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The effect of rolling schedules on the ridging resistance of ultra-thin ferritic stainless steel (FSS) 430 foil was evaluated by studying the microstructure and texture. The results show that specimens processed with three-pass cold rolling under the reductions of 40%, 40% and 31%, respectively, exhibit improved ridging resistance owing to the microstructural refinement and the texture structure optimization. A nearly 40% reduction of ridging height can be achieved using the proposed rolling schedule compared to the other two rolling schedules. In addition, the effect of annealing temperature after cold rolling on the ridging resistance of FSS 430 foil is also found to be crucial, and an optimal annealing temperature of 900 °C is obtained for FSS 430 foil with high ridging resistance. Overall, the improvement in the ridging resistance of FSS 430 foil can be attributed to the reduction in the fraction of {001}<110>  and {114}<110>  components by optimization of the rolling and annealing processes.

Diffraction gratings with high upward diffraction efficiency and large effective length are required for chip-scale light detection and ranging. We propose a diffraction grating based on a multilayer silicon nitride waveguide, which theoretically achieves an upward diffraction efficiency of 92%, a near-field effective length of 376 µm, and a far-field divergence angle of 0.105° at a wavelength of 850 nm. The diffraction grating has a high tolerance to process variations based on Monte Carlo analysis. When the conditions are ±5% layer thickness variation, ±50nm lithographic variation, and ±20nm wavelength drift, more than 71% of the grating samples have a diffraction efficiency higher than 80%, and 100% of the samples have an effective length larger than 200 µm (corresponding to a far-field divergence <0.2^∘). Furthermore, the near-field effective length of the grating with an upward diffraction efficiency above 90% can be adjusted from hundreds of microns to centimeters by changing the etching layer thickness and the grating duty cycle. This diffraction grating has a potential application in optical sensing and imaging from visible to near-IR wavelengths.

Objective: The purpose of this study was to evaluate the safety and effectiveness of vitamin E in rheumatoid arthritis patients. Methods: A computerized search of PubMed, Embase, The Cochrane Library, and Web of Science databases was conducted to find published randomized controlled trials of vitamin E in rheumatoid arthritis; the experimental group was treated with vitamin E, while the control group was treated with placebo, other drugs, or external therapy; the search period was from the time each database was established to December 31, 2021, and a meta-analysis was conducted using Rev Man 5.4 software. Results: This research eventually comprised nine publications with a total of 39,845 patients. Vitamin E supplementation was shown to be more effective in individuals with RA for sensitive joints (MD = −1.66, 95% CI − −6.32–2.99; I2= 93%; P&lt; 0.00001) and swollen joints (MD = −0.46, 95% CI − −1.98–1.07; I2= 56%; P= 0.08). Conclusions: Vitamin E’s ability to restore the intestinal barrier and improve the gastrointestinal tract may be linked to the prevention and treatment of rheumatoid arthritis. Vitamin E supplements used on a regular basis can help individuals with RA reduce joint discomfort, edema, and stiffness, as well as enhance their overall quality of life.

Background Long noncoding RNA (lncRNA) OIP5 antisense RNA 1 (OIP5-AS1) is an oncogenic lncRNA; however, its role in osteoarthritis (OA) pathology still remains unknown.Materials and Methods qRT-PCR was performed to measure the expressions of OIP5-AS1, miR-29b-3p and progranulin (PGRN) mRNA in OA cartilage tissues and normal cartilage tissues. Chondrocyte cell lines, CHON-001 and ATDC5, were treated with different doses of interleukin-1β (IL-1β) to induce the inflammatory response. Overexpression plasmids, microRNA mimics, microRNA inhibitors and small interfering RNAs were constructed and transfected into CHON-001 and ATDC5 cells. CCK-8 assay was used for determining the cell viability and Transwell assay was used for monitoring cell migration. Western blot was applied to measure the expressions of apoptosis-related proteins. Enzyme-linked immunosorbent assay (ELISA) was adopted to measure the contents of inflammatory factors. StarBase and TargetScan were used to predict the binding sites between OIP5-AS1 and miR-29b-3p, miR-29b-3p and 3′-UTR of PGRN respectively, which were verified by dual luciferase reporter assay.Results OIP5-AS1 and PGRN mRNA were downregulated while miR-29b-3p was upregulated in OA tissues and models. The up-regulated OIP5-AS1 facilitated the proliferation and migration of CHON-001 and ATDC5 cells, while ameliorated the apoptosis and inflammatory response. However, miR-29b-3p had opposite effects. PGRN was identified as a target gene of miR-29b-3p, which could be indirectly suppressed by OIP5-AS1 knockdown.Conclusion Downregulation of OIP5-AS1 induced by IL-1β could inhibit the proliferation and migration abilities of CHON-001 and ATDC5 cells and facilitate the apoptosis and inflammation response via regulating miR-29b-3p/PGRN axis.

Detecting acetone is meaningful in industrial processes and medical fields. Herein, 0D Zn-ZIF/2D Co-ZIF derived 0D ZnO/2D Co3O4 heterostructures are originally designed to improve acetone sensing properties. It is found that when the temperature is 250 °C, the 0D ZnO/2D Co3O4 possesses the highest response (4.73) to 5 ppm acetone, which is about three times more than that of pure 0D ZnO and pure 2D Co3O4. The detection limit of 0D ZnO/2D Co3O4 sensor could be as low as 100 ppb. The response/recovery time of 0D ZnO/2D Co3O4 sensor to 100 ppm acetone is only 3 s/15 s. It is demonstrated that with the introduction of 0D ZnO, the stacking of 2D Co3O4 nanosheets is inhibited and p-n heterojunctions are formed, which could significantly enhance acetone sensing performance.

