2,845 results on '"Rocca A"'
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2. Characterization and Identification of Yeast Peptides Released during Model Wine Fermentation and Lees Contact
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De Iseppi, A., Rocca, G., Marangon, M., Corich, V., Arrigoni, G., Porcellato, D., and Curioni, A.
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Aging wine on lees results in the release of different yeast components, including peptides, whose role in wine is unclear. In this study, peptides released in a synthetic must, fermented with an oenological yeast strain, and aged on lees for 180 days were quantified (RP-HPLC) and identified (LC-MS/MS) at different time points. A rapid increase in peptide concentration was observed in the first two months, with over 2600 sequences identified. During the following four months, the peptide concentration remained constant, while their variety decreased slightly, probably due to enzymatic hydrolysis to which longer and less charged sequences were more exposed. The majority of the most abundant peptides were present over the 6-month period. They mostly originated from proteins associated with glycolysis and with different stress-response mechanisms, and they showed different in silicobioactivities. These findings can contribute to understanding the role of yeast peptides in regulating the wine environment during aging.
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- 2024
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3. Update on antithrombotic therapy and body mass: a clinical consensus statement of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and the European Society of Cardiology Working Group on Thrombosis
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Gigante, Bruna, Tamargo, Juan, Agewall, Stefan, Atar, Dan, ten Berg, Jurrien, Campo, Gianluca, Cerbai, Elisabetta, Christersson, Christina, Dobrev, Dobromir, Ferdinandy, Péter, Geisler, Tobias, Gorog, Diana A, Grove, Erik L, Kaski, Juan Carlos, Rubboli, Andrea, Wassmann, Sven, Wallen, Håkan, and Rocca, Bianca
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Obesity and underweight are a growing health problem worldwide and a challenge for clinicians concerning antithrombotic therapy, due to the associated risks of thrombosis and/or bleeding. This clinical consensus statement updates a previous one published in 2018, by reviewing the most recent evidence on antithrombotic drugs based on body size categories according to the World Health Organization classification. The document focuses mostly on individuals at the extremes of body weight, i.e. underweight and moderate-to-morbid obesity, who require antithrombotic drugs, according to current guidelines, for the treatment or prevention of cardiovascular diseases or venous thromboembolism. Managing antithrombotic therapy or thromboprophylaxis in these individuals is challenging, due to profound changesin body composition, metabolism and organ function, and altered drug pharmacokinetics and pharmacodynamics, as well as weak or no evidence from clinical trials. The document also includes artificial intelligence simulations derived from in silicopharmacokinetic/pharmacodynamic models, which can mimic the pharmacokinetic changes and help identify optimal regimens of antithrombotic drugs for severely underweight or severely obese individuals. Further, bariatric surgery in morbidly obese subjects is frequently performed worldwide. Bariatric surgery causes specific and additional changes in metabolism and gastrointestinal anatomy, depending on the type of the procedure, which can also impact the pharmacokinetics of antithrombotic drugs and their management. Based on existing literature, the document provides consensus statements on optimizing antithrombotic drug management for underweight and all classes of obese patients, while highlighting the current gaps in knowledge in these complex clinical settings, which require personalized medicine and precision pharmacology.Graphical AbstractRisks of thrombosis and bleeding, antithrombotic drug management, and supporting type of evidence across body size categories. From left to right: a causal relationship between obesity and deep vein thrombosis (DVT) risk has been suggested by Mendelian randomization studies. Generally, DVT risk linearly increases from underweight to the highest body mass index classes. Despite the low risk of underweight individuals, underweight seems to have a worse prognosis once venous thrombosis has occurred. The risk of arterial thrombosis increases from normoweight to severe obesity, while the risk associated with being underweight remains less clear, possibly mimicking a U-shaped relationship. A U-shaped relationship seems to describe the risk of major bleeding associated with body size. However, the anatomical site and type of bleeding, underlying risk factors, and prognosis differ at the two extremes. Optimizing the dosing of antithrombotic drugs both in underweight and class =2 obese individuals is supported by pharmacokinetic/pharmacodynamic (PK/PD) studies and data from post hoc analyses of randomized studies, observational, and registry data as well as by artificial intelligence simulations of in silicoPK/PD models generated by population and randomized clinical trial experimental measurements. In underweight individuals, most evidence indicates better safety of reducing the daily doses of standard, fixed-dose antithrombotic drugs, while increasing the fixed dose is suggested for those in class =2 obesity. For body weight-adjusted antithrombotic drugs, individuals with higher classes of obesity may be overdosed due to a major imbalance between lean and fat mass that has a major impact on drug PK and bioavailability. On the other hand, if capping is us-//-ed, this may result in underdosing at the upper extreme of body size. Further details are reported in the Central Tables 1and 2. LMWH, low-molecular-weight heparin; OAC, oral anticoagulation; UFH, unfractionated heparin.
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- 2024
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4. Catheter ablation as an adjunctive therapy to ICD implantation in Brugada Syndrome
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Doundoulakis, Ioannis, Chiotis, Sotirios, Pannone, Luigi, Della Rocca, Domenico Giovanni, Sorgente, Antonio, Kordalis, Athanasios, Scacciavillani, Roberto, Zafeiropoulos, Stefanos, Marcon, Lorenzo, Vetta, Giampaolo, Pagkalidou, Eirini, Bala, Gezim, Almorad, Alexandre, Ströker, Erwin, Sieira, Juan, La Meir, Mark, Brugada, Pedro, Tsiachris, Dimitrios, Sarkozy, Andrea, Chierchia, Gian Battista, and de Asmundis, Carlo
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Graphical Abstract
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- 2024
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5. Heuristic Best-Fitting-Paraboloid Method for Gravity-Distorted Reflector Antennas
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Tan, Guodong, Wang, Qunbiao, Rocca, Paolo, Duan, Xuechao, Yang, Dongwu, Feng, Shufei, and Chen, Guangda
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This article presents a heuristic best-fitting-paraboloid (BFPH) method, tailored for reflector antennas subject to gravitational distortion. First, the best fitting problem is formulated a nonlinear least-squares problem (NLSP) for the distorted reflector, wherein three heuristic rules (DRs), crucial for the problem at hand, are derived based on two typical distortion modes observed in antennas. Then, a suitable optimization algorithm is employed to solve the NLSP, in which a customized strategy is developed for the definition of the initial value in order to guarantee effective and reliable final solutions. A set of numerical results are reported and discussed to demonstrate the superior performance of the BFPH method in comparison to existing state-of-the-art methods. More specifically, it supplies higher antenna gain, reduced pointing error, enhanced robustness, and better symmetry in the far-field pattern.
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- 2024
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6. A phenome-wide association study of methylated GC-rich repeats identifies a GCC repeat expansion in AFF3associated with intellectual disability
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Jadhav, Bharati, Garg, Paras, van Vugt, Joke J. F. A., Ibanez, Kristina, Gagliardi, Delia, Lee, William, Shadrina, Mariya, Mokveld, Tom, Dolzhenko, Egor, Martin-Trujillo, Alejandro, Gies, Scott J., Altman, Gabrielle, Rocca, Clarissa, Barbosa, Mafalda, Jain, Miten, Lahiri, Nayana, Lachlan, Katherine, Houlden, Henry, Paten, Benedict, Veldink, Jan, Tucci, Arianna, and Sharp, Andrew J.
