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5. Out of the box binding determines specificity of SH2 domain interaction.

Author

Müller S and Knapp S

Subjects
Binding Sites genetics, Mutation, Phosphotyrosine chemistry, Phosphotyrosine genetics, Protein Binding, Signal Transduction, Phosphotyrosine metabolism, src Homology Domains
Abstract

SH2 domains are phosphotyrosine specific interaction modules with largely overlapping sequence specificities. A recent structure by Bae et al. revealed that SH2 domain specificity can be mediated by secondary binding sites located outside the phosphotyrosine binding pocket.

Published
2009
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