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Your search keyword '"REZNIK, Vitaly"' showing total 2 results
Start Over Author "REZNIK, Vitaly" Publication Type Magazines
2 results on '"REZNIK, Vitaly"'

1. Interaction of Digibind with endogenous cardiotonic steroids from preeclamptic placentae

Author

Fedorova, Olga V, Tapilskaya, Natalia I, Bzhelyansky, Anton M, Frolova, Elena V, Nikitina, Elena R, Reznik, Vitaly A, Kashkin, Vladimir A, and Bagrov, Alexei Y

Abstract

Preeclampsia is a major cause of maternal and fetal mortality, and its pathogenesis is not fully understood. Endogenous digitalis-like cardiotonic steroids (CTS) have been implicated in the pathophysiology of preeclampsia; this is illustrated by clinical observations that Digibind, a therapeutic digoxin antibody fragment which binds CTS, lowers blood pressure and reverses Na/K-ATPase inhibition in patients with preeclampsia. Recently we reported that plasma levels of marinobufagenin (MBG), a bufadienolide vasoconstrictor CTS, are increased four-fold in patients with severe preeclampsia.

Published
2010
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2. Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension

Author

Fedorova, Olga V, Simbirtsev, Andrey S, Kolodkin, Nikolai I, Kotov, Alexander Y, Agalakova, Natalia I, Kashkin, Vladimir A, Tapilskaya, Natalia I, Bzhelyansky, Anton, Reznik, Vitaly A, Frolova, Elena V, Nikitina, Elena R, Budny, Georgy V, Longo, Dan L, Lakatta, Edward G, and Bagrov, Alexei Y

Abstract

Levels of marinobufagenin (MBG), an endogenous bufadienolide Na/K-ATPase (NKA) inhibitor, increase in preeclampsia and in NaCl-sensitive hypertension.

Published
2008
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