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GC-rich tandem repeat expansions (TREs) are often associated with DNA methylation, gene silencing and folate-sensitive fragile sites, and underlie several congenital and late-onset disorders. Through a combination of DNA-methylation profiling and tandem repeat genotyping, we identified 24 methylated TREs and investigated their effects on human traits using phenome-wide association studies in 168,641 individuals from the UK Biobank, identifying 156 significant TRE–trait associations involving 17 different TREs. Of these, a GCC expansion in the promoter of AFF3was associated with a 2.4-fold reduced probability of completing secondary education, an effect size comparable to several recurrent pathogenic microdeletions. In a cohort of 6,371 probands with neurodevelopmental problems of suspected genetic etiology, we observed a significant enrichment of AFF3expansions compared with controls. With a population prevalence that is at least fivefold higher than the TRE that causes fragile X syndrome, AFF3expansions represent a major cause of neurodevelopmental delay.
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- 2024
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7. The spreading information of YouTube videos on Phosphodiesterase 5 inhibitors: a worrisome picture from one of the most consulted internet source
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Pezone, Gabriele, Collà Ruvolo, Claudia, Cilio, Simone, Fraia, Agostino, Di Mauro, Ernesto, Califano, Gianluigi, Passaro, Francesco, Creta, Massimiliano, Capece, Marco, La Rocca, Roberto, Celentano, Giuseppe, Morra, Simone, Di Bello, Francesco, Palmieri, Alessandro, Imbimbo, Ciro, and Longo, Nicola
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Several previous studies on YouTubeTMinformation on medical topics have already been published. The current study aimed to evaluate the quality information of YouTubeTMvideos on Phosphodiesterase 5 inhibitors (PDE5-is). A systematic search on YouTube™ was conducted using 30 keyword combinations. For each keyword’s combination, the first 50 videos were recorded. The quality of videos on YouTube™ was assessed with Patient Education Materials Assessment Tool for audio‐visual content (PEMAT A/V), DISCERN score and a specified created Misinformation tool. According to the selection criteria, 229 YouTube™ videos were suitable for the analyses. Videos were stratified according to the five main identified topics: sildenafil [n= 98; 42.79%] vs tadalafil [n= 50; 21.83%] vs vardenafil [n= 44;19.21%] vs avanafil [n= 17; 7.42%] vs PDE5-is in general [n= 20; 8.73%]. The median overall PEMAT A/V Understandability score and Actionability score were 55% (interquartile range [IQR]: 42–75) and 0% (IQR = 0–67), respectively. Specifically, according to our stratification, YouTube Videos on avanafil reached higher values of both Understandability and Actionability (72.7% and 66.7, respectively) in contrast to other categories. According to DISCERN tool, the total overall median score was 29.5 (IQR = 18–41). According to Misinformation scale, the item 1 (‘sexual stimulation’) harboured an overall median score of 2 (IQR = 1–2); the item 2 (‘side effects’) an overall median score of 2 (IQR = 1–3); the item 3 (‘treatment choices’) an overall median score of 1 (IQR = 1–2); the item 4 (‘contraindications’) an overall median score of 2 (IQR = 1–2). YouTube™ is a fast and open-access source for mass information. The overall quality of the PDE5-is contents provided is sadly unsatisfactory. Nowadays, YouTube™ cannot be recommended as a reliable source of information on PDE5-is.
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- 2024
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8. An unbiased lncRNA dropout CRISPR-Cas9 screen reveals RP11-350G8.5 as a novel therapeutic target for multiple myeloma
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Grillone, Katia, Ascrizzi, Serena, Cremaschi, Paolo, Amato, Jussara, Polerà, Nicoletta, Croci, Ottavio, Rocca, Roberta, Riillo, Caterina, Conforti, Francesco, Graziano, Raffaele, Brancaccio, Diego, Caracciolo, Daniele, Alcaro, Stefano, Pagano, Bruno, Randazzo, Antonio, Tagliaferri, Pierosandro, Iorio, Francesco, and Tassone, Pierfrancesco
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•We unveiled 8 lncRNAs essential for multiple myeloma (MM) cell fitness and associated with poor prognosis and high expression in patients with MM.•We identified lncRNA RP11-350G8.5 as a therapeutic target for MM and characterized its oncogenic role and molecular and structural features.
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- 2024
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9. Histiocytosis of the orbit and its association with KRASmutations
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Francis, Jasmine H., Silverman, Rebecca F., Canestraro, Julia, Bossert, Dana, Della Rocca, David, Hatzoglou, Vaios, Abramson, David H., and Diamond, Eli L.
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- 2024
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10. An Opportunistic Source Synthesis Method for Smart Electromagnetic Environments
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Ru, Pietro Da, Benoni, Arianna, Salucci, Marco, Rocca, Paolo, and Massa, Andrea
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In the framework of the “smart electromagnetic environment” (SEME), an innovative strategy leveraging equivalence source concepts is introduced for enhancing the performance of large-scale outdoor wireless communication systems. The proposed opportunistic sources synthesis (OSS) approach is aimed at unconventionally synthesizing the primary source (i.e., the base transceiver station (BTS) antenna array) so that the complex scattering phenomena induced in the surrounding scatterers are profitably exploited to enhance the received power within user-defined regions of interest (RoIs). To yield a computationally feasible synthesis process, an innovative “embedded-plus-environment pattern” (EPEP) method is introduced. A set of representative numerical examples, concerned with realistic large-scale outdoor scenarios, is presented to assess the effectiveness and the efficiency of the proposed optimization-driven approach for a realistic SEME implementation.
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- 2024
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11. Quality of care and clinical inertia in the management of cardiovascular risk factors in patients with type 1 and type 2 diabetes: data from AMD annals
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Da Porto, A., Candido, R., Rocca, A., Manicardi, V., Nicolucci, A., Miranda, C., Cimino, E., Di Bartolo, P., Di Cianni, G., and Russo, G.
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Background: Cardiovascular disease is the leading cause of morbidity and mortality among patients with diabetes, and for this reason, all guidelines for CV risk management provide the same targets in controlling traditional CV risk factors in patients with type 1 or type 2 diabetes at equal CV risk class. Aim of our study was to evaluate and compare CV risk management in patients with type 1 and type 2 diabetes included in AMD Annals Database paying particular attention to indicators of clinical inertia. Methods: This was a multicenter, observational, retrospective study of AMD Annals Database during year 2022. Patients with diabetes were stratified on the basis of their cardiovascular risk, according to ESC-EASD guidelines. The proportion of patients not treated with lipid-lowering despite LDL cholesterol > to 100 mg/dl or the proportion of patients not treated with antihypertensive drug despite BP > 140/90 mmhg and proportion of patients with proteinuria not treated with angiotensin converting enzyme inhibitors or angiotensinogen receptor blockers (ACE/ARBs) were considered indicators of clinical inertia. The proportion of patients reaching at the same time HbA1c < 7% LDL < 70 mg/dl and BP < 130/80 mmhg were considered to have good multifactorial control. Overall quality of health care was evaluated by the Q-score. Results: Using the inclusion criteria and stratifying patients by ESC/EASD Cardiovascular Risk categories, we included in the analysis 118.442 patients at High Cardiovascular risk and 416.246 patients at Very High Cardiovascular risk. The proportion of patients with good multifactorial risk factor control was extremely low in both T1D and T2D patients in each risk class. At equal risk class, the patients with T1D had lower proportion of subjects reaching HbA1c, LDL, or Blood Pressure targets. Indicators of clinical inertia were significantly higher compared with patients with T2D at equal risk class. Data regarding patients with albuminuria not treated with RAAS inhibitors were available only for those at Very High risk and showed that the proportion of patients not treated was again significantly higher in patients with T1DM. Conclusions: In conclusion, this study provides evidence of wide undertreatment of traditional cardiovascular risk factors among patients with diabetes included in AMD Annals Database. Undertreatment seems to be more pronounced in individuals with T1D compared to those with T2D and is frequently due to clinical inertia.