Metal doping for active sites exhibits remarkable potential for improving the hydrogen evolution reaction (HER). Multi-doping and the use of a conductive substrate can further modulate catalytic performance. Herein, Nb-CoSe well dispersed in N-doped carbon nanospheres (NCs, Nb-CoSe@NC) was synthesized to serve as a conductive substrate and facilitated good dispersion of active sites for the HER. Nb doping can also change the electronic structure of CoSe, which facilitates the activity for the HER. In order to further improve the conductivity and intrinsic activity of Nb-CoSe@NC, dual, nonmetal doping was realized through gas sulfurization to prepare hierarchical Nb-CoSeS@NC. The prepared Nb-CoSeS@NC, with a core-shell structure, exhibited a low overpotential of 115 mV at 10 mA cm–2, which is smaller than that of the most doped catalysts. In addition, NCs not only improved the dispersion and conductivity of the catalyst but also prevented metal corrosion in an electrolyte, thus facilitating the long-term stability of Nb-CoSeS@NC. Moreover, the synergistic effect of the multi-doping of Nb, S, and Se was explained. This work provides a promising, multi-doping strategy for the large-scale application of transition-metal-based electrocatalysts for the HER.

Aconitine (ACO), a main active ingredient of Aconitum, is well-known for its cardiotoxicity. However, the mechanisms of toxic action of ACO remain unclear. In the current study, we investigated the cardiac effects of ACO and mesaconitine (MACO), a structurally related analog of ACO identified in Aconitumwith undocumented cardiotoxicity in guinea pigs. We showed that intravenous administration of ACO or MACO (25?µg/kg) to guinea pigs caused various types of arrhythmias in electrocardiogram (ECG) recording, including ventricular premature beats (VPB), atrioventricular blockade (AVB), ventricular tachycardia (VT), and ventricular fibrillation (VF). MACO displayed more potent arrhythmogenic effect than ACO. We conducted whole-cell patch-clamp recording in isolated guinea pig ventricular myocytes, and observed that treatment with ACO (0.3, 3?µM) or MACO (0.1, 0.3?µM) depolarized the resting membrane potential (RMP) and reduced the action potential amplitude (APA) and durations (APDs) in a concentration-dependent manner. The ACO- and MACO-induced AP remodeling was largely abolished by an INablocker tetrodotoxin (2?µM) and partly abolished by a specific Na+/K+pump (NKP) blocker ouabain (0.1?µM). Furthermore, we observed that treatment with ACO or MACO attenuated NKP current (INa/K) and increased peak INaby accelerating the sodium channel activation with the EC50of 8.36?±?1.89 and 1.33?±?0.16?µM, respectively. Incubation of ventricular myocytes with ACO or MACO concentration-dependently increased intracellular Na+and Ca2+concentrations. In conclusion, the current study demonstrates strong arrhythmogenic effects of ACO and MACO resulted from increasing the peak INavia accelerating sodium channel activation and inhibiting the INa/K. These results may help to improve our understanding of cardiotoxic mechanisms of ACO and MACO, and identify potential novel therapeutic targets for Aconitumpoisoning.

Attenuated total reflection–Fourier transform infrared spectroscopy and quantum chemical calculations were performed on tert-butyl alcohol (t-BuOH) and its binary solutions with CCl4and CHCl3. The study was focused on the free-OH stretching bands. Two resolution-enhancing methods, excess spectroscopy and two-dimensional correlation spectroscopy, were employed to examine the structural heterogeneity and search for the detailed contributors to the free-OH bands. Unexpectedly, CCl4was found not to be an inert solvent and, similar to CHCl3, formed hydrogen/halogen bonds (H-/X-bond) with t-BuOH. It was observed that the free-OH band in the t-BuOH–CHCl3system is larger and more red-shifted than that in the t-BuOH–CCl4system, indicating the stronger intermolecular interactions in the former system. Furthermore, in the t-BuOH–CHCl3system, the H-bonds are stronger than the X-bonds, while in the t-BuOH–CCl4system, both interactions are similar in strength. To assign the free-OH bands, it was found that they are not only from the free OH of the t-BuOH monomer, but they are also contributed by the quasi-free OH with the oxygen bonded to H or Cl and even the weakly H-bonded OH of t-BuOH molecules. Finally, all the identified species increased simultaneously via cosolvent addition, suggestive of the destabilization of the highly associated t-BuOH clusters.

