Search

Your search keyword '"Sánchez, Laura"' showing total 92 results
Start Over Author "Sánchez, Laura" Publication Type Magazines
92 results on '"Sánchez, Laura"'

1. The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells

Author

López-Gil, Juan Carlos, García-Silva, Susana, Ruiz-Cañas, Laura, Navarro, Diego, Palencia-Campos, Adrián, Giráldez-Trujillo, Antonio, Earl, Julie, Dorado, Jorge, Gómez-López, Gonzalo, Monfort-Vengut, Ana, Alcalá, Sonia, Gaida, Matthias M, García-Mulero, Sandra, Cabezas-Sáinz, Pablo, Batres-Ramos, Sandra, Barreto, Emma, Sánchez-Tomero, Patricia, Vallespinós, Mireia, Ambler, Leah, Lin, Meng-Lay, Aicher, Alexandra, García García de Paredes, Ana, de la Pinta, Carolina, Sanjuanbenito, Alfonso, Ruz-Caracuel, Ignacio, Rodríguez-Garrote, Mercedes, Guerra, Carmen, Carrato, Alfredo, de Cárcer, Guillermo, Sánchez, Laura, Nombela-Arrieta, César, Espinet, Elisa, Sanchez-Arevalo Lobo, Víctor Javier, Heeschen, Christopher, and Sainz, Bruno

Abstract

ObjectivePancreatic ductal adenocarcinoma (PDAC) has limited therapeutic options, particularly with immune checkpoint inhibitors. Highly chemoresistant ‘stem-like’ cells, known as cancer stem cells (CSCs), are implicated in PDAC aggressiveness. Thus, comprehending how this subset of cells evades the immune system is crucial for advancing novel therapies.DesignWe used the KPC mouse model (LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre) and primary tumour cell lines to investigate putative CSC populations. Transcriptomic analyses were conducted to pinpoint new genes involved in immune evasion. Overexpressing and knockout cell lines were established with lentiviral vectors. Subsequent in vitrococulture assays, in vivomouse and zebrafish tumorigenesis studies, and in silicodatabase approaches were performed.ResultsUsing the KPC mouse model, we functionally confirmed a population of cells marked by EpCAM, Sca-1 and CD133 as authentic CSCs and investigated their transcriptional profile. Immune evasion signatures/genes, notably the gene peptidoglycan recognition protein 1 (PGLYRP1), were significantly overexpressed in these CSCs. Modulating PGLYRP1 impacted CSC immune evasion, affecting their resistance to macrophage-mediated and T-cell-mediated killing and their tumourigenesis in immunocompetent mice. Mechanistically, tumour necrosis factor alpha (TNFα)-regulated PGLYRP1 expression interferes with the immune tumour microenvironment (TME) landscape, promoting myeloid cell-derived immunosuppression and activated T-cell death. Importantly, these findings were not only replicated in human models, but clinically, secreted PGLYRP1 levels were significantly elevated in patients with PDAC.ConclusionsThis study establishes PGLYRP1 as a novel CSC-associated marker crucial for immune evasion, particularly against macrophage phagocytosis and T-cell killing, presenting it as a promising target for PDAC immunotherapy.

Published
2024
Full Text
View/download PDF

3. A methodology to assess and select seismic fragility curves: Application to the case of Costa Rica

Author

Navas-Sánchez, Laura, Jiménez-Martínez, Maribel, González-Rodrigo, Beatriz, Hernández-Rubio, Orlando, Dávila-Migoya, Luis Diego, Orta-Rial, Belén, and Hidalgo-Leiva, Diego

Abstract

Different seismic risk studies have been carried out in the Central American region to quantify the human and economic losses caused by seismic events. The appropriate use of seismic fragility curves (FCs) allows a better approximation of the level of performance of a structural system in the face of seismic hazards. In this respect, an inadequate selection of FCs can lead to a notably unreliable estimation of damages and losses. This research contributes a methodology for assessing and selecting FCs for seismic risk studies from a catalog of existing proposals available in the literature. The methodology has been applied to the case study of Costa Rica, encompassing a bibliographic search, meetings with Central American experts, and the compilation of a catalog with the FCs used in different vulnerability projects. The conclusion drawn is that FCs with very different probabilities of damage are being used in the diverse vulnerability projects for buildings with the same attributes. Moreover, the proposed methodology allows knowing the reliability level of the FCs obtained depending on which class the curve was classified into based on its score. Therefore, it allows the adequacy and uncertainty related to the selected FCs to be established, a subject that researchers should consider in seismic vulnerability and risk studies.

