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An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion. In addition, our fusion system is cytocompatible and has potential applications in biomedical research. Stress makes them bigger: An artificial fusion system was developed in which triazole ceramide was generated at the surface of a liposome membrane through the action of Cu+. The stressed vesicle underwent membrane fusion. The results suggest that curvature inversion alone might be a sufficient driving force for membrane fusion.

•A deep learning method proposed for denoising and droplets detection from light scatterd images.•Performance assessment of standard CNN, modified ResNet, and modified U-Net architectures.•Modified U-Net architecture outperformed for denoising light-scattered spray image.•Potential for real-time processing of the experimental data using the deep neural networks.

Highly concise asymmetric total syntheses of (+)‐tetrabenazine (1), a drug for the treatment of chorea associated with Huntington’s disease, and of (+)‐α‐dihydrotetrabenazine (2), an active metabolite of 1, have been accomplished. Our synthetic route features a trans‐selective enol etherification, followed by an unprecedented cation‐dependent aza‐Claisen rearrangement to establish the carbon framework and two stereogenic centers of tetrabenazine. The syntheses consist of seven steps (34 % overall yield) for (+)‐2and eight steps (22 % overall yield) for (+)‐1.

The method applies naphthylethylamine as chiral auxiliary and amine source.

A detailed study on previously briefly published results is presented.

Tetrabenazine (I) is applied in racemic form as drug for the treatment of chorea associated with Huntington′s disease.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.