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- 2024
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12. Reversal of direct oral anticoagulants: guidance from the SSC of the ISTH
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Levy, Jerrold H., Shaw, Joseph R., Castellucci, Lana A., Connors, Jean M., Douketis, James, Lindhoff-Last, Edelgard, Rocca, Bianca, Samama, Charles Marc, Siegal, Deborah, and Weitz, Jeffrey I.
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The currently approved direct oral anticoagulants (DOACs) are increasingly used in clinical practice. Although serious bleeding risks are lower with DOACs than with vitamin K antagonists, bleeding remains the most frequent side effect. Andexanet alfa and idarucizumab are the currently approved specific reversal agents for oral factor (F)Xa inhibitors and dabigatran, respectively. Our prior guidance document was published in 2016, but with more information available on the utility and increased use of these reversal agents and other bleeding management strategies, we have updated this International Society on Thrombosis and Haemostasis guidance document on DOAC reversal. In this narrative review, we compare the mechanism of action of specific and nonspecific reversal agents, review the clinical data supporting their use, and provide guidance on when reversal is indicated. In addition, we briefly discuss the reversal of oral FXIa inhibitors, a new class of DOACs currently under clinical development.
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- 2024
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13. Der Zusammenhang zwischen betrieblicher Arbeitsschutzorganisation und Gefährdungsbeurteilung
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Sommer, Sabine, Lunau, Thorsten, Wahrendorf, Morten, Beck, David, La Rocca, Giulia, and Rigó, Mariann
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Die vorliegende Studie prüft auf der Basis der Daten der deutschen Teilstichprobe der europäischen Unternehmenserhebung über neue und aufkommende Risiken (ESENER) aus den Jahren 2014 und 2019 den Zusammenhang zwischen der Güte der betrieblichen Arbeitsschutzorganisation und der Umsetzung einer Gefährdungsbeurteilung. Zur Bestimmung der Güte der Arbeitsschutzorganisation und der Güte der Gefährdungsbeurteilung wurden verschiedene Items der ESENER-Befragung verwendet. Die Analysen wurden in Form logistischer Regressionsmodelle ausgeführt. Die Ergebnisse werden in Form von adjustierten prognostizierten Wahrscheinlichkeiten und durchschnittlichen marginalen Effekten dargestellt. In beiden untersuchten Erhebungswellen der ESENER-Befragung zeigt sich ein ausgeprägter und signifikanter Zusammenhang zwischen der Güte der Arbeitsschutzorganisation und der Umsetzung einer Gefährdungsbeurteilung, auch nach Adjustierung für Größe, Branche und Sektor. Während Betriebe mit einer Arbeitsschutzorganisation hoher Güte mehrheitlich angaben, eine umfassende Gefährdungsbeurteilung durchzuführen (2014: 56 %, 2019: 59 %), waren es für Betriebe mit einer Arbeitsschutzorganisation geringer Güte fast 40 Prozentpunkte weniger (18 % bzw. 23 %). Diese Ergebnisse sprechen dafür, dass Maßnahmen zur Stärkung der betrieblichen Arbeitsschutzorganisation zu einer verbesserten Umsetzung der Gefährdungsbeurteilung beitragen.
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- 2024
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14. Resting state functional connectivity modifications in monoaminergic circuits underpin fatigue development in patients with multiple sclerosis
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Margoni, Monica, Valsasina, Paola, Bacchetti, Anna, Mistri, Damiano, Preziosa, Paolo, Rocca, Maria A., and Filippi, Massimo
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Dysregulation of monoaminergic networks might have a role in the pathogenesis of fatigue in multiple sclerosis (MS). We investigated longitudinal changes of resting state (RS) functional connectivity (FC) in monoaminergic networks and their association with the development of fatigue in MS. Eighty-nine MS patients and 49 age- and sex-matched healthy controls (HC) underwent neurological, fatigue, and RS functional MRI assessment at baseline and after a median follow-up of 1.3 years (interquartile range = 1.01–2.01 years). Monoaminergic-related RS FC was estimated with an independent component analysis constrained to PET atlases for dopamine (DA), noradrenaline (NA), and serotonin (5-HT) transporters. At baseline, 24 (27%) MS patients were fatigued (F) and 65 were not fatigued (NF). Of these, 22 (34%) developed fatigue (DEV-FAT) at follow-up and 43 remained not fatigued (NO-FAT). At baseline, F-MS patients showed increased monoaminergic-related RS FC in the caudate nucleus vsNF-MS and in the hippocampal, postcentral, temporal, and occipital cortices vsNF-MS and HC. Moreover, F-MS patients exhibited decreased RS FC in the frontal cortex vsNF-MS and HC, and in the thalamus vsNF-MS. During the follow-up, no RS FC changes were observed in HC. NO-FAT patients showed limited DA-related RS FC modifications, whereas DEV-FAT MS patients showed increased DA-related RS FC in the left hippocampus, significant at time-by-group interaction analysis. In the NA-related network, NO-FAT patients showed decreased RS FC over time in the left superior frontal gyrus. This region showed increased RS FC in both DEV-FAT and F-MS patients; this divergent behavior was significant at time-by-group interaction analysis. Finally, DEV-FAT MS patients presented increased 5-HT-related RS FC in the angular and middle occipital gyri, while this latter region showed decreased 5-HT-related RS FC during the follow-up in F-MS patients. In MS patients, distinct patterns of alterations were observed in monoaminergic networks based on their fatigue status. Fatigue was closely linked to specific changes in the basal ganglia and hippocampal, superior frontal, and middle occipital cortices.
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- 2024
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15. Adaptive Optical Thinned Antenna Array Controlled by an Integrated Photonic Processor
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SeyedinNavadeh, SeyedMohammad, Anselmi, Nicola, Milanizadeh, Maziyar, Zanetto, Francesco, Martinez, Andres, Rocca, Paolo, Morichetti, Francesco, Massa, Andrea, and Melloni, Andrea
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A generic antenna array design approach through multi-objective optimization is adopted to design a non-uniform optical thinned array (TA) satisfying a desired far-field pattern mask and minimizing the number of radiating elements. The proposed optical TA is integrated with a silicon photonic beam-forming network (BFN) made of a mesh of tuneable Mach-Zehnder interferometer to implement a self-adaptive beam transmitter/receiver for free-space optical (FSO) systems. Experimental results demonstrate the beam steering and shaping capability of the proposed architecture, which self-configures without any need for pre-calibration.
