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Pharmacokinetics induced by drug eluting stents (DES) in coronary walls is modeled by means of a one-dimensional multi-layered model, accounting for vessel curvature and non-homogeneous properties of the arterial tissues. The model includes diffusion mechanisms, advection effects related to plasma filtration through the walls, and bio-chemical drug reactions. A non-classical Sturm–Liouville problem with discontinuous coefficients is derived, whose closed-form analytical solution is obtained via an eigenfunction expansion. Soundness and consistency of the proposed approach are shown by numerical computations based on possible clinical treatments involving both hydrophilic and hydrophobic drugs. The influence of the main model parameters on drug delivery mechanisms is analyzed, highlighting the effects induced by vessel curvature and yielding comparative indications and useful insights into the concurring mechanisms governing the pharmacokinetics. [ABSTRACT FROM AUTHOR]

For flood protection against storm tides, barriers of box-like gates hinged along a bottom axis have been designed to span the three inlets of the Venice Lagoon. While on calm days the gates are ballasted to rest horizontally on the seabed, in stormy weather they are raised by buoyancy to act as a dam which is expected to swing to and fro in unison in response to the normally incident sea waves. Previous laboratory experiments with sinusoidal waves have revealed however that neighbouring gates oscillate out of phase, at one half the wave frequency, in a variety of ways, and hence would reduce the effectiveness of the barrier. Extending the linear theory of trapped waves by Mei et al. (1994), we present here a nonlinear theory for subharmonic resonance of mobile gates allowed to oscillate about a vertical plane of symmetry. In this part (1) the evolution equation of the Landau–Stuart type is first derived for the gate amplitude. The effects of gate geometries on the coefficients in the equation are examined. After accounting for dissipation effects semi-empirically the theoretical results on the equilibrium amplitude excited by uniform incident waves are compared with laboratory experiments.

In order to examine the effects of finite bandwidth of the incident sea spectrum on the resonance of the articulated storm gates for Venice Lagoon, we consider a narrow band consisting of the carrier frequency and two sidebands. The evolution equation for the gate oscillations now has a time-periodic coefficient, and is equivalent to a non-autonomous dynamical system. For small damping and weak forcing, approximate analysis for local and global bifurcations are carried out, and extended by direct numerical simulation. Typical bifurcation scenarios are also examined by laboratory experiments.