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China's YS Biopharma has a good feeling about a phase 3 trial of its investigational PIKA rabies vaccine based on an interim readout. [ABSTRACT FROM AUTHOR]

The Apple Tree Partners biotech showed all doses triggered protective responses, providing an initial sign of the potential of the platform. [ABSTRACT FROM AUTHOR]

Public outcry over vaccine scandal in China. China slashes prices of cancer medicine to ensure affordability for all. First accelerator-based BNCT facility to be used in 2019. Oncologists suggest new therapy by freezing cancer cells. China’s self-developed cancer drug to be approved by year end. China approves first domestically developed anti-HIV drug. Chinese researchers develop ultra-thin sensor that makes fast inflammation testing. China’s pilot program uses AI to detect cancer. Sanofi opens USD 77 million clinical big data R&D facility in Chengdu. AI beats human doctors in neuroimaging recognition contest. Cleveland Clinic to have international program in Shanghai. [ABSTRACT FROM AUTHOR]

The article reports that rabies post-exposure prophylaxis in malnourished children elicited a protective immune response. According to recent research conducted by researcher G. Sampath and collaborators, published in a 2005 issue of the journal "Vaccine," over half of the world's malnourished children live in Asia where more than 90% of reported human rabies deaths occur. In order to determine the effect of malnutrition on the immune response to rabies post-exposure prophylaxis, 45 children with moderate to severe protein energy malnutrition, who were exposed to potentially rabid animals were enrolled in a clinical trial. Patients received purified chick embryo cell rabies vaccine on days 0, 3, 7, 14, and 30.

This article cites a study which says that Rabies prophylaxis in malnourished children provides protection. Over half of the world's malnourished children live in Asia where more than 90% of reported human rabies deaths occur. In order to determine the effect of malnutrition on the immune response to rabies post-exposure prophylaxis (PEP), 45 children with moderate to severe protein energy malnutrition (PEM), who were exposed to potentially rabid animals were enrolled in a clinical trial. G. The research was conducted by Sampath and collaborators. Sampath and associates published their study in "Vaccine."

Reports that Scientists from the U.S. have designed a recombinant rabies viruses for wildlife vaccination. Examination of the production level of the recombinant vaccine candidates; Analysis on the genetic stability of live rabies virus; Detection of the pathogenicity of the G genes of the virus.

Reports that Scientists from Brazil have produced a Vero-cell rabies vaccine using serum-free medium. Details on the development of the viral suspension; Determination on the application of the serum-free medium in the facilitation of the process; Benefits of the usability of the vaccine in countries with health problem on rabies.

Cites a study conducted by researchers in Brazil, which found that increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Evaluation of macrophage activity, cytokine serum concentration, serum neutralizing antibodies and lethality by rabies in Swiss mice experimentally infected with street rabies virus and submitted to or not to antirabies vaccination and immunomodulation with P. acnes; Observation that greater survival rates higher IL-10 and low IL-6 serum concentration in vaccinated animals treated using P. acnes.

Examines the efficacy of live vaccinia-rabies virus recombinants to elicit elevated levels of neutralizing antibody in B-lymphocyte deficient A/WySynJ mice. Characteristics of commercially available cell culture rabies vaccines; Failure of the cell culture vaccine to protect the mice; Effectiveness of a single immunization of a vaccinia recombinant in protecting the subject after vaccination.