Published
2023
Full Text
View/download PDF

6. Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes

Author

Sarafidis, Pantelis, Agarwal, Rajiv, Pitt, Bertram, Wanner, Christoph, Filippatos, Gerasimos, Boletis, John, Tuttle, Katherine R., Ruilope, Luis M., Rossing, Peter, Toto, Robert, Anker, Stefan D., Liu, Zhi-Hong, Joseph, Amer, Ahlers, Christiane, Brinker, Meike, Lawatscheck, Robert, Bakris, George, Aizenberg, Diego, Bartolacci, Inés, Besada, Diego, Bittar, Julio, Chahin, Mariano, Elbert, Alicia, Gelersztein, Elizabeth, Liberman, Alberto, Maffei, Laura, Manghi, Federico Pérez, Sanabria, Hugo, Vallejos, Augusto, Viñes, Gloria, Wassermann, Alfredo, Abhayaratna, Walter, Acharya, Shamasunder, Ekinci, Elif, Lee, Darren, MacIsaac, Richard, Mah, Peak Mann, Nelson, Craig, Packham, David, Pape, Alexia, Roger, Simon, Stephenson, Hugo, Suranyi, Michael, Wittert, Gary, Vale, Elizabeth, Colman, Peter, Colquhoun, David, Ellis, Chris, Joshua, Kim, Pedagogos, Eugenia, Regal, Paul, Topliss, Duncan, Vandeleur, James, Verjans, Johan, Wittert, Gary, Wynne, Katie-Jane, Clodi, Martin, Ebenbichler, Christoph, Fliesser-Görzer, Evelyn, Hanusch, Ursula, Krebs, Michael, Lhotta, Karl, Ludvik, Bernhard, Mayer, Gert, Neudorfer, Peter, Paulweber, Bernhard, Prager, Rudolf, Preiß, Wolfgang, Prischl, Friedrich, Schernthaner, Gerit-Holger, Sourij, Harald, Wiesholzer, Martin, Drexel, Heinz, Oberbauer, Rainer, Schönherr, Hans-Robert, Doubel, Peter, Engelen, Wendy, Gillard, Pieter, Hougardy, Jean-Michel, Krzesinski, Jean-Marie, Maes, Bart, Speeckaert, Marijn, Stas, Koen, van Gaal, Luc, Vanbelleghem, Hilde, Duyck, Francis, Scheen, André, Antunes, Daniela, Botelho, Roberto, Brito, Claudia, Canani, Luis, Canziani, Maria Eugenia, Cerqueira, Maria, de Paula, Rogerio, Eliaschewitz, Freddy, Figueiredo, Carlos Eduardo, Forti, Adriana, Hissa, Miguel, Leite, Emerson Lima Maurilo, Noronha, Irene, Paolino, Bruno, Paschoalin, Nathalia, Paschoalin, Raphael, Filho, Roberto Pecoits, Pereira, Marcio, Portes, Evandro, Precoma, Dalton, Rea, Rosangela, Riella, Miguel, Salles, Joao Eduardo, Vasconcellos, Eduardo, Vencio, Sergio, Bacci, Marcelo, Maia, Lilia, Villacorta, Aline, Apostolova, Emiliya, Boshnyashka, Radostina, Farah, Ghassan, Georgiev, Dimitar, Gushterova, Valentina, Klyuchkova, Neli, Lucheva, Mariya, Manova, Petya, Minkova, Dotska, Nonchev, Boyan, Pichmanova, Mariyana, Prakova, Zhulieta, Rangelov, Rangel, Rashkov, Rosen, Stanchev, Pavel, Stoyanovska-Elencheva, Bilyana, Tagarev, Zhivko, Temelkova-Kurktschieva, Theodora, Vasileva, Svetla, Yoncheva-Mihaylova, Mariana, Marinchev, Angel, Miteva, Mariya, Barre, Paul, Carlson, Brian, Conway, James, Cournoyer, Serge, Dumas, Richard, Fikry, Sameh, Goluch, Richard, Hamet, Pavel, Hart, Randolph, Henein, Sam, Liutkus, Joanne, Madore, Francois, Martinho, Valdemar, Mazza, Giuseppe, McFarlane, Philip, Keefe, Dennis O′, Peterson, Sean, Schwartz, Daniel, Shu, Daniel, Steele, Andrew, Tellier, Guy, Tennankore, Karthik, Tobe, Sheldon, Tsoukas, George, Tytus, Richard, Vitou, Louise, Walsh, Michael, Weisnagel, Stanley, Wilderman, Igor, Yale, Jean-Francois, El Boreky, Fadia, Kelly, Alan, Leiter, Lawrence, Teitelbaum, Ivor, Cobos, Jorge, Godoy, Juan, González, Fernando, Lobos, Sergio, Palma, Juan Carlos, Prieto Dominguez, Juan Carlos, Reyes, Eliana, Romero, Carmen, Saavedra, Victor, Vega, Mario, Medina, Marcelo, Varleta, Paola, Bu, Ruifang, Cai, Hanqing, Chen, Nan, Chen, Qinkai, Chen, Dejun, Cheng, Jinluo, Dong, Youping, Dong, Junwu, Guan, Tianjun, Hao, Chuanming, Huang, Wen, Jiang, Fangfang, Lei, Minxiang, Li, Ling, Li, Zhonghe, Li, Xuemei, Li, Jingmei, Li, Yan, Liang, Xinling, Liang, Bo, Liu, Fang, Liu, Yinghong, Liu, Yuantao, Liu, Zhihong, Long, Gang, Lu, Guoyuan, Lu, Weiping, Lu, Yibing, Luo, Ping, Ma, Jianhua, Mo, Zhaohui, Niu, Jianying, Peng, Ai, Shen, Jiansong, Shen, Feixia, Shi, Bingyin, Su, Qing, Sun, Zhuxing, Tang, Shuifu, Tong, Nanwei, Wang, Hao, Wang, Xinjun, Wang, Guixia, Wang, Jianqin, Wang, Yangang, Wang, Li, Wei, Jiali, Wu, Tianfeng, Wu, Chaoqing, Xing, Changying, Xiong, Fei, Xu, Xudong, Xu, Ning, Yan, Tiekun, Yang, Jinkui, Yin, Aiping, Zeng, Longyi, Zhang, Hao, Zhang, Yanlin, Zhang, Ying, Zhao, Wenjing, Zhao, Zhiquan, Zheng, Hongguang, Zhong, Ling, Zhu, Dalong, Zhuang, Yongze, Du, Yuming, Fang, Yi, Guo, Weiying, Jiang, Sheng, Kuang, Jian, Li, Dongmei, Li, Hongmei, Li, Yinan, Li, Yuxiu, Liu, Jian, Liu, Yu, Miao, Heng, Peng, Wen, Wang, Lihua, Xu, Mingtong, Zhong, Liyong, Zhu, Jun, Arango, Clara, Barrera, Sandra, López, Nelly Beltrán, Benitez, Diego, Blanco, Guillermo, Cadena, Andrés, Coronel, Julian, Cure, Carlos, Durán, Carlos, González, Alexander, Guzmán, Gustavo, Hernández, Eric, Ibarra, Jaime, Jaramillo, Carlos, Jaramillo, Nicolás, Kattah, William, Molina, Dora, Sánchez, Gregorio, Terront, Mónica, Trujillo, Freddy, Urina, Miguel, Vargas, Ruben, Villegas, Iván, Yupanqui, Hernán, Arcos, Edgar, Aroca, Gustavo, Barreto, Germán, Bermudez, Andres, Botero, Rodrigo, Cárdenas, Tatiana, Figueroa, Wilmer, Jaramillo, Mónica, Liévano, Manuel, López, Mónica, Molina, Dora, Rosero, Ricardo, Trillos, Pedro, Alferi, Dino, Brada, Michal, Brezina, Jiri, Bucek, Petr, Edelsberger, Tomas, Gulakova, Drahomira, Zapletalova, Jitka Hasalova, Hola, Olga, Hornova, Lucie, Houdova, Jana, Hrmova, Helena, Karasek, David, Kopecka, Sarka, Kovar, Richard, Krcova, Eva, Kuchar, Jiri, Kutejova, Vlasta, Lubanda, Hana, Matyasek, Ivo, Mokrejsova, Magdalena, Okenka, Libor, Prazny, Martin, Pumprla, Jiri, Tomanek, Pavel, Andersen, Ulla, Andries, Alin, Bech, Jesper, Faber, Jens, Gislason, Gunnar, Hangaard, Jørgen, Pacyk, Grzegorz Jaroslaw, Juhl, Claus, Krarup, Thure, Lindhardt, Morten, Madsbad, Sten, Nielsen, Joan, Pedersen-Bjergaard, Ulrik, Poulsen, Per, Rasmussen, Ole, Rossing, Peter, Schousboe, Karoline, Gram, Jeppe, Lauridsen, Thomas, Pedersen, Erling, Thorsteinsson, Birger, Flöjt, Päivi, Honkasalo, Mikko, Honkasalo, Mikko, Humaloja, Kari, Kananen, Kristiina, Kantola, Ilkka, Koistinen, Arvo, Korsoff, Pirkko, Lahtela, Jorma, Nieminen, Sakari, Nieminen, Tuomo, Sadeharju, Karita, Strand, Jorma, Sulosaari, Sakari, Cariou, Bertrand, Chantrel, François, Clavel, Sylvaine, Combe, Christian, Fauvel, Jean-Pierre, Gallouj, Karim, Gouet, Didier, Guerci, Bruno, Guerrot, Dominique, Hourmant, Maryvonne, Klein, Alexandre, Mariat, Christophe, Marre, Michel, Mesbah, Rafik, Le Meur, Yannick, Monier, Arnaud, Moranne, Olivier, Roussel, Ronan, Serusclat, Pierre, Vendrely, Benoit, Verges, Bruno, Zaoui, Philippe, Axthelm, Christoph, Bergmann, Andreas, Birkenfeld, Andreas L., Braun, Hermann, Busch, Klaus, Contzen, Christel, Degenhardt, Stefan, Derwahl, Karl, Giebel, Thomas, Hagenow, Andreas, Haller, Hermann, Hasslacher, Christoph, Horacek, Thomas, Jungmair, Wolfgang, Kloos, Christof, Koch, Thorsten, Krüger, Thilo, Mühlfeld, Anja, Müller, Joachim, Pfützner, Andreas, Pistrosch, Frank, Rinke, Andrea, Rose, Ludger, Rump, Lars, Schettler, Volker, Schiefke, Ingolf, Schlichthaar, Heike, Schröppel, Bernd, Schöll, Norbert, Schubert, Kristin, Schürholz, Thomas, Sigal, Helena, Stemler, Lutz, Strack, Georg, Täschner, Heidrun, Toursarkissian, Nicole, Tschöpe, Diethelm, Ulmer, Achim, van der Giet, Markus, Wanner, Christoph, Winkelmann, Bernhard R., Boletis, Ioannis, Dimitriadis, George, Hatziagelaki, Erifili, Iatrou, Christos, Ioannidis, Ioannis, Kounadi, Theodora, Makriniotou, Ioanna, Papadopoulou, Dorothea, Papagianni, Aikaterini, Passadakis, Ploumis, Piaditis, George, Stefanidis, Ioannis, Ip, Tai Pang, Lee, Paul, Andrea Luk, On Yan, Ma, Ronald, Chow, Wing Sun, Wang, Angela, Yeung, Vincent, Bajcsi, Dora, Danos, Peter, Harcsa, Eleonora, Kalina, Akos, Kazup, Szilvia, Keltai, Katalin, Kirschner, Robert, Kiss, Julianna, Kovacs, Laszlo, Lamboy, Beata, Literati-Nagy, Botond, Mileder, Margit, Nagy, Laszlo, Noori, Ebrahim, Nyirati, Gabor, Petro, Gizella, Schneider, Karoly, Simon, Judit, Szocs, Albert, Vasas, Szilard, Wudi, Krisztina, Zilahi, Zsolt, Zsom, Marianna, Eustace, Joe, Holian, John, Reddan, Donal, Meara, Yvonne