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La réadaptation cardiaque (RC) après angioplastie coronaire pour syndrome coronarien aigu (SCA) ou chronique (SCC) est sous-utilisée en France, malgré son efficacité démontrée sur la morbi-mortalité et son rapport coût-efficacité favorable. L'objectif était d’étudier, à partir de bases de données de vie réelle, le rôle des caractéristiques sociogéographiques des patients dans leur participation à la RC.

Patients with autosomal recessive spinal muscular atrophy (SMA) usually carry a homozygous deletion of exons 7 and 8 of the telomeric survival motor neuron (SMNT) gene, although an isolated deletion of SMN Texon 8 has never been found. We now report on 2 patients with the typical fetures of SMA types II and III, who carried a homozygous deletion of SMNTexon 8 but retained SMNT7. Importantly, to exclude a sequence conversion event of telomeric exon 8, we amplified a fragment that spanned exons 7 and 8 of the SMN gene. The resulting 1,010‐base pair (bp) fragments were subjected to nested polymerase chain reaction (PCR) on exon 7. The subsequent restriction analysis failed to show any products of telomeric exon 7, as the site for primer 541 C1120 was lost in both alleles. These findings indicate a homozygous deletion of SMNTexon 8. Direct sequencing of the cloned 1,010‐bp fragment further confirmed that these 2 SMA patients did not possess telomeric exon 8. The present findings provide evidence that an isolated deletion of SMNTexon 8 is associated with the milder subtypes of SMA. Our data also demonstrate that the additional deletion of the NAIP gene exacerbates the severity of the disease.

Indocyanine green (ICG) is commonly used to visualize cerebral vasculature, particularly in the management of cerebral aneurysms. There have also been attempts to use ICG for visualization of tumors. Injection of ICG followed by immediate fluorescence microscopy is limited by the short time window for imaging and administration and restricted depth of imaging. Second Window Indocyanine Green (SWIG) addresses these issues by allowing for longer contrast times and the imaging of deeper regions of brain tissue. Biopsy of spinal cord lesions is often difficult for a variety of reasons, including the delicate nature of the tissue and differentiating normal from lesional tissue visually, especially in lesions with heterogeneous enhancement.