which is a combination of small resections and conservative procedure. This operative strategy leads us to believe that nonresectional surgery could be selectively performed even in patients with perforating Crohn's disease.

Published
1998
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22. Reducing the Occupational Risk of Infections for the Surgeon: Multicentric National Survey on More Than 15,000 Surgical Procedures

Author

Pietrabissa, Andrea, Merigliano, Stefano, Montorsi, Marco, Poggioli, Gilberto, Stella, Marco, Borzomati, Domenico, Ciferri, Enrico, Rossi, Giuseppe, and Doglietto, Gianbattista

Abstract

The objective of this study was to find the incidence of accidental exposures to blood and body fluids among surgeons during operations and to describe their dynamics. A probabilistic model was also used to predict the cumulative 30-year risk to the surgeon of contracting hepatitis B and C viruses (HBV, HCV) or human immunodeficiency virus (HIV) infection and estimate the effect of preventive strategies in reducing this risk. A multicentric prospective survey, based on self-administered questionnaires, was conducted during a period of 6 months in 39 Italian hospitals. An accidental exposure to blood or body fluids occurred in 9.2% of 15,375 operations. In about 2% of procedures a parenteral-type injury, such as actual skin puncture or eye contamination, was suffered by the operating surgeon. A needle-stick injury was the commonest accident, and its occurrence was found to vary with the phase of the procedure and its length. The current lifetime risk of acquiring HBV, HCV, and HIV infection in our regions was estimated to be as high as 42.7%, 34.8%, and 0.54%, respectively. The adoption of preventive strategies is expected to reduce this risk to 21% for HBV, 16.6% for HCV, and 0.23% for HIV infection. Active immunization of surgeons against HBV is strongly recommended. The case is also made for the use of a face-shield combined with a permanent change in our surgical practice capable of reducing the current high rate of parenteral injuries.

Published
1997
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23. Redo pouches: Salvaging of failed ileal pouch-anal anastomoses

Author

Poggioli, Gilberto, Marchetti, Floriano, Selleri, Simonetta, Laureti, Silvio, Stocchi, Luca, and Gozzetti, Giuseppe

Abstract

From October 1, 1984 to December 31, 1991 at the Clinica Chirurgica II of the University of Bologna, 140 patients submitted to ileal pouch-anal anastomosis for ulcerative colitis (UC) and familial adenomatous polyposis (FAP). Nineteen patients (13.5 percent) developed septic complications. Of these, 11 patients (7.8 percent) had pelvic sepsis. Eight patients required further surgical intervention. Five patients underwent the redo pouch procedure. Another redo pouch was performed in a patient who had previously, in another hospital, had an ileal pouch-anal anastomosis placed and then removed because of ischemic necrosis of the reservoir. No deaths are reported in the reoperated patients. Currently, five of the six patients who underwent the redo pouch procedure have a well-functioning ileoanal anastomosis. The redo pouch procedure should always be attempted prior to the establishment of pelvic fibrosis.

Published
1993
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24. Fat-induced heal brake in humans: A dose-dependent phenomenon correlated to the plasma levels of peptide YY

Author

Pironi, Loris, Stanghellini, Vincenzo, Miglioli, Mario, Corinaldesi, Roberto, De Giorgio, Roberto, Ruggeri, Enrico, Tosetti, Cesare, Poggioli, Gilberto, Morselli^Labate, Antonio M., Monetti, Nino, Gozzetti, Giuseppe, Barbara, Luigi, and Go, Vay Liang W.

Abstract

Background:Upper gastrointestinal motility is reguated by the presence of nutrients in the distal gut. The present study evaluated whether lipid-induced ileal brake on gastric empting (1) can be elicited by low fat concentrations; (2) is a dose-dependent phenomenon; and (3) is related to gastrointestinal peptide release. Methods:Seven patients were studied in the defunctionalized stage of total colectomy, on three separate occasions. On each study day, patients ate a meal labeled in the solid component; 30 minutes later, one of the following solutions was randomly infused into the ileal pouch: 0.9% saline, 2% oleic acid, and 20% oleic acid. Plasma concentrations of peptide YY (PYY), enteroglucagon, neurotensin, and motilin were measured. Results:Both oleic acid solutions slowed gastric emptying compared with saline (P< 0.001), the effect being dose dependent (P< 0.001). Ileal infusions did not modify neurotensin and enteroglucagon levels but induced a dose-dependent increase of PYY (P< 0.01) and a borderline decrease of motilin (P= 0.05) levels. Slower rates of gastric emptying were related to increased plasma concentrations of PYY (r= 0.615; P< 0.05). Conclusions:This study shows that (1) the ileal brake on gastric emptying can be evoked by low doses of lipids in the distal ileum; (2) the delay of gastric emptying is related to the release of PYY; and (3) both phenomena are dose dependent.

Published
1993
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25. Correction: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability

Author

Giuffrida, Paolo, Arpa, Giovanni, Grillo, Federica, Klersy, Catherine, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D’Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Ferrero, Stefano, Furlan, Daniela, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C., Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D’Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada M., Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D’Incà, Renata, Zingone, Fabiana, D’Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Bonetti, Luca Reggiani, Astegiano, Marco, Biletta, Elena, Cantoro, Laura, Giannone, Antonino G., Orlandi, Augusto, Papi, Claudio, Perfetti, Vittorio, Quaquarini, Erica, Sandri, Giancarlo, Silano, Marco, Usai, Paolo, Barresi, Valeria, Ciccocioppo, Rachele, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Viglio, Alessandra, Paulli, Marco, Corazza, Gino R., Solcia, Enrico, Vanoli, Alessandro, and Di Sabatino, Antonio

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020
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27. Reply

Author

Gionchetti, Paolo, Poggioli, Gilberto, Rizzello, Fernando, and Campieri, Massimo

Published
2004
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