O′, Abramof Ness, Rosane, Adawi, Faiad, Armaly, Zaher, Atar, Shaul, Bashkin, Amir, Ben Chetrit, Sydney, Yanay, Noa Berar, Chernin, Gil, Darawsha, Mahmud, Efrati, Shai, Elias, Mazen, Farber, Evgeny, Glandt, Mariela, Grossman, Ehud, Halabi, Majdi, Harman-Boehm, Ilana, Khazim, Khaled, Liberty, Idit, Minuchin, Oscar, Mosenzon, Ofri, Nakhoul, Farid, Nimer, Assy, Schwartz, Doron, Wainstein, Julio, Yagil, Yoram, Zukermann, Robert, Avogaro, Angelo, Battaglia, Giovanni Giorgio, Bevilacqua, Maurizio Tiziano, Bonora, Enzo, Bossi, Carlo Antonio, Calabrò, Paolo, Cavalot, Franco Luigi, Cimino, Roberto, Cozzolino, Mario Gennaro, David, Salvatore, Emdin, Michele, Fiaccadori, Enrico, Fiorina, Paolo, Giorda, Carlo Bruno, Gregorini, Maria Cristina, La Manna, Gaetano, Maggi, Davide Carlo, Manti, Roberta, Meregalli, Giancarla, Pani, Antonello, Parvanova, Aneliy Ilieva, Perico, Norberto, Piatti, PierMarco, Pisani, Antonio, Pontiroli, Antonio Ettore, Ponzani, Paola, Santorelli, Gennaro, Santoro, Domenico, Scanziani, Renzo, Teatini, Ugo, Tonolo, Giancarlo, Trevisan, Roberto, Veronelli, Anna Maria, Viviani, Giorgio Luciano, Araki, Hideo, Bando, Yukihiro, Ebisui, Osamu, Fujita, Naruhiro, Fukasawa, Hirotaka, Furuya, Ryuichi, Hamamoto, Yoshiyuki, Hamasaki, Akihiro, Hasegawa, Kotaro, Hatazaki, Masahiro, Hayashi, Terumasa, Higashi, Takayuki, Hirohata, Yoshihide, Horinouchi, Shuji, Hoshi, Ayumu, Imoto, Hirofumi, Inagaki, Akemi, Inagaki, Masayuki, Inaguma, Daijo, Inoue, Toshihiko, Ishii, Masao, Ishiko, Tamayo, Isono, Motohide, Jinnouchi, Hideaki, Kanai, Hidetoshi, Kanda, Daisuke, Kanehara, Hideo, Kashima, Masayuki, Kataoka, Yuko, Katayama, Shigehiro, Kato, Kiyoe, Katsuki, Takeshi, Kawamitsu, Katsunori, Kawasaki, Satsuki, Kikuchi, Fumi, Kikuchi, Hidetoshi, Kishimoto, Rui, Kobayashi, Kunihisa, Koide, Junko, Komi, Rieko, Kubota, Miyuki, Kuriya, Genpei, Kurose, Takeshi, Kusano, Yoshiro, Hajime, Maeda, Matsubayashi, Sunao, Matsumoto, Kazunari, Matsumura, Naoya, Matsuo, Yasuto, Matsuoka, Naoki, Miyaoka, Hiroaki, Miyata, Satoshi, Morita, Takeshi, Murakami, Isao, Murao, Satoshi, Nakamura, Udai, Nakayama, Mikihiro, Nakazawa, Jun, Nohara, Sakae, Nomiyama, Takashi, Noritake, Masayuki, Oda, Yoshiaki, Ogiwara, Takayuki, Ohashi, Hiroshi, Okamoto, Hideki, Okino, Shinichi, Osonoi, Takeshi, Sasaki, Nobuhiro, Sayo, Yoshitaka, Sekigami, Taiji, Shibasaki, Taro, Shibata, Hirotaka, Shimoyama, Tatsushi, Shinoda, Junji, Sobajima, Hiroshi, Sugitatsu, Kazuya, Sugiura, Toshiyuki, Sugiyama, Toru, Suzuki, Daisuke, Suzuki, Hiroyuki, Suzuki, Masaaki, Takeda, Asami, Tanaka, Asami, Tanaka, Seiichi, Tsunematsu, Izumi, Ueda, Yasuo, Uekihara, Soichi, Ujihara, Makoto, Yajima, Ken, Yamada, Daishiro, Yamada, Masayo, Yamagata, Kazuo, Yamakawa, Ken, Yamakawa, Fumiko, Yamasaki, Yoshimitsu, Yambe, Yuko, Yanagida, Taihei, Yanai, Hidekatsu, Yanase, Toshihiko, Yasuda, Tetsuyuki, Kriauciuniene, Dovile, Lasiene, Jurate, Navickas, Antanas, Radzeviciene, Lina, Urbanaviciene, Egle, Urbonas, Gediminas, Velaviciene, Audrone, Abd Ghani, Rohana, Aziz, Nor Azizah, Lee, Li Yuan, Loh, Chek Loong, Ali, Norhaliza Mohd, Noor, Nurain Mohd, Fatnoon Nik Ahmad, Nik Nur, Ratnasingam, Jeyakantha, Halimi Bin Wan Hasan, Wan Hasnul, Izani Wan Mohamed, Wan Mohd, Khir, Rizmy Najme, Mohamad, Masni, Alexander Tan, Tong Boon, Avila Pardo, Sandro, Adrian, Miriam Bastidas, Wong, Alfredo Chew, Escobedo de la Peña, Jorge, Salmón, Guillermo Fanghänel, Gálvez, Guillermo González, Ochoa, Ramiro Gutiérrez, Santana, Saúl Irizar, Rovalo, Magdalena Madero, Machado, Gustavo Méndez, Ruiz, Luis Nevarez, Ibarra, Denisse Ramos, López, Gabriel Ramos, Reyna, Leobardo Sauque, Ortiz, Gustavo Solache, Ortiz, Rafael Valdez, Mesa, Juan Villagordoa, Salazar, Melchor Alpizar, Hernández, Pedro García, González, José, Soto, José Lazcano, Mendoza, Arturo Saldaña, Santana, Sergio Irizar, Vilchis, Elvira González, Bakker, R.C., Barendregt, J.N.M., Boonstra, A.H., Bos, Willem, Brouwer, C.B., Buren, M. van, Gansevoort, Ron, Kooy, Adriaan, Krekels, Marielle, Leendert, Ruud J.M. van, Lieverse, Louis A.G., Luik, P.T., Penne, E. Lars, Gregoor, Peter Smak, Vogt, Liffert, Born, Bert-Jan van den, Baker, John, Crawford, Veronica, Cutfield, Rick, Dunn, Peter, Krebs, Jeremy, Nirmalaraj, Kingsley, Scott, Russell, Smuts, Nine, Titchener, Janet, Eriksen, Erik, Finnes, Trine, Høivik, Hans, Karlsson, Thomas, Munk, Peter Scott, Radtke, Maria, Risberg, Knut, Rocke, Jan, Solnør, Leidulv, Stenehjem, Aud-Eldrid, Tafjord, Anne-Beathe, Asprusten, Emil, Hagemeier, Robert, Høye, Kjetil, Selsås, Hilde, Thorup, Frode, Wium, Cecilie, Pamugas, Glenda, Panelo, Araceli, Perez, Ronald, Tanque, Maribel, Tirador, Louie, Villa, Michael, Bautista, Albert, Catindig, Elizabeth, Manalo, Carlo, Mirasol, Roberto, Butrymowicz, Patrycja, Ciechanowski, Kazimierz, Cieslik, Grazyna, Franek, Edward, Gumprecht, Janusz, Hoffmann, Michal, Krzykowska, Jolanta, Kurnatowska, Ilona, Landa, Katarzyna, Madrzejewski, Adam, Madziarska, Katarzyna, Mazur, Stanislaw, Napora, Piotr, Nowicki, Michal, Ocicka-Kozakiewicz, Anna, Rewerska, Barbara, Rusicka, Teresa, Ruxer, Jan, Skokowska, Ewa, Stankiewicz, Andrzej, Stompor, Tomasz, Tiuryn-Petrulewicz, Agnieszka, Wasilewska, Katarzyna, Wierusz-Wysocka, Bogna, Wnetrzak-Michalska, Renata, Jedynasty, Krystyna, Anand, Izabela Sein, Almeida, Edgar, Ballesteros, Rosa, Barreto, Carlos, Beirao, Idalina, Birne, Rita, Esteves, Cesar, Guia, Jose, Heitor, Susana, Marques, Olinda, Melo, Pedro, Nolasco, Fernando, Pereira, Amalia, Roque, Cristina, Rosario, Francisco, Silva, Gil, Silva, Ana, Teixeira e Costa, Fernando, Lobos, Ana Vila, Alves, Ana Rita, Brandao, Ilidio, Carvalho, Rui, Coelho, Joao, Lourenco, Ana, Matos, Pedro, Rosario, Vanisa, Neves, Joao Sergio, Cortes-Maisonet, Gregorio, Roman-Miranda, Amaury, Brito-Peguero, Yudit, Colon-Vega, Gildred, Albota, Adrian, Bala, Cornelia, Barbonta, Hortensia, Caceaune, Elena, Catrinoui, Doina, Constantin, Ciprian, Dumitrescu, Adriana, Mindrescu, Nicoleta, Mistode, Cristina, Negrisanu, Gabriela, Onaca, Adriana, Paveliu, Silvia, Pintilei, Ella, Pop, Lavinia, Popa, Amorin, Popescu, Alexandrina, Radulian, Gabriela, Szilagyi, Iosif, Turcu, Liana, Vacaru, Georgeta, Vlad, Adrian, Filimon, Adriana, Veresiu, Ioan, Antsiferov, Mikhail, Arkhipov, Mikhail, Babkin, Andrey, Barbarash, Olga, Baranov, Vitaliy, Chernyavskaya, Elena, Demko, Arkadiy, Dreval, Alexander, Edin, Anton, Ermakova, Polina, Fadeev, Valentin, Galyavich, Albert, Gaysina, Leyla, Gordeev, Ivan, Ipatko, Irina, Kalashnikova, Marina, Khalimov, Yuriy, Klimontov, Vadim, Kobalava, Zhanna, Kosmacheva, Elena, Koziolova, Natalya, Sergey Levashov, Lyudmila Kvitkova, Libis, Roman, Marasaev, Vyacheslav, Malykh, Natalia, Martynenko, Vladimir, Malyutina, Sofya, Merai, Imad, Mkrtumyan, Ashot, Nechaeva, Galina, Petunina, Nina, Palyutin, Shamil, Pimenov, Leonid, Rechkova, Elena, Rodionova, Tatyana, Rymar, Oksana, Sardinov, Ruslan, Semenova, Olga, Sherenkov, Alexander, Solovev, Oleg, Smolyarchuk, Elena, Strongin, Leonid, Ukhanova, Olga, Verlan, Nadezhda, Vorokhobina, Natalya, Yakhontov, Davyd, Yakushin, Sergey, Zakharova, Elena, Zalevskaya, Alsu, Zanozina, Olga, Zhdanova, Elena, Zhukova, Larisa, Zykova, Tatyana, Argunova, Yulia, Nikolaev, Konstantin, Villevalde, Svetlana, Fang Sum, Chee, Suhail, Sufi Muhummad, San Tan, Ru, Vathsala, Anantharaman, Wong, Edmund, Bee, Yong Mong, Babikova, Jana, Buganova, Ingrid, Dzupina, Andrej, Ochodnicka, Zuzana, Sosovec, Dalibor, Spodniakova, Denisa, Minarik, Peter, Ahmed, Fayzal, Amod, Aslam, Bhana, Sindeep, Distiller, Larry, Jansen van