Among practical metal additives, boron (B) has a high volumetric heating value, making it a promising choice as a fuel additive. Although B can theoretically yield a large amount of energy upon complete combustion, its combustion is retarded by the initial presence of B oxide, which coats the surfaces of B particle. To improve the ignition and combustion properties of B powder, LiOH and NH4F were used as precursors to synthesize uniformly LiF-coated B composites (LiF-B) in situ. The LiF-B mixture was also prepared for comparison using a physical method. X-ray diffraction (XRD), Fourier-transform infrared (FTIR), scanning electron microscope (SEM), and energy-dispersive X-ray spectroscopy (EDS) were used to characterize the morphologies and compositions of the products. The thermal and combustion properties of the samples were characterized by thermal gravity-differential thermal gravity (TG-DTG), differential scanning calorimetry (DSC) and closed bomb experiment. The XRD, FTIR, SEM and EDS results demonstrated the successful preparation of the coated LiF-B sample. The TG-DTG and closed bomb experiment results indicated that the addition of LiF decreased the ignition temperature of B powder, and increasing its reaction efficiency. DSC results show that when LiF-B was added, the released heat of underwater explosive increased by 6727.2, 7280.4 and 3109.6 J/g at heating rates of 5, 10, and 15 °C/min, respectively. Moreover, LiF-B decreased the activation energy of secondary combustion reaction of explosive system as calculated through Kissinger's method by 28.9%, which indicated an excellent catalytic effect for the thermal decomposition of underwater explosive. The results reveal that LiF can improve the combustion efficiency of B powder, thereby increasing the total energy of explosives. The mechanical sensitivity increased slightly after adding LiF-B to the underwater explosive. Compared to the underwater explosive with added B, the mechanical sensitivity of the explosive with added LiF-B was significantly lower.

This study aims to present long-term follow-up results of the reverse dorsolateral proximal phalangeal island flap designed for reconstruction of large fingertip and pulp defects.

Generally sensing mechanisms of gas sensors based on metal-oxide semiconductors greatly depend on temperature, suggesting temperature modulation can be applied as a vital method to effectively enhance the sensor response. In this paper, we reported a strategy of quick-cooling operating temperature mode in the course of gas sensing process to elevate the O2 gas response while maintaining low heating energy consumption. La-SnO2 nanofibers synthesized by electrospinning were chosen as gas sensing materials. The O2 gas responses by employing quick-cooling operation mode are significantly improved compared with those obtained by traditional isothermal test. The improved O2 response is contributed to a higher coverage of negatively charged oxygen ions as a result of quick cooling. Our research offers a facile route to detect gas at low temperature with high response. More importantly, the strategy demonstrated here could also be extended to other gas sensor as long as its gas response is related to the sensor temperature.

Xu et al.’s recent experimental work (Adv. Mater. 2017, 29, 1702007) suggested that C3N is a potential candidate as Li-ion battery with unusual electrochemical characteristics. However, the obvious capacity loss (from 787.3 to 383.3 mA h·g–1) occurs after several cycles, which restricts its high performance. To understand and further solve this issue, in the present study, we have studied the intercalation processes of Li ions into C3N via first-principle simulations. The results reveal that the Li-ion theoretical capacity in pure C3N is only 133.94 mA h·g–1, the value is obviously lower than experimental one. After examining the experimental results in detail, it is found that the chemical component of the as-generated CxN structure is actually C2.67N with N excess. In this case, the calculated theoretical capacity is 837.06 mA h·g–1, while part of Li ions are irreversibly trapped in C2.67N, resulting in the capacity loss. This phenomenon is consistent with the experimental results. Accordingly, we suggest that N excess C3N, but not pure C3N, is the proposed Li-ion battery material in Xu et al.’s experiment. To solve the capacity loss issue and maintain the excellent performance of C3N-based anode material, the C3N with slightly excess C (C3.33N), which has been successfully fabricated in the experiment, is considered in view of its relatively low chemical activity as compared with N excess C3N. Our results reveal that the C excess C3N is a potential Li-ion battery material, which exhibits the low open circle voltage (0.12 V), high reversible capacity (840.35 mA h·g–1), fast charging/discharging rate, and good electronic conductivity.

The aim of this study was to analyse the long-term functional, subjective, and psychological results after single-digit replantation.

In order to avoid the pumping unit damaging caused by strength failure in actual work, this paper builds reliability calculation formula and reliability point estimation model based on SSI. The finite element simulation software is used in this paper to simulate the internal stress of the pumping unit and the strength of oil-conveying pipe. This paper also analysis the oil pressure distribution of the pumping unit internal and the oil-conveying pipe and the deformation degree of the pipeline in normal work. The research results confirm that the stress is much weaker than the material strength, which indicates that the design of the strength is reasonable.

To observe the efficacy of auricular acupoint sticking based on conventional treatment in treating pain in early-stage extremity trauma. A hundred eligible patients with acute soft tissue injury or acute closed fracture were randomized into an observation group and a control group by their admission sequence, 50 cases in each group. The two groups both received routine management including routine checking, external fixing, traction, raising up the affected limb, etc., as well as cold compress with Chinese medication (Xiao Zhong Zhi Tong Powder). In addition to the routine management, the control group was given oral administration of amidopyrine and phenacetin compound tablet, 1 tablet per dose, twice a day, which was then taken only when necessary or terminated after pain subsided. The observation group was given auricular acupoint sticking in addition to the routine management. The two groups were compared in terms of numerical rating scale (NRS) score, therapeutic efficacy and adverse reactions after pain was relieved. After the intervention, the NRS scores dropped significantly in both groups (P<0.01); the NRS score in the observation group was significantly lower than that in the control group (P<0.05). The total effective rate in the observation group was superior to that in the control group (P<0.05). There were no severe adverse reactions in the two groups. Based on routine management, auricular acupoint sticking can produce a more significant efficacy in treating pain in early-stage extremity trauma compared to amidopyrine and phenacetin compound tablet; it can effectively reduce pain of the affected limb and prevent complications; it’s easy-to-operate and safe; patients can learn and understand it easily; its efficacy is confirmed; it enhances the satisfaction degree of the inpatients. Therefore, this method is worth promoting in clinic. 观察在常规治疗基础上运用耳穴贴压疗法治疗四肢创伤早期疼痛的效果。 将符合纳入标准 的100例急性软组织损伤或急性闭合性骨折的患者按入院先后随机分为观察组和对照组, 每组50例。两组均予常 规治疗, 包括病情观察、按需外固定、牵引、抬高患肢等, 并给予中药(消肿止痛散)冷敷。对照组在常规治疗基 础上口服去痛片, 每次1片, 2次/d, 疼痛减轻后改必要时服用或停服。观察组在常规治疗基础上予以耳穴贴压。患 者疼痛缓解后, 比较两组患者的疼痛程度数字量表(NRS), 疗效和不良反应。 治疗后, 两组NRS 评分均较本 组治疗前明显降低, 组内差异均有统计学意义(均P<0.01); 观察组NRS 评分低于对照组, 组间差异有统计学意义 (P<0.05)。观察组总有效率优于对照组(P<0.05)。两组均未发生严重不良反应。 在常规治疗基础上运用耳 穴贴压疗法治疗四肢创伤早期疼痛效果优于加服去痛片, 能有效减轻患肢疼痛症状, 减少并发症, 且方法操作简 单、安全, 患者易学易懂, 疗效确切, 有效提高住院患者满意度, 值得临床推广应用。

