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5 results on '"Rutter, Charlotte E"'

1. Risk factors for SARS-CoV-2 infection at a UK electricity-generating company: a test-negative design case-control study

Author

Rutter, Charlotte E, van Tongeren, Martie, Fletcher, Tony, Rhodes, Sarah, Chen, Yiqun, Hall, Ian, Warren, Nicholas, and Pearce, Neil

Abstract

ObjectivesIdentify workplace risk factors for SARS-CoV-2 infection, using data collected by a UK electricity-generating company.MethodsUsing a test-negative design case-control study, we estimated the OR of infection by job category, site, test reason, sex, vaccination status, vulnerability, site outage and site COVID-19 weekly risk rating, adjusting for age, test date and test type.ResultsFrom an original 80 077 COVID-19 tests, there were 70 646 included in the final analysis. Most exclusions were due to being visitor tests (5030) or tests after an individual first tested positive (2968).Women were less likely to test positive than men (OR=0.71; 95% CI 0.58 to 0.86). Test reason was strongly associated with positivity and although not a cause of infection itself, due to differing test regimes by area, it was a strong confounder for other variables. Compared with routine tests, tests due to symptoms were highest risk (94.99; 78.29 to 115.24), followed by close contact (16.73; 13.80 to 20.29) and broader-defined work contact 2.66 (1.99 to 3.56). After adjustment, we found little difference in risk by job category, but some differences by site with three sites showing substantially lower risks, and one site showing higher risks in the final model.ConclusionsIn general, infection risk was not associated with job category. Vulnerable individuals were at slightly lower risk, tests during outages were higher risk, vaccination showed no evidence of an effect on testing positive, and site COVID-19 risk rating did not show an ordered trend in positivity rates.

Published
2024
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2. International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from a population-based cross-sectional disadvantaged populations eGFR epidemiology (DEGREE) study

Author

Rutter, Charlotte E., Njoroge, Mary, Cooper, Phil, Dorairaj, Prabhakaran, Jha, Vivekanand, Kaur, Prabhdeep, Mohan, Sailesh, Tatapudi, Ravi Raju, Biggeri, Annibale, Rohloff, Peter, Hathaway, Michelle H., Crampin, Amelia, Dhimal, Meghnath, Poudyal, Anil, Bernabe-Ortiz, Antonio, O’Callaghan-Gordo, Cristina, Chulasiri, Pubudu, Gunawardena, Nalika, Ruwanpathirana, Thilanga, Wickramasinghe, S.C., Senanayake, Sameera, Kitiyakara, Chagriya, Gonzalez-Quiroz, Marvin, Cortés, Sandra, Jakobsson, Kristina, Correa-Rotter, Ricardo, Glaser, Jason, Singh, Ajay, Hamilton, Sophie, Nair, Devaki, Aragón, Aurora, Nitsch, Dorothea, Robertson, Steven, Caplin, Ben, Pearce, Neil, Aekplakorn, Wichai, Anand, Shuchi, Aragón, Aurora, Bernabe-Ortiz, Antonio, Biggeri, Annibale, Burdmann, Emmanuel, Caplin, Ben, Catelan, Dolores, Chulasiri, Pubudu, Cooper, Philip, Correa-Rotter, Ricardo, Cortés, Sandra, Crampin, Amelia, de Santiago, Melissa, Dhimal, Meghnath, Doccioli, Chiara, Dorairaj, Prabhakaran, Dorevitch, Samuel, Ferreccio, Catterina, Glaser, Jason, Gonzalez-Quiroz, Marvin, Granadillo, Emily, Gualan, Monsermin, Gummidi, Balaji, Gunawardena, Nalika, Hamilton, Sophie, Hathaway, Michelle, Jakobsson, Kristina, Jarhyan, Prashant, Jha, Vivekanand, John, Oomen, Johnson, Richard J., Kaur, Prabhdeep, Kitiyakara, Chagriya, Kongtip, Pornpimol, Kromhout, Hans, Levin, Adeera, Madero, Magdalena, McLean, Estelle, Miranda, J. Jaime, Mkandawire, Joseph, Mohan, Sailesh, Murali, Sharan, Nair, Devaki, Nakanga, Wisdom, Nitsch, Dorothea, Njoroge, Mary, Nyirenda, Moffat, O'Callaghan-Gordo, Cristina, Pearce, Neil, Poudyal, Anil, Prasad, Narayan, Quirós-Alcalá, Lesliam, Remuzzi, Giuseppe, Robertson, Steven, Rohloff, Peter, Romero-Sandoval, Natalia, Ruiz-Alejos, Andrea, Rutter, Charlotte, Ruwanpathirana, Thilanga, Sakthivel, Manikandanesan, Saran, Rajiv, Senanayake, Sameera, Shaw, Leah, Singh, Ajay, Smeeth, Liam, Sotomayor, Camilo, Tatapudi, Ravi Raju, Tuiz, Eva, Venkateshmurthy, Nikhil Srinivasapura, Venugopal, Vidhya, and Wickramasinghe, S.C.

