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Start Over Author "S Zha" Publication Type Magazines
2 results on '"S Zha"'

1. The Cellular Pharmacokinetics of HIV Protease Inhibitors: Current Knowledge and Future Perspectives

Author

Zha, Weibin, S. Zha, Beth, Zhou, Fang, Zhou, Huiping, and Wang, Guangji

Abstract

HIV protease inhibitors (PIs) are the cornerstone of Highly Active Antiretroviral Therapy (HAART). Their antiretroviral potent is attributable to their pharmacokinetic properties. Yet, as the pharmacologic target of HIV PIs is localized within HIV-infected cells, cellular pharmacokinetic properties must also be determined to predict not only efficacy, but also toxicity. In this review, we review recent studies about cellular pharmacokinetics of current marketed HIV PIs, as well as the physicochemical properties of HIV PIs and their drug transporters and enzymes. Additionally, a summary of potential strategies for optimizing cellular pharmacokinetics of HIV PIs and initial ideas to study cellular pharmacokinetics is also discussed. Cellular pharmacokinetics of HIV PIs is an important budding field of research that will significantly influence efficacy and toxicity profiles of these essential drugs, and we hope our review will aid in fundamental knowledge for future research.

Published
2012

2. Mre11: roles in DNA repair beyond homologous recombination.

Author

Zha S, Boboila C, and Alt FW

Subjects
ATP-Binding Cassette Transporters genetics, ATP-Binding Cassette Transporters metabolism, Acid Anhydride Hydrolases, Animals, Ataxia Telangiectasia Mutated Proteins, Carrier Proteins genetics, Carrier Proteins metabolism, Cell Cycle Proteins genetics, Cell Cycle Proteins metabolism, DNA Repair Enzymes genetics, DNA-Binding Proteins genetics, Embryonic Stem Cells metabolism, Histones genetics, Histones metabolism, Humans, MRE11 Homologue Protein, Mice, Mice, Knockout, Models, Biological, Nuclear Proteins genetics, Nuclear Proteins metabolism, Protein Binding, Protein Serine-Threonine Kinases genetics, Protein Serine-Threonine Kinases metabolism, Recombination, Genetic, Tumor Suppressor Proteins genetics, Tumor Suppressor Proteins metabolism, DNA Repair, DNA Repair Enzymes metabolism, DNA-Binding Proteins metabolism
Published
2009
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