A good dispersion of powders is crucial to obtain the sintered materials with superior properties. In this paper, the application of different dispersants in fabricating Ti (C,N)-based cermets was investigated. The effect of dispersant on the microstructure and mechanical properties of cermet materials was studied by observing the microstructure, indention cracks and fracture morphology using scanning electron microscope (SEM), and by measuring the transverse rupture strength (TRS), Vickers hardness (HV) and fracture toughness (KIC). The results reveal that the dispersant oleic acid is helpful for the dispersion of Ti (C,N)-based cermet powders, and can contribute to the homogeneous microstructure and stable mechanical properties of the cermet materials. Compared with the cermets fabricated with polyethylene glycol (PEG), the microstructure of cermets fabricated with oleic acid shows more homogeneously distributed Ti (C,N) particles embedded into more evenly spread binder phases without agglomerations of Ti (C,N) grains. The cermets fabricated with oleic acid possess better comprehensive mechanical properties, with higher transverse rupture strength, hardness and a bit lower fracture toughness than the cermets fabricated with PEG.

As a third-generation tear agent, dibenz[b,f][1,4]oxazepine (CR) has been widely used for anti-terrorism and riot control efforts. To improve the efficiency of CR use and determine the toxicity of its decomposition products, it is necessary to study its thermal stability and thermal decomposition behaviour. The mass loss and thermal behaviour of CR were studied at different heating rates using thermogravimetry (TGA) and differential scanning calorimetry (DSC) techniques. The gas products were analyzed using Fourier transform infrared (FTIR) spectroscopy. The present work also studied the thermal decomposition characteristics of CR for temperatures in the 200–600 °C range using the pyrolysis-gas chromatography/mass spectrometry (PY-GC/MS) technique, and the decomposition products were identified. The results show that CR fuses at approximately 69 °C, and that the heating rate has a relatively strong influence on the extrapolated initial decomposition temperature. In the absence of oxygen, when the heating rate is 2 °C min−1, CR starts to decompose at 172 °C. The mechanism of the thermal decomposition is described by the Zhuralev–Lesokin–Tempelman equation, , and the activation energy is approximately 230 kJ mol−1. In the thermal pyrolysis experiment, the first step of thermal decomposition of CR occurs between 200 and 300 °C. Below 600 °C, in an aerobic environment, the pyrolysis reaction occurs to produce 2-aminodiphenyl ether, whereas the oxidizing reaction occurs to produce 10,11-dihydrodibenz[b,f][1,4]oxazepin-11-one, with the products obtained independent of temperature. According to the experimental results, the burning temperature for a mixture of CR and fireworks is suggested to be below 200 °C.

Ti2C is one of the thinnest layers in MXene family with high potential for applications. In the present study, the adsorption of NH3, H2, CH4, CO, CO2, N2, NO2, and O2on monolayer Ti2CO2was investigated by using first-principles simulations to exploit its potential applications as gas sensor or capturer. Among all the gas molecules, only NH3could be chemisorbed on Ti2CO2with apparent charge transfer of 0.174 e. We further calculated the current–voltage (I–V) relation using the nonequilibrium Green’s function (NEGF) method. The transport feature exhibits distinct responses with a dramatic change of I–Vrelation before and after NH3adsorption on Ti2CO2. Thus, we predict that Ti2CO2could be a promising candidate for the NH3sensor with high selectivity and sensitivity. On the other hand, the adsorption of NH3on Ti2CO2could be further strengthened with the increase of applied strain on Ti2CO2, while the adsorption of other gases on Ti2CO2is still weak under the same strain, indicating that the capture of NH3on Ti2CO2under the strain is highly preferred over other gas molecules. Moreover, the adsorbed NH3on Ti2CO2could be escapable by releasing the applied strain, which indicates the capture process is reversible. Our study widens the application of monolayer Ti2CO2not only as the battery material, but also as the potential gas sensor or capturer of NH3with high sensitivity and selectivity.

Porous graphene has been easily synthesized by hydrothermal treating reduced graphene oxide in alkaline solution, and the porous structure was confirmed by transmission electron microscope. When used as supercapacitor electrode, porous graphene holds a specific capacitance of 88 F g-1 at an ultra-high current density of 50 A g-1, an increase of about 83% compared with that for the pristine graphene sheets. The results demonstrate that porous graphene opens a new and short way for ion transportation. Furthermore our findings provide a novel strategy to fabricate porous graphene and the process is simple, low-cost and environmentally friendly.