Abstract

The disadvantaged populations eGFR (estimated glomerular filtration rate) epidemiology (DEGREE) study was designed to gain insight into the burden of chronic kidney disease (CKD) of undetermined cause (CKDu) using standard protocols to estimate the general-population prevalence of low eGFR internationally. Therefore, we estimated the age-standardized prevalence of eGFR under 60 ml/min per 1.73m2in adults aged 18-60, excluding participants with commonly known causes of CKD; an ACR (albumin/creatinine ratio) over 300 mg/g or equivalent, or self-reported or measured (HT) hypertension or (DM) diabetes mellitus, stratified by sex and location. We included population-representative surveys conducted around the world that were either designed to estimate CKDu burden or were re-analyses of large surveys. There were 60,964 participants from 43 areas across 14 countries, with data collected 2007- 2023. The highest prevalence was seen in rural men in Uddanam, India (14%) and Northwest Nicaragua (14%). Prevalence above 5% was generally only observed in rural men, with exceptions for rural women in Ecuador (6%) and parts of Uddanam (6%‒8%), and for urban men in Leon, Nicaragua (7%). Outside of Central America and South Asia, prevalence was below 2%. Our observations represent the first attempts to estimate the prevalence of eGFR under 60 without commonly known causes of CKD around the world, as an estimate of CKDu burden, and provide a starting point for global monitoring. It is not yet clear what drives the differences, but available evidence supports a high general-population burden of CKDu in multiple areas within Central America and South Asia, although the possibility that unidentified clusters of disease may exist elsewhere cannot be excluded.

Published
2025
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4. Worldwide trends in the burden of asthma symptoms in school-aged children: Global Asthma Network Phase I cross-sectional study

Author

Asher, M Innes, Rutter, Charlotte E, Bissell, K, Chiang, Chen-Yuan, El Sony, Asma, Ellwood, Eamon, Ellwood, Philippa, García-Marcos, Luis, Marks, Guy B, Morales, Eva, Mortimer, Kevin, Pérez-Fernández, Virginia, Robertson, Steven, Silverwood, Richard J, Strachan, David P, Pearce, Neil, Bissell, Karen, Chiang, Chen-Yuan, Ellwood, Eamon, Ellwood, Philippa, Marks, Guy B, Masekela, Refiloe, Morales, Eva, Mortimer, Kevin, Pearce, Neil, Strachan, David, Ellwood, Philippa, Ellwood, Eamon, Martinez-Torres, Antonela, Morales, Eva, Pérez-Fernández, Virginia, Pearce, Neil, Robertson, Stephen, Rutter, Charlotte, Silverwood, Richard, Strachan, David, Mallol, Javier, Soto-Martínez, Manuel, Cabrera Aguilar, Angelita, Douros, Konstantinos, Sabir, Mohammed, Singh, Meenu, Singh, Virendra, Sukumaran, Thevaruparambil Unny, Awasthi, Shally, Kabra, Sushil Kumar, Salvi, Sundeep, García-Almaráz, Roberto, Mérida-Palacio, J. Valente, Del Río Navarro, Blanca E, González-Díaz, Sandra Nora, Navarrete-Rodriguez, Elsy Maureen, Sánchez, José Félix, Falade, Adegoke G, Zar, Heather J, López-Silvarrey Varela, Angel, González Díaz, Carlos, Nour, Magde, Dib, Gazal, Mohammad, Yousser, Huang, Jing-Long, Chinratanapisit, Sasawan, Soto-Quirós, Manuel E, Vichyanond, Pakit, Aguilar, Pedro, Barba, Sergio, Kumar, Lata, Sharma, S K, Linares-Zapién, Francisco J, Onadeko, Babatunde O, Musa, Omer Abdel Aziz, Aguirre, Viviana, Baeza-Bacab, Manuel, Mohammad, Samira, Cortez, Eliana, Gratziou, Christina H, Chopra, Kamlesh, Hanumante, Neeta Milind, Nelson, Hugo, Rubio, Alfonso Delgado, Hsieh, Kue-Hsiung, and Shah, Jayant

Abstract

Asthma is the most common chronic disease in children globally. The Global Asthma Network (GAN) Phase I study aimed to determine if the worldwide burden of asthma symptoms is changing.

Published
2021
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5. Are Environmental Factors for Atopic Eczema in ISAAC Phase Three due to Reverse Causation?