Rensburg, Dirkie, Joshi, Mukesh, Joshi, Shaifali, Lakha, Deepak, Mitha, Essack, Podgorski, Gracjan, Ranjith, Naresh, Rayner, Brian, Rheeder, Paul, Sarvan, Mohamed, Seeber, Mary, Siebert, Heidi, Tayob, Mohammed, Trokis, Julien, Urbach, Dorothea, van Zyl, Louis, Jansen van Rensburg, Dirkie, Choi, Bum-Soon, Choi, Moon Gi, Chung, ChoonHee, Hwang, YouCheol, Kim, ChongHwa, Kim, InJoo, Kim, JaeHyeon, Kim, SinGon, Kim, SungGyun, Kim, Tae Hee, Lee, WooJe, Lee, ByungWan, Lee, Kang Wook, Oh, Kook-Hwan, Oh, Ji Eun, Oh, Yun Kyu, Oh, Dong-Jin, Park, Junbeom, Shin, Seok Joon, Sung, Su-Ah, Yu, Jae Myung, Chung, HyeSoo, Huh, Ji Hye, Kang, JunGoo, Kim, ChulSik, Kim, HyeSoon, Kim, NamHoon, Lim, Soo, Cho, Young Min, Park, Cheol Young, Agraz, Irene, Ampudia, Francisco Javier, Bouarich, Hanane, Calero, Francesca, Castro, Cristina, Guldris, Secundino Cigarrán, Garrit, Josep Cruzado, de Álvaro, Fernando, Galcerán, Josep, Albarrán, Olga González, Jaras, Julio Hernández, Ibernón, Meritxell, Deben, Francisco Martínez, Ma, Esteban, Dolores Martínez, Pascual Izuel, José María, Martins, Judith, Mediavilla, Juan, Michán, Alfredo, Santos, Julio Pascual, Poch, Esteban, Rusillo, Manuel Polaina, Juan, Carlos Sánchez, Olmo, Rafael Santamaría, Segura de la Morena, José Julián, Soto, Alfonso, Troya, Maribel, Castro, Fernando Cereto, Fernández, Pablo Gómez, Sánchez, Laura Fuentes, Moya, Mercedes González, Marrero, Domingo Hernández, Maroto, Gonzalo Piedrola, Redón, Josep, Seron, Daniel, Bruchfeld, Annette, Curiac, Dan, Eliasson, Ken, Frank, Malin, Guron, Gregor, Hellberg, Olof, Hellgren, Margareta, Larnefeldt, Hans, Lindholm, Carl-Johan, Löndahl, Magnus, Rein-Hedin, Erik, Soveri, Inga, Spaak, Jonas, Tengmark, Bengt-Olov, Lif-Tiberg, Cornelia, Månflod, Johan, Nguyen, Han, Ackermann, Daniel, Bilz, Stefan, Burnier, Michel, Forster, Christian, Kalbermatter, Stefan, Kistler, Andreas, Pechère-Bertschi, Antoinette, Schultes, Bernd, Laimer, Markus, Rudofsky, Gottfried, Strey, Christopher, Wuerzner, Gregoire, Chang, Chiz-Tzung, Hung, Cheng-Chieh, Jiang, Ju-Ying, Lee, Chien-Te, Lin, Shuei-Liong, Tarng, Der-Cherng, Tu, Shih-Te, Wu, Mai-Szu, Wu, Ming-Ju, Chuang, Lee-Ming, Deerochanawong, Chaicharn, Kitiyakara, Chagriya, Ophascharoensuk, Vuddhidej, Pongchaiyakul, Chatlert, Satirapoj, Bancha, Kosachunhanan, Natapong, Sritara, Piyamitr, Eren, Necmi, Gul, Ibrahim, Gulel, Okan, Kocyigit, Ismail, Kumbasar, Abdulbaki, Sahin, Idris, Sari, Ramazan, Sayin, Burak, Tavli, Talat, Ustundag, Sedat, Yenicerioglu, Yavuz, Badak, Ozer, Cayli, Murat, Oguz, Aytekin, Ozdogan, Oner, Sari, Ibrahim, Temizhan, Ahmet, Tigen, Mustafa, Turk, Ugur, Yilmaz, Huseyin, Yilmaz, Mehmet, Bondarets, Iryna, Botsyurko, Volodymyr, Chernikova, Viktoriia, Donets, Oleksandra, Fushtey, Ivan, Grachova, Mariia, Isayeva, Anna, Kogut, Dmytro, Komisarenko, Julia, Kravchun, Nonna, Malyar, Kateryna, Mankovsky, Borys, Martynyuk, Liliya, Maslyanko, Vitaliy, Myshanych, Halyna, Pererva, Larysa, Pertseva, Nataliia, Serhiyenko, Oleksandr, Smirnov, Ivan, Sokolova, Liubov, Stryzhak, Vasyl, Vlasenko, Maryna, Isayeva, Ganna, Larin, Oleksandr, AbouSaleh, Ahmad, Barratt, Jonathan, Dang, Cuong, Kahal, Hassan, Kirk, Adam, Kilvert, Anne, Kon, Sui Phi, McCafferty, Kieran, Patel, Dipesh, Rice, Sam, Vijayaraman, Arutchelvam, Wong, Yuk-ki, Gibson, Martin, Wahba, Mona, Zaidi, Reza, Bilous, Rudy, Johnson, Andrew, Kalathil, Dhanya, Kilvert, Anne, Kyriakidou, Christina, Mathew, Amit, Mukhtar, Rasha, Munsoor, Imrozia, Poterajlo, Anton, Swift, Pauline, Acosta, Idalia, Adams, Atoya, Adler, Sharon, Ajani, Dilawar, Ali, Slamat, Alicic, Radica, Al-Karadsheh, Amer, Alla, Sreedhara, Allison, D., Andrawis, Nabil, Arif, Ahmed, Awad, Ahmed, Azizad, Masoud, Bahrami, Michael, Bansal, Shweta, Barag, Steven, Barakzoy, Ahmad, Barney, Mark, Barzilay, Joshua, Bashir, Khalid, Bautista, Jose, Beddhu, Srinivasan, Belo, Diogo, Benjamin, Sabrina, Berenji, Ramin, Bhargava, Anuj, Birriel, Jose, Brietzke, Stephen, Brosius, Frank, Brusco, Osvaldo, Burgner, Anna, Busch, Robert, Canadas, Rafael, Caramori, Maria, Cardona, Jose, Case, Christopher, Cruz, Humberto, Dandillaya, Ramprasad, Dawoud, Dalia, Din, Zia, Dixon, Bradley, Doshi, Ankur, Drakakis, James, El Shahawy, Mahfouz, El-Meanawy, Ashraf, El-Shahawy, Mohammed, Evans, John, Fadda, George, Farooq, Umar, Fernando, Roland, Fink, Raymond, First, Brian, Fitz-Patrick, David, Flack, John, Fluck, Patrick, Fogelfeld, Leon, Fonseca, Vivian, Frias, Juan, Galphin, Claude, Garcia-Mayol, Luis, Goldstein, Gary, Gonzalez, Edgar, Gonzalez-Abreu, Francisco, Gore, Ashwini, Grant, David, Habwe, Violet, Hamilton, Maxine, Hammoud, Jamal, Handelsman, Stuart, Hartman, Israel, Heigerick, Glenn, Henry, Andrew, Hernandez, German, Hernandez-Cassis, Carlos, Herrera, Carlos, Hertel, Joachim, Huang, Wenyu, Iglesias, Rogelio, Iranmanesh, Ali, Jackson, Timothy, Jain, Mahendra, Jamerson, Kenneth, Johnson, Karen, Judd, Eric, Kaplan, Joshua, Kayali, Zeid, Khan, Bobby, Khan, Muhammad, Kharait, Sourabh, Kirkman, M. Sue, Kopyt, Nelson, Kotzker, Wayne, Kovesdy, Csaba, Kreit, Camil, Krishna, Arvind, Kronfli, Saeed, Lee, Keung, LeJeune, Derek, Lemus, Brenda, Leon-Forero, Carlos, Linfert, Douglas, Lora, Henry, Lurie, Alexander, Maddukuri, Geetha, Magno, Alexander, Maletz, Louis, Mandayam, Sreedhar, Markell, Mariana, Mayfield, Ronald, Mbogua, Caroline, McMullen, Dierdre, Meisner, Carl, Minton, Stephen, Mocherla, Bharat, Mohandas, Rajesh, Montero, Manuel, Moustafa, Moustafa, Nadkarni, Salil, Nakhle, Samer, Navarro, Jesus, Neyra, Nilda, Nica, Romanita, Nicol, Philip, Norwood, Paul, Numrungroad, Visal, Donovan, Richard O′, Odugbesan, A., Paoli-Bruno, Jorge, Parikh, Samir, Patel, Rakesh, Peixoto, Aldo, Pergola, Pablo, Perlman, Alan, Pettis, Karlton, Pisoni, Roberto, Ponduchi, Mirela, Posada, Jorge, Prabhakar, Sharma, Radhakrishnan, Jai, Rahman, Mahboob, Raina, Rupesh, Rastogi, Anjay, Reisin, Efrain, Rendell, Marc, Robertson, David, Rocco, Michael, Romeu, Hugo, Rosas, Sylvia, Rosenfeld, Jack, Ross, Dennis, Rothman, Jeffrey, Rudolph, Lance, Ruhullah, Yusuf, Ruoff, Gary, Ryu, Jeffrey, Sahani, Mandeep, Sam, Ramin, Samuels, Garfield, Sanchez, William, Santos, Vladimir, Satko, Scott, Saxena, Sanjeev, Scott, David, Seco, Gilberto, Seek, Melvin, Serota, Harvey, Shafi, Tariq, Shahid, Nauman, Shanik, Michael, Sharma, Santosh, Sinha, Arjun, Smelser, James, Smith, Mark, Soe, Kyaw, Solomon, Richard, Soroka, Eugene, Soufer, Joseph, Spinowitz, Bruce, Spry, Leslie, Suarez, Rosa, Subramanian, Bala, Szerlip, Harold, Tamirisa, Aparna, Thomson, Stephen, Tran, Tuan-Huy, Treger, Richard, Trullenque, Gretel, Turk, Thomas, Umpierrez, Guillermo, Urbach, Daniel, Valdes, Martin, Valika, Shujauddin, Vega, Damaris, Weissman, Peter, Whaley-Connell, Adam, Winston, Jonathan, Wise, Jonathan, Wynne, Alan, Zeig, Steven, Abdel-Rahman, Emaad, Abreu, Edel, Awad, Alaa, Bahri, Nader, Bertsch, John, Bleich, David, Bornfreund, Jonathan, Brar, Harjeet, Brian, Susan, Brinson, Cynthia, Bruschetta, Humberto, Carpio, Jose, Cohen, Steven, Cosby, John, Dhanireddy, Soni, Diaz, Jorge, Dunn, Fredrick, Eppanapally, Sabitha, Fayad, Joseph, Goel, Archana, Govindaraju, Kanakadurga, Halpern, Stephen, Jones, Audrey, Kaye, William, Knight, Herbert, Koch, Stanley, Kohli, Nandini, Lastra, Guido, Lerman, Sam, Loredo, Jorge, Lovre, Dragana, Mandviwala, Mustafa, Martin, Earl, Meyer, Jill, Murray, John, Oliver, David, Oparil, Suzanne, Penabad, Jesus, Pereira, Isabel, Popeil, Larry, Quesada, Gonzalo, Ramanathan, Kodangudi, Ramos-Gonez, Luis, Rastegar, Mandana, Rastogi, Padmashri, Rondon, Juan, Roy-Chaudhury, Prabir, Smith, David, Williamson, Don, Womack, Catherine, Yamout, Hala, Yuryev, Michael, Chu, Phuong, Van Hoang, Lam, Khanh, Tran, Phi Nga, Nguyen Thi, Son, Pham Nguyen, Tran, Lan Phuong, Le, Thuy Khuong, Nguyen, Boi Ngoc, Nguyen, Thao, Nui, Nguyen Minh, Nam, Tran Quang, and Tran, Kim Chi