Porous graphene is a collection of graphene-related materials which exhibits properties distinct from those of graphene, and it has widespread potential applications in various fields. Several approaches have been developed to produce porous graphene. However, the large-scale production of porous graphene nanosheets still remains a great challenge. Moreover, the costs of some methods are prohibitive for its commercial production and the processes are too complicated and time-consuming. In this work, we propose a simple and green method by which graphene nanosheets can be etched by sodium hydroxide under autogenous pressure at 180 °C. The morphologies and surface elements of the porous graphene nanosheets and sizes of pores were characterized. It is demonstrated that the one-step etching of graphene nanosheets is an effective method to obtain large-scale porous graphene nanosheets with high and uniform porosity. The pores in the porous graphene nanosheets were 6 nm depth (the same as the thickness of the graphene nanosheets) and 30-50 nm width.

An octadecyl silica hollow fiber (OSHF) was prepared by a template method. The characteristics of the OSHF were evaluated by scanning electron microscopy, elemental analysis and a pore size analyzer. It was an ideal material for solid phase microextraction. The performance of it was thus studied by extracting polycyclic aromatic hydrocarbons (PAHs) in water samples. The results demonstrated that under the optimal extraction conditions, the linearities were 0.6–60, 1–60 and 2–60 ng mL−1for different PAHs with all regression coefficients higher than 0.976. The limits of detection were in the range of 31.5 to 97.9 pg mL−1for these analytes.

Organic amendment is considered as an effective way to increase soil organic carbon (SOC) stock in croplands. To better understand its potential for SOC sequestration, whether SOC saturation could be observed in an intensive agricultural ecosystem receiving long-term composted manure were examined. Different SOC pools were isolated by physical fractionation techniques of a Cambisol soil under a long-term manure experiment with wheat-maize cropping in North China Plain. A field experiment was initiated in 1993, with 6 treatments including control (i.e., without fertilization), chemical fertilizer only, low rate of traditional composted manure (7.5 t ha−1), high rate of traditional composted manure (15 t ha−1), low rate of bio-composted manure (7.5 t ha−1) and high rate of bio-composted manure (15 t ha−1). The results showed that consecutive (for up to 20 years) composted manure amendments significantly improved soil macro-aggregation, aggregate associated SOC concentration, and soil structure stability. In detail, SOC concentration in the sand-sized fraction (>53 μm) continued to increase with manure application rate, while the silt (2–53 μm) and clay (>2 μm) particles showed no further increase with greater C inputs, exhibiting the C saturation. Further physical separation of small macro-aggregates (250–2 000 μm) into subpools showed that the non-protected coarse particulate organic matter (cPOM, >250 μm) was the fraction in which SOC continued to increase with increasing manure application rate. In contrast, the chemical and physical protected C pools (i.e., micro-aggregates and silt-clay occluded in the small macro-aggregates) exhibited no additional C sequestration when the manure application rate was increased. It can be concluded that repeated manure amendments can increase soil macro-aggregation and lead to the increase in relatively stable C pools, showing hierarchical saturation behavior in the intensive cropping system of North China Plain.

Cultural landscape reflects the historical and traditional heritage of a place and has a symbolic significance and function. Place identity is a kind of psychological experience gradually achieved through perception, acceptation and satisfaction with a place and by living for some time in certain environment. The widespread and rapid acceleration of modernization and globalization lead to many places achieving "non-places" characteristics and homogenous landscapes, even in ethnic areas. This construction research attempts to grasp the inner relationship between cultural landscape and place identity in ethnic areas, and introduce the theory of sense of place and some methods that may shape rational cultural landscapes, seek some specific constructing measures to make the cultural landscapes more harmonious with environment, hence to enhance and strengthen place identify of ethnic groups and cultivate the delicate physical culture landscape against the background of emerging globalization.

With the development of Internet technology, cloud computing has been widely applied to various industries as a new service delivery model in recent years. The cloud service providers must provide services for many customs at the same time. So a large number of different applications must be deployed and the application deployment problem becomes more and more important. How to deploy the application according to their different performance requirements has an important effect on improving the quality of service, enhancing user experience and reducing the service cost. However, for service providers, improving service quality and reducing service cost are contradictory. In this paper, the application deployment problem is modeled as the application deployment graph. Then by using the Pareto optimal thought, a multi-objective optimization algorithm is proposed. It makes that the service providers use less cost to provide the better service quality for users.

Recombinant Newcastle disease virus (rNDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently in clinical trials. In this study, we have evaluated the possibility to enhance the cancer therapeutic potential of NDV by means of inserting both interleukin-2 (IL-2) and tumor necrosis factor-related apoptosis inducing ligand (TRAIL) delivered by rNDV. We demonstrated that rNDV expressing TRAIL (rNDV-TRAIL) or both human IL-2 and TRAIL (rNDV-IL-2-TRAIL) significantly enhanced inherent anti-neoplastic of rNDV by inducing apoptosis. And we showed that apoptosis-related genes mRNA expression was increased after treated with rNDV-TRAIL or rNDV-IL-2-TRAIL compared with rNDV and rNDV-IL-2. We also demonstrated that both rNDV-IL-2 and rNDV-IL-2-TRAIL induced proliferation of the CD4+and CD8+in treated mice and elicited expression of TNF-α and IFN-γ antitumor cytokines. These mice treated with oncolytic agents exhibited significant reduction in tumor development compared with mice treated with the parental virus. In addition, experiments in both hepatocellular carcinoma and melanoma-bearing mice demonstrated that the genetically engineered rNDV-IL-2-TRAIL exhibited prolonged animals’ survival compared with rNDV, rNDV-IL-2, and rNDV-TRAIL. In conclusion, the immunotherapy and oncolytic virotherapy properties of NDV can be enhanced by the introduction of IL-2 and TRAIL genes, whose products initiated a broad cascade of immunological affects and induced tumor cells apoptosis in the microenvironment of the immune system.

