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A recent study conducted at the All India Institute of Medical Sciences (AIIMS) in Assam, India, explored the use of diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping in diagnosing active sacroiliitis in patients with axial seronegative spondyloarthropathy (SpA). The study included 26 patients with active sacroiliitis and compared them to healthy controls. The researchers found that DWI MRI imaging with ADC value mapping was a sensitive diagnostic technique for detecting active sacroiliitis and assessing treatment response in patients with axial seronegative SpA. This research provides valuable insights into the diagnosis and management of this condition. [Extracted from the article]

A recent study conducted at the University Teaching Hospital in Ancona, Italy, highlights the challenges and advancements in imaging sacroiliac (SI) pain. The researchers emphasize the importance of accurate imaging techniques, such as magnetic resonance imaging (MRI) or computed tomography (CT), to supplement conventional radiography for an accurate diagnosis. The study discusses various conditions that can cause SI pain, including inflammation, degenerative changes, infections, and cancer. The researchers also provide insights into the distribution of lesions and strategies for selecting the best imaging modalities. This information can be valuable for healthcare professionals treating patients with suspected inflammatory back pain. [Extracted from the article]

A recent study conducted at King Abdulaziz University Hospital in Jeddah, Saudi Arabia, aimed to estimate the annual incidence of sacroiliitis, an inflammation of the sacroiliac joint that commonly presents as chronic back pain. The study analyzed patients' records of diagnostic imaging of the sacroiliac joint using magnetic resonance imaging (MRI), computed tomography, and X-ray. The results showed an annual incidence of sacroiliitis of 28.17%, with an increase to 36% in 2015. The study concluded that MRI was the most effective modality for diagnosis, although other modalities may be used depending on the preclinical probability. [Extracted from the article]

A study conducted at United Arab Emirates University in Al Ain has found a potential link between the acne medication isotretinoin and the development of sacroiliitis, a condition characterized by inflammation of the sacroiliac joints. The study presented two cases of patients who developed sacroiliitis after starting isotretinoin treatment. The precise mechanisms behind this association are not well understood, but it is believed to involve immunomodulation and the alteration of cytokine balance. Clinicians should be aware of this potential adverse effect when prescribing isotretinoin and monitor patients for musculoskeletal symptoms. Further research is needed to better understand the underlying pathways involved. [Extracted from the article]

Researchers from Tohoku Medical and Pharmaceutical University in Sendai, Japan, have published a case report on pyomyositis, a rare condition caused by non-typhoidal Salmonella bacteremia. The report describes the case of a 25-year-old man who was hospitalized with symptoms including fever, acute buttock pain, and difficulty moving. The patient was diagnosed with piriformis pyomyositis and pyogenic sacroiliitis, and was successfully treated with antimicrobial therapy. The researchers emphasize the importance of identifying the source of infection and closely examining the patient's background in cases of non-typhoidal Salmonella bacteremia. [Extracted from the article]

Researchers from the Rheumatology Department in Lisbon, Portugal have published a case report on VEXAS syndrome, an autoinflammatory syndrome caused by UBA1 mutations. The syndrome can mimic rheumatologic disorders, leading to delayed diagnosis. The researchers describe a case of atypical presentation resembling late-onset axial spondylarthritis, which later progressed to a systemic inflammatory syndrome. Treatment with the drug azacitidine showed activity in controlling inflammation and the mutant clone. The researchers discuss the potential relevance of molecular remission in VEXAS syndrome and emphasize the importance of a multidisciplinary team for the care of these complex patients. [Extracted from the article]

An 18-year-old woman developed sacroiliitis, a condition characterized by inflammation in the sacroiliac joints, while being treated with isotretinoin for acne. She experienced low back pain and difficulty walking, and was admitted to the hospital. It was discovered that she had been taking isotretinoin, and further tests confirmed the diagnosis of isotretinoin-induced sacroiliitis. Treatment with methylprednisolone and nonsteroidal anti-inflammatory drugs (NSAIDs) was initiated, and additional medications were added later on. The patient showed clinical improvement and follow-up imaging showed resolution of the sacroiliitis. [Extracted from the article]