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- 2024
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16. Genome assembly of two California isolates of Seiridium cardinale(BM-138-000494 and BM-138-000479)
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Scali, Edoardo, Rocca, Gianni Della, Danti, Roberto, Garbelotto, Matteo, Barberini, Sara, and Emiliani, Giovanni
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- 2024
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17. Oral anticoagulation in patients with left ventricular thrombus: a systematic review and meta-analysis
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Haller, Paul M, Kazem, Niema, Agewall, Stefan, Borghi, Claudio, Ceconi, Claudio, Dobrev, Dobromir, Cerbai, Elisabetta, Grove, Erik Lerkevang, Kaski, Juan Carlos, Lewis, Basil S, Niessner, Alexander, Rocca, Bianca, Rosano, Giuseppe, Savarese, Gianluigi, Schnabel, Renate B, Semb, Anne Grete, Sossalla, Samuel, Wassmann, Sven, and Sulzgruber, Patrick
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- 2024
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18. Editorial Special Article Collection on Antennas and Propagation for Emerging 5G/6G Communications
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Falcone, Francisco, Khalily, Mohsen, Chen, Zhi Ning, Rappaport, Theodore, and Rocca, Paolo
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Wireless communication systems have become key players in enabling highly interactive and context-aware scenarios, with a broad range of applications and sectors, spanning from industry, logistics, healthcare, transportation, or massive telemetry, just to name a few. The need for connectivity has been further spanned by new ways of handling and organizing information, within the framework of the Internet of Things and the evolution towards proactive and predictive environments, such as those foreseen in Cognitive cities. This evolution has led to the need of ever increasingly demanding key performance indicators of wireless communication devices and systems of current 5G and future 6G networks, with transmission rates in the Tbps range, latencies of
$100~\mu $ $10^{7}$ [1] . RIS apertures are large w.r.t. operational frequency and they are expected to operate predominantly in near field, which necessitates the generation of near field codebooks and imaging patterns. The performance of RIS metasurfaces in near field is considered in[2] , that involves generation of near field codebooks and imaging patterns.- Published
- 2024
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19. Fascicular Substrate Modification to Treat Human Ventricular Fibrillation
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Bode, Weeranun D., Mohanty, Sanghamitra, Burkhardt, John D., Torlapati, Prem G., Gianni, Carola, La Fazia, Vincenzo M., Della Rocca, Domenico G., Bassiouny, Mohamed, Gallinghouse, G. Joseph, Horton, Rodney, Al-Ahmad, Amin, Zhang, Xiao-Dong, Zou, Fengwei, Di Biase, Luigi, Santangeli, Pasquale, and Natale, Andrea
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Purkinje fibers play an important role in initiation and maintenance of ventricular fibrillation (VF) and polymorphic ventricular tachycardia (PMVT). Fascicular substrate modification (FSM) approaches have been suggested to treat recurrent VF in case reports and small case series.
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- 2024
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20. Sequence and assembly of the genome of Seiridium unicorne, isolate CBS 538.82, causal agent of cypress canker disease
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Scali, Edoardo, Rocca, Gianni Della, Danti, Roberto, Garbelotto, Matteo, Barberini, Sara, Baroncelli, Riccardo, and Emiliani, Giovanni
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- 2024
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21. Insights on the fungal communities associated with needle reddening of the endangered Abies nebrodensis
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Frascella, Arcangela, Barberini, Sara, Della Rocca, Gianni, Emiliani, Giovanni, Di Lonardo, Vincenzo, Secci, Stefano, and Danti, Roberto
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Abies nebrodensisis a species of fir endemic to Sicily, represented by only 30 trees in the natural population and is currently classified as critically endangered by IUCN. In such context, monitoring its health status is essential for the proper management and preservation of this species. Phytosanitary surveys of trees of the natural population of A. nebrodensisand on potted plants raised in the local forest nursery were carried out, and the phyllosphere fungal community was investigated. The health condition of trees in the natural population were fairly good, with needle reddening and blight as the most frequently observed symptoms on the foliage, while in the nursery similar disorders were registered on about the 1.3% of potted plants. Results on fungal isolations highlighted the presence of species belonging to Valsa, Cytospora(which includes anamorphs of Valsa) and Rhizosphaeragenera as the most represented on both reddened and green needles; these results suggest that these fungi likely live as endophytes, resuming their growth when needles are affected by environmental stressors such as wind, hail, mechanical wounds and do not represent a biotic constraint for A. nebrodensis. The disorders observed appear mostly as a consequence of the harsh site in which the relic species lives. Together with the fungal community observed on symptomatic and healthy needles, they indicate that A. nebrodensisadapted and tolerates its altered habitat.
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- 2024
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22. Diagnostic Criteria for Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, and Myelin Oligodendrocyte Glycoprotein–immunoglobulin G-associated Disease
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Filippi, Massimo, Preziosa, Paolo, Margoni, Monica, and Rocca, Maria A.
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The diagnostic workup of multiple sclerosis (MS) has evolved considerably. The 2017 revision of the McDonald criteria shows high sensitivity and accuracy in predicting clinically definite MS in patients with a typical clinically isolated syndrome and allows an earlier MS diagnosis. Neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein–immunoglobulin G-associated disease (MOGAD) are recognized as separate conditions from MS, with specific diagnostic criteria. New MR imaging markers may improve diagnostic specificity for these conditions, thus reducing the risk of misdiagnosis. This study summarizes the most recent updates regarding the application of MR imaging for the diagnosis of MS, NMOSD, and MOGAD.