Non-ecological phenomenon of tourism industry makes it improve eco-efficiency and sustainable development. Eco-efficiency and emergy methods are the useful instrument for eco-system, and indicate an empirical relation between environment cost and environment impact. The paper puts forward 4 steps of the tourism industry ecological evaluation by eco-efficiency and emergy analysis. They are: draw tourism industry emergy system diagram; decision research area and set up an emergy evaluation table; set up eco-efficiency index system of tourism industry; collect data and calculate the eco-efficiency of tourism industry. Finally, some questions are discussed: how does the eco-efficiency of tourism industry compare to other sectors of the national and global economy; how to improve eco-efficiency of tourism industry; can eco-efficiency assess the sustainability of tourism industry?

C/C-ZrC composites were prepared by precursor infiltration and pyrolysis using the organic zirconium as precursor. The conversion mechanisms of the precursors such as the thermal behavior, structural evolution, phase composition, microstructure, composition of the precursors and products were analyzed by thermal gravimetric analyzer, Fourier transform infrared spectrometer, X-ray diffraction and scanning electron microscope. The results indicate that the ZrC precursor transforms to inorganic ZrO2from room temperature to 1200 °C, then reduces to ZrC at 1600 °C through the carbothermal reduction reaction. The microstructure of the C/C-ZrC composites was also investigated. The composites exhibit an interesting structure, a coating composed of ZrC ceramic covers the exterior of the composite, and the ZrC ceramic is embedded in the pores of the matrix inside the composite.

In teaching process of student psychological education, we introduce multimedia technology. It can not only improve the students' interest in learning, but also help the teacher using teaching aids reasonably to complete the teaching goal. In this paper we use multimedia technology to create classroom scene of psychological education, and use ps-cs5 software to design scene cartoon of multimedia student psychological education. Introducing the cartoon to the teaching contents improves the classroom more vivid and lively. In order to improve the performance of multimedia design, we use the Newton iterative method to accelerate the calculation process, finally get the residual convergence curve and the positive index of students' psychological response through calculation. It provides technical references for research on multimedia psychological teaching.

The article aimed at Heat exchanger tube sheet welding experiment and its processing technology programs in a certain enterprise and using the ABAQUS software to proceed simulation on high strength and matrix alloy surfacing transition alloy materials (soft or corrosion protection), which can acquire the temperature and stress field after welding which has been testified the rationality by test result, then determining the suitable heat source model and the welding parameters. At the same time, welding dynamic simulation research result provide adequate theoretical basis for welding test and lay the foundation of optimizing the process and method of surfacing welding. Through the methods of combining theoretical research and experimental verification,under the premise that meet tube sheet properties and strength of materials and related technical requirements,which reduce test cost and time and shorten manufacturing cycle and the methods have guiding significance for establishment of welding procedure.

The performance of spiral wound gasket with different angle of V-type steel belt is researched, which includes effect of angle of V-type steel belt and pressure on compression rate and rebound rate. The results indicate that, when the pressure is same, the compression rate of spiral wound gasket decreases and rebound rate of spiral wound gasket increases with the angle of V-type steel belt increasing. When the angle of V-type steel belt is different, the optimum preloading need adjust in order to spiral wound gasket work well. For spiral wound gasket DN80, the optimum pre-pressure should be controlled within 45~55 MPa when angle of V-type steel belt is 80-degree, and the optimum pre-pressure should increase with angle of V-type steel belt increasing.

In order to adapt to the demand of depot station safety management work, the Security Monitoring and Early Warning System of Oil Depot Station is designed. The system has the function of network services, database, parameter and video monitoring and security analysis and early warning. Practical application shows that this system has the advantages of simple operation and powerful monitoring. It has the important practical significance to improve the level of safety management of oil depot station.

The effect of biochar on soil respiration (Rs) over one maize-growing season was studied after 5 years of consecutive application in an intensive cropland in the North China Plain. The experiment was carried out in randomly arranged plots with four treatments being evaluated. Three replications were conducted per treatment: a control plot without biochar addition (CK), biochar incorporated at 4.5tha-1year-1 (BC4.5), biochar incorporated at 9.0tha-1year-1 (BC9.0), and incorporated wheat straw (SR). The Rs was determined throughout the growing season of maize in 2012. Soil temperature and moisture were measured simultaneously at 5cm depth. The results showed that the seasonal and diurnal variations of Rs in the four different treatments were approximately equal, and there was a positive correlation between Rs and soil temperature. The Rs values of treatments BC4.5 and BC9.0 were significantly lower than of SR but not CK. Significant correlations between Rs and soil temperature and soil moisture were observed. Soil temperature had a stronger effect on Rs than did soil moisture, and Rs was more sensitive to soil temperature in the biochar treatments than in the SR and CK treatments. The application of biochar and straw increased the soil active organic carbon content, but an obvious relationship between Rs and the soil active organic carbon content was not found.