Published
2023
Full Text
View/download PDF

7. "WE'RE GOING TO BE WHERE NO ONE ELSE IS": In the wake of the devastation wrought by Hurricane Maria, journalists in Puerto Rico are doubling down on independent news organizations.

Author

PÉREZ SÁNCHEZ, LAURA N.

Subjects
*MASS media, *FINANCIAL crises, *NATURAL disasters, *POLITICAL stability
Abstract

The article focuses on the challenges and initiatives of independent media outlets in Puerto Rico. It highlights the difficulties faced by media organizations in Puerto Rico due to natural disasters, economic crises, and political instability. It further discusses the closure and subsequent digital relaunch of La Perla del Sur, a prominent independent newspaper in Ponce, Puerto Rico.

Published
2023

8. Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers

Author

Martín, Alberto, Epifano, Carolina, Vilaplana-Marti, Borja, Hernández, Iván, Macías, Rocío I. R., Martínez-Ramírez, Ángel, Cerezo, Ana, Cabezas-Sainz, Pablo, Garranzo-Asensio, Maria, Amarilla-Quintana, Sandra, Gómez-Domínguez, Déborah, Caleiras, Eduardo, Camps, Jordi, Gómez-López, Gonzalo, Gómez de Cedrón, Marta, Ramírez de Molina, Ana, Barderas, Rodrigo, Sánchez, Laura, Velasco-Miguel, Susana, and Pérez de Castro, Ignacio

Abstract

Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its immediate consequence, aneuploidy, trigger adverse effects on cellular homeostasis that need to be overcome by anti-stress mechanisms. As such, these safeguard responses represent a tumor-specific Achilles heel, since CIN and aneuploidy are rarely observed in normal cells. Recent data have revealed that epitranscriptomic marks catalyzed by RNA-modifying enzymes change under various stress insults. However, whether aneuploidy is associated with such RNA modifying pathways remains to be determined. Through an in silico search for aneuploidy biomarkers in cancer cells, we found TRMT61B, a mitochondrial RNA methyltransferase enzyme, to be associated with high levels of aneuploidy. Accordingly, TRMT61B protein levels are increased in tumor cell lines with an imbalanced karyotype as well as in different tumor types when compared to control tissues. Interestingly, while TRMT61B depletion induces senescence in melanoma cell lines with low levels of aneuploidy, it leads to apoptosis in cells with high levels. The therapeutic potential of these results was further validated by targeting TRMT61B in transwell and xenografts assays. We show that TRM61B depletion reduces the expression of several mitochondrial encoded proteins and limits mitochondrial function. Taken together, these results identify a new biomarker of aneuploidy in cancer cells that could potentially be used to selectively target highly aneuploid tumors.

Published
2023
Full Text
View/download PDF

9. SIRGAS reference frame analysis at DGFI–TUM

Author

Sánchez, Laura, Drewes, Hermann, Kehm, Alexander, and Seitz, Manuela

Abstract

The Deutsches Geodätisches Forschungsinstitut (DGFI) has been involved in the research activities of the Latin American Reference Frame SIRGAS since its establishment in 1993. DGFI coordinated the SIRGAS Global Positioning System campaigns of 1995 and 2000 and acted as an analysis centre of both campaigns contributing to the first two SIRGAS realisations known as SIRGAS95 and SIRGAS2000. In 1996, DGFI established the Regional Network Associate Analysis Centre for SIRGAS of the International GNSS (Global Navigation Satellite System) Service (IGS RNAAC SIRGAS) and took on responsibility for processing the SIRGAS continuously operating stations and generating weekly position solutions. Later followed the determination of cumulative (multi-year) solutions, consisting of station positions and constant velocities, providing accurate solutions for the SIRGAS reference frame. DGFI was integrated into the Technical University of Munich (TUM) in 2015, becoming DGFI–TUM, and based on the SIRGAS operational analyses, it continues investigating strategies to guarantee the reliability of the reference frame through time. This includes the estimation of the reference frame kinematics, evaluation, modelling, and reduction of seismic and post-seismic deformations on the reference frame, and modelling crustal kinematics in the SIRGAS region by continuous velocity models. This article summarises analysis strategies and science data products developed by DGFI–TUM as a SIRGAS analysis centre and as the IGS RNAAC SIRGAS. Special care is given to the determination of the most recent SIRGAS reference frame solution called SIRGAS2022, which is based on the second SIRGAS reprocessing campaign performed by DGFI–TUM to obtain homogeneously computed SIRGAS daily and weekly station position solutions referring to the IGS reference frame IGS14/IGb14 since January 2000.

Published
2022
Full Text
View/download PDF

11. MANNosylation of Mesoporous Silica Nanoparticles Modifies TLR4 Localization and NF‐κB Translocation in T24 Bladder Cancer Cells

Author

Hohagen, Mariam, Sánchez, Laura, Herbst, Ann‐Jacqueline, Kählig, Hanspeter, Shin, Jae Won, Berry, David, Del Favero, Giorgia, and Kleitz, Freddy

Abstract

D‐mannose is widely used as non‐antibiotic treatment for bacterial urinary tract infections. This application is based on a well‐studied mechanism of binding to the type 1 bacterial pili and, therefore, blocking bacteria adhesion to the uroepithelial cells. To implement D‐mannose into carrier systems, the mechanism of action of the sugar in the bladder environment is also relevant and requires investigation. Herein, two different MANNosylation strategies using mesoporous silica nanoparticles (MSNs) are described. The impact of different chemical linkers on bacterial adhesion and bladder cell response is studied via confocal microscopy imaging of the MSN interactions with the respective organisms. Cytotoxicity is assessed and the expression of Toll‐like receptor 4 (TLR4) and caveolin‐1 (CAV‐1), in the presence or absence of simulated infection with bacterial lipopolysaccharide (LPS), is evaluated using the human urinary bladder cancer cell line T24. Further, localisation of the transcription factor NF‐κB due to the MANNosylated materials is examined over time. The results show that MANNosylation modifies bacterial adhesion to the nanomaterials and significantly affects TLR4, caveolin‐1, and NF‐κB in bladder cells. These elements are essential components of the inflammatory cascade/pathogens response during urinary tract infections. These findings demonstrate that MANNosylation is a versatile tool to design hybrid nanocarriers for targeted biomedical applications. Upon MANNosylation of dendritic mesoporous silica nanoparticles (DMSNs), stimulation of TLR4 can be observed in T24 bladder cancer cells. DMSN‐phenyl‐mannose materials returned patterns resembling receptor‐mediated internalization via endocytosis. Treatment with DMSN‐NCO‐mannose results in evenly distributed signals. Incubation of these materials with fimbriated and non‐fimbriated bacteria shows only selective adhesion of DMSN‐NCO‐mannose with fimbriated bacteria, and no selective adhesion for DMSN‐phenyl‐mannose.