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- 2024
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23. Ureteral access sheaths in RIRS: a retrospective, comparative, single-center study
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Celentano, Giuseppe, Barone, Biagio, La Rocca, Roberto, Massanova, Matteo, Napolitano, Luigi, Prezioso, Domenico, Abate, Marco, Mirto, Benito Fabio, Fusco, Ferdinando, and Crocetto, Felice
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- 2024
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24. Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
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Ekanem, Emmanuel, Neuzil, Petr, Reichlin, Tobias, Kautzner, Joseph, van der Voort, Pepijn, Jais, Pierre, Chierchia, Gian-Battista, Bulava, Alan, Blaauw, Yuri, Skala, Tomas, Fiala, Martin, Duytschaever, Mattias, Szeplaki, Gabor, Schmidt, Boris, Massoullie, Grégoire, Neven, Kars, Thomas, Olivier, Vijgen, Johan, Gandjbakhch, Estelle, Scherr, Daniel, Johannessen, Arne, Keane, David, Boveda, Serge, Maury, Philippe, García-Bolao, Ignacio, Anic, Ante, Hansen, Peter Steen, Raczka, Franck, Lepillier, Antoine, Guyomar, Yves, Gupta, Dhiraj, Van Opstal, Jurren, Defaye, Pascal, Sticherling, Christian, Sommer, Philipp, Kucera, Pavel, Osca, Joaquin, Tabrizi, Fariborz, Roux, Antoine, Gramlich, Michael, Bianchi, Stefano, Adragão, Pedro, Solimene, Francesco, Tondo, Claudio, Russo, Antonio Dello, Schreieck, Jürgen, Luik, Armin, Rana, Obaida, Frommeyer, Gerrit, Anselme, Frédéric, Kreis, Ingo, Rosso, Raphael, Metzner, Andreas, Geller, Laszlo, Baldinger, Samuel H., Ferrero, Angel, Willems, Stephan, Goette, Andreas, Mellor, Greg, Mathew, Shibu, Szumowski, Lukasz, Tilz, Roland, Iacopino, Saverio, Jacobsen, Peter Karl, George, Andrikopoulos, Osmancik, Pavel, Spitzer, Stefan, Balasubramaniam, Richard, Parwani, Abdul Shokor, Deneke, Thomas, Glowniak, Andrzej, Rossillo, Antonio, Pürerfellner, Helmut, Duncker, David, Reil, Peter, Arentz, Thomas, Steven, Daniel, Olalla, Juan José, de Jong, Jonas S. S. G., Wakili, Reza, Abbey, Selim, Timo, Gottschling, Asso, Antonio, Wong, Tom, Pierre, Bertrand, Ewertsen, Niels Christian, Bergau, Leonard, Lozano-Granero, Cristina, Rivero, Maximo, Breitenstein, Alexander, Inkovaara, Jaakko, Fareh, Samir, Latcu, Decebal Gabriel, Linz, Dominik, Müller, Patrick, Ramos-Maqueda, Javier, Beiert, Thomas, Themistoclakis, Sakis, Meininghaus, Dirk Grosse, Stix, Günter, Tzeis, Stylianos, Baran, Jakub, Almroth, Henrik, Munoz, Daniel Rodriguez, de Sousa, João, Efremidis, Michalis, Balsam, Pawel, Petru, Jan, Küffer, Thomas, Peichl, Petr, Dekker, Lukas, Della Rocca, Domenico G., Moravec, Ondrej, Funasako, Moritoshi, Knecht, Sebastien, Jauvert, Gael, Chun, Julian, Eschalier, Romain, Füting, Anna, Zhao, Alexandre, Koopman, Pieter, Laredo, Mikael, Manninger, Martin, Hansen, Jim, O’Hare, Daniel, Rollin, Anne, Jurisic, Zrinka, Fink, Thomas, Chaumont, Corentin, Rillig, Andreas, Gunawerdene, Melanie, Martin, Claire, Kirstein, Bettina, Nentwich, Karin, Lehrmann, Heiko, Sultan, Arian, Bohnen, Jan, Turagam, Mohit K., and Reddy, Vivek Y.
- Abstract
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K study we assessed the safety of PFA by studying the post-approval use of this treatment modality. Of the 116 centers performing post-approval PFA with a pentaspline catheter, data were received from 106 centers (91.4% participation) regarding 17,642 patients undergoing PFA (mean age 64, 34.7% female, 57.8% paroxysmal AF and 35.2% persistent AF). No esophageal complications, pulmonary vein stenosis or persistent phrenic palsy was reported (transient palsy was reported in 0.06% of patients; 11 of 17,642). Major complications, reported for ~1% of patients (173 of 17,642), were pericardial tamponade (0.36%; 63 of 17,642) and vascular events (0.30%; 53 of 17,642). Stroke was rare (0.12%; 22 of 17,642) and death was even rarer (0.03%; 5 of 17,642). Unexpected complications of PFA were coronary arterial spasm in 0.14% of patients (25 of 17,642) and hemolysis-related acute renal failure necessitating hemodialysis in 0.03% of patients (5 of 17,642). Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation. PFA has the potential to be transformative for the management of patients with AF.
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- 2024
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25. Caracterización molecular de aislamientos de Listeria monocytogenesde origen humano y alimentario en Argentina, 2018-2023
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Gianecini, Ricardo Ariel, Cipolla, Lucía, Rocca, Florencia, Campos, Josefina, Poklepovich, Tomás, and Prieto, Mónica
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•Clones circulantes de L. monocytogenescon distintos grados de virulencia en Argentina.•Predominio del clon hipervirulento CC1 en muestras de humanos y alimentos.•Identificación de aislamientos con elevada y posible relación epidemiológica.
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- 2024
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26. Byzantine-robust federated learning performance evaluation via distance-statistical aggregations
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Harguess, Joshua D., Bastian, Nathaniel D., Pace, Teresa L., Colosimo, Francesco, and Rocca, Giovanni
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- 2024
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27. The IMP research on business networks: a systematic literature review and research agenda
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Guercini, Simone, Rocca, Antonella La, and Perna, Andrea
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More than 40 years of Industrial Marketing and Purchasing (IMP) research have revealed that in b2b markets, business exchange is carried out in continuous buyer–seller relationships. This involves direct and indirect interaction and dynamics resulting in significant related social and material investments and in extensive interdependencies that confer on the business landscape a market-as-network structure. Since the introduction of this ideas, research on business networks has been richly alimented by researchers of the IMP community. Yet, we do not have a clear overview of what this literature has covered in the last twenty years (in the period 2002–2022), in parallel with the many changes that have affected business landscape. With this study, we aim to examine what is the status of the last 20 years of IMP literature specifically dealing with thebusiness networks level of analysis (45 articles) and to offer key directions for imminent research in this domain while analyzing and synthesizing extant literature.
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- 2024
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28. Older Tissue Age Derived From Abdominal Computed Tomography Biomarkers of Muscle, Fat, and Bone Is Associated With Chronic Conditions and Higher Mortality
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Rule, Andrew D., Grossardt, Brandon R., Weston, Alexander D., Garner, Hillary W., Kline, Timothy L., Chamberlain, Alanna M., Allen, Alina M., Erickson, Bradley J., Rocca, Walter A., and St. Sauver, Jennifer L.
- Abstract
To determine whether body composition derived from medical imaging may be useful for assessing biologic age at the tissue level because people of the same chronologic age may vary with respect to their biologic age.
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- 2024
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29. Spatial correspondence among regional gene expressions and gray matter volume loss in multiple sclerosis
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Preziosa, Paolo, Storelli, Loredana, Tedone, Nicolò, Margoni, Monica, Mistri, Damiano, Azzimonti, Matteo, Filippi, Massimo, and Rocca, Maria A.
- Abstract
In multiple sclerosis (MS), a non-random and clinically relevant pattern of gray matter (GM) volume loss has been described. Whether differences in regional gene expression might underlay distinctive pathological processes contributing to this regional variability has not been explored yet. Two hundred eighty-six MS patients and 172 healthy controls (HC) underwent a brain 3T MRI, a complete neurological evaluation and a neuropsychological assessment. Using Allen Human Brain Atlas, voxel-based morphometry and MENGA platform, we integrated brain transcriptome and neuroimaging data to explore the spatial cross-correlations between regional GM volume loss and expressions of 2710 genes involved in MS (p< 0.05, family-wise error-corrected). Enrichment analyses were performed to evaluate overrepresented molecular functions, biological processes and cellular components involving genes significantly associated with voxel-based morphometry-derived GM maps (p< 0.05, Bonferroni-corrected). A diffuse GM volume loss was found in MS patients compared to HC and it was spatially correlated with 74 genes involved in GABA neurotransmission and mitochondrial oxidoreductase activity mainly expressed in neurons and astrocytes. A more severe GM volume loss was spatially associated, in more disabled MS patients, with 44 genes involved in mitochondrial integrity of all resident cells of the central nervous system (CNS) and, in cognitively impaired MS patients, with 64 genes involved in mitochondrial protein heterodimerization and oxidoreductase activities expressed also in microglia and endothelial cells. Specific differences in the expressions of genes involved in synaptic GABA receptor activities and mitochondrial functions in resident CNS cells may influence regional susceptibility to MS-related excitatory/inhibitory imbalance and oxidative stress, and subsequently, to GM volume loss.
