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The impact of cancer on outcome of persons with coronavirus disease 2019 (COVID-19) after infection with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is controversial. We studied 1859 subjects with COVID-19 from seven centers in Wuhan, China, 65 of whom had cancer. We found having cancer was an independent risk factor for in-hospital death from COVID-19 in persons <65 years (hazard ratio [HR]?=?2.45, 95% confidence interval [CI], 1.04, 5.76; P?=?0.041) but not in those =65 years (HR?=?1.12 [0.56, 2.24]; P?=?0.740). It was also more common in those not in complete remission. Risks of in-hospital death were similar in subjects with solid cancers and those with hematological cancers. These data may help predict outcomes of persons with cancer and COVID-19.

We studied 1859 subjects with confirmed COVID-19 from seven centers in Wuhan 1651 of whom recovered and 208 died. We interrogated diverse covariates for correlations with risk of death from COVID-19. In multi-variable Cox regression analyses increased hazards of in-hospital death were associated with several admission covariates: (1) older age (HR = 1.04; 95% Confidence Interval [CI], 1.03, 1.06 peryear increase; P< 0.001); (2) smoking (HR = 1.84 [1.17, 2.92]; P= 0.009); (3) admission temperature per°C increase (HR = 1.32 [1.07, 1.64]; P= 0.009); (4) Log10neutrophil-to-lymphocyte ratio (NLR; HR = 3.30 [2.10, 5.19]; P< 0.001); (5) platelets per10 E + 9/L decrease (HR = 0.996 [0.994, 0.998]; P= 0.001); (6) activated partial thromboplastin (aPTT) persecond increase (HR = 1.04 [1.02, 1.05]; P< 0.001); (7) Log10D-dimer permg/l increase (HR = 3.00 [2.17, 4.16]; P< 0.001); and (8) Log10serum creatinine perμmol/L increase (HR = 4.55 [2.72, 7.62]; P< 0.001). In piecewise linear regression analyses Log10NLR the interval from ≥0.4 to ≤1.0 was significantly associated with an increased risk of death. Our data identify covariates associated with risk of in hospital death in persons with COVID-19.

We studied admission and dynamic demographic, hematological and biochemical co-variates in 1449 hospitalized subjects with coronavirus infectious disease-2019 (COVID-19) in five hospitals in Wuhan, Hubei province, China. We identified two admission co-variates: age (Odds Ratio [OR] = 1.18, 95% Confidence Interval [CI] [1.02, 1.36]; P= 0.026) and baseline D-dimer (OR = 3.18 [1.48, 6.82]; P= 0.003) correlated with an increased risk of death in persons with COVID-19. We also found dynamic changes in four co-variates, Δ fibrinogen (OR = 6.45 [1.31, 31.69]; P= 0.022), Δ platelets (OR = 0.95 [0.90–0.99]; P= 0.029), Δ C-reactive protein (CRP) (OR = 1.09 [1.01, 1.18]; P= 0.037), and Δ lactate dehydrogenase (LDH) (OR = 1.03 [1.01, 1.06]; P= 0.007) correlated with an increased risk of death. The potential risk factors of old age, high baseline D-dimer, and dynamic co-variates of fibrinogen, platelets, CRP, and LDH could help clinicians to identify and treat subjects with poor prognosis.