An 18-year-old woman developed sacroiliitis, a condition characterized by inflammation of the sacroiliac joints, while being treated with isotretinoin for acne. She experienced low back pain and difficulty walking, and was admitted to the hospital. It was discovered that she had been receiving isotretinoin, and further tests confirmed the diagnosis of isotretinoin-induced sacroiliitis. Treatment with methylprednisolone was discontinued and she was started on cloxacillin, etoricoxib, and infliximab, which led to clinical improvement. Follow-up imaging showed resolution of the sacroiliitis after two months. [Extracted from the article]

A recent study conducted by researchers at New York University Grossman School of Medicine focuses on the epidemiology of sacroiliitis in inflammatory bowel disease (IBD). Sacroiliitis is a musculoskeletal manifestation of IBD that can lead to joint destruction and chronic pain if left untreated. The study suggests that sacroiliitis can be detected through abdominal imaging obtained in IBD patients, but only a small fraction of these patients were seen by rheumatologists. The researchers recommend early detection through clinical screening tools in IBD clinics and timely referral to rheumatologists for further evaluation and treatment. They also highlight the need for future studies to expand our understanding of IBD-associated sacroiliitis and identify novel targeted therapies for this condition. [Extracted from the article]

A recent study conducted in Istanbul, Turkey, evaluated the use of magnetic resonance imaging (MRI) with the Canadian Spondyloarthritis Research Consortium-Sacroiliac Inflammatory Scoring System (SPARCC-SIS) for diagnosing sacroiliitis in children. The study found that the SPARCC-SIS scoring system, which assesses inflammation in the sacroiliac joints, correlated with the clinical diagnosis of sacroiliitis. The most common MRI findings in children with sacroiliitis were bone marrow edema, capsulitis, synovitis, and erosion. The researchers concluded that MRI without contrast material can be used to diagnose and grade sacroiliitis in children, aiding clinicians in treatment decisions. [Extracted from the article]

A recent study conducted by researchers at Lebanese University explores the case of a twenty-one-year-old girl who was diagnosed with brucellosis, a zoonotic disease commonly found in Lebanon due to the consumption of raw meat and unpasteurized cheese. The patient's condition progressed to piriformis myositis with sacroiliitis, a rare complication of brucellosis, due to non-adherence to the prescribed antibiotic regimen. The researchers successfully treated the patient with a combination of intravenous gentamycin, rifampin, and doxycycline. The study highlights the need for suspicion of brucella-myositis in patients presenting with fever and back pain. [Extracted from the article]

A case report from Tallaght University Hospital in Dublin, Ireland, discusses a rare complication of acute appendicitis called sacroiliitis. The report describes the case of a 27-year-old male patient who developed sacroiliitis after undergoing laparoscopic appendectomy for acute appendicitis. The patient experienced severe right hip pain and lower back pain, and an MRI scan revealed infection around the right sacroiliac joint. Staphylococcus aureus was found in the patient's blood culture, and he was treated with intravenous antibiotics followed by oral antibiotics. The report emphasizes the importance of early diagnosis and appropriate treatment for reducing complications. [Extracted from the article]

A recent report from Yarmouk University in Jordan discusses the condition of sacroiliitis, which is inflammation of the sacroiliac joint and a common cause of lower back pain. The report highlights the various imaging techniques used to detect sacroiliitis, such as radiography, MRI, and CT scans. Treatment options range from conservative methods to invasive procedures, and recent advancements in artificial intelligence offer more precise detection of the condition through imaging. The researchers conducted a review of sacroiliitis using imaging data from sources like PubMed and Scopus, focusing on the radiological aspects of the condition. [Extracted from the article]

A recent study conducted at Sri Guru Ram Das University of Health Sciences in Punjab, India, aimed to investigate the magnetic resonance imaging (MRI) findings and inflammatory markers in inflammatory sacroiliitis. The study involved 30 patients with sacroiliitis who underwent an MRI of the sacroiliac joint. The researchers found that periarticular edema was the most common finding, with the iliac aspect being more commonly involved. The study also revealed that inflammatory laboratory parameters, such as erythrocyte sedimentation rate and C-reactive protein levels, were increased in higher grades of sacroiliitis. The researchers concluded that MRI can help grade sacroiliitis into mild, moderate, and severe, and that HLA-B27, although not specific to inflammatory sacroiliitis, increases in higher grades of the condition. [Extracted from the article]