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- 2024
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30. REPERTI LIGURI DI SAGA PEDO (PALLAS) E NOTE SULL’ALLEVAMENTO DI UNA NINFA (ORTHOPTERA, TETTIGONIIDAE)
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Galli, Loris, Rocca, Giuliano, and BioStor
- Published
- 2006
31. Bayesian data fusion approach for InSAR and topographic bridge displacement monitoring
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Glisic, Branko, Limongelli, Maria Pina, Ng, Ching Tai, Tonelli, Daniel, Zini, Mattia, Simeoni, Lucia, Rocca, Alfredo, Perissin, Daniele, Costa, Carlo, Quattrociocchi, David, and Zonta, Daniele
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- 2024
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32. External Quality Assessment (EQA) scheme for serological diagnostic test for SARS-CoV-2 detection in Sicily Region (Italy), in the period 2020–2022
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Di Gaudio, Francesca, Brunacci, Giuseppina, Cucina, Annamaria, Giaccone, Vita, Raso, Maria, Lundari, Anna, Cancilleri, Antonio, Buffa, Vito, Russo, Eleonora, Vasto, Sonya, La Rocca, Mario, and Indelicato, Sergio
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- 2024
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33. Peptide receptor radionuclide therapy with 177Lu- or 90Y-SSTR peptides in malignant pheochromocytomas (PCCs) and paragangliomas (PGLs): results from a single institutional retrospective analysis
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Rubino, Manila, Di Stasio, Giuseppe Danilo, Bodei, Lisa, Papi, Stefano, Rocca, Paola Anna, Ferrari, Mahila Esmeralda, Fodor, Cristiana Iuliana, Bagnardi, Vincenzo, Frassoni, Samuele, Mei, Riccardo, Fazio, Nicola, Ceci, Francesco, and Grana, Chiara Maria
- Abstract
Background: Malignant pheochromocytomas (PCCs) and paragangliomas (PGLs) are rare tumors and available systemic therapies are limited. Aim: To explore the role of peptide receptor radionuclide therapy (PRRT) with Yttrium-90 (
90 Y) and Lutetium-177 (177 Lu) peptides in pheochromocytomas (PCCs) and paragangliomas (PGLs). Methods: We retrospectively analyzed more than 1500 patients with histologically proven neuroendocrine tumors treated with177 Lu- or90 Y-DOTA-TATE or –TOC between 1999 to 2017 at our Institute. Overall, 30 patients with confirmed malignant PCCs and PGLs matched inclusion/exclusion criteria and were considered eligible for this analysis. Results: Thirty (n= 30) patients were treated: 22 with PGLs and 8 with PCCs (12 M and 18 F, median age 47 [IQR: 35–60 years]). Eighteen patients (n= 18) had head and neck PGLs, 3 patients thoracic PGLs and 1 patient abdominal PGL. Sixteen patients (53%) had locally advanced and fourteen (47%) had metastatic disease. Twenty-seven (90%) patients had disease progression at baseline. Four (13%) patients were treated with90 Y, sixteen (53%) with177 Lu and ten (33%) with90 Y +177 Lu respectively. The median total cumulative activity from treatment with90 Y- alone was 9.45 GBq (range 5.11–14.02 GBq), from177 Lu- alone was 21.9 GBq (7.55–32.12 GBq) and from the combination treatment was 4.94 GBq from90 Y- and 6.83 GBq from177 Lu- (ranges 1.04–10.1 and 2.66–20.13 GBq, respectively). Seven out of 30 (23%) patients had partial response and 19 (63%) stable disease. Median follow up was 8.9 years (IQR: 2.9–12). The 5-y and 10-y PFS was 68% (95% CI: 48–82) and 53% (95% CI: 33–69), respectively, whereas 5-y and 10-y OS was 75% (95% CI: 54–87) and 59% (95% CI: 38–75), respectively. Grade 3 or 4 acute hematological toxicity occurred in three patients, two with leucopenia and one with thrombocytopenia, respectively. Conclusion: PRRT with177 Lu- or90 Y-DOTA-TATE or –TOC is feasible and well tolerated in advanced PGLs and PCCs.- Published
- 2024
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34. Daily low-dose tadalafil may reduce the penile curvature progression rate in patients with acute Peyronie’s disease: a retrospective comparative analysis
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Spirito, Lorenzo, Manfredi, Celeste, La Rocca, Roberto, Napolitano, Luigi, Di Girolamo, Antonio, Capece, Marco, Trama, Francesco, Sciorio, Carmine, Sokolakis, Ioannis, Creta, Massimiliano, and Arcaniolo, Davide
- Abstract
The aim of this study was to evaluate the clinical outcomes of patients in acute phase of Peyronie’s disease (PD) treated with daily low-dose of Tadalafil. An observational retrospective study involving patients in acute phase of PD with erectile dysfunction (ED) was designed. All subjects were offered Tadalafil 5 mg one tablet a day. Men who accepted treatment were compared to patients who refused Tadalafil. Penile curvature progression was chosen as the primary outcome. PD Questionnaire (PDQ) and IIEF-5 scores were selected as secondary outcomes. A total of 191 patients were included in the study (108 intervention vs. 83 control). Penile curvature progression rate was significantly lower in subjects taking Tadalafil at 12 weeks (25.9% vs. 39.7%, p= 0.042). Mean IIEF-5 score improved in the intervention group, becoming significantly higher compared to the observation group at 12 weeks (19.3 vs. 11.2 points, p< 0.001). Mean PDQ-Overall and PDQ-Penile Pain scores only improved in the intervention group and the statistically significant differences at baseline between groups became not statistically significant at 12 weeks (p= 0.001 vs. p= 0.232 and p< 0.001 vs. p= 0.078, respectively). Daily low-dose Tadalafil in patients with acute phase of PD seems to significantly reduce the penile curvature progression rate compared to observation, especially when it is administrated early. It also appears to improve erectile function and PD-related symptoms.
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- 2024
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35. Acute Kidney Injury Resulting From Hemoglobinuria After Pulsed-Field Ablation in Atrial Fibrillation
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Mohanty, Sanghamitra, Casella, Michela, Compagnucci, Paolo, Torlapati, Prem Geeta, Della Rocca, Domenico Giovanni, La Fazia, Vincenzo Mirco, Gianni, Carola, Chierchia, Gian-Battista, MacDonald, Bryan, Mayedo, Angel, Khan, Umer N., Allison, John, Bassiouny, Mohamed, Gallinghouse, G. Joseph, Burkhardt, John D., Horton, Rodney, Al-Ahmad, Amin, Di Biase, Luigi, de Asmundis, Carlo, Russo, Antonio Dello, and Natale, Andrea
- Abstract
High-voltage pulses can cause hemolysis.