Published
2024
Full Text
View/download PDF

12. Lung transplantation from controlled donation after circulatory death using simultaneous abdominal normothermic regional perfusion: A single center experience

Author

Mora, Victor, Ballesteros, Maria Angeles, Naranjo, Sara, Sánchez, Laura, Suberviola, Borja, Iturbe, David, Cimadevilla, Bonifacio, Tello, Sandra, Alvarez, Carlos, and Miñambres, Eduardo

Abstract

Despite the benefits of abdominal normothermic regional perfusion (A-NRP) for abdominal grafts in controlled donation after circulatory death (cDCD), there is limited information on the effect of A-NRP on the quality of the cDCD lungs. We aimed to study the effect of A-NRP in lungs obtained from cDCD and its impact on recipients´ outcomes. This is a study comparing outcomes of lung transplants (LT) from cDCD donors (September 2014 to December 2021) obtained using A-NRP as the abdominal preservation method. As controls, all lung recipients transplanted from donors after brain death (DBD) were considered. The primary outcomes were lung recipient 3-month, 1-year, and 5-year survival. A total of 269 LT were performed (60 cDCD and 209 DBD). There was no difference in survival at 3 months (98.3% cDCD vs. 93.7% DBD), 1 year (90.9% vs. 87.2%), and 5 years (68.7% vs. 69%). LT from the cDCD group had a higher rate of primary graft dysfunction grade 3 at 72 h (10% vs. 3.4%; p <.001). This is the largest experience ever reported with the use of A-NRP combined with lung retrieval in cDCD donors. This combined method is safe for lung grafts presenting short-term survival outcomes equivalent to those transplanted through DBD.

Published
2022
Full Text
View/download PDF

14. Incidence of Kidney Replacement Therapy and Subsequent Outcomes Among Patients With Systemic Lupus Erythematosus: Findings From the ERA Registry

Author

Derner, Ondrej, Kramer, Anneke, Hruskova, Zdenka, Arici, Mustafa, Collart, Frederic, Finne, Patrik, Fuentes Sánchez, Laura, Harambat, Jérôme, Hemmelder, Marc H., Hommel, Kristine, Kerschbaum, Julia, De Meester, Johan, Palsson, Runolfur, Segelmark, Mårten, Skrunes, Rannveig, Traynor, Jamie P., Zurriaga, Oscar, Massy, Ziad A., Jager, Kitty J., Stel, Vianda S., and Tesar, Vladimir

Abstract

There is a dearth of data characterizing patients receiving kidney replacement therapy (KRT) for kidney failure due to systemic lupus erythematosus (SLE) and their clinical outcomes. The aim of this study was to describe trends in incidence and prevalence of KRT among these patients as well as to compare their outcomes versus those of patients treated with KRT for diseases other than SLE.

Published
2022
Full Text
View/download PDF

15. High-resolution regional gravity field modeling in data-challenging regions for the realization of geopotential-based height systems

Author

Liu, Qing, Schmidt, Michael, Sánchez, Laura, Moisés, Leidy, and Cortez, Diego

Abstract

Abstract: Modern height systems are based on the combination of satellite positioning and gravity field models of high resolution. However, in many regions, especially developing or newly industrializing countries, there is no (reliable) regional gravity model at all, due to challenges such as limited data availability, unknown/low data quality, and missing metadata. This paper addresses this issue in a case study of Colombia, where eight decades of historical terrestrial and airborne gravity measurements are available but widely contain systematic errors, outliers, and biases. Correspondingly, processing strategies and structures are proposed and applied to validate and improve the quality of old gravity datasets. A novel method is developed based on spherical radial basis functions (SRBFs) for estimating biases, which are found in different airborne surveys with values exceeding 40 mGal. The validity of this bias estimation method is demonstrated both by a simulation test and by the evaluation of the airborne data in comparison to the SATOP (SAtellite-TOPography) model, which merges the satellite-only global gravity model GOCO06s with the Earth2014 topography model. The terrestrial and airborne data are then combined with a global gravity model (GGM), ultra-high-resolution topography models, as well as altimetry-derived gravity anomalies from DTU21GRA for the offshore areas. The results are presented in terms of height anomalies (QGeoidCOL2023), and they are thoroughly validated using GPS/leveling data both in the absolute and relative manner. The standard deviation in comparison to the GPS/leveling data after applying a correction surface to account for the datum inconsistencies amounts to 15.76 cm, which is 27% smaller compared to the mean standard deviation value given by five recent high-resolution GGMs, and 36% smaller than the one delivered by the latest South American quasi-geoid model QGEOID2021. The relative validation results show that QGeoidCOL2023 performs better, i.e., delivers lower RMS errors than the GGMs and QGEOID2021 in all the baseline length groups. These results indicate the validity and benefits of the developed methods and procedures, which can be used for other data-challenging areas to facilitate the realization of geopotential-based height systems. Graphical Abstract:

Published
2024
Full Text
View/download PDF

16. Visualization Technologies for Learning and Teaching Veterinary Acarology and Entomology

Author

Vega-Garzón, Juan C., Robayo-Sánchez, Laura N., Cruz-Maldonado, Oscar A., and Cortés-Vecino, Jesús A.

Abstract

Educational technologies are tools and resources used for improving teaching, learning, and creative inquiry. Visualization technologies (VTs) fall within this category and comprise a high diversity of strategies from simple infographics to complex forms of visual data analysis. Traditionally, parasitology has been a challenging subject in medical and veterinary degree courses due to the high number of scientific names, morphological characters, and complex life cycles, among other factors. This has been reinforced by conventional teaching methods with limited innovation strategies. Here we present the design and evaluation of an interactive album of veterinary acarology and entomology, “Álbum Interactivo de Acarología y Entomología Veterinaria” (AIAEV). This tool was assessed through three strategies: (1) a mean grade comparison between veterinary parasitology classes before and after VT implementation, (2) a system usability scale (SUS), and (3) a student/user satisfaction index. The grade value was higher in the class after implementation, the SUS total score was 80.05 (excellent), and 93.75% considered it a useful tool. This is the first study aimed at investigating the use of VTs to teach veterinary acarology and entomology and shows promising results to develop and implement digital technologies in this and other veterinary curricula disciplines.

Published
2022
Full Text
View/download PDF

17. Mindfulness en la salud sexual y bienestar psicológico de profesionales y cuidadores/as de personas en riesgo de exclusión social

Author

Sánchez-Sánchez, Laura C. and Valderrama Rodríguez, María Fernanda

Abstract

El objetivo del estudio fue explorar el efecto del programa basado en mindfulness (MBSR) en la salud sexual y bienestar psicológico de profesionales y voluntarios de Médicos del Mundo que atienden personas en riesgo de exclusión social, como víctimas de prostitución forzada.

Published
2022
Full Text
View/download PDF

18. Association Between Urine Sediment Examination and Adverse Outcomes in Hospitalized Patients with AKI and Severe COVID-19

Author

Vasquez, Julio A. Vasquez, Martinez-Sanchez, Froylan David, Castro, Luis A. Bastida, Diaz-Jarquin, Alejandra, Vargas-Sánchez, Laura Viviana, Perez, Fidel Ivan Flores, Garza, Omhariany Medina, Hernández, Javier Andrés Meza, Zarza, Victor Manuel P., Moreno-Novales, Rafael, García, Juan Carlos G., Salinas-Ramirez, Mauricio A., Juarez, Joana B., and Tenorio-Aguirre, Erika K.

Published
2023
Full Text
View/download PDF

20. Anti-dsDNA Antibodies Increase the Cardiovascular Risk in Systemic Lupus Erythematosus Promoting a Distinctive Immune and Vascular Activation

Author

Patiño-Trives, Alejandra María, Pérez-Sánchez, Carlos, Pérez-Sánchez, Laura, Luque-Tévar, María, Ábalos-Aguilera, M. Carmen, Alcaide-Ruggiero, Lourdes, Arias-de la Rosa, Iván, Román-Rodríguez, Cristóbal, Seguí, Pedro, Espinosa, Mario, Font, Pilar, Barbarroja, Nuria, Escudero-Contreras, Alejandro, Antonio González-Reyes, José, Manuel Villalba, José, Collantes-Estévez, Eduardo, Aguirre-Zamorano, M. Ángeles, and López-Pedrera, Chary

Abstract

Supplemental Digital Content is available in the text.

Published
2021
Full Text
View/download PDF

21. Caracterización clínica, según niveles de glucemia, de pacientes hospitalizados por COVID-19: serie de casos.

Author

Stulin, Irene, de Oca, Maria Montes, Blanco, Gabriela, Sánchez, Laura, Silva, Isabel-Carlota, Quevedo, Jennireth, Arvelo, Maria Cristina, Valera, Nathalia, Papa, Irene, Bacci, Santiago, de Abreu, Fátima, Villarroel, Héctor, Carlos Catari, Juan, Luis Lopez, José, Moran, Brigitte, Cárdenas, Claudio, Santucci, Saverio, Luis Viloria, José, Gómez, Jerry, and Martinelli, Antonio

Published
2021
Full Text
View/download PDF

22. Protecting the soil is protecting the climate WASWAC and IUSS position paper on the inter linkages of soil and climate change

Author

Rubio, José L., Reyes-Sánchez, Laura B., Duihu, Ning, Costantini, Edoardo A.C., Horn, Rainer, and Zlatic, Miodrag

Abstract

•The anthropic climate change destabilizes the resilience of soil resources which simultaneously are important as climate regulators.•The potential of the soil as a climate regulator is an important option that has not yet been adequately developed in the fight against climate change.•History reveals that the conservation of soil and water resources has been crucial to the longevity of any civilization and has therefore shaped human history.•A radical change in the way we perceive and use soil resources is necessary to address climate change and preserve an enabling future for the new generations.