Desorption of Coalbed Methane is one of the key controls to CBM recovery ratio and production capacity. This paper discusses the impact of engineered measures on CBM overall desorption and production capacity with CBM model of Eclipse numerical simulation software. The simulation results show that: with the extension of hydraulic fracture half-length, overall desorption of coal reservoir increased and CBM production capacity improved, daily gas production, maximum gas production and stable yield time increased correspondingly; in different deployment of spacing and well network, the smaller spacing is beneficial to the overall desorption of coal reservoir, but its production can not keep stability because of the serious decline in the late stage of development, while the larger spacing shows in the opposite way.

Ring-opening copolymerization (co-ROP) of cyclic aryl ester dimers could promote the chain-ring equilibration toward the formation of linear polymer and decrease the content of cyclic dimers in the resulting polymer, since ring-opening polymerization (ROP) of aromatic cyclic oligomers is driven by entropy changes.

The 3# high rank coal in Qinshui basin frequently takes place of falling block, sloughing hole, leaking and pipe-stuck during drilling operation. The third open of 12-11-3H well in Qinping is consist of 2 main-branch and 6 sub-branch, using fuzzy-ball drilling fluid for 3 days accomplishing a footage of 4 189.49m. In order to adjust performance of drilling fluid, mix 4 fuzzy-ball drilling fluid additives SDS, SDBS, HES PAM together according to different well condition. The density of this drilling fluid is from 0.96 to 1.08g/cm3. The plastic viscosity of it is from 7 to 17mPa.s, the yield value is from 4.0 to 10.22Pa. After using this fuzzy-ball drilling fluid, the drilling rate has increase to 95%, completing the geological demand with an average drilling rate of 12.65m/h. Compared with adjacent well, the drilling rate has been raised 11.55% with no serious falling block, sloughing or leaking in whole well. However the solid control equipments still need to be strengthened for further improving drilling rate and economic benefits.

The purpose of the article is to solve the talent-post matching problem of material warehouse. From basic quality, job quality, ability quality 3 respects, the index and standard of talent-post matching degree was analyzed. The talent-post matching model of Material warehouse was build by using the method of support vector machine. An example of verification was given. The results show that the model can accurately evaluate the talent-post matching degree and has very important significance on the management of human resources of Material warehouse.

Preparation of cyclic aryl ketone oligomers containing the iso-phthaloyl moiety by Friedel-Crafts acylation reaction is described. These cyclic oligomers are characterized by a combination of MALDI-TOF-MS and NMR analyses. The cyclic aryl ketone oligomers readily undergo anionic ring-opening polymerization in the melt by using potassium 4, 4-biphenoxide as the initiator, affording linear, high molecular weight poly (ether ketone) s with excellent thermal stability.

In order to analyze wide frequency band corona current characteristics of the UHV bundled conductors, a corona current measurement system is developed. The corona current signal is transmitted to the lower computer through the wireless network. And the current signal collected in this way is safe and reliable. The de-noise method with wavelet analysis is introduced and compared with some common used methods. The result of the de-noising analysis of the wide frequency band corona currents of bundled conductors in the corona cage shows that the wavelet analysis method could be used to de-noise high frequency corona current in the corona cage, and the de-noising effect is apparent.

The transmission line corridor will inevitably cross the icing area in China. Icing will influence the corona characteristics of transmission lines. In order to deeply analyze the influence law of the icing to corona loss characteristics, an icing test platform that can be utilized to simulate icing conditions was built. Icing test was done in the corona cage of 1.8m×1.8m×4m. Through changing the conductivity of freezing water and the length of icicle, corona loss of the icing conductor was measured and the surface electric field was also simulated with the software ANSYS. The results show that the length of icicle is an important factor affecting the corona loss of the AC conductor and the conductivity of freezing water on that impact is not obvious. Owing to the icicles, the distortion of the conductor electric field is serious. With the increase of icicle length, conductor corona loss value increases significantly. When the length of icicle increases to about 18mm, the increase of the corona loss value is no longer obvious trending to be saturated . The simulation results coincided with the experimental results very well.

n order to study the effect of attitude for corona inception voltage of AC transmission lines conductors in the altitude areas ranging from 0 to 3000 meters, conducted a series of tests about the corona characteristics of AC six-bundle conductors based on the mobile corona cage at Wuhan, Xining and Haibei respectively. Recorded the number of photons after conductors corona discharge by ultraviolet imaging detector. Conductor corona inception voltages were acquired by the tangent method. The measurement result shows that conductors corona inception voltage decrease with increasing altitude. Corona inception voltage is reduced about 8.12% if altitude rises 1000m. The exponential and linear correction equations suitable for 6 × LGJ-400/50 conductors are introduced. The maximum tolerance is less than 5% and meets the engineering needs.

With the rapid development of UHV power system in China, corona effect has also been paid more and more attention, systematic study of corona phenomenon and its influence factor would give important reference value to the design of UHV transmission line. In this paper, 2D and 3D simulation model of the corona cage have been established through the ANSYS simulation software. The 2D model only can be calculated and analyzed for a specific cross section, and the 3D model can reflect the field distribution over the whole wires, is superiority than 2D model, and this 3D modeling method can provide reference to wire which surface attached with dirt, rain, snow, and other asymmetric model.

