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Multiple sequence alignment has been the traditional and well established approach of sequence analysis and comparison, though it is time and memory consuming. As the scale of sequencing data is increasing day by day, the importance of faster yet accurate alignment-free methods is on the rise. Several alignment-free sequence analysis methods have been established in the literature in recent years, which extract numerical features from genomic data to analyze sequences and also to estimate phylogenetic relationship among genes and species. Minimal Absent Word (MAW) is an effective concept for representing characteristics of a sequence in an alignment-free manner. In this study, we present CD-MAWS, a distance measure based on cosine of the angle between composition vectors constructed using minimal absent words, for sequence analysis in a computationally inexpensive manner. We have benchmarked CD-MAWS using several AFProject datasets, such as Fish mtDNA, E.coli, Plants, Shigella and Yersinia datasets, and found it to perform quite well. Applied on several other biological datasets such as mammal mtDNA, bacterial genomes and viral genomes, CD-MAWS resolved phylogenetic relationships similar to or better than state-of-the-art alignment-free methods such as Mash, Skmer, Co-phylog and kSNP3.

Recent technology development of logic devices based on 2-D semiconductors such as MoS2, WS2, and WSe2 has triggered great excitement, paving the way to practical applications. Making low-resistance p-type contacts to 2-D semiconductors remains a critical challenge. The key to addressing this challenge is to find high-work function metallic materials which also introduce minimal metal-induced gap states (MIGSs) at the metal/semiconductor interface. In this work, we perform a systematic computational screening of novel metallic materials and their heterojunctions with monolayer WSe2 based on ab initio density functional theory and quantum device simulations. Two contact strategies, van der Waals (vdW) metallic contact and bulk semimetallic contact, are identified as promising solutions to achieving Schottky-barrier-free and low-contact-resistance p-type contacts for WSe2 p-type field-effect transistor (pFETs). Good candidates of p-type contact materials are found based on our screening criteria, including 1H-NbS2, 1H-TaS2, and 1T-TiS2 in the vdW metal category, as well as Co3Sn2S2 and TaP in the bulk semimetal category. Simulations of these new p-type contact materials suggest reduced MIGS, less Fermi-level pinning effect, negligible Schottky barrier height and small contact resistance (down to $20~\Omega \mu \text{m}$ ).

AbstractIn this study, a new technique is presented combining perturbation method and harmonic balance (HB) method and adopted to investigate a fourth order nonlinear Duffing equation with strong nonlinearity. The advantage of the proposed method is that the method can provide good results even the nonlinearity is strong. The result obtained by the proposed method is compared with the corresponding numerical results to verify the accuracy of the method. The results are also compared with the previous perturbation method results found in literature. Besides, the damped and undamped cases are studied, and the internal resonance is found for undamped case.

In the present work, Zn1-xAgxO (x = 0, 0.03, 0.05, and 0.07) nanoparticles were synthesized by the sol-gel synthesis method. Microstructural, morphological, optical, and antibacterial characterizations were performed. The wurtzite crystalline structure was confirmed through XRD analysis. The maximum crystallite size was found for Zn0.93Ag0.07O (∼22.36 nm). Rietveld refinement was performed to understand better crystal symmetry. The optical band gap property exhibited a decremental pattern with the increasing Ag content. The lowest band gap was achieved by Zn0.93Ag0.07O (∼3.26 eV). The Fourier transform infrared spectroscopy (FTIR) analysis ensured the bond stretching of Zn–O and Ag–O near the absorbance band of 490 cm−1. Further, the Thermogravimetric analysis (TGA) was performed to determine the samples' weight loss, and the minimum weight loss was observed for Zn0.93Ag0.07O (∼9–11%). Finally, the antibacterial characterization was performed using Escherichia coli(gram-negative bacteria), and again Zn0.93Ag0.07O exhibited better performances than other synthesized nanoparticles.

We numerically debrief a prism based SPR biosensor in this paper exploiting a single layer of Alfa-Tin Selenide (α-SnSe) that is not brought to light till today. This material exhibits incredible features with an analogous formation like graphene and phosphorene, and for this instance, a great contemplation is taken by the researchists utilizing a biomolecular recognition element (BRE) for modeling biosensors. The paper centers around the exploration of the effective advancement of surface plasmon resonance (SPR) biosensors by covering the gold (Au)/ silver (Ag)/ copper (Cu) layer with the α-SnSe monolayer. The proposed sensor consists of the structure of prism-(Au/Ag/Cu)-(α-SnSe)-Phosphorene-sensing medium. A dramatic sensitivity enhancement is reported by the analyses in the entire performance of this raised sensor while inserting an α-SnSe layer in between Au/Ag/Cu and phosphorene. The sensitivity for the proposed biosensors displays a maximal grade of 96.43 deg./RIU, 81.43 deg./RIU, and 74.29 deg./RIU for Au, Ag, and Cu based structures, respectively. It can be observed that the sensitivity of Au flourished biosensor is better than that of Ag or Cu based structures. Our outcomes also reveal that SPR sensors with α-SnSe monolayer can be utilized in demonstrative petitions, and their exalted sensitivity and little intentness of analyte are required. Consequently, the raised biosensor exhibits an in-mint condition ventilator in the direction of sensing petitions.

Abstract: Combining Krylov–Bogoliubov–Mitropolskii (KBM) and harmonic balance methods, an analytical technique is presented to determine approximate solutions of nonlinear oscillatory systems with damping. The first approximate perturbation solutions in which the unperturbed solutions contain two harmonic terms agree with numerical solutions nicely even if the damping force is significant. With suitable examples it has been shown that the combination of classical KBM and harmonic balance methods sometimes fails to measure satisfactory results; but the combination of extended KBM method (by Popov) and harmonic balance method always give the desired results. The method is illustrated by several examples and the solutions are compared to some existing solutions. [Copyright &y& Elsevier]

• A new method based differential transformation method is presented in this study. • The proposed method reduces the algebraic complexity. • All the related equations are linear and easy to solve. • Some nonlinear problems are studied. A new technique has been presented for solving strong nonlinear oscillatory problems. The solution is independent of trigonometric functions, and the determination of unknown coefficients related to the proposed solution is very simple. The method is illustrated by examples. For a large amplitude of oscillation of some nonlinear oscillators, the solution nicely agrees with the corresponding numerical solution. [ABSTRACT FROM AUTHOR]