Researchers at Inha University in South Korea have developed an artificial intelligence (AI) diagnostic model for sacroiliitis, an inflammatory condition of the sacroiliac joints that often causes lower back pain. The AI model was trained using radiological images and achieved high accuracy in detecting and grading sacroiliitis. The researchers believe that this model has the potential to improve diagnostic accuracy, optimize treatment plans, and enhance patient outcomes. The study included 492 patients and utilized the DenseNet121 algorithm, a convolutional neural network with 201 layers. [Extracted from the article]

A systematic review conducted by researchers from Daegu University in South Korea examined the performance of machine learning algorithms in discriminating sacroiliitis features on MRI scans. The researchers searched various databases for studies published between 2008 and June 2023 and found ten relevant studies. The studies reported varying performance indices, such as area under the curve, sensitivity, and specificity, which were comparable to those of human radiologists. However, the researchers noted issues such as small sample sizes, overfitting, and under-reporting, highlighting the need for further well-designed and transparent studies in this area. The full article can be accessed for free through the provided link. [Extracted from the article]

Researchers at Sungkyunkwan University School of Medicine in Seoul, South Korea, have developed an artificial intelligence (AI) model for detecting sacroiliitis, a condition associated with axial spondyloarthritis, using magnetic resonance imaging (MRI). The AI model utilizes two-stage framework, with one network extracting regions of interest (ROIs) to locate the sacroiliac joints and another network determining the presence of sacroiliitis in the localized ROIs. The model demonstrated improved performance when using maximum intensity projection (MIP) techniques and data augmentation. This AI model has the potential to aid in the wider clinical application of MRI for the detection of sacroiliitis. [Extracted from the article]

A recent study conducted at Health Science University has reported a case of a 36-year-old female patient with inflammatory sacroiliitis and a simple bone cyst in the iliac bone on the same side. Simple bone cysts are benign lytic bone lesions that can cause pathological fractures, and they are usually asymptomatic. The prevalence of simple bone cysts in the whole body is reported to be 0.30/100000, with only 2% of these cysts found in the pelvis. This case is believed to be the first instance of an iliac simple bone cyst coexisting with sacroiliitis on the same side. For more information, the full study can be accessed through the Hitit Medical Journal. [Extracted from the article]

A recent study from Fukushima Medical University School of Medicine in Japan has reported on a case of colchicine-resistant sacroiliitis in a Japanese patient with Familial Mediterranean Fever (FMF). FMF is a hereditary autoinflammatory disease characterized by acute monoarthritis with pain and hydrarthrosis. The patient in this case study had FMF-related axial joint involvement and experienced symptoms despite ongoing colchicine treatment. Canakinumab treatment was ultimately successful in resolving the sacroiliitis symptoms. This research provides valuable insights into the management of FMF-associated axial joint involvement. [Extracted from the article]

Conversely, Magnetic Resonance Imaging (MRI) is the preferred technique for detecting bone marrow edema, although it is a complex process requiring extensive expertise. Keywords: Diagnostics; Health and Medicine EN Diagnostics Health and Medicine 5108 5108 1 08/21/23 20230825 NES 230825 2023 AUG 25 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on diagnostics. Keywords for this news article include: University Hospital Heraklion, Heraklion, Greece, Europe, Diagnostics, Health and Medicine. [Extracted from the article]

A total of 46 symptomatic patients were found to have MRI-proven sacroiliitis of 3 different etiologies: juvenile idiopathic arthritis (JIA) (n = 17), familial Mediterranean fever (FMF) (n = 14), and chronic nonbacterial osteomyelitis (CNO) (n = 8). Keywords: Health and Medicine; Inflammation; Pediatrics EN Health and Medicine Inflammation Pediatrics 26 26 1 08/07/23 20230812 NES 230812 2023 AUG 12 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Current study results on agriculture have been published. [Extracted from the article]