A wide frequency band DC corona current measurement system is introduced in this paper. GPS technology is applied to make sure that the voltage and current signal are collected synchronously. The wide band corona current signal is transmitted to the lower computer by the wireless network of 300M/s. The wide frequency band DC corona current waveform was gained in the Ultra High Voltage (UHV) Test Base in Wuhan, which can reflect the high frequency pulses of the corona current, and corona currents of 6 bundle conductor LGJ630-45 in dry and rain (rain rate 20mm/h) conditions are gained. The corona current in the rain condition is much larger than that in the dry condition.

Preparation of macrocyclic aryl ketone oligomers containing the phthaloyl moiety by Friedel-Crafts acylation reaction is described. Detailed structural characterization of these oligomers confirmed the cyclic nature by a combination of MALDI-TOF-MS and GPC analyses. The cyclic aryl ketone oligomers are amorphous and readily undergo anionic ring-opening polymerization in the melt by using potassium 4, 4-biphenoxide as the initiator, producing linear, high molecular weight poly (ether ketone) s with excellent thermal stability.

Altitude rise result in air pressure reduces. Mason-Schamp ionic mobility equation shows that air pressure change can lead to the ionic mobility change. So a set of simple and economical ionic mobility measurement device system was designed which can simulate different altitudes. The device can measure ionic mobility of single gas or mixed gases at different altitudes. It includes that drift tube, ion source, ion gate, ion current detection system, migration gas preparation system, pressure regulating system and shield iron boxes.

The effects of biochar on alkaline soils in high-yielding agricultural fields remain poorly understood. Nitrate variation in soils due to biochar application without a change in soil pH, is a great concern relating to both crop yield and nitrate leaching. In this study, we monitored changes in dynamics of soil nitrate accumulation and effects on grain yield due to biochar application in a temperate, high-yielding region. Biochar derived from corncob was applied to an alkaline soil at biochar rates (kg ha-1) of 0 (CK), 2250 (C1), and 4500 (C2) for each of two crop seasons in 2007. A treatment with 750kg biochar-based fertiliser ha-1 (CN) for each of two crop seasons was also included. Biochar had no significant effect on soil water content to 1m soil depth. Biochar tended to increase the soil cation exchange capacity (CEC) in the 0–20cm soil layer and nitrate retention to 1m soil profile, but there was no significant difference between biochar treatments and CK. Grain yield of C1, C2, and CN was improved by 10.3%, 16.9%, and 15.5% compared with CK, respectively, but only C2 was significantly different from CK. Grain yields of winter wheat with biochar application showed a trend similar to soil CEC and average soil-nitrate retention, suggesting that the increases in grain yield were mainly attributable to improvements in soil CEC and soil nitrate retention due to biochar application in the alkaline soil. In conclusion, the effects of biochar on soil water retention, soil nitrate retention, and grain yield were very limited in alkaline soil in a high-yielding region.

The yaw rock-breaking processes of roadheader single pick at different positions have been simulated by using LS-DYNA, and the dynamic process that pick-shaped cutters cut hard-rock has been analyzed with the technique of SPH(Smooth Particle Hydrodynamics). It has been found that separating rock into smooth particle hydrodynamics(SPH) units can effectively simulate and analyze deformation, damage and other phenomena of rock to lay a foundation of pick design, processing and failure modes analysis. The results of calculations show that this kind of new algorithm is feasible and effective to simulate rock penetration and pick mechanics problems.

In order to analyze the relationship between energy consumption and environmental pollution, grey theory has been applied. By making use of the correlative statistic data, inherent grey relevancy between energy consumption and environmental pollution of China has been discussed as an example, and different impact degrees that various energies consumption have on environmental quality of China has been ascertained by calculating the grey relevancy degree. The results show that fuel oil, coal, coal oil, crude oil and gasoline are the energy varieties that have great impact on environmental quality, while natural gas has less impact on environmental quality. In the end, energy consumption development strategies that can improve environmental quality have been put forward to offer scientific gist for adjusting energy consumption structure, improving environmental quality and actualizing sustainable development between energy consumption and environment.

In order to improve the engineering performance of lightweight design on the driving axle housing, lightweight, structural mechanics, fatigue strength and dynamics are applied in the multidisciplinary design optimization. Firstly, finite element model of driving axle housing was established and its accuracy was verified through bench tests. Secondly, driving axle housing system was divided into multiple sub-discipline systems and design variables of multidisciplinary lightweight design were determined, in order to solve the problems of large amount of data transmission and complex calculation, sparse grid approach was used to establish high accuracy approximate model of each discipline. Lastly, mass of driving axle housing and difference values of first six order modal frequencies before and after lightweight design were optimized through Non-dominated Sorted Genetic Algorithm-Ⅱ, the Pareto optimal solution set was obtained. In optimization results, masses of driving axle housing are all decreased compared to the initial design, meanwhile, the dynamic performance, structural static intensity and fatigue life are all ensured.

Aim at some problem in fault diagnose: the characteristic frequency depends on the speed, the spectrum is complex , which are easy to diagnose error when in the variable conditions, and it is often difficult to identify the fault positioning in the frequency domain. the paper puts forward a new method: Variable condition bearing fault diagnosis basing on time-domain and artificial intelligence , not depend on speed and frequency domain. This method use vibration signal, calculates the kurtosis, skewness, rms etc 12 time-domain value, then these character vectors are sent to the neural network classifier to complete fault type pattern recognition, Finally, the same faults are sent to the next neural network for fault positioning and damage extent identification. The experimental result showed that using this method can obtain very good effect.