- Published
- 2024
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36. New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2023
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Tamargo, Juan, Agewall, Stefan, Borghi, Claudio, Ceconi, Claudio, Cerbai, Elisabetta, Dan, Gheorghe A, Ferdinandy, Péter, Grove, Erik Lerkevang, Rocca, Bianca, Magavern, Emma, Sulzgruber, Patrick, Semb, Anne Grete, Sossalla, Samuel, Niessner, Alexander, Kaski, Juan Carlos, and Dobrev, Dobromir
- Abstract
Although cardiovascular diseases (CVDs) are the leading cause of death worldwide, their pharmacotherapy remains suboptimal. Thus, there is a clear unmet need to develop more effective and safer pharmacological strategies. In this review, we summarize the most relevant advances in cardiovascular pharmacology in 2023, including the approval of first-in-class drugs that open new avenues for the treatment of atherosclerotic CVD and heart failure (HF). The new indications of drugs already marketed (repurposing) for the treatment of obstructive hypertrophic cardiomyopathy, hypercholesterolaemia, type 2 diabetes, obesity, and HF; the impact of polypharmacy on guideline-directed drug use is highlighted as well as results from negative clinical trials. Finally, we end with a summary of the most important phase 2 and 3 clinical trials assessing the efficacy and safety of cardiovascular drugs under development for the prevention and treatment of CVDs.
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- 2024
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37. «Les meilleurs joueurs sont plutôt intelligents».
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Rocca, Federico
- Published
- 2024
38. Development of widefield time-resolved fluorescence anisotropy imaging (TR-FAIM) using a single photon avalanche diode (SPAD) array
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Periasamy, Ammasi, So, Peter T. C., König, Karsten, Obeid Mogridge, Louis, Nedbal, Jakub, Awale, Shirwa, Tallis, Jess, Johnston, Emily J., Mattioli Della Rocca, Francesco, Rosser, Susan J., Henderson, Robert K., and Suhling, Klaus
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- 2024
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39. The Method of Metaphysics and the Architectonic: Remarks on Gava’s Kant’s Critique of Pure Reason and the Method of Metaphysics
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La Rocca, Claudio
- Abstract
AbstractThe article addresses some aspects of Gava’s book, highlighting two main points: (1) the notion of philosophy in a cosmic sense; (2) its connection with the meaning of the concept of method. Regarding (1) I show how Gava’s interpretation of the systematic concept of philosophy does not account adequately for the scholastic concept. This has consequences for the notion of philosophy in a cosmic sense itself; its nature as an objective archetype and its personification in the ideal of a master of wisdom are not properly emphasized. These features are closely related to Kant’s claim that philosophy cannot be learned, which is connected with Kant’s peculiar idea of method. Regarding (2), I argue that ‘method’ for Kant does not concern only the construction of scientific systems, but also the establishment of a way of thinking, a stance embracing thought and action. The meaning of the postulates and the notion of ‘faith’ thus acquire a ‘weaker’ connotation, as an attitude, habitus, aimed at the establishment and promotion of a ‘life-structuring’ rationality, and not as an alternative route to a theoretical ‘commitment’.
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- 2024
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40. Poly(vinylpyridine-co-vinylpyridine N-oxide) Excipients Mediate Rapid Dissolution and Sustained Supersaturation of Posaconazole Amorphous Solid Dispersions
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Liu, Yu-Sheng, Della Rocca, Joseph, Schenck, Luke, Koynov, Athanas, Sifri, Renee J., Winston, Matthew S., and Frank, Derek S.
- Abstract
The chemical structure of excipients molecularly mixed in an amorphous solid dispersion (ASD) has a significant impact on properties of the ASD including dissolution behavior, physical stability, and bioavailability. Polymers used in ASDs require a balance between hydrophobic and hydrophilic functionalities to ensure rapid dissolution of the amorphous dispersion as well as sustained supersaturation of the drug in solution. This work demonstrates the use of postpolymerization functionalization of poly(vinylpyridine) excipients to elucidate the impact of polymer properties on the dissolution behavior of amorphous dispersions containing posaconazole. It was found that N-oxidation of pyridine functionalities increased the solubility of poly(vinylpyridine) derivatives in neutral aqueous conditions and allowed for nanoparticle formation which supplied posaconazole into solution at concentrations exceeding those achieved by more conventional excipients such as hydroxypropyl methylcellulose acetate succinate (HPMCAS) or Eudragit E PO. By leveraging these functional modifications of the parent poly(vinylpyridine) excipient to increase polymer hydrophilicity and minimize the effect of polymer on pH, a new polymeric excipient was optimized for rapid dissolution and supersaturation maintenance for a model compound.
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- 2024
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41. Pulsed-Field Ablation Does Not Worsen Baseline Pulmonary Hypertension Following Prior Radiofrequency Ablations
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Mohanty, Sanghamitra, Della Rocca, Domenico Giovanni, Torlapati, Prem Geeta, Chierchia, Gian-Battista, Dello Russo, Antonio, Casella, Michela, Gianni, Carola, MacDonald, Bryan, Mayedo, Angel, La Fazia, Vincenzo Mirco, Bassiouny, Mohamed, Gallinghouse, G. Joseph, Burkhardt, John D., Horton, Rodney, Al-Ahmad, Amin, Di Biase, Luigi, Pannone, Luigi, de Asmundis, Carlo, and Natale, Andrea
- Abstract
Studies have reported development of pulmonary hypertension (PH) secondary to reduced LA compliance following AF ablation.
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- 2024
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42. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Day, Jeremy, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Basnyat, B, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Gyanwali, P, Hamers, RL, Huyen, T, Jagne, A, Karkey, A, Kestelyn, E, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Reith, C, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, 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J, Wong, K, Wong, M, Wong, N, Wong, S, Wong, T, Wood, A, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, B, Xia, Z, Y Ellis, T, Yacoba, E, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, W, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, M, Yates, T, Ye, J, Yearwood Martin, C, Yein, K, Yelnoorkar, F, Yeoh, A, Yeung, C, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yu, C, Yuan, J, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-M, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, E, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
- Abstract
Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with usual care on duration of hospital stay for children with PIMS-TS and to compare tocilizumab (anti-IL-6 receptor monoclonal antibody) or anakinra (anti-IL-1 receptor antagonist) with usual care for those with inflammation refractory to initial treatment.
- Published
- 2024
- Full Text
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43. CONTRIBUTIONS TO THE KNOWLEDGE OF SICILIAN FRESHWATER FISHES. II. NOTES ON SOME ALLOCHTHONOUS SP RECENTLY INTRODUCED
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Russo, G, La Rocca, S, Violani, S, Zava, Bruno, and BioStor
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- 1999
44. MEANINGFUL: CONNECTIONS: Promoting students' discourse comprehension
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Rocca, Micaela and Cevasco, Jazmin
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Students ,Education ,General interest - Abstract
Discourse comprehension is central for student learning. It involves the establishment of meaningful connections among text ideas and the activation of background knowledge. Prior studies have suggested that text properties, [...]