For more information on this research see: Automatic Image Segmentation and Grading Diagnosis of Sacroiliitis Associated With As Using a Deep Convolutional Neural Network On Ct Images. Keywords: Zhuhai; People's Republic of China; Asia; Ankylosing Spondylitis; Convolutional Network; Diagnostics and Screening; Emerging Technologies; Health and Medicine; Machine Learning; Musculoskeletal Diseases and Conditions; Networks; Neural Networks EN Zhuhai People's Republic of China Asia Ankylosing Spondylitis Convolutional Network Diagnostics and Screening Emerging Technologies Health and Medicine Machine Learning Musculoskeletal Diseases and Conditions Networks Neural Networks 3127 3127 1 07/03/23 20230707 NES 230707 2023 JUL 7 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Investigators publish new report on Musculoskeletal Diseases and Conditions - Ankylosing Spondylitis. [Extracted from the article]

Arthritis, Familial Mediterranean Fever, Health and Medicine, Hereditary Autoinflammatory Diseases and Conditions, Joint Diseases and Conditions, Musculoskeletal Diseases and Conditions Keywords: Arthritis; Familial Mediterranean Fever; Health and Medicine; Hereditary Autoinflammatory Diseases and Conditions; Joint Diseases and Conditions; Musculoskeletal Diseases and Conditions EN Arthritis Familial Mediterranean Fever Health and Medicine Hereditary Autoinflammatory Diseases and Conditions Joint Diseases and Conditions Musculoskeletal Diseases and Conditions 6363 6363 1 06/19/23 20230623 NES 230623 2023 JUN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in familial mediterranean fever. [Extracted from the article]

Keywords: Health and Medicine; Histopathology; Life Sciences; Physiology EN Health and Medicine Histopathology Life Sciences Physiology 3510 3510 1 05/29/23 20230602 NES 230602 2023 JUN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- New study results on physiology have been published. Health and Medicine, Histopathology, Life Sciences, Physiology. [Extracted from the article]

Adana, Turkey, Eurasia, Bone Diseases and Conditions, Bone Research, Bone Resorption, Drugs and Therapies, Genetics, Health and Medicine, Musculoskeletal Diseases and Conditions, Osteolysis, Pediatrics Keywords: Adana; Turkey; Eurasia; Bone Diseases and Conditions; Bone Research; Bone Resorption; Drugs and Therapies; Genetics; Health and Medicine; Musculoskeletal Diseases and Conditions; Osteolysis; Pediatrics EN Adana Turkey Eurasia Bone Diseases and Conditions Bone Research Bone Resorption Drugs and Therapies Genetics Health and Medicine Musculoskeletal Diseases and Conditions Osteolysis Pediatrics 62 62 1 05/08/23 20230512 NES 230512 2023 MAY 13 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Musculoskeletal Diseases and Conditions - Osteolysis is the subject of a report. [Extracted from the article]

Keywords: Antimetabolites; Antineoplastics; Antipsoriatics; Antirheumatics; Arthritis; Autoimmune Diseases and Conditions; Diet and Nutrition; Drugs and Therapies; Health and Medicine; Joint Diseases and Conditions; Methotrexate Therapy; Musculoskeletal Diseases and Conditions; Pharmaceuticals; Psoriatic Arthritis; Rheumatology; Vitamin D; Vitamins EN Antimetabolites Antineoplastics Antipsoriatics Antirheumatics Arthritis Autoimmune Diseases and Conditions Diet and Nutrition Drugs and Therapies Health and Medicine Joint Diseases and Conditions Methotrexate Therapy Musculoskeletal Diseases and Conditions Pharmaceuticals Psoriatic Arthritis Rheumatology Vitamin D Vitamins 1333 1333 1 04/10/23 20230410 NES 230410 2023 APR 10 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- A new study on psoriatic arthritis is now available. Antimetabolites, Antineoplastics, Antipsoriatics, Antirheumatics, Arthritis, Autoimmune Diseases and Conditions, Diet and Nutrition, Drugs and Therapies, Health and Medicine, Joint Diseases and Conditions, Methotrexate Therapy, Musculoskeletal Diseases and Conditions, Pharmaceuticals, Psoriatic Arthritis, Rheumatology, Vitamin D, Vitamins. [Extracted from the article]