Published
2024
Full Text
View/download PDF

23. 4-Hydroxybenzoic Acid Rescues the Multisystemic Disease and Perinatal Lethality in a Mouse Model of Mitochondrial Disease

Author

Corral-Sarasa, Julia, Martínez-Gálvez, Juan Manuel, González-García, Pilar, Wendling, Olivia, Jiménez-Sánchez, Laura, López-Herrador, Sergio, Quinzii, Catarina M., Díaz-Casado, María Elena, and López, Luis C.

Abstract

Coenzyme Q (CoQ) deficiency syndrome is conventionally treated with limited efficacy using exogenous CoQ10. Poor outcome results from low absorption and bioavailability of CoQ10, and clinical heterogenicity of the disease. Here, we demonstrate that supplementation with 4-hydroxybenzoic acid (4HB), the precursor of the benzoquinone ring in the CoQ biosynthetic pathway, completely rescues the multisystemic disease and perinatal lethality in a mouse model of CoQ deficiency. 4HB stimulates endogenous CoQ biosynthesis in tissues of Coq2mutant mice, normalizing mitochondrial function and rescuing cardiac insufficiency, edema, and neurodevelopmental delay. In contrast, exogenous CoQ10supplementation falls short in fully restoring the phenotype. The treatment is translatable to human use, as proven by in vitrostudies in skin fibroblasts from patients with pathogenic variants in COQ2. The therapeutic approach extends to other disorders characterized by deficiencies in the production of 4HB, early steps of CoQ biosynthesis, and instances of secondary CoQ deficiency.

Published
2024
Full Text
View/download PDF

24. Concordancia interobservador e intraobservador en PET/TC [18F]DCFPyL según los criterios TNM molecular y PSMA-RADS 2.0

Author

Guerra-Gómez, Miriam, Rodríguez-Pajuelo, Ana, Brero-Sánchez, Laura, Cuenca-Cuenca, Juan Ignacio, Álvarez-Pérez, Rosa María, Freire-Macías, José María, and Jiménez-Hoyuela García, José Manuel

Abstract

El [18F]DCFPyL es un radiofármaco dirigido al antígeno prostático específico de membrana (PSMA) cada vez más extendido en la práctica clínica. El objetivo fue evaluar la concordancia entre tres médicos nucleares con distintos niveles de experiencia en estudios de PET-PSMA, según los criterios actualizados PSMA-RADS 2.0 y el TNM molecular.

Published
2024
Full Text
View/download PDF

26. Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells

Author

López-Sánchez, Laura M., Mena, Rafael, Guil-Luna, Silvia, Mantrana, Ana, Peñarando, Jon, Toledano-Fonseca, Marta, Conde, Francisco, De la Haba-Rodríguez, Juan R., Aranda, Enrique, and Rodríguez-Ariza, Antonio

Abstract

Cancer stem cells (CSCs) are involved in the resistance of estrogen (ER)-positive breast tumors against endocrine therapy. On the other hand, nitric oxide (NO) plays a relevant role in CSC biology, although there are no studies addressing how this important signaling molecule may contribute to resistance to antihormonal therapy in ER+breast cancer. Therefore, we explored whether targeting NO in ER+breast cancer cells impacts CSC subpopulation and sensitivity to hormonal therapy with tamoxifen. NO was targeted in ER+breast cancer cells by specific NO depletion and NOS2 silencing and mammosphere formation capacity, stem cell markers and tamoxifen sensitivity were analyzed. An orthotopic breast tumor model in mice was also performed to analyze the efficacy of NO-targeted therapy plus tamoxifen. Kaplan–Meier curves were made to analyze the association of NOS2 gene expression with survival of ER+breast cancer patients treated with tamoxifen. Our results show that targeting NO inhibited mamosphere formation, CSC markers expression and increased the antitumoral efficacy of tamoxifen in ER+breast cancer cells, whereas tamoxifen-resistant cells displayed higher expression levels of NOS2 and Notch-1 compared with parental cells. Notably, NO-targeted therapy plus tamoxifen was more effective than either treatment alone in an orthotopic breast tumor model in immunodeficient mice. Furthermore, low NOS2 expression was significantly associated with a higher metastasis-free survival in ER+breast cancer patients treated with tamoxifen. In conclusion, our data support that NO-targeted therapy in ER+breast cancer may contribute to increase the efficacy of antihormonal therapy avoiding the development of resistance to these treatments.

Published
2021
Full Text
View/download PDF

27. Transthyretin amyloidosis with cardiomyopathy after domino liver transplantation: Results of a cross‐sectional study

Author

Grande‐Trillo, Antonio, Baliellas, Carmen, Lladó, Laura, Casasnovas, Carlos, Franco‐Baux, Joaquín V., Gracia‐Sánchez, Laura, Gómez‐Bravo, Miguel Á., González‐Vilatarsana, Emma, Caballero‐Gullón, Luis, Echeverri, Eduardo, and González‐Costello, José

Abstract

Domino liver transplantation (DLT) has been used widely in patients with hereditary amyloid transthyretin (ATTR) amyloidosis. New‐onset polyneuropathy in recipients of DLT has been reported, but there are few cases of cardiac involvement reported. We aimed to perform a cross‐sectional study for ATTR amyloidosis with cardiomyopathy (ATTR‐CM) in DLT recipients. We evaluated 23 living DLT recipients a median of 9 years since DLT at 2 referral centers with a systematic cardiac evaluation, including bone scintigraphy. Median age was 72 years, 91% had hypertension, 35% had diabetes mellitus, 67% had chronic renal failure, and 8 patients (35%) developed new‐onset polyneuropathy. Only 13% had a normal electrocardiogram and a normal echocardiography, and most of them showed some conduction disturbance or increase in left ventricular wall thickness, but only 1 patient with a Glu89Lys mutation developed ATTR‐CM diagnosed by bone scintigraphy and endomyocardial biopsy. None of the recipients of a DLT with Val30Met mutation showed cardiac involvement by bone scintigraphy. In conclusion, DLT from Val30Met donors seems to be safe regarding the development of ATTR‐CM. Evaluation of cardiomyopathy in DLT recipients is challenging due to concomitant comorbidities and in this context, bone scintigraphy can be helpful to evaluate ATTR‐CM. Liver donors with non‐Val30Met mutations and cardiomyopathy may pose increased risk for domino liver recipients to develop cardiomyopathy from transthyretin amyloidosis after transplantation.

Published
2021
Full Text
View/download PDF

30. A novel de novo MTORgain-of-function variant in a patient with Smith-Kingsmore syndrome and Antiphospholipid syndrome

Author

Rodríguez-García, María Elena, Cotrina-Vinagre, Francisco Javier, Bellusci, Marcello, Martínez de Aragón, Ana, Hernández-Sánchez, Laura, Carnicero-Rodríguez, Patricia, Martín-Hernández, Elena, and Martínez-Azorín, Francisco

Abstract

We report the clinical, biochemical and genetic findings from a Spanish girl of Caucasian origin who presented with macrocephaly, dysmorphic facial features, developmental delay, hypotonia, combined oxidative phosphorylation (OxPhos) deficiency, epilepsy and anti-phospholipid antibodies (aPL). Whole-exome sequencing (WES) uncovered a heterozygous variant in the MTORgene (NM_004958.3: c.7235A>T: p.(Asp2412Val)) that encodes for the Serine/threonine-protein kinase mTOR. The substrates phosphorylation experiments demonstrated that this variant exerts its effect by gain-of-function (GOF) and autosomal dominant mechanism. GOF variants in this protein have been associated with Smith-Kingsmore syndrome (SKS), a rare autosomal dominant disorder characterized by intellectual disability, macrocephaly, seizure, developmental delay and dysmorphic facial features. Furthermore, the mTOR pathway has been demonstrated previously to be involved in many types of endothelium injuries including the antiphospholipid syndrome (APS), a systemic autoimmune disease characterized by the production of aPL with recurrent vascular thrombosis. Therefore, our patient is the first one with an mTOR variant and diagnosed with SKS and APS. In conclusion, our data expand both the genetic and phenotypic spectrum associated with MTORgene variants.