Author

Rutter, Charlotte E., Silverwood, Richard J., Williams, Hywel C., Ellwood, Philippa, Asher, Innes, Garcia-Marcos, Luis, Strachan, David P., Pearce, Neil, Langan, Sinéad M., Aït-Khaled, N., Anderson, H.R., Asher, M.I., Beasley, R., Björkstén, B., Brunekreef, B., Crane, J., Ellwood, P., Flohr, C., Foliaki, S., Forastiere, F., García-Marcos, L., Keil, U., Lai, C.K.W., Mallol, J., Mitchell, E.A., Montefort, S., Odhiambo, J., Pearce, N., Robertson, C.F., Stewart, A.W., Strachan, D., von Mutius, E., Weiland, S.K., Weinmayr, G., Williams, H.C., Wong, G., Asher, M.I., Clayton, T.O., Ellwood, E., Ellwood, P., Mitchell, E.A., Stewart, A.W., Baena-Cagnani, C.E., Gómez, M., Howitt, M.E., Weyler, J., Pinto-Vargas, R., Petrolera de Salud, Caja, Cunha, A.J. D.A., de Freitas Souza, L., Kuaban, C., Ferguson, A., Rennie, D., Standring, P., Aguilar, P., Amarales, L., Benavides, L.A., Contreras, A., Chen, Y.-Z., Kunii, O., Pan, Q. Li, Zhong, N.-S., Aristizábal, G., Cepeda, A.M., Ordoñez, G.A., Bustos, C., Riikjärv, M.-A., Melaku, K., Sa’aga-Banuve, R., Pekkanen, J., Hypolite, I.E., Novák, Z., Zsigmond, G., Awasthi, S., Bhave, S., Hanumante, N.M., Jain, K.C., Joshi, M.K., Mantri, S.N., Pherwani, A.V., Rego, S., Sabir, M., Salvi, S., Setty, G., Sharma, S.K., Singh, V., Sukumaran, T., Suresh Babu, P.S., Kartasasmita, C.B., Konthen, P., Suprihati, W., Masjedi, M.R., Steriu, A., Koffi, B.N., Odajima, H., al-Momen, J.A., Imanalieva, C., Kudzyte, J., Quah, B.S., Teh, K.H., Montefort, S., Baeza-Bacab, M., Barragán-Meijueiro, M., Del-Río-Navarro, B.E., García-Almaráz, R., González-Díaz, S.N., Linares-Zapién, F.J., Merida-Palacio, J.V., Ramírez-Chanona, N., Romero-Tapia, S., Romieu, I., Bouayad, Z., Asher, M.I., MacKay, R., Moyes, C., Pattemore, P., Pearce, N., Onadeko, B.O., Cukier, G., Chiarella, P., Cua-Lim, F., Brêborowicz, A., Solé, D., Sears, M., Aguirre, V., Barba, S., Shah, J., Baratawidjaja, K., Nishima, S., de Bruyne, J., Tuuau-Potoi, N., Lai, C.K., Lee, B.W., El Sony, A., and Anderson, R.

Abstract

Some previously described environmental associations for atopic eczema may be due to reverse causation. We explored the role of reverse causation by comparing individual- and school-level results for multiple atopic eczema risk factors. The International Study of Asthma and Allergies in Childhood (i.e, ISAAC) Phase Three surveyed children in schools (the sampling unit) regarding atopic eczema symptoms and potential risk factors. We assessed the effect of these risk factors on atopic eczema symptoms using mixed-effect logistic regression models, first with individual-level exposure data and second with school-level exposure prevalence. Overall, 546,348 children from 53 countries were included. At ages 6–7 years, the strongest individual-level associations were with current paracetamol use (odds ratio [OR] = 1.45, 95% confidence interval [CI] = 1.37–1.54), which persisted at school-level (OR = 1.55, 95% CI = 1.10–2.21), early-life antibiotics (OR = 1.41, 95% CI = 1.34–1.48), and early-life paracetamol use (OR = 1.28, 95% CI = 1.21–1.36), with the former persisting at the school level, whereas the latter was no longer observed (OR = 1.35, 95% CI = 1.00–1.82 and OR = 0.94, 95% CI = 0.69–1.28, respectively). At ages 13–14 years, the strongest associations at the individual level were with current paracetamol use (OR = 1.57, 95% CI = 1.51–1.63) and open-fire cooking (OR = 1.46, 95% CI = 1.33–1.62); both were stronger at the school level (OR = 2.57, 95% CI = 1.84–3.59 and OR = 2.38, 95% CI = 1.52–3.73, respectively). Association with exposure to heavy traffic (OR = 1.31, 95% CI = 1.27–1.36) also persisted at the school level (OR = 1.40, 95% CI = 1.07–1.82). Most individual- and school-level effects were consistent, tending to exclude reverse causation.

Published
2019
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