Drugs and Therapies, Enterobacteriaceae, Epidemiology, Gammaproteobacteria, Gram-Negative Bacteria, Gram-Negative Facultatively Anaerobic Rods, Proteobacteria, Salmonella Keywords: Drugs and Therapies; Enterobacteriaceae; Epidemiology; Gammaproteobacteria; Gram-Negative Bacteria; Gram-Negative Facultatively Anaerobic Rods; Proteobacteria; Salmonella EN Drugs and Therapies Enterobacteriaceae Epidemiology Gammaproteobacteria Gram-Negative Bacteria Gram-Negative Facultatively Anaerobic Rods Proteobacteria Salmonella 872 872 1 04/03/23 20230407 NES 230407 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Fresh data on salmonella are presented in a new report. [Extracted from the article]

Sacroiliitis was detected in 54.8% of ERA patients, 2.3% of FMF patients, and 12.5% of IBD patients. Keywords: Ankara; Turkey; Eurasia; Diagnostics and Screening; Digestive System Diseases and Conditions; Health and Medicine; Inflammatory Bowel Disease; Pediatrics EN Ankara Turkey Eurasia Diagnostics and Screening Digestive System Diseases and Conditions Health and Medicine Inflammatory Bowel Disease Pediatrics 2023 MAR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Digestive System Diseases and Conditions - Inflammatory Bowel Disease is the subject of a report. [Extracted from the article]

Based on the investigations, he was diagnosed with sacroiliitis secondary to isotretinoin. B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 30-year-old man developed sacroiliitis during treatment with isotretinoin for acne vulgaris (AV) [ I duration of treatment i I to reaction onset not stated i ]. Oral isotretinoin and sacroiliitis: causal link or coincidence?. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event A 77-year-old woman developed disseminated I Mycobacterium tuberculosis i and I Enterococcal sacroiliitis i during immunosuppressive treatment with prednisone [ I route, dosage and duration of treatment to reactions onsets not stated i ]. The woman had a history of hypertension and rheumatoid arthritis and was on chronic prednisone therapy for rheumatoid arthritis. [Extracted from the article]

For patients who develop inflammatory back pain (IBP) while receiving isotretinoin for acne vulgaris, many have MRI-proven sacroiliitis, according to study results reported in I Clinical Rheumatology i , although the MRI findings completely resolve after isotretinoin discontinuation. Patients with IBP were assessed for C-reactive protein (CRP), and underwent plain radiographs and MRI of the sacroiliac joints. MRI identified sacroiliitis in 52 patients, which was bilateral in 37 patients. [Extracted from the article]

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event In a study, four boys aged 15-17 years were described, who developed sacroiliitis while receiving treatment with isotretinoin for nodulocystic acne. All the boys received treatment with sulfasalazine and indomethacin; two were responsive to sulfasalazine and indomethacin treatment, while the other two were unresponsive to sulfasalazine and indomethacin treatment. [Extracted from the article]

A 40-year-old man developed pulmonary tuberculosis and tuberculous sacroiliitis while receiving immunosupressive therapy with azathioprine, cyclophosphamide, prednisone and mycophenolate-mofetil for microscopic polyangiitis [ I dosages and routes not stated i ]. Chest radiograph revealed bilateral apical tuberculosis, direct microscopic examination of sputum was positive for tuberculosis. One month later, his sputum resulted negative for acid-fast bacilli, but his right buttock pain worsened and a fluctuant mass appeared. [Extracted from the article]

B Author comment: b I "Isotretinoin can be used in the treatment of HS; however, it may paradoxically lead to skin lesions or worsen the existing lesions. Isotretinoin, which is commonly used in the treatment of severe acne, is associated with several side effects, including rheumatic side effects and rarely sacroiliiti""Herein, we report two cases who received isotretinoin for acne vulgaris and developed bilateral sacroiliitis and HS lesions.". [Extracted from the article]