Published
2019
Full Text
View/download PDF

31. Reforma pensional: un análisis desde los derechos fundamentales y el principio de sostenibilidad financiera.

Author

Botero Díaz, Jorge Alberto, Cataño Correa, Carlos Arturo, Jurado Sánchez, Laura Victoria, and Garzón Castro, Rodrigo

Subjects
PENSION reform, PUBLIC spending, FINANCIAL institutions, CULTURAL adaptation
Abstract

Copyright of Nuevo Derecho is the property of Institucion Universitaria de Envigado, Faculta de Derecho y Ciencias Politicas y Juridicas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
Full Text
View/download PDF

32. Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma

Author

Vázquez-Domínguez, Irene, González-Sánchez, Laura, López-Nieva, Pilar, Fernández-Navarro, Pablo, Villa-Morales, María, Cobos-Fernández, María Á., Sastre, Isabel, F. Fraga, Mario, F. Fernández, Agustín, Malumbres, Marcos, Salazar-Roa, María, Graña-Castro, Osvaldo, Santos, Javier, Llamas, Pilar, López-Lorenzo, José L., and Fernández-Piqueras, José

Abstract

FBXW7is a driver gene in T-cell lymphoblastic neoplasia acting through proteasome degradation of key proto-oncogenes. FBXW7 encodes three isoforms, α, β and γ, which differ only in the N-terminus. In this work, massive sequencing revealed significant downregulation of FBXW7in a panel of primary T-cell lymphoblastic lymphomas characterised by the absence of mutations in its sequence. We observed that decreased expression mainly affected the FBXW7βisoform and to a lesser extent FBXW7αand may be attributed to the combined effect of epigenetic changes, alteration of upstream factors and upregulation of miRNAs. Transient transfections with miRNA mimics in selected cell lines resulted in a significant decrease of total FBXW7expression and its different isoforms separately, with the consequent increment of critical substrates and the stimulation of cell proliferation. Transient inhibition of endogenous miRNAs in a T-cell lymphoblastic-derived cell line (SUP-T1) was capable of reversing these proliferative effects. Finally, we show how FBXW7 isoforms display different roles within the cell. Simultaneous downregulation of the α and γ isoforms modulates the amount of CCNE1, whilst the β-isoform alone was found to have a prominent role in modulating the amount of c-MYC. Our data also revealed that downregulation of all isoforms is a sine qua noncondition to induce a proliferative pattern in our cell model system. Taking these data into account, potential new treatments to reverse downregulation of all or a specific FBXW7isoform may be an effective strategy to counteract the proliferative capacity of these tumour cells.

Published
2019
Full Text
View/download PDF

33. Gene selection and disease prediction from gene expression data using a two-stage hetero-associative memory

Author

Cleofas-Sánchez, Laura, Sánchez, J., and García, Vicente

Abstract

In general, gene expression microarrays consist of a vast number of genes and very few samples, which represents a critical challenge for disease prediction and diagnosis. This paper develops a two-stage algorithm that integrates feature selection and prediction by extending a type of hetero-associative neural networks. In the first level, the algorithm generates the associative memory, whereas the second level picks the most relevant genes. With the purpose of illustrating the applicability and efficiency of the method proposed here, we use four different gene expression microarray databases and compare their classification performance against that of other renowned classifiers built on the whole (original) feature (gene) space. The experimental results show that the two-stage hetero-associative memory is quite competitive with standard classification models regarding the overall accuracy, sensitivity and specificity. In addition, it also produces a significant decrease in computational efforts and an increase in the biological interpretability of microarrays because worthless (irrelevant and/or redundant) genes are discarded.

Published
2019
Full Text
View/download PDF

34. Camelids in the south of the Iberian Peninsula in Roman and medieval times. Osteological evidence from the city of Cordoba (Spain)

Author

Cantal, José Antonio Riquelme, Anguita, Juan Manuel Garrido, Huertas, Antonio Delgado, Sánchez, Laura Aparicio, Nieto, Eduardo Ruiz, Torres, Arsenio Granados, Gallegos, Laura Arenas, Expósito, Adrián Ruiz, Ruiz, Alejandro Beltrán, Ramírez, Rocío Ávila, and de la Cruz, José Clemente Martín

Abstract

•We have incorporated to the state of the art the new camelid findings in the Iberian Peninsula for the analyzed periods.•The osteometric results will help to understand the dimensions and robustness of camelids from Roman and medieval times in the Iberian Peninsula.•According to stable isotopes, some of the medieval specimens may have come from other geographical areas, perhaps North Africa.

Published
2023
Full Text
View/download PDF

35. Mastitis granulomatosa idiopática

Author

Delgado, Elena, Sánchez, Laura, Mejía, Elaine, Paño, José Ramón, Güemes, Antonio, and Gil, Ismael

Abstract

La mastitis granulomatosa idiopática (MGI) es una enfermedad mamaria benigna, infrecuente, de tipo inflamatorio y de causa desconocida. La MGI afecta con mayor frecuencia a mujeres jóvenes. Clínicamente se presenta como una masa periférica, unilateral e inflamatoria. El tratamiento óptimo es la terapia corticoidea, en ocasiones siendo necesaria la resección de tejido afecto.

Published
2020
Full Text
View/download PDF

37. Susceptibility of Zebrafish to Vesicular Stomatitis Virus Infection

Author

Guerra-Varela, Jorge, Baz-Martínez, Maite, Da Silva-Álvarez, Sabela, Losada, Ana Paula, Quiroga, María Isabel, Collado, Manuel, Rivas, Carmen, and Sánchez, Laura

Abstract

AbstractThe zebrafish, Danio rerio, has become recognized as a valuable model for infectious diseases. Here we evaluated the susceptibility of zebrafish to be infected with the mammalian vesicular stomatitis virus (VSV). Both zebrafish cells and embryos were highly susceptible to VSV infection. Mortalities exceeded 80% in infected embryos and were preceded by the invasion of the central nervous system by VSV. Live imaging of the infection with GFP-VSV as well as virus titration from infected fish confirmed the viral replication. Immunohistochemical analysis of embryonic fish provided evidence of viral antigens as well as of the apoptosis marker caspase-3 in the brain, eye, liver, pronephros, and skeletal muscle. So far, this is the first report describing the susceptibility of zebrafish to the mammalian virus VSV.

Published
2018
Full Text
View/download PDF

47. Efectos del condroitín sulfato sobre la respuesta cerebral a la estimulación dolorosa en pacientes con artrosis de rodilla. Estudio de resonancia magnética funcional aleatorizado, doble ciego y controlado con placebo

Author

Monfort, Jordi, Pujol, Jesús, Contreras-Rodríguez, Oren, Llorente-Onaindia, Jone, López-Solà, Marina, Blanco-Hinojo, Laura, Vergés, Josep, Herrero, Marta, Sánchez, Laura, Ortiz, Hector, Montañés, Francisco, Deus, Joan, and Benito, Pere

Abstract

La artrosis de rodilla es causa de dolor e incapacidad funcional. Uno de los problemas para evaluar la eficacia de los analgésicos ha sido la falta de medidas objetivas de dolor, aunque la resonancia magnética funcional (RMf) ha surgido como un medio útil para objetivar la respuesta del cerebro a la estimulación dolorosa. Hemos investigado el efecto del condroitín sulfato (CS) sobre la respuesta del cerebro a la estimulación dolorosa de la rodilla en pacientes con artrosis mediante RMf.

Published
2017
Full Text
View/download PDF

48. Dinuclear RuII(bipy)2Derivatives: Structural, Biological, and in Vivo Zebrafish Toxicity Evaluation

Author

Lenis-Rojas, Oscar A., Roma-Rodrigues, Catarina, Fernandes, Alexandra R., Marques, Fernanda, Pérez-Fernández, David, Guerra-Varela, Jorge, Sánchez, Laura, Vázquez-García, Digna, López-Torres, Margarita, Fernández, Alberto, and Fernández, Jesús J.

Abstract

Ruthenium-based drugs exhibit interesting properties as potential anticancer pharmaceuticals. We herein present the synthesis and characterization of a new family of ruthenium complexes with formulas [{Ru(bipy)2}2(μ-L)][CF3SO3]4(L = bptz, 1a) and [{Ru(bipy)2}2(μ-L)][CF3SO3]2(L = arphos, 2a; dppb, 3a; dppf, 4a), which were synthesized from the Ru(II) precursor compound cis-Ru(bipy)2Cl2. The complexes were characterized by elemental analysis, mass spectrometry, 1H and 31P{1H} NMR, IR spectroscopy, and conductivity measurements. The molecular structures for three Ru(II) compounds were determined by single-crystal X-ray diffraction. The newly developed compounds interact with CT-DNA by intercalation, in particular, 2a, 3a, and 4a, which also seemed to induce some extent of DNA degradation. This effect seemed to be related with the formation of reactive oxygen species. The cytotoxic activity was evaluated against A2780, MCF7, and MDAMB231 human tumor cells. Compounds 2aand 4awere the most cytotoxic with activity compared to cisplatin (∼2 μM, 72 h) in the A2780 cisplatin sensitive cells. All the compounds induced A2780 cell death by apoptosis, however, to a lesser extent for compounds 4aand 2a. For these compounds, the mechanism of cell death in addition to apoptosis seemed to involve autophagy. In vivo toxicity was evaluated using the zebrafish embryo model. LC50estimates varied from 5.397 (3a) to 39.404 (1a) mg/L. Considering the in vivo toxicity in zebrafish embryos and the in vitro cytotoxicity in cancer cells, compound 1aseems to be the safest having no effect on dechirionation and presenting a good antiproliferative activity against ovarian carcinoma cells.

Published
2017
Full Text
View/download PDF

50. Information and Communication Technologies Impact on Family Relationship

Author

Romero-Ruiz, Karin, Echeverri-Sánchez, Laura, Peña-Plata, Juan, Vásquez-Giraldo, Stephanía, Aguilera-Cardona, Milady, Herazo-Avendaño, Carolina, Valencia-Arias, Alejandro, and Bran-Piedrahita, Lemy

Abstract

ICT have influenced and modified economic, politic, social and cultural structures. The purpose of the study applied to sample of Medellin City is exploring how the use of ICT haven affected the family. ICT have enabled to a large flow of information that reinforces the nuclear family, but also have caused a detriment in their communication processes and family life. As a conclusion, It is pertinent to encourage further researches to evaluate the ICTs’ impact in the relation processes from a qualitative approach and through longitudinal studies, and exploring how new technologies have redefined the concepts of family life in modern societies.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results