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- 2021
45. Yes to More Civics; No to More of the Same.
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Wolfe-Rocca, Ursula
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Civics -- Study and teaching ,Constitutional law -- Study and teaching ,Basic education -- Evaluation - Abstract
Working as a social studies teacher for almost two decades, I have noticed a predictable and perennial pattern. A study is published showing some alarming deficit in the knowledge of [...]
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- 2021
46. Samuel R. Delany as Genre Flaneur: Encountering Science Fiction in Dhalgren
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Rocca, A.J.
- Abstract
ABSTRACT:Samuel R. Delany's Dhalgren (1975) moves through different genres and styles of literature in much the same way that Walter Benjamin's flaneur moves through the spaces of the city. Delany as a writer makes contact with any number of other traditions outside of science fiction, but he expresses no radical desire to revolutionize sf or move it into mainstream literature. Delany does not assimilate or synthesize outside influences into his work so much as he encounters them. In Starboard Wine (1984), his book of sf criticism, Delany defines "encounter" in literature as the interpretation of a text associated with one genre through the reading protocols associated with another. I argue that "encounter" is analogous to "contact," a concept from Delany's Times Square Red, Times Square Blue (1999) that relates to the real, physical interaction of individuals in an urban environment. Nowhere is this convergence of literary encounter and urban contact clearer than in his novel, Dhalgren. Dhalgren uses the city as a conceptual framework for encounters among a diverse array of influences including myth, poetry, autobiography, and literary modernism. These types of encounters are also plentiful in Delany's earlier work, but Dhalgren pushes them to a point where even sf itself is decentered and becomes just one more thing to be met in the space of the city.
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- 2024
47. Modeling contaminant outgassing and free molecular transport processes for the cryogenic SPHEREx observatory
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Alred, John M., Moore, Bradley D., Susca, Sara, Ricchiuti, Valentina, Rocca, Jennifer M., and Soares, Carlos E.
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- 2024
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48. Severity of Ischemic Stroke After Left Atrial Appendage Closure vs Nonwarfarin Oral Anticoagulants
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Turagam, Mohit K., Kawamura, Iwanari, Neuzil, Petr, Nair, Devi, Doshi, Shephal, Valderrabano, Miguel, Hala, Pavel, Della Rocca, Domenico, Gibson, Douglas, Funasako, Moritoshi, Ha, Grace, Lee, Bridget, Musikantow, Daniel, Yoo, David, Flautt, Thomas, Dukkipati, Srinivas, Natale, Andrea, Gurol, Mahmut E., Halperin, Jonathan, Mansour, Moussa, and Reddy, Vivek Y.
- Abstract
Strokes after left atrial appendage closure (LAAC) prophylaxis are generally less severe than those after warfarin prophylaxis—thought to be secondary to more hemorrhagic strokes with warfarin. Hemorrhagic strokes are similarly infrequent with direct oral anticoagulant (DOAC) prophylaxis, so the primary subtype after either LAAC or DOAC prophylaxis is ischemic stroke (IS).
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- 2024
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49. Mobile element insertions in rare diseases: a comparative benchmark and reanalysis of 60,000 exome samples
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Wijngaard, Robin, Demidov, German, O’Gorman, Luke, Corominas-Galbany, Jordi, Yaldiz, Burcu, Steyaert, Wouter, de Boer, Elke, Vissers, Lisenka E. L. M., Kamsteeg, Erik-Jan, Pfundt, Rolph, Swinkels, Hilde, den Ouden, Amber, te Paske, Iris B. A. W., de Voer, Richarda M., Faivre, Laurence, Denommé-Pichon, Anne-Sophie, Duffourd, Yannis, Vitobello, Antonio, Chevarin, Martin, Straub, Volker, Töpf, Ana, van der Kooi, Anneke J., Magrinelli, Francesca, Rocca, Clarissa, Hanna, Michael G., Vandrovcova, Jana, Ossowski, Stephan, Laurie, Steven, and Gilissen, Christian
- Abstract
Mobile element insertions (MEIs) are a known cause of genetic disease but have been underexplored due to technical limitations of genetic testing methods. Various bioinformatic tools have been developed to identify MEIs in Next Generation Sequencing data. However, most tools have been developed specifically for genome sequencing (GS) data rather than exome sequencing (ES) data, which remains more widely used for routine diagnostic testing. In this study, we benchmarked six MEI detection tools (ERVcaller, MELT, Mobster, SCRAMble, TEMP2 and xTea) on ES data and on GS data from publicly available genomic samples (HG002, NA12878). For all the tools we evaluated sensitivity and precision of different filtering strategies. Results show that there were substantial differences in tool performance between ES and GS data. MELT performed best with ES data and its combination with SCRAMble increased substantially the detection rate of MEIs. By applying both tools to 10,890 ES samples from Solve-RD and 52,624 samples from Radboudumc we were able to diagnose 10 patients who had remained undiagnosed by conventional ES analysis until now. Our study shows that MELT and SCRAMble can be used reliably to identify clinically relevant MEIs in ES data. This may lead to an additional diagnosis for 1 in 3000 to 4000 patients in routine clinical ES.
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- 2024
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50. PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey
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Cerbelli, Bruna, Cirillo, Alessio, Pomati, Giulia, Pernazza, Angelina, Ascione, Andrea, Pisegna, Simona, Pisano, Annalinda, Leopizzi, Martina, Pignataro, Maria Gemma, Costarelli, Leopoldo, Mulè, Antonino, Vecchione, Andrea, Catalano, Piera, Coppola, Luigi, Perrone, Giuseppe, Perracchio, Letizia, Anemona, Lucia, Mastracchio, Antonio, Nardi, Stefano, Reitano, Renato, Massari, Annalisa, Grillo, Lucia Rosalba, Liberati, Fabrizio, Della Rocca, Carlo, Marchetti, Paolo, Botticelli, Andrea, and D’Amati, Giulia
- Abstract
Background: Immunotherapy has revolutionized the approach to metastatic triple-negative breast cancers. Atezolizumab was approved for patients with metastatic triple-negative breast cancers whose tumors express PD-L1, determined by SP 142 assay. To assess the availability and practice of SP142 test we administered a survey to all the 15 pathology departments of the Lazio Region during a six-month period.Methods: The survey comprised 12 questions regarding the availability of SP142 in the pathology departments, the percentage of positive tests, the difficulties of pathologists in cases close to cut-off value and the tested samples.Results: The SP142 assay was available in only eight centers. In case of positive result, most centers (5/8, 62.5%) reported values of PD-L1 expression ranging from > 1 to ⩽ 5%, with values close to the cut-off point (⩾ 1% or < 1%) being the greatest challenge. Most of the centers (6/8, 75%) tested material from both their own and other hospitals. In most centers, the evaluations were performed either on primary tumors or metastasis, in particular lymph nodes (5/8, 62.5%), followed by lung (3/8, 37.5%) and liver (1/8, 12.5%) metastasis.Conclusion: Our results raise some important issues concerning the evaluation of PD-L1 in the “real-life” setting, providing strategies for its implementation.
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- 2024
- Full Text
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